array:23 [
  "pii" => "S021056910079601X"
  "issn" => "02105691"
  "doi" => "10.1016/S0210-5691(00)79601-X"
  "estado" => "S300"
  "fechaPublicacion" => "2000-08-01"
  "aid" => "79601"
  "copyright" => "Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L."
  "copyrightAnyo" => "2000"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "rev"
  "cita" => "Med Intensiva. 2000;24:267-74"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 8904
    "formatos" => array:3 [
      "EPUB" => 160
      "HTML" => 1271
      "PDF" => 7473
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0210569100796021"
    "issn" => "02105691"
    "doi" => "10.1016/S0210-5691(00)79602-1"
    "estado" => "S300"
    "fechaPublicacion" => "2000-08-01"
    "aid" => "79602"
    "copyright" => "Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Med Intensiva. 2000;24:275-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2797
      "formatos" => array:3 [
        "EPUB" => 152
        "HTML" => 1098
        "PDF" => 1547
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Shock anafiláctico e infarto de miocardio por rotura espontánea de quiste hidatídico"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "275"
          "paginaFinal" => "277"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Anaphilactic Shock and Myocardial Infarction Due to Spontaneous Rupture of Hydatid Cyst"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:2 [
        0 => array:2 [
          "autoresLista" => "V.E. Merlo GonzáLez,, F. Árbol Linde, C. Contreras Rosino, P. LóPez Onega"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "V.E."
              "apellidos" => "Merlo GonzáLez,"
            ]
            1 => array:2 [
              "nombre" => "F."
              "apellidos" => "Árbol Linde"
            ]
            2 => array:2 [
              "nombre" => "C."
              "apellidos" => "Contreras Rosino"
            ]
            3 => array:2 [
              "nombre" => "P."
              "apellidos" => "LóPez Onega"
            ]
          ]
        ]
        1 => array:2 [
          "autoresLista" => "F. Marcos Sánchez, F. Santomé Argibay"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "F."
              "apellidos" => "Marcos Sánchez"
            ]
            1 => array:2 [
              "nombre" => "F."
              "apellidos" => "Santomé Argibay"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796021?idApp=WMIE"
    "url" => "/02105691/0000002400000006/v1_201304241157/S0210569100796021/v1_201304241157/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0210569100796008"
    "issn" => "02105691"
    "doi" => "10.1016/S0210-5691(00)79600-8"
    "estado" => "S300"
    "fechaPublicacion" => "2000-08-01"
    "aid" => "79600"
    "copyright" => "Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Med Intensiva. 2000;24:264-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1980
      "formatos" => array:3 [
        "EPUB" => 126
        "HTML" => 954
        "PDF" => 900
      ]
    ]
    "es" => array:7 [
      "idiomaDefecto" => true
      "titulo" => "Enfermedad cerebrovascular aguda y los servicios de Cuidados Críticos y Urgencias en Andalucía. La experiencia del grupo EVASCAN"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "264"
          "paginaFinal" => "266"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Grupo Evascan"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Grupo"
              "apellidos" => "Evascan"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796008?idApp=WMIE"
    "url" => "/02105691/0000002400000006/v1_201304241157/S0210569100796008/v1_201304241157/es/main.assets"
  ]
  "es" => array:13 [
    "idiomaDefecto" => true
    "titulo" => "Nuevos fibrinolíticos para el tratamiento del infarto agudo de miocardio"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "267"
        "paginaFinal" => "274"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "P. Jiménez Gómez, J.M. Gulias López, S. Calvo Barros, M.J. Castro Orjales, P. Rascado Sedes"
        "autores" => array:5 [
          0 => array:3 [
            "nombre" => "P. Jiménez"
            "apellidos" => "Gómez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "J&#46;M&#46; Gulias"
            "apellidos" => "L&#243;pez"
          ]
          2 => array:2 [
            "nombre" => "S&#46; Calvo"
            "apellidos" => "Barros"
          ]
          3 => array:2 [
            "nombre" => "M&#46;J&#46; Castro"
            "apellidos" => "Orjales"
          ]
          4 => array:2 [
            "nombre" => "P&#46; Rascado"
            "apellidos" => "Sedes"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Unidad Coronaria&#46; Servicio de Medicina Intensiva&#46; &#193;rea del Coraz&#243;n&#46; Hospital Juan Canalejo&#46; A&#46; Coru&#241;a"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "1"
            "correspondencia" => "Correspondencia&#58; Dr&#46; P&#46; Jim&#233;nez G&#243;mez&#46; Unidad Coronaria&#46; Servicio de Medicina Intensiva&#46; Hospital Juan Canalejo&#46; Carretera de las Jubias de arriba&#44; 84&#46; 15006 A Coru&#241;a"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Novel Fibrinolytics for Treatment of Acute Myocardial Infarction"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaAceptado" => "2000-02-17"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec82343"
          "palabras" => array:2 [
            0 => "fibrinol&#237;ticos"
            1 => "infarto agudo de miocardio"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec82344"
          "palabras" => array:2 [
            0 => "Fibrinolytic agents"
            1 => "acute myocardial infarction"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El tratamiento fibrinol&#237;tico ha mejorado significativamente el pron&#243;stico de los pacientes con infarto agudo de miocardio&#46; Pero esta estrategia terap&#233;utica tiene limitaciones importantes como son&#58; la escasa utilizaci&#243;n&#44; no conseguir &#243;ptima reperfusi&#243;n en todos los pacientes y las complicaciones sobre todo hemorr&#225;gicas que en ocasiones pueden ser graves</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se est&#225;n investigando f&#225;rmacos que eviten o disminuyan estos problemas&#44; que act&#250;en m&#225;s r&#225;pidamente&#44; sean m&#225;s f&#225;ciles de administrar&#44; lo que facilitar&#237;a el uso prehospitalario&#44; y que tengan m&#225;s capacidad l&#237;tica y menores complicaciones hemorr&#225;gicas</p>"
      ]
      "en" => array:1 [
        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The fibrinolytic agents have improved significantly the prognosis of patients with acute myocardial infarction&#44; but this therapy has significant limitations like&#58; they remain underutilized&#44; do not get an optimal reperfusion in all patients and they can cause complications&#44; mainly bleeding&#44; sometimes serious</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">There are under investigation newer drugs to prevent or decrease these problems&#44; drugs that work faster and that are of easier administration&#46; These new drugs would allow a prehospital use and they would have a greater lytic power and less bleedding complications</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:46 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; De Wood"
                            1 => "J&#46; Spores"
                            2 => "R&#46; Notske"
                            3 => "L&#46;T&#46; Mouser"
                            4 => "R&#46; Burroughs"
                            5 => "M&#46;S&#46; Golden"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM198010163031601"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1980"
                        "volumen" => "303"
                        "paginaInicial" => "897"
                        "paginaFinal" => "901"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7412821"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Initial experience with transluminal recanalization of recenly occluded infarct-related coronary artery in acute myocardial infarction comparison with conventinally treated patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;T&#46; Rentrop"
                            1 => "H&#46; Blanke"
                            2 => "K&#46;R&#46; Karsch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cardiol"
                        "fecha" => "1979"
                        "volumen" => "2"
                        "paginaInicial" => "92"
                        "paginaFinal" => "105"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/162452"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Gruppo Italiano per lo Studio della Streptochinasi nell&#8217;Infarto Mioc&#225;rdico &#40;GISSI&#41;&#46; Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1986"
                        "volumen" => "1"
                        "paginaInicial" => "397"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2563564"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Second International Study of Infact Survival &#40;ISIS-2&#41;&#46; Randomised trial of intravenous streptikinase oral aspirin&#44; both or neither among 17&#46;187 cases of suspected acute myocardial infarction"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1988"
                        "volumen" => "2"
                        "paginaInicial" => "349"
                        "paginaFinal" => "360"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2569551"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "The GUSTO Investigators&#46; An International Randomized Trial Comparing Four Thrombolytic Strategies for Acute Myocardial Infarction"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199309023291001"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1993"
                        "volumen" => "329"
                        "paginaInicial" => "673"
                        "paginaFinal" => "682"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8204123"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "The GUSTO angiographic Investigators&#46;The Effects of Tissue Plasminogen Activator&#44; Streptokinase&#44; or Both on Coronary-Artery Patency&#44; Ventricular function&#44; and Survival after Acute Myocardial Infarction"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1993"
                        "volumen" => "329"
                        "paginaInicial" => "1&#46;650"
                        "paginaFinal" => "1&#46;652"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8247085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular biology of plasminogen activators&#58; what are the clinical implications of drug design&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Smalling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "1996"
                        "volumen" => "78"
                        "numero" => "suppl 12 A"
                        "paginaInicial" => "2"
                        "paginaFinal" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8990404"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Fibrinolytic Therapy Trialists &#40;FTT&#41; Colaborative Group&#46; Indications for fibrinolytic therapy in suspected acute myocardial infarction&#58; collaborative overview of early mortalitymajor morbidity results from all randomised trials of more than 1000 patients"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "The lancet"
                        "fecha" => "1994"
                        "volumen" => "343"
                        "paginaInicial" => "311"
                        "paginaFinal" => "322"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variabilidad en el manejo y pron&#243;stico a corto y medio plazo del infarto de miocardio en Espa&#241;a&#58; el estudio PRIAMHO"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Cabad&#233;s"
                            1 => "L&#46; L&#243;pez-Besc&#243;s"
                            2 => "F&#46; Ar&#243;s"
                            3 => "A&#46; Loma-Osorio"
                            4 => "X&#46; Bosch"
                            5 => "P&#46; Pab&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "1999"
                        "volumen" => "52"
                        "paginaInicial" => "767"
                        "paginaFinal" => "775"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10563151"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An&#225;lisis de los retrasos en el tratamiento del s&#237;ndrome coronario agudo&#46; Datos del registro ARIAM"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "E&#46; Aguayo"
                            1 => "A&#46; Reina"
                            2 => "M&#46; Colmenero"
                            3 => "M&#46; Barranco"
                            4 => "M&#46; Pola"
                            5 => "M&#46; Jim&#233;nez"
                            6 => "grupo ARIAM"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "1999"
                        "volumen" => "23"
                        "paginaInicial" => "280"
                        "paginaFinal" => "287"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Optimizaci&#243;n del tratamiento trombol&#237;tico en el infarto agudo de miocardio&#58; papel de los nuevos f&#225;rmacos fibrinoselectivos y de la asociaci&#243;n con los nuevos antitromb&#243;ticos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Siches"
                            1 => "X&#46; Bosch"
                            2 => "A&#46; Betriu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "1998"
                        "volumen" => "51"
                        "paginaInicial" => "178"
                        "paginaFinal" => "191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9577163"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biochemical and pharmacologic comparison of thrombolytic agents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46; Stringer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Pharmacotherapy"
                        "fecha" => "1996"
                        "volumen" => "16"
                        "numero" => "5 pt 2"
                        "paginaInicial" => "1&#46;195"
                        "paginaFinal" => "1&#46;265"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8947994"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thrombolytic agents &#8211; an overview"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Gulba"
                            1 => "C&#46; Bode"
                            2 => "M&#46; Runge"
                            3 => "K&#46; Huber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Hematol"
                        "fecha" => "1996"
                        "volumen" => "73"
                        "numero" => "Suppl I"
                        "paginaInicial" => "S9"
                        "paginaFinal" => "S27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8853112"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reteplase a review of its pharmacological properties and clinical efficacy in the management of acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Noble"
                            1 => "D&#46; Mc Tavish"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Drugs"
                        "fecha" => "1996"
                        "volumen" => "42"
                        "paginaInicial" => "589"
                        "paginaFinal" => "605"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of thrombolytic drugs in the management of myocardial infarction&#46; Comparative clinical trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46; Weaver"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "1996"
                        "volumen" => "17"
                        "numero" => "Suppl F"
                        "paginaInicial" => "9"
                        "paginaFinal" => "15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8960443"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacological and clinical impact of the unique molecular structure of a new plasminogen activator"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Smalling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "1997"
                        "volumen" => "18"
                        "numero" => "Suppl F"
                        "paginaInicial" => "F11"
                        "paginaFinal" => "F16"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9447335"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "More Rapid&#44; complete and stable coronary thrombolysis with bolus administration of reteplase compared with alteplase infusion in acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "R&#46; Smalling"
                            1 => "C&#46; Bode"
                            2 => "J&#46; Kalbfleisch"
                            3 => "S&#46; Sen"
                            4 => "P&#46; Limbourg"
                            5 => "F&#46; Forycki"
                            6 => "the Rapid investigators"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1995"
                        "volumen" => "91"
                        "paginaInicial" => "2&#46;725"
                        "paginaFinal" => "2&#46;732"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7796512"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939409000968"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomized comparison of coronary thrombolytisis achieved with double-bolus reteplase &#40;recombinant plasminogen activator&#41; in patients with acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "C&#46; Bode"
                            1 => "R&#46; Smalling"
                            2 => "G&#46; Berg"
                            3 => "C&#46; Burnett"
                            4 => "G&#46; Lorch"
                            5 => "J&#46; Kalbfleisch"
                            6 => "the RAPID II investigators"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1996"
                        "volumen" => "94"
                        "paginaInicial" => "891"
                        "paginaFinal" => "898"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8790022"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "International Joint Efficacy Comparison of thrombolytics&#46; Randomised&#44; double-blind comparison of reteplase double-bolus administration with streptokinase in acute myocardial infarction &#40;INJECT&#41;&#58; trial to investigate equivalence"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1995"
                        "volumen" => "346"
                        "paginaInicial" => "329"
                        "paginaFinal" => "336"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7623530"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "The GUSTO III Investigators&#46; A comparison of Reteplase with Alteplase for acute myocardial infarction"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199710023371404"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1997"
                        "volumen" => "337"
                        "paginaInicial" => "1&#46;118"
                        "paginaFinal" => "1&#46;123"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9395430"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of reteplase and alteplase on platelet aggregation and mayor receptor expression during the first 24 hours of acute myocardial infarction treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46; Gurbel"
                            1 => "V&#46; Serebruany"
                            2 => "A&#46; Shustov"
                            3 => "R&#46; Bahr"
                            4 => "C&#46; Carpo"
                            5 => "E&#46; Ohman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "1998"
                        "volumen" => "31"
                        "paginaInicial" => "1&#46;466"
                        "paginaFinal" => "1&#46;473"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9626828"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glycoprotein IIb&#47;IIIa blockade and thrombolytics&#58; Early lessons from the SPEED and GUSTO IV trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Califf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1999"
                        "volumen" => "138"
                        "paginaInicial" => "S12"
                        "paginaFinal" => "S15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10385786"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New variant of human tissue plasminogen activator &#40;TPA&#41; with enhanced efficacy and lower incidence of bledding caompared with recombinant human TPA"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Benedict"
                            1 => "D&#46; Phil"
                            2 => "C&#46; Refino"
                            3 => "B&#46; Keit"
                            4 => "R&#46; Pakala"
                            5 => "N&#46; Poni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1995"
                        "volumen" => "92"
                        "paginaInicial" => "3&#46;032"
                        "paginaFinal" => "3&#46;040"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8521580"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TNK-Tissue Plasminigen Activator in Acute Myocardial Infarction&#46; Results of the Thrombolysis in Myocardial Infarction &#40;TIMI 10 A&#41; Dose-Ranging Trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "C&#46; Cannon"
                            1 => "C&#46; McCabe"
                            2 => "M&#46; Gibson"
                            3 => "M&#46; Ghali"
                            4 => "R&#46; Sequena"
                            5 => "E&#46; Braunwald"
                            6 => "the TIMI 10A investigators"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1997"
                        "volumen" => "95"
                        "paginaInicial" => "351"
                        "paginaFinal" => "356"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9008448"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TNK-Tissue plasminogen activator compared with front-loaded alteplase in acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "C&#46;H&#46; Cannon"
                            1 => "C&#46; Gibson"
                            2 => "Cabe C Mc"
                            3 => "A&#46; Adgey"
                            4 => "M&#46; Scheweiger"
                            5 => "E&#46; Braunwald"
                            6 => "the TIMI 10B investigators"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "98"
                        "paginaInicial" => "2&#46;805"
                        "paginaFinal" => "2&#46;814"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9867443"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "For the ASSENT-1 investigators&#46; Safety assessment of single-bolus administration of TNK tissue-plasminogen activator in acute myocardial infarction&#58; the ASSENT-1 trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Van de Werf"
                            1 => "C&#46; Cannon"
                            2 => "A&#46; Luyten"
                            3 => "K&#46; Houbracken"
                            4 => "C&#46; Mc Cabe"
                            5 => "S&#46; Berioli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1999"
                        "volumen" => "137"
                        "paginaInicial" => "786"
                        "paginaFinal" => "791"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10220625"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "For the ASSENT-2 trial investigators&#46; Single- bolus tenectelase compared with front-loaded alteplase in acute myocardial infarction&#58; the ASSENT-2 double-blind randomised trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Van de Werf"
                            1 => "J&#46; Adjey"
                            2 => "D&#46; Ardissino"
                            3 => "P&#46; Armstrong"
                            4 => "Ph Aylward"
                            5 => "G&#46; Barbash"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1999"
                        "volumen" => "354"
                        "paginaInicial" => "716"
                        "paginaFinal" => "722"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10475182"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thrombolysis for acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46; White"
                            1 => "F&#46; Van de Werf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "97"
                        "paginaInicial" => "1&#46;632"
                        "paginaFinal" => "1&#46;646"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9657477"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of a weight-adjusted single-bolus plasminogen activator in patients with myocardial infarction&#46; A double-blind randomized angiographic trial of lanoteplase versus alteplase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "P&#46; Heijer"
                            1 => "F&#46; Vermeer"
                            2 => "E&#46; Ambrosioni"
                            3 => "Z&#46; Sadowoki"
                            4 => "Send&#243;n JL Lopez"
                            5 => "R&#46; Van Essen"
                            6 => "of the In-TIME investigators group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "98"
                        "paginaInicial" => "2&#46;117"
                        "paginaFinal" => "2&#46;125"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9867443"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New Plasminogen Activators&#58; A clinical Review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Ross"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cardiol"
                        "fecha" => "1999"
                        "volumen" => "22"
                        "paginaInicial" => "165"
                        "paginaFinal" => "171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10084057"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Novel Thrombolytic Agents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Verstraete"
                            1 => "H&#46; Lijnen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Drugs Ther"
                        "fecha" => "1994"
                        "volumen" => "8"
                        "paginaInicial" => "801"
                        "paginaFinal" => "812"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7742258"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "PRIMI Trial Study Group&#46; Randomised Double-Blind Trial of Recombinant Pro-urokinase against Streptokinase in Acute Myocardial Infarction"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1989"
                        "volumen" => "1"
                        "paginaInicial" => "863"
                        "paginaFinal" => "867"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2564949"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rate of fibrinogen breakdown related to coronary patency and Bleeding complications in patients with thrombolysis in acute myocardial infarction&#46; Results from the PRIMI Trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "H&#46; Ostermann"
                            1 => "H&#46; Schmitz-Huebner"
                            2 => "J&#46; Windeler"
                            3 => "F&#46; Bar"
                            4 => "J&#46; Meyer"
                            5 => "J&#46; Van de Loo"
                            6 => "for the PRIMI Trial Study Group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "1992"
                        "volumen" => "13"
                        "paginaInicial" => "1&#46;225"
                        "paginaFinal" => "1&#46;232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1493827"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Time course of left ventricular function and coronary patency after saruplase vs streptokinase in acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Schofer"
                            1 => "M&#46; Lins"
                            2 => "G&#46; Mathey"
                            3 => "F&#46; Sheehan"
                            4 => "the PRIMI Trial Study Group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "1993"
                        "volumen" => "14"
                        "paginaInicial" => "958"
                        "paginaFinal" => "963"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8375422"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thrombolysis with Saruplase versus Streptokinase in acute myocardial infarction&#58; Five-year results of the PRIMI trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Spiecker"
                            1 => "J&#46; Windeler"
                            2 => "F&#46; Vermeer"
                            3 => "R&#46; Michels"
                            4 => "R&#46; Seabra-Gomes"
                            5 => "J&#46; Von Dahl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1999"
                        "volumen" => "138"
                        "paginaInicial" => "518"
                        "paginaFinal" => "524"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10467203"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of Saruplase and Alteplase in Acute Myicardial Infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "F&#46; B&#228;r"
                            1 => "J&#46; Meyer"
                            2 => "F&#46; Vermeer"
                            3 => "R&#46; Michels"
                            4 => "B&#46; Charbonnier"
                            5 => "K&#46; Haerten"
                            6 => "for the SESAM Study Group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "1997"
                        "volumen" => "79"
                        "paginaInicial" => "727"
                        "paginaFinal" => "732"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9070549"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomized&#44; double-blind study comparing saruplase with streptokinase therapy in acute myocardial infarction&#58; the COMPASS Equivalence Trial of saruplase and streptokinase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "U&#46; Tebbe"
                            1 => "R&#46; Michels"
                            2 => "J&#46; Adgey"
                            3 => "J&#46; Boland"
                            4 => "A&#46; Caspi"
                            5 => "B&#46; Chanbonnier"
                            6 => "for the COMASS Investigators"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "1998"
                        "volumen" => "31"
                        "paginaInicial" => "487"
                        "paginaFinal" => "493"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9502624"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recombinant Staphylokinase variants With Altered Inmunoreactivity&#58; construction and characterization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Collen"
                            1 => "R&#46; Bernaerts"
                            2 => "P&#46; Declerck"
                            3 => "F&#46; De Cock"
                            4 => "E&#46; Demarsin"
                            5 => "J&#46; Stephane"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1996"
                        "volumen" => "94"
                        "paginaInicial" => "197"
                        "paginaFinal" => "206"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8674179"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Pilot Study on bolus Administration of Recombinant Staphylokinase for Coronary Artery Thrombolysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Vanderschueren"
                            1 => "D&#46; Collen"
                            2 => "F&#46; Van de Werf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thromb Haemost"
                        "fecha" => "1996"
                        "volumen" => "76"
                        "paginaInicial" => "541"
                        "paginaFinal" => "544"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8902993"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomized coronary patency trial of double-bolus recombinant staphylokinase versus front-loaded alteplase in acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Vanderschueren"
                            1 => "J&#46; Dens"
                            2 => "P&#46; Kerdsinchai"
                            3 => "W&#46; Desmet"
                            4 => "M&#46; Vrolix"
                            5 => "F&#46; De Man"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1997"
                        "volumen" => "134"
                        "paginaInicial" => "213"
                        "paginaFinal" => "219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9313600"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "for the doublebolus study investigators and angiographic assessment of alteplase&#58; double-bolus and front-loaded infusion regimens in myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Bleich"
                            1 => "A&#46; Adgey"
                            2 => "R&#46; Mc Mechan"
                            3 => "T&#46; Love"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1998"
                        "volumen" => "136"
                        "paginaInicial" => "741"
                        "paginaFinal" => "748"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9778080"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Comparison of continuos infusion of alteplase with double-bolus administration for acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Van de Wer"
                            1 => "the COBALT investigators"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199710023371404"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1997"
                        "volumen" => "337"
                        "paginaInicial" => "1&#46;124"
                        "paginaFinal" => "1&#46;130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9395430"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sixty-minute alteplase protocol&#58; a new accelerated recombinant tissue-type plasminogen activator regimen for thrombolysis in acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Gulba"
                            1 => "P&#46; Tanswell"
                            2 => "R&#46; Dechend"
                            3 => "M&#46; Sosada"
                            4 => "A&#46; Weis"
                            5 => "J&#46; Waigand"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "1997"
                        "volumen" => "30"
                        "paginaInicial" => "1&#46;611"
                        "paginaFinal" => "1&#46;617"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9385915"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sequential combination thrombolytic therapy for acute myocardial infarction&#58; results of the pro-urokinase and t-PA enhancement of thrombolysis &#40;PATENT&#41; trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "S&#46; Zarich"
                            1 => "G&#46; Kowalchuk"
                            2 => "D&#46; Weaver"
                            3 => "J&#46; Loscalzo"
                            4 => "M&#46; Sassower"
                            5 => "K&#46; Manzo"
                            6 => "for the PATENT study group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "1995"
                        "volumen" => "26"
                        "paginaInicial" => "374"
                        "paginaFinal" => "379"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7608437"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IIb&#47;IIIa Receptor blockade in acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Ferguson"
                            1 => "K&#46; Taqi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1999"
                        "volumen" => "138"
                        "paginaInicial" => "S164"
                        "paginaFinal" => "S170"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10426877"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abciximab Facilitates the rate and Extent of thrombolysis&#46; Results of the Thrombolysis In Myocardial Infarction &#40;TIMI&#41; 14 Trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Antman"
                            1 => "R&#46; Giugliano"
                            2 => "C&#46; Gibson"
                            3 => "C&#46; Mc Cabe"
                            4 => "P&#46; Coussement"
                            5 => "N&#46; Kleiman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1999"
                        "volumen" => "99"
                        "paginaInicial" => "2&#46;720"
                        "paginaFinal" => "2&#46;732"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10385496"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/02105691/0000002400000006/v1_201304241157/S021056910079601X/v1_201304241157/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "34"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Revisi&#243;n"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02105691/0000002400000006/v1_201304241157/S021056910079601X/v1_201304241157/es/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021056910079601X?idApp=WMIE"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Nuevos fibrinolíticos para el tratamiento del infarto agudo de miocardio
Novel Fibrinolytics for Treatment of Acute Myocardial Infarction
P. Jiménez Gómez1, J.M. Gulias López, S. Calvo Barros, M.J. Castro Orjales, P. Rascado Sedes
Unidad Coronaria. Servicio de Medicina Intensiva. Área del Corazón. Hospital Juan Canalejo. A. Coruña
Leído
26498
Veces
se ha leído el artículo
21352
Total PDF
5146
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S021056910079601X"
  "issn" => "02105691"
  "doi" => "10.1016/S0210-5691(00)79601-X"
  "estado" => "S300"
  "fechaPublicacion" => "2000-08-01"
  "aid" => "79601"
  "copyright" => "Sociedad Espa&#241;ola de Medicina Intensiva&#44; Critica y Unidades Coronarias &#40;SEMICYUC&#41; and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
  "copyrightAnyo" => "2000"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "rev"
  "cita" => "Med Intensiva. 2000;24:267-74"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 8904
    "formatos" => array:3 [
      "EPUB" => 160
      "HTML" => 1271
      "PDF" => 7473
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0210569100796021"
    "issn" => "02105691"
    "doi" => "10.1016/S0210-5691(00)79602-1"
    "estado" => "S300"
    "fechaPublicacion" => "2000-08-01"
    "aid" => "79602"
    "copyright" => "Sociedad Espa&#241;ola de Medicina Intensiva&#44; Critica y Unidades Coronarias &#40;SEMICYUC&#41; and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Med Intensiva. 2000;24:275-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2797
      "formatos" => array:3 [
        "EPUB" => 152
        "HTML" => 1098
        "PDF" => 1547
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Shock anafil&#225;ctico e infarto de miocardio por rotura espont&#225;nea de quiste hidat&#237;dico"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "275"
          "paginaFinal" => "277"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Anaphilactic Shock and Myocardial Infarction Due to Spontaneous Rupture of Hydatid Cyst"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:2 [
        0 => array:2 [
          "autoresLista" => "V&#46;E&#46; Merlo Gonz&#225;Lez&#44;, F&#46; &#193;rbol Linde, C&#46; Contreras Rosino, P&#46; L&#243;Pez Onega"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "V&#46;E&#46;"
              "apellidos" => "Merlo Gonz&#225;Lez&#44;"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "&#193;rbol Linde"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Contreras Rosino"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "L&#243;Pez Onega"
            ]
          ]
        ]
        1 => array:2 [
          "autoresLista" => "F&#46; Marcos S&#225;nchez, F&#46; Santom&#233; Argibay"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Marcos S&#225;nchez"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Santom&#233; Argibay"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796021?idApp=WMIE"
    "url" => "/02105691/0000002400000006/v1_201304241157/S0210569100796021/v1_201304241157/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0210569100796008"
    "issn" => "02105691"
    "doi" => "10.1016/S0210-5691(00)79600-8"
    "estado" => "S300"
    "fechaPublicacion" => "2000-08-01"
    "aid" => "79600"
    "copyright" => "Sociedad Espa&#241;ola de Medicina Intensiva&#44; Critica y Unidades Coronarias &#40;SEMICYUC&#41; and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Med Intensiva. 2000;24:264-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1980
      "formatos" => array:3 [
        "EPUB" => 126
        "HTML" => 954
        "PDF" => 900
      ]
    ]
    "es" => array:7 [
      "idiomaDefecto" => true
      "titulo" => "Enfermedad cerebrovascular aguda y los servicios de Cuidados Cr&#237;ticos y Urgencias en Andaluc&#237;a&#46; La experiencia del grupo EVASCAN"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "264"
          "paginaFinal" => "266"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Grupo Evascan"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Grupo"
              "apellidos" => "Evascan"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796008?idApp=WMIE"
    "url" => "/02105691/0000002400000006/v1_201304241157/S0210569100796008/v1_201304241157/es/main.assets"
  ]
  "es" => array:13 [
    "idiomaDefecto" => true
    "titulo" => "Nuevos fibrinol&#237;ticos para el tratamiento del infarto agudo de miocardio"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "267"
        "paginaFinal" => "274"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "P&#46; Jim&#233;nez G&#243;mez, J&#46;M&#46; Gulias L&#243;pez, S&#46; Calvo Barros, M&#46;J&#46; Castro Orjales, P&#46; Rascado Sedes"
        "autores" => array:5 [
          0 => array:3 [
            "nombre" => "P&#46; Jim&#233;nez"
            "apellidos" => "G&#243;mez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "J&#46;M&#46; Gulias"
            "apellidos" => "L&#243;pez"
          ]
          2 => array:2 [
            "nombre" => "S&#46; Calvo"
            "apellidos" => "Barros"
          ]
          3 => array:2 [
            "nombre" => "M&#46;J&#46; Castro"
            "apellidos" => "Orjales"
          ]
          4 => array:2 [
            "nombre" => "P&#46; Rascado"
            "apellidos" => "Sedes"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Unidad Coronaria&#46; Servicio de Medicina Intensiva&#46; &#193;rea del Coraz&#243;n&#46; Hospital Juan Canalejo&#46; A&#46; Coru&#241;a"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "1"
            "correspondencia" => "Correspondencia&#58; Dr&#46; P&#46; Jim&#233;nez G&#243;mez&#46; Unidad Coronaria&#46; Servicio de Medicina Intensiva&#46; Hospital Juan Canalejo&#46; Carretera de las Jubias de arriba&#44; 84&#46; 15006 A Coru&#241;a"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Novel Fibrinolytics for Treatment of Acute Myocardial Infarction"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaAceptado" => "2000-02-17"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec82343"
          "palabras" => array:2 [
            0 => "fibrinol&#237;ticos"
            1 => "infarto agudo de miocardio"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec82344"
          "palabras" => array:2 [
            0 => "Fibrinolytic agents"
            1 => "acute myocardial infarction"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El tratamiento fibrinol&#237;tico ha mejorado significativamente el pron&#243;stico de los pacientes con infarto agudo de miocardio&#46; Pero esta estrategia terap&#233;utica tiene limitaciones importantes como son&#58; la escasa utilizaci&#243;n&#44; no conseguir &#243;ptima reperfusi&#243;n en todos los pacientes y las complicaciones sobre todo hemorr&#225;gicas que en ocasiones pueden ser graves</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se est&#225;n investigando f&#225;rmacos que eviten o disminuyan estos problemas&#44; que act&#250;en m&#225;s r&#225;pidamente&#44; sean m&#225;s f&#225;ciles de administrar&#44; lo que facilitar&#237;a el uso prehospitalario&#44; y que tengan m&#225;s capacidad l&#237;tica y menores complicaciones hemorr&#225;gicas</p>"
      ]
      "en" => array:1 [
        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The fibrinolytic agents have improved significantly the prognosis of patients with acute myocardial infarction&#44; but this therapy has significant limitations like&#58; they remain underutilized&#44; do not get an optimal reperfusion in all patients and they can cause complications&#44; mainly bleeding&#44; sometimes serious</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">There are under investigation newer drugs to prevent or decrease these problems&#44; drugs that work faster and that are of easier administration&#46; These new drugs would allow a prehospital use and they would have a greater lytic power and less bleedding complications</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:46 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; De Wood"
                            1 => "J&#46; Spores"
                            2 => "R&#46; Notske"
                            3 => "L&#46;T&#46; Mouser"
                            4 => "R&#46; Burroughs"
                            5 => "M&#46;S&#46; Golden"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM198010163031601"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1980"
                        "volumen" => "303"
                        "paginaInicial" => "897"
                        "paginaFinal" => "901"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7412821"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Initial experience with transluminal recanalization of recenly occluded infarct-related coronary artery in acute myocardial infarction comparison with conventinally treated patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;T&#46; Rentrop"
                            1 => "H&#46; Blanke"
                            2 => "K&#46;R&#46; Karsch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cardiol"
                        "fecha" => "1979"
                        "volumen" => "2"
                        "paginaInicial" => "92"
                        "paginaFinal" => "105"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/162452"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Gruppo Italiano per lo Studio della Streptochinasi nell&#8217;Infarto Mioc&#225;rdico &#40;GISSI&#41;&#46; Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1986"
                        "volumen" => "1"
                        "paginaInicial" => "397"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2563564"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Second International Study of Infact Survival &#40;ISIS-2&#41;&#46; Randomised trial of intravenous streptikinase oral aspirin&#44; both or neither among 17&#46;187 cases of suspected acute myocardial infarction"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1988"
                        "volumen" => "2"
                        "paginaInicial" => "349"
                        "paginaFinal" => "360"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2569551"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "The GUSTO Investigators&#46; An International Randomized Trial Comparing Four Thrombolytic Strategies for Acute Myocardial Infarction"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199309023291001"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1993"
                        "volumen" => "329"
                        "paginaInicial" => "673"
                        "paginaFinal" => "682"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8204123"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "The GUSTO angiographic Investigators&#46;The Effects of Tissue Plasminogen Activator&#44; Streptokinase&#44; or Both on Coronary-Artery Patency&#44; Ventricular function&#44; and Survival after Acute Myocardial Infarction"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1993"
                        "volumen" => "329"
                        "paginaInicial" => "1&#46;650"
                        "paginaFinal" => "1&#46;652"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8247085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular biology of plasminogen activators&#58; what are the clinical implications of drug design&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Smalling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "1996"
                        "volumen" => "78"
                        "numero" => "suppl 12 A"
                        "paginaInicial" => "2"
                        "paginaFinal" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8990404"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Fibrinolytic Therapy Trialists &#40;FTT&#41; Colaborative Group&#46; Indications for fibrinolytic therapy in suspected acute myocardial infarction&#58; collaborative overview of early mortalitymajor morbidity results from all randomised trials of more than 1000 patients"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "The lancet"
                        "fecha" => "1994"
                        "volumen" => "343"
                        "paginaInicial" => "311"
                        "paginaFinal" => "322"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variabilidad en el manejo y pron&#243;stico a corto y medio plazo del infarto de miocardio en Espa&#241;a&#58; el estudio PRIAMHO"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Cabad&#233;s"
                            1 => "L&#46; L&#243;pez-Besc&#243;s"
                            2 => "F&#46; Ar&#243;s"
                            3 => "A&#46; Loma-Osorio"
                            4 => "X&#46; Bosch"
                            5 => "P&#46; Pab&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "1999"
                        "volumen" => "52"
                        "paginaInicial" => "767"
                        "paginaFinal" => "775"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10563151"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An&#225;lisis de los retrasos en el tratamiento del s&#237;ndrome coronario agudo&#46; Datos del registro ARIAM"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "E&#46; Aguayo"
                            1 => "A&#46; Reina"
                            2 => "M&#46; Colmenero"
                            3 => "M&#46; Barranco"
                            4 => "M&#46; Pola"
                            5 => "M&#46; Jim&#233;nez"
                            6 => "grupo ARIAM"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "1999"
                        "volumen" => "23"
                        "paginaInicial" => "280"
                        "paginaFinal" => "287"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Optimizaci&#243;n del tratamiento trombol&#237;tico en el infarto agudo de miocardio&#58; papel de los nuevos f&#225;rmacos fibrinoselectivos y de la asociaci&#243;n con los nuevos antitromb&#243;ticos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Siches"
                            1 => "X&#46; Bosch"
                            2 => "A&#46; Betriu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "1998"
                        "volumen" => "51"
                        "paginaInicial" => "178"
                        "paginaFinal" => "191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9577163"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biochemical and pharmacologic comparison of thrombolytic agents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46; Stringer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Pharmacotherapy"
                        "fecha" => "1996"
                        "volumen" => "16"
                        "numero" => "5 pt 2"
                        "paginaInicial" => "1&#46;195"
                        "paginaFinal" => "1&#46;265"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8947994"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thrombolytic agents &#8211; an overview"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Gulba"
                            1 => "C&#46; Bode"
                            2 => "M&#46; Runge"
                            3 => "K&#46; Huber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Hematol"
                        "fecha" => "1996"
                        "volumen" => "73"
                        "numero" => "Suppl I"
                        "paginaInicial" => "S9"
                        "paginaFinal" => "S27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8853112"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reteplase a review of its pharmacological properties and clinical efficacy in the management of acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Noble"
                            1 => "D&#46; Mc Tavish"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Drugs"
                        "fecha" => "1996"
                        "volumen" => "42"
                        "paginaInicial" => "589"
                        "paginaFinal" => "605"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of thrombolytic drugs in the management of myocardial infarction&#46; Comparative clinical trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46; Weaver"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "1996"
                        "volumen" => "17"
                        "numero" => "Suppl F"
                        "paginaInicial" => "9"
                        "paginaFinal" => "15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8960443"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacological and clinical impact of the unique molecular structure of a new plasminogen activator"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Smalling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "1997"
                        "volumen" => "18"
                        "numero" => "Suppl F"
                        "paginaInicial" => "F11"
                        "paginaFinal" => "F16"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9447335"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "More Rapid&#44; complete and stable coronary thrombolysis with bolus administration of reteplase compared with alteplase infusion in acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "R&#46; Smalling"
                            1 => "C&#46; Bode"
                            2 => "J&#46; Kalbfleisch"
                            3 => "S&#46; Sen"
                            4 => "P&#46; Limbourg"
                            5 => "F&#46; Forycki"
                            6 => "the Rapid investigators"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1995"
                        "volumen" => "91"
                        "paginaInicial" => "2&#46;725"
                        "paginaFinal" => "2&#46;732"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7796512"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939409000968"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomized comparison of coronary thrombolytisis achieved with double-bolus reteplase &#40;recombinant plasminogen activator&#41; in patients with acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "C&#46; Bode"
                            1 => "R&#46; Smalling"
                            2 => "G&#46; Berg"
                            3 => "C&#46; Burnett"
                            4 => "G&#46; Lorch"
                            5 => "J&#46; Kalbfleisch"
                            6 => "the RAPID II investigators"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1996"
                        "volumen" => "94"
                        "paginaInicial" => "891"
                        "paginaFinal" => "898"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8790022"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "International Joint Efficacy Comparison of thrombolytics&#46; Randomised&#44; double-blind comparison of reteplase double-bolus administration with streptokinase in acute myocardial infarction &#40;INJECT&#41;&#58; trial to investigate equivalence"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1995"
                        "volumen" => "346"
                        "paginaInicial" => "329"
                        "paginaFinal" => "336"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7623530"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "The GUSTO III Investigators&#46; A comparison of Reteplase with Alteplase for acute myocardial infarction"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199710023371404"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1997"
                        "volumen" => "337"
                        "paginaInicial" => "1&#46;118"
                        "paginaFinal" => "1&#46;123"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9395430"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of reteplase and alteplase on platelet aggregation and mayor receptor expression during the first 24 hours of acute myocardial infarction treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46; Gurbel"
                            1 => "V&#46; Serebruany"
                            2 => "A&#46; Shustov"
                            3 => "R&#46; Bahr"
                            4 => "C&#46; Carpo"
                            5 => "E&#46; Ohman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "1998"
                        "volumen" => "31"
                        "paginaInicial" => "1&#46;466"
                        "paginaFinal" => "1&#46;473"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9626828"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glycoprotein IIb&#47;IIIa blockade and thrombolytics&#58; Early lessons from the SPEED and GUSTO IV trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Califf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1999"
                        "volumen" => "138"
                        "paginaInicial" => "S12"
                        "paginaFinal" => "S15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10385786"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New variant of human tissue plasminogen activator &#40;TPA&#41; with enhanced efficacy and lower incidence of bledding caompared with recombinant human TPA"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Benedict"
                            1 => "D&#46; Phil"
                            2 => "C&#46; Refino"
                            3 => "B&#46; Keit"
                            4 => "R&#46; Pakala"
                            5 => "N&#46; Poni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1995"
                        "volumen" => "92"
                        "paginaInicial" => "3&#46;032"
                        "paginaFinal" => "3&#46;040"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8521580"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TNK-Tissue Plasminigen Activator in Acute Myocardial Infarction&#46; Results of the Thrombolysis in Myocardial Infarction &#40;TIMI 10 A&#41; Dose-Ranging Trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "C&#46; Cannon"
                            1 => "C&#46; McCabe"
                            2 => "M&#46; Gibson"
                            3 => "M&#46; Ghali"
                            4 => "R&#46; Sequena"
                            5 => "E&#46; Braunwald"
                            6 => "the TIMI 10A investigators"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1997"
                        "volumen" => "95"
                        "paginaInicial" => "351"
                        "paginaFinal" => "356"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9008448"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TNK-Tissue plasminogen activator compared with front-loaded alteplase in acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "C&#46;H&#46; Cannon"
                            1 => "C&#46; Gibson"
                            2 => "Cabe C Mc"
                            3 => "A&#46; Adgey"
                            4 => "M&#46; Scheweiger"
                            5 => "E&#46; Braunwald"
                            6 => "the TIMI 10B investigators"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "98"
                        "paginaInicial" => "2&#46;805"
                        "paginaFinal" => "2&#46;814"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9867443"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "For the ASSENT-1 investigators&#46; Safety assessment of single-bolus administration of TNK tissue-plasminogen activator in acute myocardial infarction&#58; the ASSENT-1 trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Van de Werf"
                            1 => "C&#46; Cannon"
                            2 => "A&#46; Luyten"
                            3 => "K&#46; Houbracken"
                            4 => "C&#46; Mc Cabe"
                            5 => "S&#46; Berioli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1999"
                        "volumen" => "137"
                        "paginaInicial" => "786"
                        "paginaFinal" => "791"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10220625"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "For the ASSENT-2 trial investigators&#46; Single- bolus tenectelase compared with front-loaded alteplase in acute myocardial infarction&#58; the ASSENT-2 double-blind randomised trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Van de Werf"
                            1 => "J&#46; Adjey"
                            2 => "D&#46; Ardissino"
                            3 => "P&#46; Armstrong"
                            4 => "Ph Aylward"
                            5 => "G&#46; Barbash"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1999"
                        "volumen" => "354"
                        "paginaInicial" => "716"
                        "paginaFinal" => "722"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10475182"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thrombolysis for acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46; White"
                            1 => "F&#46; Van de Werf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "97"
                        "paginaInicial" => "1&#46;632"
                        "paginaFinal" => "1&#46;646"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9657477"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of a weight-adjusted single-bolus plasminogen activator in patients with myocardial infarction&#46; A double-blind randomized angiographic trial of lanoteplase versus alteplase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "P&#46; Heijer"
                            1 => "F&#46; Vermeer"
                            2 => "E&#46; Ambrosioni"
                            3 => "Z&#46; Sadowoki"
                            4 => "Send&#243;n JL Lopez"
                            5 => "R&#46; Van Essen"
                            6 => "of the In-TIME investigators group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "98"
                        "paginaInicial" => "2&#46;117"
                        "paginaFinal" => "2&#46;125"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9867443"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New Plasminogen Activators&#58; A clinical Review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Ross"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cardiol"
                        "fecha" => "1999"
                        "volumen" => "22"
                        "paginaInicial" => "165"
                        "paginaFinal" => "171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10084057"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Novel Thrombolytic Agents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Verstraete"
                            1 => "H&#46; Lijnen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Drugs Ther"
                        "fecha" => "1994"
                        "volumen" => "8"
                        "paginaInicial" => "801"
                        "paginaFinal" => "812"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7742258"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "PRIMI Trial Study Group&#46; Randomised Double-Blind Trial of Recombinant Pro-urokinase against Streptokinase in Acute Myocardial Infarction"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1989"
                        "volumen" => "1"
                        "paginaInicial" => "863"
                        "paginaFinal" => "867"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2564949"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rate of fibrinogen breakdown related to coronary patency and Bleeding complications in patients with thrombolysis in acute myocardial infarction&#46; Results from the PRIMI Trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "H&#46; Ostermann"
                            1 => "H&#46; Schmitz-Huebner"
                            2 => "J&#46; Windeler"
                            3 => "F&#46; Bar"
                            4 => "J&#46; Meyer"
                            5 => "J&#46; Van de Loo"
                            6 => "for the PRIMI Trial Study Group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "1992"
                        "volumen" => "13"
                        "paginaInicial" => "1&#46;225"
                        "paginaFinal" => "1&#46;232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1493827"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Time course of left ventricular function and coronary patency after saruplase vs streptokinase in acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Schofer"
                            1 => "M&#46; Lins"
                            2 => "G&#46; Mathey"
                            3 => "F&#46; Sheehan"
                            4 => "the PRIMI Trial Study Group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "1993"
                        "volumen" => "14"
                        "paginaInicial" => "958"
                        "paginaFinal" => "963"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8375422"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thrombolysis with Saruplase versus Streptokinase in acute myocardial infarction&#58; Five-year results of the PRIMI trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Spiecker"
                            1 => "J&#46; Windeler"
                            2 => "F&#46; Vermeer"
                            3 => "R&#46; Michels"
                            4 => "R&#46; Seabra-Gomes"
                            5 => "J&#46; Von Dahl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1999"
                        "volumen" => "138"
                        "paginaInicial" => "518"
                        "paginaFinal" => "524"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10467203"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of Saruplase and Alteplase in Acute Myicardial Infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "F&#46; B&#228;r"
                            1 => "J&#46; Meyer"
                            2 => "F&#46; Vermeer"
                            3 => "R&#46; Michels"
                            4 => "B&#46; Charbonnier"
                            5 => "K&#46; Haerten"
                            6 => "for the SESAM Study Group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "1997"
                        "volumen" => "79"
                        "paginaInicial" => "727"
                        "paginaFinal" => "732"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9070549"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomized&#44; double-blind study comparing saruplase with streptokinase therapy in acute myocardial infarction&#58; the COMPASS Equivalence Trial of saruplase and streptokinase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "U&#46; Tebbe"
                            1 => "R&#46; Michels"
                            2 => "J&#46; Adgey"
                            3 => "J&#46; Boland"
                            4 => "A&#46; Caspi"
                            5 => "B&#46; Chanbonnier"
                            6 => "for the COMASS Investigators"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "1998"
                        "volumen" => "31"
                        "paginaInicial" => "487"
                        "paginaFinal" => "493"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9502624"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recombinant Staphylokinase variants With Altered Inmunoreactivity&#58; construction and characterization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Collen"
                            1 => "R&#46; Bernaerts"
                            2 => "P&#46; Declerck"
                            3 => "F&#46; De Cock"
                            4 => "E&#46; Demarsin"
                            5 => "J&#46; Stephane"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1996"
                        "volumen" => "94"
                        "paginaInicial" => "197"
                        "paginaFinal" => "206"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8674179"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Pilot Study on bolus Administration of Recombinant Staphylokinase for Coronary Artery Thrombolysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Vanderschueren"
                            1 => "D&#46; Collen"
                            2 => "F&#46; Van de Werf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thromb Haemost"
                        "fecha" => "1996"
                        "volumen" => "76"
                        "paginaInicial" => "541"
                        "paginaFinal" => "544"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8902993"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomized coronary patency trial of double-bolus recombinant staphylokinase versus front-loaded alteplase in acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Vanderschueren"
                            1 => "J&#46; Dens"
                            2 => "P&#46; Kerdsinchai"
                            3 => "W&#46; Desmet"
                            4 => "M&#46; Vrolix"
                            5 => "F&#46; De Man"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1997"
                        "volumen" => "134"
                        "paginaInicial" => "213"
                        "paginaFinal" => "219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9313600"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "for the doublebolus study investigators and angiographic assessment of alteplase&#58; double-bolus and front-loaded infusion regimens in myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Bleich"
                            1 => "A&#46; Adgey"
                            2 => "R&#46; Mc Mechan"
                            3 => "T&#46; Love"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1998"
                        "volumen" => "136"
                        "paginaInicial" => "741"
                        "paginaFinal" => "748"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9778080"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Comparison of continuos infusion of alteplase with double-bolus administration for acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Van de Wer"
                            1 => "the COBALT investigators"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199710023371404"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1997"
                        "volumen" => "337"
                        "paginaInicial" => "1&#46;124"
                        "paginaFinal" => "1&#46;130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9395430"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sixty-minute alteplase protocol&#58; a new accelerated recombinant tissue-type plasminogen activator regimen for thrombolysis in acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Gulba"
                            1 => "P&#46; Tanswell"
                            2 => "R&#46; Dechend"
                            3 => "M&#46; Sosada"
                            4 => "A&#46; Weis"
                            5 => "J&#46; Waigand"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "1997"
                        "volumen" => "30"
                        "paginaInicial" => "1&#46;611"
                        "paginaFinal" => "1&#46;617"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9385915"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sequential combination thrombolytic therapy for acute myocardial infarction&#58; results of the pro-urokinase and t-PA enhancement of thrombolysis &#40;PATENT&#41; trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "S&#46; Zarich"
                            1 => "G&#46; Kowalchuk"
                            2 => "D&#46; Weaver"
                            3 => "J&#46; Loscalzo"
                            4 => "M&#46; Sassower"
                            5 => "K&#46; Manzo"
                            6 => "for the PATENT study group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "1995"
                        "volumen" => "26"
                        "paginaInicial" => "374"
                        "paginaFinal" => "379"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7608437"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IIb&#47;IIIa Receptor blockade in acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Ferguson"
                            1 => "K&#46; Taqi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1999"
                        "volumen" => "138"
                        "paginaInicial" => "S164"
                        "paginaFinal" => "S170"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10426877"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abciximab Facilitates the rate and Extent of thrombolysis&#46; Results of the Thrombolysis In Myocardial Infarction &#40;TIMI&#41; 14 Trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Antman"
                            1 => "R&#46; Giugliano"
                            2 => "C&#46; Gibson"
                            3 => "C&#46; Mc Cabe"
                            4 => "P&#46; Coussement"
                            5 => "N&#46; Kleiman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1999"
                        "volumen" => "99"
                        "paginaInicial" => "2&#46;720"
                        "paginaFinal" => "2&#46;732"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10385496"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/02105691/0000002400000006/v1_201304241157/S021056910079601X/v1_201304241157/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "34"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Revisi&#243;n"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02105691/0000002400000006/v1_201304241157/S021056910079601X/v1_201304241157/es/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021056910079601X?idApp=WMIE"
]
Información del artículo
ISSN: 02105691
Idioma original: Español
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 21 34 55
2024 Octubre 101 284 385
2024 Septiembre 95 295 390
2024 Agosto 73 241 314
2024 Julio 71 178 249
2024 Junio 77 236 313
2024 Mayo 110 244 354
2024 Abril 74 193 267
2024 Marzo 63 200 263
2024 Febrero 60 245 305
2024 Enero 67 254 321
2023 Diciembre 57 265 322
2023 Noviembre 50 305 355
2023 Octubre 70 327 397
2023 Septiembre 76 330 406
2023 Agosto 54 173 227
2023 Julio 88 212 300
2023 Junio 86 100 186
2023 Mayo 44 111 155
2023 Abril 70 230 300
2023 Marzo 89 303 392
2023 Febrero 124 270 394
2023 Enero 127 273 400
2022 Diciembre 111 215 326
2022 Noviembre 104 255 359
2022 Octubre 77 231 308
2022 Septiembre 85 357 442
2022 Agosto 55 167 222
2022 Julio 24 204 228
2022 Junio 33 206 239
2022 Mayo 41 251 292
2022 Abril 53 239 292
2022 Marzo 50 172 222
2022 Febrero 37 154 191
2022 Enero 50 193 243
2021 Diciembre 43 161 204
2021 Noviembre 49 201 250
2021 Octubre 65 193 258
2021 Septiembre 64 259 323
2021 Agosto 55 200 255
2021 Julio 52 189 241
2021 Junio 57 240 297
2021 Mayo 69 230 299
2021 Abril 152 600 752
2021 Marzo 78 350 428
2021 Febrero 92 242 334
2021 Enero 76 198 274
2020 Diciembre 54 235 289
2020 Noviembre 67 304 371
2020 Octubre 60 192 252
2020 Septiembre 56 276 332
2020 Agosto 48 295 343
2020 Julio 67 297 364
2020 Junio 39 213 252
2020 Mayo 63 288 351
2020 Abril 46 385 431
2020 Marzo 30 212 242
2020 Febrero 86 460 546
2020 Enero 39 195 234
2019 Diciembre 47 235 282
2019 Noviembre 36 266 302
2019 Octubre 36 370 406
2019 Septiembre 45 529 574
2019 Agosto 55 350 405
2019 Julio 46 315 361
2019 Junio 34 425 459
2019 Mayo 48 595 643
2019 Abril 31 416 447
2019 Marzo 19 187 206
2019 Febrero 27 177 204
2019 Enero 30 250 280
2018 Diciembre 45 312 357
2018 Noviembre 57 197 254
2018 Octubre 25 122 147
2018 Septiembre 10 107 117
2018 Agosto 13 83 96
2018 Julio 13 90 103
2018 Junio 15 77 92
2018 Mayo 8 68 76
2018 Abril 14 101 115
2018 Marzo 5 81 86
2018 Febrero 9 73 82
2018 Enero 9 70 79
2017 Diciembre 10 60 70
2017 Noviembre 10 72 82
2017 Octubre 6 48 54
2017 Septiembre 13 87 100
2017 Agosto 7 30 37
2017 Julio 7 51 58
2017 Junio 21 94 115
2017 Mayo 18 62 80
2017 Abril 14 53 67
2017 Marzo 11 101 112
2017 Febrero 8 97 105
2017 Enero 9 69 78
2016 Diciembre 17 38 55
2016 Noviembre 24 75 99
2016 Octubre 36 63 99
2016 Septiembre 83 198 281
2016 Agosto 153 181 334
2016 Julio 48 115 163
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Medicina Intensiva
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?