A retrospective analysis of possible renal toxicity associated with vancomycin in patients with health care-associated methicillin-resistant Staphylococcus aureus pneumonia
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2023, International Journal of Antimicrobial AgentsEffect of renal clearance on vancomycin area under the concentration–time curve deviations in critically ill patients
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2021, Journal of Global Antimicrobial ResistanceCost–benefit analysis comparing trough, two-level AUC and Bayesian AUC dosing for vancomycin
2021, Clinical Microbiology and InfectionCitation Excerpt :Older guidelines recommended the use of single trough samples (hence referred to simply as ‘troughs’) for vancomycin dosing [1]. However, using single trough samples as a means for targeting a therapeutic range of 15–20 mg/L is associated with increased rates of nephrotoxicity while minimally improving outcomes [2–5]. Subsequently, troughs were shown to be poorly predictive of AUC [6].
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