Trauma/Critical CareCentrifugal pumps and hemolysis in pediatric extracorporeal membrane oxygenation (ECMO) patients: An analysis of Extracorporeal Life Support Organization (ELSO) registry data
Section snippets
Methods
Data for this study were obtained from the ELSO registry. This registry is a voluntary database to which 160 member institutions from across the world report data. Multiple data elements are captured in the registry, including patient demographics, clinical parameters (before and during ECMO), circuit configuration (including pump type), complications, and survival to decannulation and to discharge. A data set of all ECMO runs for patients 18 years and younger between 2010 and 2015 was extracted
Results
15,111 patients aged birth to 18 years underwent 15,903 cannulations reported to ELSO between 2010 and 2015. Of these, 14,776 ECMO runs for 14,026 patients had pump type recorded. For the multivariate analysis we included only the 13,941 runs that had data recorded for all of the parameters of interest. 27 different pump types were used; with 60.4% of ECMO runs performed using centrifugal pumps, and 39.6% using roller pumps. 54.8% of the ECMO runs were on male and 44.3% were on female patients.
Discussion
In this study, the authors review data from the ELSO database to determine whether or not there is an association between pump type (centrifugal versus roller) and occurrence of hemolysis in pediatric patients. The ELSO database is a large registry that includes voluntarily-entered data from patients treated at ELSO-member organizations in the US and abroad. The size and scope of the data set would support the idea that generalizable conclusions may be drawn from it. This study demonstrates a
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