TY - JOUR T1 - Risk factors and outcomes of severe acute respiratory failure requiring invasive mechanical ventilation in cancer patients: A retrospective cohort study JO - Medicina Intensiva (English Edition) T2 - AU - Martos-Benítez,F.D. AU - Gutiérrez-Noyola,A. AU - Badal,M. AU - Dietrich,N.A. SN - 02105691 M3 - 10.1016/j.medin.2017.08.004 DO - 10.1016/j.medin.2017.08.004 UR - https://medintensiva.org/es-risk-factors-outcomes-severe-acute-articulo-S0210569117302267 AB - ObjectivesTo determine the risk factors for severe acute respiratory failure requiring invasive mechanical ventilation (SARF-MV) and its effect upon clinical outcomes in critically ill cancer patients. DesignA retrospective cohort study was carried out. SettingA 12-bed oncological intensive care unit (ICU) from January 2014 to December 2015. PatientsA total of 878 consecutive cancer patients were included. Patients with an ICU stay of ≤1 day were excluded. The final sample size was 691 patients. InterventionsNone. VariablesClinical variables at ICU admission were extracted from the medical records. The primary outcome was SARF-MV. We also measured ICU and hospital mortality, as well as length of stay. ResultsThe SARF-MV rate was 15.8%. The multivariate analysis identified brain tumour (OR 14.54; 95%CI 3.86–54.77; p<0.0001), stage IV cancer (OR 3.47; 95%CI 1.26–9.54; p=0.016), sepsis upon admission (OR 2.28; 95%CI 1.14–4.56; p=0.020) and an APACHE II score≥20 points (OR 5.38; 95%CI 1.92–15.05; p=0.001) as being independently associated to SARF-MV. Compared with the patients without SARF-MV, those with SARF-MV had a prolonged length of ICU stay (p<0.0001), a lower ICU survival rate (p<0.0001) and a lower hospital survival rate (p<0.0001). ConclusionsA number of clinical factors are related to SARF-MV. In this regard, SARF-MV is a powerful factor independently correlated to poor outcomes. Future studies should investigate means for preventing SARF-MV in critically ill cancer patients, which may have an impact upon outcomes. ER -