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Vol. 42. Num. 8.November 2018
Pages e19-e22Pages 461-516
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Vol. 42. Num. 8.November 2018
Pages e19-e22Pages 461-516
Review
DOI: 10.1016/j.medine.2018.08.003
Alternative statistical methods and their application to research in intensive care setting
Métodos estadísticos alternativos y su aplicación a la investigación en Cuidados Intensivos
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A. Gutiérrez-Pizarrayaa,
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boticariors@gmail.com

Corresponding author.
, E. García-Cabrerab, E. Álvarez-Márqueza
a Unidad Clínica de Cuidados Intensivos, Hospital Universitario Virgen Macarena, Sevilla, Spain
b Delos Clinical, Sevilla, Spain
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Abstract

In nested case-control studies, sampling of controls is usually done by density of incidence and pairing. With regard to the classic control cases studies, nested ones are more efficient, allow the calculation of the incidence of the disease and they have more internal validity due to the lower presence of bias. Competitive risks techniques can be used if we study different types of events and focus on the time and type of the first event. Recursive partitioning is a type of multivariate analysis whose purpose is the construction of classification algorithms, and it is especially useful when there are a large number of predictive variables with complex relationships with the event.

Keywords:
Hybrid design
Nested case-control
Competitive events
Recursive partitions
Resumen

En los estudios de casos y controles anidados, el muestreo de los controles se hace habitualmente por densidad de incidencia y mediante emparejamiento. Con respecto a los casos control clásicos, son más eficientes, permiten el cálculo de la incidencia de la enfermedad y cuentan con más validez interna por la menor presencia de sesgo. Las técnicas de riesgos competitivos pueden usarse si se estudian diferentes tipos de eventos y nos centramos en el tiempo y el tipo del primer evento. El particionamiento recursivo es un tipo de análisis multivariante cuyo propósito es la construcción de algoritmos de clasificación, especialmente útiles cuando hay un gran número de variables predictoras con relaciones complejas con el evento objeto de estudio.

Palabras clave:
Diseño híbrido
Caso-control anidado
Eventos competitivos
Particiones recursivas

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