Case report
Extracorporeal Membrane Oxygenation as a Bridge to Emergency Heart-Lung Transplantation in a Patient With Idiopathic Pulmonary Arterial Hypertension

https://doi.org/10.1016/j.healun.2008.01.016Get rights and content

Lung transplantation with or without cardiac transplantation offers the only hope of long-term, symptom-free survival for patients with advanced idiopathic pulmonary arterial hypertension. We describe a patient who underwent an emergency pulmonary embolectomy. During surgery, it was discovered that the patient had idiopathic pulmonary arterial hypertension. After the patient was weaned from cardiopulmonary bypass, pulmonary hypertension caused right-sided heart failure, and a right ventricular assist device was inserted to compensate. Because of profound bleeding from the endotracheal tube, the patient was placed on extracorporeal membrane oxygenation in the hope of bridging the patient to heart–lung transplantation. Extracorporeal membrane oxygenation was required for 10 days until a donor heart and lung became available. The patient recovered from the transplant operation and was discharged home 76 days later.

Section snippets

Case Report

In June 2005, a 21-year-old woman was admitted to a hospital in another state because she had been experiencing progressive exertional dyspnea for 6 months. Transthoracic echocardiography revealed pulmonary artery pressures of 75 mm Hg and normal left ventricular systolic and diastolic function. A complete workup did not reveal the secondary causes of her pulmonary hypertension.

The patient was subsequently transferred to our institution for further care. On admission, her blood pressure was

Comment

The patient described here had cardiopulmonary failure due to chronic elevation of pulmonary artery pressures. Tissue plasminogen activator was administered, followed by an attempted embolectomy because of the presumed pulmonary embolus in the pulmonary artery. Although we used TEE pre-operatively and intraoperatively, the utility of TEE as a diagnostic test for pulmonary embolism is limited,1, 2 and the patient’s condition was too unstable to permit further confirmatory tests such as spiral

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