se ha leído el artículo
array:23 [ "pii" => "S021056910079601X" "issn" => "02105691" "doi" => "10.1016/S0210-5691(00)79601-X" "estado" => "S300" "fechaPublicacion" => "2000-08-01" "aid" => "79601" "copyright" => "Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L." "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Med Intensiva. 2000;24:267-74" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 8904 "formatos" => array:3 [ "EPUB" => 160 "HTML" => 1271 "PDF" => 7473 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210569100796021" "issn" => "02105691" "doi" => "10.1016/S0210-5691(00)79602-1" "estado" => "S300" "fechaPublicacion" => "2000-08-01" "aid" => "79602" "copyright" => "Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Intensiva. 2000;24:275-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2797 "formatos" => array:3 [ "EPUB" => 152 "HTML" => 1098 "PDF" => 1547 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Shock anafiláctico e infarto de miocardio por rotura espontánea de quiste hidatídico" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "275" "paginaFinal" => "277" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Anaphilactic Shock and Myocardial Infarction Due to Spontaneous Rupture of Hydatid Cyst" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "V.E. Merlo GonzáLez,, F. Árbol Linde, C. Contreras Rosino, P. LóPez Onega" "autores" => array:4 [ 0 => array:2 [ "nombre" => "V.E." "apellidos" => "Merlo GonzáLez," ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Árbol Linde" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Contreras Rosino" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "LóPez Onega" ] ] ] 1 => array:2 [ "autoresLista" => "F. Marcos Sánchez, F. Santomé Argibay" "autores" => array:2 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Marcos Sánchez" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Santomé Argibay" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796021?idApp=WMIE" "url" => "/02105691/0000002400000006/v1_201304241157/S0210569100796021/v1_201304241157/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210569100796008" "issn" => "02105691" "doi" => "10.1016/S0210-5691(00)79600-8" "estado" => "S300" "fechaPublicacion" => "2000-08-01" "aid" => "79600" "copyright" => "Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Med Intensiva. 2000;24:264-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1980 "formatos" => array:3 [ "EPUB" => 126 "HTML" => 954 "PDF" => 900 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Enfermedad cerebrovascular aguda y los servicios de Cuidados Críticos y Urgencias en Andalucía. La experiencia del grupo EVASCAN" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "264" "paginaFinal" => "266" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Grupo Evascan" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Grupo" "apellidos" => "Evascan" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796008?idApp=WMIE" "url" => "/02105691/0000002400000006/v1_201304241157/S0210569100796008/v1_201304241157/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Nuevos fibrinolíticos para el tratamiento del infarto agudo de miocardio" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "267" "paginaFinal" => "274" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "P. Jiménez Gómez, J.M. Gulias López, S. Calvo Barros, M.J. Castro Orjales, P. Rascado Sedes" "autores" => array:5 [ 0 => array:3 [ "nombre" => "P. Jiménez" "apellidos" => "Gómez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "J.M. Gulias" "apellidos" => "López" ] 2 => array:2 [ "nombre" => "S. Calvo" "apellidos" => "Barros" ] 3 => array:2 [ "nombre" => "M.J. Castro" "apellidos" => "Orjales" ] 4 => array:2 [ "nombre" => "P. Rascado" "apellidos" => "Sedes" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad Coronaria. Servicio de Medicina Intensiva. Área del Corazón. Hospital Juan Canalejo. A. Coruña" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Dr. P. Jiménez Gómez. Unidad Coronaria. Servicio de Medicina Intensiva. Hospital Juan Canalejo. Carretera de las Jubias de arriba, 84. 15006 A Coruña" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Novel Fibrinolytics for Treatment of Acute Myocardial Infarction" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2000-02-17" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82343" "palabras" => array:2 [ 0 => "fibrinolíticos" 1 => "infarto agudo de miocardio" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec82344" "palabras" => array:2 [ 0 => "Fibrinolytic agents" 1 => "acute myocardial infarction" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El tratamiento fibrinolítico ha mejorado significativamente el pronóstico de los pacientes con infarto agudo de miocardio. Pero esta estrategia terapéutica tiene limitaciones importantes como son: la escasa utilización, no conseguir óptima reperfusión en todos los pacientes y las complicaciones sobre todo hemorrágicas que en ocasiones pueden ser graves</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se están investigando fármacos que eviten o disminuyan estos problemas, que actúen más rápidamente, sean más fáciles de administrar, lo que facilitaría el uso prehospitalario, y que tengan más capacidad lítica y menores complicaciones hemorrágicas</p>" ] "en" => array:1 [ "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The fibrinolytic agents have improved significantly the prognosis of patients with acute myocardial infarction, but this therapy has significant limitations like: they remain underutilized, do not get an optimal reperfusion in all patients and they can cause complications, mainly bleeding, sometimes serious</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">There are under investigation newer drugs to prevent or decrease these problems, drugs that work faster and that are of easier administration. These new drugs would allow a prehospital use and they would have a greater lytic power and less bleedding complications</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:46 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.A. De Wood" 1 => "J. Spores" 2 => "R. Notske" 3 => "L.T. Mouser" 4 => "R. Burroughs" 5 => "M.S. Golden" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198010163031601" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1980" "volumen" => "303" "paginaInicial" => "897" "paginaFinal" => "901" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7412821" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Initial experience with transluminal recanalization of recenly occluded infarct-related coronary artery in acute myocardial infarction comparison with conventinally treated patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.T. Rentrop" 1 => "H. Blanke" 2 => "K.R. Karsch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cardiol" "fecha" => "1979" "volumen" => "2" "paginaInicial" => "92" "paginaFinal" => "105" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/162452" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Gruppo Italiano per lo Studio della Streptochinasi nell’Infarto Miocárdico (GISSI). Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1986" "volumen" => "1" "paginaInicial" => "397" "paginaFinal" => "402" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2563564" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Second International Study of Infact Survival (ISIS-2). Randomised trial of intravenous streptikinase oral aspirin, both or neither among 17.187 cases of suspected acute myocardial infarction" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1988" "volumen" => "2" "paginaInicial" => "349" "paginaFinal" => "360" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2569551" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "The GUSTO Investigators. An International Randomized Trial Comparing Four Thrombolytic Strategies for Acute Myocardial Infarction" ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199309023291001" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1993" "volumen" => "329" "paginaInicial" => "673" "paginaFinal" => "682" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8204123" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "The GUSTO angiographic Investigators.The Effects of Tissue Plasminogen Activator, Streptokinase, or Both on Coronary-Artery Patency, Ventricular function, and Survival after Acute Myocardial Infarction" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1993" "volumen" => "329" "paginaInicial" => "1.650" "paginaFinal" => "1.652" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8247085" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular biology of plasminogen activators: what are the clinical implications of drug design?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Smalling" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1996" "volumen" => "78" "numero" => "suppl 12 A" "paginaInicial" => "2" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8990404" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Fibrinolytic Therapy Trialists (FTT) Colaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortalitymajor morbidity results from all randomised trials of more than 1000 patients" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "The lancet" "fecha" => "1994" "volumen" => "343" "paginaInicial" => "311" "paginaFinal" => "322" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Variabilidad en el manejo y pronóstico a corto y medio plazo del infarto de miocardio en España: el estudio PRIAMHO" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Cabadés" 1 => "L. López-Bescós" 2 => "F. Arós" 3 => "A. Loma-Osorio" 4 => "X. Bosch" 5 => "P. Pabón" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Cardiol" "fecha" => "1999" "volumen" => "52" "paginaInicial" => "767" "paginaFinal" => "775" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10563151" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Análisis de los retrasos en el tratamiento del síndrome coronario agudo. Datos del registro ARIAM" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "E. Aguayo" 1 => "A. Reina" 2 => "M. Colmenero" 3 => "M. Barranco" 4 => "M. Pola" 5 => "M. Jiménez" 6 => "grupo ARIAM" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Intensiva" "fecha" => "1999" "volumen" => "23" "paginaInicial" => "280" "paginaFinal" => "287" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optimización del tratamiento trombolítico en el infarto agudo de miocardio: papel de los nuevos fármacos fibrinoselectivos y de la asociación con los nuevos antitrombóticos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Siches" 1 => "X. Bosch" 2 => "A. Betriu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Cardiol" "fecha" => "1998" "volumen" => "51" "paginaInicial" => "178" "paginaFinal" => "191" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9577163" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biochemical and pharmacologic comparison of thrombolytic agents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K. Stringer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Pharmacotherapy" "fecha" => "1996" "volumen" => "16" "numero" => "5 pt 2" "paginaInicial" => "1.195" "paginaFinal" => "1.265" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8947994" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thrombolytic agents – an overview" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Gulba" 1 => "C. Bode" 2 => "M. Runge" 3 => "K. Huber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Ann Hematol" "fecha" => "1996" "volumen" => "73" "numero" => "Suppl I" "paginaInicial" => "S9" "paginaFinal" => "S27" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8853112" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reteplase a review of its pharmacological properties and clinical efficacy in the management of acute myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Noble" 1 => "D. Mc Tavish" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Drugs" "fecha" => "1996" "volumen" => "42" "paginaInicial" => "589" "paginaFinal" => "605" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of thrombolytic drugs in the management of myocardial infarction. Comparative clinical trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "W. Weaver" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur Heart J" "fecha" => "1996" "volumen" => "17" "numero" => "Suppl F" "paginaInicial" => "9" "paginaFinal" => "15" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8960443" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacological and clinical impact of the unique molecular structure of a new plasminogen activator" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Smalling" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur Heart J" "fecha" => "1997" "volumen" => "18" "numero" => "Suppl F" "paginaInicial" => "F11" "paginaFinal" => "F16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9447335" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "More Rapid, complete and stable coronary thrombolysis with bolus administration of reteplase compared with alteplase infusion in acute myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "R. Smalling" 1 => "C. Bode" 2 => "J. Kalbfleisch" 3 => "S. Sen" 4 => "P. Limbourg" 5 => "F. Forycki" 6 => "the Rapid investigators" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Circulation" "fecha" => "1995" "volumen" => "91" "paginaInicial" => "2.725" "paginaFinal" => "2.732" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7796512" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0002939409000968" "estado" => "S300" "issn" => "00029394" ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized comparison of coronary thrombolytisis achieved with double-bolus reteplase (recombinant plasminogen activator) in patients with acute myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "C. Bode" 1 => "R. Smalling" 2 => "G. Berg" 3 => "C. Burnett" 4 => "G. Lorch" 5 => "J. Kalbfleisch" 6 => "the RAPID II investigators" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1996" "volumen" => "94" "paginaInicial" => "891" "paginaFinal" => "898" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8790022" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "International Joint Efficacy Comparison of thrombolytics. Randomised, double-blind comparison of reteplase double-bolus administration with streptokinase in acute myocardial infarction (INJECT): trial to investigate equivalence" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1995" "volumen" => "346" "paginaInicial" => "329" "paginaFinal" => "336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7623530" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "The GUSTO III Investigators. A comparison of Reteplase with Alteplase for acute myocardial infarction" ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199710023371404" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1997" "volumen" => "337" "paginaInicial" => "1.118" "paginaFinal" => "1.123" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9395430" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of reteplase and alteplase on platelet aggregation and mayor receptor expression during the first 24 hours of acute myocardial infarction treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Gurbel" 1 => "V. Serebruany" 2 => "A. Shustov" 3 => "R. Bahr" 4 => "C. Carpo" 5 => "E. Ohman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "1998" "volumen" => "31" "paginaInicial" => "1.466" "paginaFinal" => "1.473" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9626828" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glycoprotein IIb/IIIa blockade and thrombolytics: Early lessons from the SPEED and GUSTO IV trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Califf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "1999" "volumen" => "138" "paginaInicial" => "S12" "paginaFinal" => "S15" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10385786" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New variant of human tissue plasminogen activator (TPA) with enhanced efficacy and lower incidence of bledding caompared with recombinant human TPA" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Benedict" 1 => "D. Phil" 2 => "C. Refino" 3 => "B. Keit" 4 => "R. Pakala" 5 => "N. Poni" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1995" "volumen" => "92" "paginaInicial" => "3.032" "paginaFinal" => "3.040" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8521580" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TNK-Tissue Plasminigen Activator in Acute Myocardial Infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI 10 A) Dose-Ranging Trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "C. Cannon" 1 => "C. McCabe" 2 => "M. Gibson" 3 => "M. Ghali" 4 => "R. Sequena" 5 => "E. Braunwald" 6 => "the TIMI 10A investigators" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1997" "volumen" => "95" "paginaInicial" => "351" "paginaFinal" => "356" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9008448" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TNK-Tissue plasminogen activator compared with front-loaded alteplase in acute myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "C.H. Cannon" 1 => "C. Gibson" 2 => "Cabe C Mc" 3 => "A. Adgey" 4 => "M. Scheweiger" 5 => "E. Braunwald" 6 => "the TIMI 10B investigators" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1998" "volumen" => "98" "paginaInicial" => "2.805" "paginaFinal" => "2.814" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9867443" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "For the ASSENT-1 investigators. Safety assessment of single-bolus administration of TNK tissue-plasminogen activator in acute myocardial infarction: the ASSENT-1 trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Van de Werf" 1 => "C. Cannon" 2 => "A. Luyten" 3 => "K. Houbracken" 4 => "C. Mc Cabe" 5 => "S. Berioli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "1999" "volumen" => "137" "paginaInicial" => "786" "paginaFinal" => "791" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10220625" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "For the ASSENT-2 trial investigators. Single- bolus tenectelase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 double-blind randomised trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Van de Werf" 1 => "J. Adjey" 2 => "D. Ardissino" 3 => "P. Armstrong" 4 => "Ph Aylward" 5 => "G. Barbash" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1999" "volumen" => "354" "paginaInicial" => "716" "paginaFinal" => "722" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10475182" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thrombolysis for acute myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. White" 1 => "F. Van de Werf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1998" "volumen" => "97" "paginaInicial" => "1.632" "paginaFinal" => "1.646" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9657477" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of a weight-adjusted single-bolus plasminogen activator in patients with myocardial infarction. A double-blind randomized angiographic trial of lanoteplase versus alteplase" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "P. Heijer" 1 => "F. Vermeer" 2 => "E. Ambrosioni" 3 => "Z. Sadowoki" 4 => "Sendón JL Lopez" 5 => "R. Van Essen" 6 => "of the In-TIME investigators group" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1998" "volumen" => "98" "paginaInicial" => "2.117" "paginaFinal" => "2.125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9867443" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New Plasminogen Activators: A clinical Review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Ross" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cardiol" "fecha" => "1999" "volumen" => "22" "paginaInicial" => "165" "paginaFinal" => "171" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10084057" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novel Thrombolytic Agents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Verstraete" 1 => "H. Lijnen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cardiovasc Drugs Ther" "fecha" => "1994" "volumen" => "8" "paginaInicial" => "801" "paginaFinal" => "812" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7742258" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "PRIMI Trial Study Group. Randomised Double-Blind Trial of Recombinant Pro-urokinase against Streptokinase in Acute Myocardial Infarction" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1989" "volumen" => "1" "paginaInicial" => "863" "paginaFinal" => "867" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2564949" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rate of fibrinogen breakdown related to coronary patency and Bleeding complications in patients with thrombolysis in acute myocardial infarction. Results from the PRIMI Trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "H. Ostermann" 1 => "H. Schmitz-Huebner" 2 => "J. Windeler" 3 => "F. Bar" 4 => "J. Meyer" 5 => "J. Van de Loo" 6 => "for the PRIMI Trial Study Group" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "1992" "volumen" => "13" "paginaInicial" => "1.225" "paginaFinal" => "1.232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1493827" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Time course of left ventricular function and coronary patency after saruplase vs streptokinase in acute myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Schofer" 1 => "M. Lins" 2 => "G. Mathey" 3 => "F. Sheehan" 4 => "the PRIMI Trial Study Group" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "1993" "volumen" => "14" "paginaInicial" => "958" "paginaFinal" => "963" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8375422" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thrombolysis with Saruplase versus Streptokinase in acute myocardial infarction: Five-year results of the PRIMI trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Spiecker" 1 => "J. Windeler" 2 => "F. Vermeer" 3 => "R. Michels" 4 => "R. Seabra-Gomes" 5 => "J. Von Dahl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "1999" "volumen" => "138" "paginaInicial" => "518" "paginaFinal" => "524" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10467203" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of Saruplase and Alteplase in Acute Myicardial Infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "F. Bär" 1 => "J. Meyer" 2 => "F. Vermeer" 3 => "R. Michels" 4 => "B. Charbonnier" 5 => "K. Haerten" 6 => "for the SESAM Study Group" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1997" "volumen" => "79" "paginaInicial" => "727" "paginaFinal" => "732" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9070549" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized, double-blind study comparing saruplase with streptokinase therapy in acute myocardial infarction: the COMPASS Equivalence Trial of saruplase and streptokinase" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "U. Tebbe" 1 => "R. Michels" 2 => "J. Adgey" 3 => "J. Boland" 4 => "A. Caspi" 5 => "B. Chanbonnier" 6 => "for the COMASS Investigators" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "1998" "volumen" => "31" "paginaInicial" => "487" "paginaFinal" => "493" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9502624" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recombinant Staphylokinase variants With Altered Inmunoreactivity: construction and characterization" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Collen" 1 => "R. Bernaerts" 2 => "P. Declerck" 3 => "F. De Cock" 4 => "E. Demarsin" 5 => "J. Stephane" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1996" "volumen" => "94" "paginaInicial" => "197" "paginaFinal" => "206" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8674179" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A Pilot Study on bolus Administration of Recombinant Staphylokinase for Coronary Artery Thrombolysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Vanderschueren" 1 => "D. Collen" 2 => "F. Van de Werf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thromb Haemost" "fecha" => "1996" "volumen" => "76" "paginaInicial" => "541" "paginaFinal" => "544" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8902993" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized coronary patency trial of double-bolus recombinant staphylokinase versus front-loaded alteplase in acute myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Vanderschueren" 1 => "J. Dens" 2 => "P. Kerdsinchai" 3 => "W. Desmet" 4 => "M. Vrolix" 5 => "F. De Man" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "1997" "volumen" => "134" "paginaInicial" => "213" "paginaFinal" => "219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9313600" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "for the doublebolus study investigators and angiographic assessment of alteplase: double-bolus and front-loaded infusion regimens in myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Bleich" 1 => "A. Adgey" 2 => "R. Mc Mechan" 3 => "T. Love" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "1998" "volumen" => "136" "paginaInicial" => "741" "paginaFinal" => "748" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9778080" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A Comparison of continuos infusion of alteplase with double-bolus administration for acute myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Van de Wer" 1 => "the COBALT investigators" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199710023371404" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1997" "volumen" => "337" "paginaInicial" => "1.124" "paginaFinal" => "1.130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9395430" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sixty-minute alteplase protocol: a new accelerated recombinant tissue-type plasminogen activator regimen for thrombolysis in acute myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Gulba" 1 => "P. Tanswell" 2 => "R. Dechend" 3 => "M. Sosada" 4 => "A. Weis" 5 => "J. Waigand" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "1997" "volumen" => "30" "paginaInicial" => "1.611" "paginaFinal" => "1.617" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9385915" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sequential combination thrombolytic therapy for acute myocardial infarction: results of the pro-urokinase and t-PA enhancement of thrombolysis (PATENT) trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "S. Zarich" 1 => "G. Kowalchuk" 2 => "D. Weaver" 3 => "J. Loscalzo" 4 => "M. Sassower" 5 => "K. Manzo" 6 => "for the PATENT study group" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "1995" "volumen" => "26" "paginaInicial" => "374" "paginaFinal" => "379" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7608437" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IIb/IIIa Receptor blockade in acute myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Ferguson" 1 => "K. Taqi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "1999" "volumen" => "138" "paginaInicial" => "S164" "paginaFinal" => "S170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10426877" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Abciximab Facilitates the rate and Extent of thrombolysis. Results of the Thrombolysis In Myocardial Infarction (TIMI) 14 Trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Antman" 1 => "R. Giugliano" 2 => "C. Gibson" 3 => "C. Mc Cabe" 4 => "P. Coussement" 5 => "N. Kleiman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1999" "volumen" => "99" "paginaInicial" => "2.720" "paginaFinal" => "2.732" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10385496" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02105691/0000002400000006/v1_201304241157/S021056910079601X/v1_201304241157/es/main.assets" "Apartado" => array:4 [ "identificador" => "34" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Revisión" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02105691/0000002400000006/v1_201304241157/S021056910079601X/v1_201304241157/es/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021056910079601X?idApp=WMIE" ]
año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 21 | 34 | 55 |
2024 Octubre | 101 | 284 | 385 |
2024 Septiembre | 95 | 295 | 390 |
2024 Agosto | 73 | 241 | 314 |
2024 Julio | 71 | 178 | 249 |
2024 Junio | 77 | 236 | 313 |
2024 Mayo | 110 | 244 | 354 |
2024 Abril | 74 | 193 | 267 |
2024 Marzo | 63 | 200 | 263 |
2024 Febrero | 60 | 245 | 305 |
2024 Enero | 67 | 254 | 321 |
2023 Diciembre | 57 | 265 | 322 |
2023 Noviembre | 50 | 305 | 355 |
2023 Octubre | 70 | 327 | 397 |
2023 Septiembre | 76 | 330 | 406 |
2023 Agosto | 54 | 173 | 227 |
2023 Julio | 88 | 212 | 300 |
2023 Junio | 86 | 100 | 186 |
2023 Mayo | 44 | 111 | 155 |
2023 Abril | 70 | 230 | 300 |
2023 Marzo | 89 | 303 | 392 |
2023 Febrero | 124 | 270 | 394 |
2023 Enero | 127 | 273 | 400 |
2022 Diciembre | 111 | 215 | 326 |
2022 Noviembre | 104 | 255 | 359 |
2022 Octubre | 77 | 231 | 308 |
2022 Septiembre | 85 | 357 | 442 |
2022 Agosto | 55 | 167 | 222 |
2022 Julio | 24 | 204 | 228 |
2022 Junio | 33 | 206 | 239 |
2022 Mayo | 41 | 251 | 292 |
2022 Abril | 53 | 239 | 292 |
2022 Marzo | 50 | 172 | 222 |
2022 Febrero | 37 | 154 | 191 |
2022 Enero | 50 | 193 | 243 |
2021 Diciembre | 43 | 161 | 204 |
2021 Noviembre | 49 | 201 | 250 |
2021 Octubre | 65 | 193 | 258 |
2021 Septiembre | 64 | 259 | 323 |
2021 Agosto | 55 | 200 | 255 |
2021 Julio | 52 | 189 | 241 |
2021 Junio | 57 | 240 | 297 |
2021 Mayo | 69 | 230 | 299 |
2021 Abril | 152 | 600 | 752 |
2021 Marzo | 78 | 350 | 428 |
2021 Febrero | 92 | 242 | 334 |
2021 Enero | 76 | 198 | 274 |
2020 Diciembre | 54 | 235 | 289 |
2020 Noviembre | 67 | 304 | 371 |
2020 Octubre | 60 | 192 | 252 |
2020 Septiembre | 56 | 276 | 332 |
2020 Agosto | 48 | 295 | 343 |
2020 Julio | 67 | 297 | 364 |
2020 Junio | 39 | 213 | 252 |
2020 Mayo | 63 | 288 | 351 |
2020 Abril | 46 | 385 | 431 |
2020 Marzo | 30 | 212 | 242 |
2020 Febrero | 86 | 460 | 546 |
2020 Enero | 39 | 195 | 234 |
2019 Diciembre | 47 | 235 | 282 |
2019 Noviembre | 36 | 266 | 302 |
2019 Octubre | 36 | 370 | 406 |
2019 Septiembre | 45 | 529 | 574 |
2019 Agosto | 55 | 350 | 405 |
2019 Julio | 46 | 315 | 361 |
2019 Junio | 34 | 425 | 459 |
2019 Mayo | 48 | 595 | 643 |
2019 Abril | 31 | 416 | 447 |
2019 Marzo | 19 | 187 | 206 |
2019 Febrero | 27 | 177 | 204 |
2019 Enero | 30 | 250 | 280 |
2018 Diciembre | 45 | 312 | 357 |
2018 Noviembre | 57 | 197 | 254 |
2018 Octubre | 25 | 122 | 147 |
2018 Septiembre | 10 | 107 | 117 |
2018 Agosto | 13 | 83 | 96 |
2018 Julio | 13 | 90 | 103 |
2018 Junio | 15 | 77 | 92 |
2018 Mayo | 8 | 68 | 76 |
2018 Abril | 14 | 101 | 115 |
2018 Marzo | 5 | 81 | 86 |
2018 Febrero | 9 | 73 | 82 |
2018 Enero | 9 | 70 | 79 |
2017 Diciembre | 10 | 60 | 70 |
2017 Noviembre | 10 | 72 | 82 |
2017 Octubre | 6 | 48 | 54 |
2017 Septiembre | 13 | 87 | 100 |
2017 Agosto | 7 | 30 | 37 |
2017 Julio | 7 | 51 | 58 |
2017 Junio | 21 | 94 | 115 |
2017 Mayo | 18 | 62 | 80 |
2017 Abril | 14 | 53 | 67 |
2017 Marzo | 11 | 101 | 112 |
2017 Febrero | 8 | 97 | 105 |
2017 Enero | 9 | 69 | 78 |
2016 Diciembre | 17 | 38 | 55 |
2016 Noviembre | 24 | 75 | 99 |
2016 Octubre | 36 | 63 | 99 |
2016 Septiembre | 83 | 198 | 281 |
2016 Agosto | 153 | 181 | 334 |
2016 Julio | 48 | 115 | 163 |