TY - JOUR T1 - Mechanical ventilation in acute respiratory distress syndrome: The open lung revisited JO - Medicina Intensiva T2 - AU - Amado-Rodríguez,L. AU - del Busto,C. AU - García-Prieto,E. AU - Albaiceta,G.M. SN - 02105691 M3 - 10.1016/j.medin.2016.12.012 DO - 10.1016/j.medin.2016.12.012 UR - https://medintensiva.org/es-mechanical-ventilation-in-acute-respiratory-articulo-S0210569117300281 AB - Acute respiratory distress syndrome (ARDS) is still related to high mortality and morbidity rates. Most patients with ARDS will require ventilatory support. This treatment has a direct impact upon patient outcome and is associated to major side effects. In this regard, ventilator-associated lung injury (VALI) is the main concern when this technique is used. The ultimate mechanisms of VALI and its management are under constant evolution. The present review describes the classical mechanisms of VALI and how they have evolved with recent findings from physiopathological and clinical studies, with the aim of analyzing the clinical implications derived from them. Lastly, a series of knowledge-based recommendations are proposed that can be helpful for the ventilator assisted management of ARDS at the patient bedside. ER -