TY - JOUR T1 - Impact of a modification of the clinical practice guide of the American Academy of Pediatrics in the management of severe acute bronchiolitis in a pediatric intensive care unit JO - Medicina Intensiva (English Edition) T2 - AU - Guitart,C. AU - Alejandre,C. AU - Torrús,I. AU - Balaguer,M. AU - Esteban,E. AU - Cambra,F.J. AU - Jordan,I. SN - 21735727 M3 - 10.1016/j.medine.2019.10.008 DO - 10.1016/j.medine.2019.10.008 UR - https://medintensiva.org/en-impact-modification-clinical-practice-guide-articulo-S217357272030076X AB - ObjectiveTo describe the characteristics and evolution of patients with bronchiolitis admitted to a pediatric intensive care unit, and compare treatment pre- and post-publication of the American Academy of Pediatrics clinical practice guide. DesignA descriptive and observational study was carried out between September 2010 and September 2017. SettingPediatric intensive care unit. PatientsInfants under one year of age with severe bronchiolitis. InterventionsTwo periods were compared (2010–14 and 2015–17), corresponding to before and after modification of the American Academy of Pediatrics guidelines for the management of bronchiolitis in hospital. Main variablesPatient sex, age, comorbidities, severity, etiology, administered treatment, bacterial infections, respiratory and inotropic support, length of stay and mortality. ResultsA total of 706 patients were enrolled, of which 414 (58.6%) males, with a median age of 47 days (IQR 25–100.25). Median bronchiolitis severity score (BROSJOD) upon admission: 9 points (IQR 7–11). Respiratory syncytial virus appeared in 460 (65.16%) patients. The first period (2010–14) included 340 patients and the second period (2015–17) 366 patients. More adrenalin and hypertonic saline nebulizations and more corticosteroid treatment were administered in the second period. More noninvasive ventilation and less conventional mechanical ventilation were used, and less inotropic support was needed, with no significant differences. The antibiotherapy rate decreased significantly (p=0.003). ConclusionsDespite the decrease in antibiotherapy, the use of nebulizations and glucocorticoids in these patients should be limited, as recommended by the guide. ER -