Elsevier

JACC: Heart Failure

Volume 8, Issue 11, November 2020, Pages 903-913
JACC: Heart Failure

Mini-Focus: Heart Failure and Cardiogenic Shock
Clinical Research
Complete Hemodynamic Profiling With Pulmonary Artery Catheters in Cardiogenic Shock Is Associated With Lower In-Hospital Mortality

https://doi.org/10.1016/j.jchf.2020.08.012Get rights and content
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Abstract

Objectives

The purpose of this study was to investigate the association between obtaining hemodynamic data from early pulmonary artery catheter (PAC) placement and outcomes in cardiogenic shock (CS).

Background

Although PACs are used to guide CS management decisions, evidence supporting their optimal use in CS is lacking.

Methods

The Cardiogenic Shock Working Group (CSWG) collected retrospective data in CS patients from 8 tertiary care institutions from 2016 to 2019. Patients were divided by Society for Cardiovascular Angiography and Interventions (SCAI) stages and outcomes analyzed by the PAC-use group (no PAC data, incomplete PAC data, complete PAC data) prior to initiating mechanical circulatory support (MCS).

Results

Of 1,414 patients with CS analyzed, 1,025 (72.5%) were male, and 494 (34.9%) presented with myocardial infarction; 758 (53.6%) were in SCAI Stage D shock, and 263 (18.6%) were in Stage C shock. Temporary MCS devices were used in 1,190 (84%) of those in advanced CS stages. PAC data were not obtained in 216 patients (18%) prior to MCS, whereas 598 patients (42%) had complete hemodynamic data. Mortality differed significantly between PAC-use groups within the overall cohort (p < 0.001), and each SCAI Stage subcohort (Stage C: p = 0.03; Stage D: p = 0.05; Stage E: p = 0.02). The complete PAC assessment group had the lowest in-hospital mortality than the other groups across all SCAI stages. Having no PAC assessment was associated with higher in-hospital mortality than complete PAC assessment in the overall cohort (adjusted odds ratio: 1.57; 95% confidence interval: 1.06 to 2.33).

Conclusions

The CSWG is a large multicenter registry representing real-world patients with CS in the contemporary MCS era. Use of complete PAC-derived hemodynamic data prior to MCS initiation is associated with improved survival from CS.

Key Words

cardiogenic shock
hemodynamics
mechanical circulatory support
pulmonary artery catheter

Abbreviations and acronyms

AMI
acute myocardial infarction
CO
cardiac output
CS
cardiogenic shock
DHF
decompensated heart failure
ECMO
extracorporeal membrane oxygenation
IABP
intra-aortic balloon pump
MCS
mechanical circulatory support
PAC
pulmonary artery catheter
PCWP
pulmonary capillary wedge pressure
RAP
right atrial pressure
SCAI
Society for Cardiovascular Angiography and Interventions

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The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Heart Failure author instructions page.

Drs. Garan and Kanwar contributed equally to the manuscript.