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Vol. 50. Núm. 9.
(Septiembre 2026)
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Vol. 50. Núm. 9.
(Septiembre 2026)
Original article

The place of the TAPSE/PASP in the diagnosis of right heart dysfunction in critically ill patients

El lugar del TAPSE/PASP en el diagnóstico de la disfunción ventricular derecha en pacientes críticamente enfermos
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Emine Ünal Cerana,
Autor para correspondencia
unallemine@yahoo.com

Corresponding author.
, Gül Gürselb, Osman Tamer Şahinc, Merve Tatlılıoğlub, Serra Duygulub
a Gazi University School of Medicine Department of Anaesthesiology, Division of Critical Care Medicine, Turkey
b Gazi University School of Medicine Department of Pulmonary Disease Division of Critical Care Medicine, Turkey
c Gazi University School of Medicine Department of Internal Medicine, Division of Critical Care Medicine, Turkey
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Abstract
Objective

ICU patients with cardiac and chronic respiratory failure (CRF) often experience increased right heart load, necessitating reliable parameters to assess right heart dysfunction (RHD). This study evaluates the right ventriculo-pulmonary artery (RV-PA) uncoupling ratio’s (TAPSE/PASP’s) diagnostic role for RHD in ICU setting.

Design

Single-center retrospective observational cohort study.

Patients

One hundred and thirty-three adult ICU patients from a tertiary hospital.

Interventions

None.

Main variables of interest

Echocardiographic and clinical data were analyzed. Patients were stratified by TAPSE/PASP tertiles (<0.30, 0.30–0.50, >0.50). TAPSE/PASP was compared with other RHD parameters. ROC curve analysis, decision curve analysis, net reclassification index and integrated discrimination improvement analysis were used to evaluate its diagnostic accuracy and place in clinical decision for treatment.

Results

Lower TAPSE/PASP ratios correlated with enlarged right and left cardiac chambers, reduced left and right ventricular outflow tract velocity time integrals, stroke volume, cardiac output, and ejection fraction. TAPSE/PASP outperformed other RHD parameters in reflecting biventricular structural and functional changes, diagnosing more cases. Based on predefined echocardiographic criteria (TAPSE < 16 mm or RV-FAC < 35%), ROC analysis identified an optimal TAPSE/PASP cutoff of 0.48 mm/mmHg (AUC = 0.702, 95% CI: [0.579−0.825], P < .05)). Decision curve analysis demonstrated that using the TAPSE/PASP ratio provides a consistently higher net benefit across a clinically relevant range of threshold probabilities (approximately 10%–40%) compared to using TAPSE alone.

Conclusion

TAPSE/PASP effectively assesses RV-PA uncoupling and RHD in medical ICU patients. While the ratio does not offer superior diagnostic accuracy, it provides additional clinical decision support for treatment decisions compared to TAPSE alone.

Keywords:
Critical care
Respiratory failure
TAPSE/PASP
Pulmonary hypertension
Right heart failure
Intensive care unit
Resumen
Objetivo

Los pacientes de UCI con insuficiencia cardíaca y enfermedad respiratoria crónica (ERC) suelen presentar un aumento de la carga del corazón derecho, lo que hace necesario contar con parámetros fiables para evaluar la disfunción del corazón derecho (DCD). Este estudio evalúa el papel diagnóstico de la razón de desacoplamiento ventrículo derecho–arteria pulmonar (VD-AP) (TAPSE/PASP) para la DCD en el entorno de cuidados intensivos.

Diseño

Estudio de cohorte observacional retrospectivo de un solo centro.

Pacientes

133 pacientes adultos ingresados en la UCI de un hospital terciario.

Intervenciones

Ninguna.

Variables principales de interés

Se analizaron datos ecocardiográficos y clínicos. Los pacientes se estratificaron por tertiles de TAPSE/PASP (<0,30; 0,30–0,50; >0,50). TAPSE/PASP se comparó con otros parámetros de DCD. Se emplearon análisis de curvas ROC, análisis de curvas de decisión, índice de reclasificación neta y análisis de mejora de la discriminación integrada para evaluar su precisión diagnóstica y su utilidad en la toma de decisiones clínicas.

Resultados

Las razones más bajas de TAPSE/PASP se correlacionaron con dilatación de las cavidades cardíacas derechas e izquierdas, reducción de los integrales velocidad–tiempo en los tractos de salida ventriculares izquierdo y derecho, volumen sistólico, gasto cardíaco y fracción de eyección. TAPSE/PASP superó a otros parámetros de DCD al reflejar los cambios estructurales y funcionales biventriculares, diagnosticando un mayor número de casos. Según los criterios ecocardiográficos predefinidos (TAPSE < 16 mm o FAC-VD < 35%), el análisis ROC identificó un punto de corte óptimo de TAPSE/PASP de 0,48 mm/mmHg (AUC = 0,702; IC 95%: 0,579–0,825; P < ,05). El análisis de curvas de decisión mostró que el uso del cociente TAPSE/PASP proporciona un beneficio neto consistentemente mayor en un rango clínicamente relevante de probabilidades umbral (aproximadamente 10–40%) en comparación con el uso de TAPSE solo.

Conclusiónes

TAPSE/PASP evalúa de manera efectiva el desacoplamiento VD-AP y la DCD en pacientes de UCI médica. Aunque el cociente no ofrece una precisión diagnóstica superior, proporciona un apoyo adicional en la toma de decisiones clínicas terapéuticas en comparación con la TAPSE por sí sola.

Palabras clave:
Cuidados críticos
Insuficiencia respiratoria
TAPSE/PASP
Hipertensión pulmonar
Insuficiencia cardiaca derecha
Unidad de cuidados intensivos

Artículo

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