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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">During recent months&#44; a series of up-dating articles about lung transplant published by members of PLUTO Network &#40;Postoperative Lung Transplant Network&#41; and Grupo de Trasplantes de SEMICYUC&#44; have appeared in Medicina Intensiva&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Even though lung transplant &#40;LT&#41; results have been improving over the last thirty years&#44; and it is accepted as a real therapeutic option for patients in end-stage disease&#44; some issues are still open&#46; Dr&#46; Rello&#39;s article lays down a challenge in terms of developing strategies to increase lung retrieval rates&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Generally speaking&#44; efficiency in lung retrieval is very poor&#44; due to the physiological changes deriving from brain death &#40;BD&#41; and difficulties in the management of potential donors&#46; Efficiency in lung harvesting is usually under 16&#37; of all potential donors&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> This is due to the fact that lung dysfunction is frequent in patients with severe brain damage&#59; between 15 and 20&#37; develop ALI&#47;SDRA&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This&#44; together with changes related to BD such as neurogenic oedema or related to base pathologies including pneumonia or bronchoaspiration&#44; explain the deterioration in oxygen exchange&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Different authors agree that having a specialized team for managing potential donors will result in more organs for transplant&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;6</span></a> Although there is no unique treatment model when talking about donor management&#44; there are different strategies called &#8220;protective strategies&#8221; related to the mechanical ventilation parameters which are widely accepted&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Some authors propose &#8220;aggressive&#8221; procurement such as the use of systematic bronchoscopy or recruitment manoeuvres with high or very high PEEP&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Scarcity of grafts for transplant is partially due to poor efficiency and the fact that there is no evidence supporting the ultra-strict accepted criteria&#46; Present expanded criteria includes&#58; age<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>55&#44; smoking antecedents&#44; abnormal chest X-ray &#40;unilateral&#58; for aspiration or trauma&#41;&#44; or even known positive sputum culture and the use of organs with Pa02<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>300<span class="elsevierStyleHsp" style=""></span>mmHg through recruitment manoeuvres or ex vivo perfusion&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Perhaps the moment has arrived to extend current criteria even further&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Another proposed strategy to increase the organ pool is the use of lungs from NHBD &#40;non heart-beating donors&#41;&#58; Maastricht type II &#40;uncontrolled donors&#41; and type III &#40;controlled&#41;&#44; although these represent a small percentage of transplanted lungs&#46; Results with organs proceeding from NHBD type II are acceptable related to mortality and survival rates&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Yet some other strategies are far removed from our desired intention&#44; for example&#44; the risky procedure of living lung donation&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Dr&#46; Masclans et al&#46;&#44; state in their special article<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> that whilst training for resident doctors in terms of organ donation is of good quality&#44; as courses are performed all over the country&#44; there is little or no emphasis at the level of immediate transplant post-operatory care&#44; management of immunosuppressant treatment and complications&#44; specifically linked to rejection and infection&#46; Bearing in mind that the current training plan dates back to 1996&#44; some degree of modernization should be considered&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Dr&#46; Masclans et al&#46; suggest that training in these increasingly complex areas could be useful for both resident doctors and indeed any doctors coming into contact with this type of patients&#46; To be familiar with the process will make dealing with this kind of patients easier&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Moving on to the main issues within the post-operatory period we find three related articles&#58; primary graft dysfunction &#40;PGD&#41;&#44; antibiotic prophylaxis&#47;infectious disease and advances in immunosuppression&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">PGD is a common postoperative complication&#59; between 15 and 20&#37; of patients will present some degree of dysfunction&#46; The Consensus Document of ISHLT in 2005<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> defines as a non cardiogenic pulmonary oedema less than 72<span class="elsevierStyleHsp" style=""></span>h of reperfusion and at the same time alterations of lung parenchyma&#46; The degree of PGD &#40;1-3&#41; correlated to the outcome and survival rates&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Treatment&#44; as referred to by Dr&#46; Su&#225;rez L&#243;pez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> should be underpinned from two perspectives&#58; &#40;1&#41; that of excellent donor management &#40;attempting to minimize the inflammatory response due to BD&#41; and avoidance of further complications&#44; where the awareness and dedication of intensive care doctors is indispensable&#46; &#40;2&#41; Managing the post-operative period so as to anticipate the following kinds of problems&#58; hemodynamic stabilization&#44; antibiotic prophylactic treatment&#44; individualization of immunosuppression&#44; taking into account the physiological condition of this type of patient&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Graft rejection is the next challenge to solve in LT&#46; An acceptable balance between immunosuppression and side effects is the sought-after end-point&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">We now know the different mechanisms involved in rejection&#46; Up till now we have only paid attention to the cellular rejection &#40;mediated by T cells&#41;&#46; Nowadays we also know that humoral rejection &#40;mediated by antibody&#8211;anti HLA&#41; influences the immediate and long term LT outcome&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">One of the difficulties in this field is the current impossibility of performing the cross-match before surgery in order to not only select the ideal match&#44; but also the amount of antigens carried by the transplanted graft&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">An excellent revision is performed by Dr&#46; J&#46;M&#46; Borro regarding the evolution of immune response mechanisms and the different therapeutic regimes currently in place&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> although the immunosuppressive regime in LT is far from being a uniform practice&#46; Induction treatment has increased in the last 8 years &#40;with polyclonal antilymphocyte globulins at the beginning&#44; converting to interleukin-2 receptor antagonists and alemtuzumab today&#41;&#46; Induction with IL-2R is correlated with better long term outcomes&#44; with a lower number of acute rejection episodes and delayed kidney lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> However&#44; in 2010&#44; only 50&#37; of patients had some type of induction representing a clear drop in this practice &#40;ISHLT 2012&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> The majority of immunosuppressive treatments include three drugs&#58; a calcineurin inhibitor&#44; an anti-proliferative drug and steroids&#46; In the long term immunosuppressive regime&#44; trends are more prone to maintain tacrolimus plus mycophenolic acid although there are other possibilities such as cyclosporine or azatioprine&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;17</span></a> Ideally&#44; the immunosuppressive regime should be tailored to each patient&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Whilst infection is relatively common in the post-operative period&#44; there is no consensus regarding the antibiotic prophylaxis&#46; The use of double or triple antibiotic therapy immediately after the surgery is common&#44; followed by the introduction of antifungals<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> and any cytomegalovirus &#40;CMV&#41; prophylaxis&#46; So far the length of treatment after LT has not been agreed upon&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Dr&#46; J&#46; Sacanell states&#44; as a result of a survey fulfilled for the seven active LT programs in Spain&#44; that the most frequent prophylactic antifungal used is inhaled amphotericin B&#44; which changes with the appearance of bronchospasms to a second line antifungal&#46; In that sense&#44; anidulafungin is used as a preferred second line treatment&#44; even though micafungin has provided greater efficiency against <span class="elsevierStyleItalic">Aspergillus</span> sp&#46; and <span class="elsevierStyleItalic">Candida</span> sp&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Finally&#44; a different approach is offered by Dr&#46; R&#46; Vicente et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> who considered the use of mechanical devices like extracorporeal membrane oxygenation &#40;ECMO&#41; which have created some expectation&#46; ECMO could be used &#40;and the results are acceptable&#41; as a bridge to transplant &#40;BTT&#41;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> in extremely ill patients who would otherwise die while awaiting a graft&#44; or even in conscious patients who are on waiting list&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> It is also used for management of primary graft dysfunction within the postoperative period&#44; allowing physicians to sustain treatment and offer the possibility of survival to some patients while the graft is recovering&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">It is important not to forget that LT is a relatively <span class="elsevierStyleItalic">new</span> field of transplant and consequently all technological and other advances are currently at the experimental stage&#46; Much work and effort is still required by all the professionals involved&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span></span>"
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                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2006"
                        "volumen" => "174"
                        "paginaInicial" => "710"
                        "paginaFinal" => "716"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16799075"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management to optimize organ procurement in brain dead donors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Mascia"
                            1 => "I&#46; Mastromauro"
                            2 => "S&#46; Viberti"
                            3 => "M&#46; Vincenzi"
                            4 => "M&#46; Zanello"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Minerva Anestesiol"
                        "fecha" => "2009"
                        "volumen" => "75"
                        "paginaInicial" => "125"
                        "paginaFinal" => "133"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18636057"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intensivist-led management of brain-dead donors is associated with an increase in organ recovery for transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Singbartl"
                            1 => "R&#46; Murugan"
                            2 => "A&#46;M&#46; Kaynar"
                            3 => "D&#46;W&#46; Crippen"
                            4 => "S&#46;A&#46; Tisherman"
                            5 => "K&#46; Shutterly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-6143.2011.03485"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Transplant"
                        "fecha" => "2011"
                        "volumen" => "11"
                        "paginaInicial" => "1517"
                        "paginaFinal" => "1521"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21449934"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aggressive management of lung donors classified as unacceptable&#58; excellent recipient survival one year after transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Straznicka"
                            1 => "D&#46;M&#46; Follette"
                            2 => "M&#46;D&#46; Eisner"
                            3 => "P&#46;F&#46; Roberts"
                            4 => "R&#46;L&#46; Menza"
                            5 => "W&#46;D&#46; Babcock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "2002"
                        "volumen" => "124"
                        "paginaInicial" => "250"
                        "paginaFinal" => "258"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12167784"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Achieving donor management goals before deceased donor procurement is associated with more organs transplanted per donor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46;J&#46; Malinoski"
                            1 => "M&#46;C&#46; Daly"
                            2 => "M&#46;S&#46; Patel"
                            3 => "C&#46; Oley-Graybill"
                            4 => "C&#46;E&#46; Foster"
                            5 => "A&#46; Salim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/TA.0b013e31822779e5"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2011"
                        "volumen" => "71"
                        "paginaInicial" => "990"
                        "paginaFinal" => "995"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21808207"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation&#58; a randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Mascia"
                            1 => "D&#46; Pasero"
                            2 => "A&#46;S&#46; Slutsky"
                            3 => "M&#46;J&#46; Arguis"
                            4 => "M&#46; Berardino"
                            5 => "S&#46; Grasso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2010.1796"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2010"
                        "volumen" => "304"
                        "paginaInicial" => "2620"
                        "paginaFinal" => "2627"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21156950"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aggressive lung donor management increases graft procurement without increasing renal graft loss after transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Mi&#241;ambres"
                            1 => "M&#46;A&#46; Ballesteros"
                            2 => "E&#46; Rodrigo"
                            3 => "A&#46; Garc&#237;a-Migu&#233;lez"
                            4 => "J&#46; Llorca"
                            5 => "J&#46;C&#46; Ruiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1399-0012.2012.01690.x"
                      "Revista" => array:2 [
                        "tituloSerie" => "Clin Transplant"
                        "fecha" => "2012"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung transplantation with uncontrolled non-heart-beating donor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46;A&#46; Mungu&#237;a-Canales"
                            1 => "J&#46;L&#46; Campo-Ca&#241;averal de la Cruz"
                            2 => "S&#46; Crowley-Carrasco"
                            3 => "D&#46; Lazo-P&#233;rez"
                            4 => "L&#46; Mac&#237;as-Sotuela"
                            5 => "A&#46; Varela-de Ugarte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cir Cir"
                        "fecha" => "2012"
                        "volumen" => "80"
                        "paginaInicial" => "86"
                        "paginaFinal" => "91"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22472160"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung procurement for transplantation&#58; new criteria for lung donor selection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;P&#46; Moretti"
                            1 => "C&#46; Betto"
                            2 => "M&#46; Gambacorta"
                            3 => "S&#46; Vesconi"
                            4 => "M&#46; Scalamogna"
                            5 => "E&#46;M&#46; Benazzi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.transproceed.2010.03.103"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplant Proc"
                        "fecha" => "2010"
                        "volumen" => "42"
                        "paginaInicial" => "1053"
                        "paginaFinal" => "1055"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20534222"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Objetivos docentes en la formaci&#243;n de m&#233;dicos residentes en trasplante de &#243;rganos s&#243;lidos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;R&#46; Masclans"
                            1 => "R&#46; Vicente"
                            2 => "M&#46;A&#46; Ballesteros"
                            3 => "J&#46; Sabater"
                            4 => "O&#46; Roca"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medin.2012.03.012"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2012"
                        "volumen" => "36"
                        "paginaInicial" => "584"
                        "paginaFinal" => "588"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22980670"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ISHLT Working Group on Primary Lung Graft Dysfunction&#46; Report of the ISHLT Working Group on Primary Lung Graft Dysfunction&#46; Part II&#46; Definition&#46; A consensus statement of the International Society for Heart and Lung Transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Christie"
                            1 => "M&#46; Carby"
                            2 => "R&#46; Bag"
                            3 => "P&#46; Corris"
                            4 => "M&#46; Hertz"
                            5 => "D&#46; Weill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.healun.2004.11.049"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Heart Lung Transplant"
                        "fecha" => "2005"
                        "volumen" => "24"
                        "paginaInicial" => "1454"
                        "paginaFinal" => "1459"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16210116"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ISHLT Working Group on Primary Lung Graft Dysfunction&#46; Report of the ISHLT Working Group on Primary Lung Graft Dysfunction&#46; Part V&#46; Predictors and outcomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;M&#46; Arcasoy"
                            1 => "A&#46; Fisher"
                            2 => "R&#46;R&#46; Hachem"
                            3 => "M&#46; Scavuzzo"
                            4 => "Ware LB"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.healun.2004.11.314"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Heart Lung Transplant"
                        "fecha" => "2005"
                        "volumen" => "24"
                        "paginaInicial" => "1483"
                        "paginaFinal" => "1488"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16210119"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disfunci&#243;n primaria del injerto tras el trasplante pulmonar"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46;J&#46; Su&#225;rez L&#243;pez"
                            1 => "E&#46; Mi&#241;ambres"
                            2 => "J&#46;C&#46; Robles Arista"
                            3 => "M&#46;A&#46; Ballesteros"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medin.2012.03.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2012"
                        "volumen" => "36"
                        "paginaInicial" => "506"
                        "paginaFinal" => "512"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22673134"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Avances en la inmunosupresi&#243;n del trasplante pulmonar"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;M&#46; Borro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medin.2012.05.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2013"
                        "volumen" => "37"
                        "paginaInicial" => "44"
                        "paginaFinal" => "49"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22854620"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Registry of the International Society for Heart and Lung Transplantation&#58; twenty-seventh official adult lung and heart-lung transplant report&#8212;2010"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Christie"
                            1 => "L&#46;B&#46; Edwards"
                            2 => "A&#46;Y&#46; Kucheryavaya"
                            3 => "P&#46; Aurora"
                            4 => "F&#46; Dobbels"
                            5 => "R&#46; Kirk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Heart Lung Transplant"
                        "fecha" => "2010"
                        "paginaInicial" => "1104"
                        "paginaFinal" => "1118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9855450"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Registro Espa&#241;ol de Trasplante Pulmonar&#58; primer informe de resultados &#40;2006&#8211;2010&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Coll"
                            1 => "F&#46; Santos"
                            2 => "P&#46; Ussetti"
                            3 => "M&#46; Canela"
                            4 => "J&#46;M&#46; Borro"
                            5 => "M&#46; De La Torre"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arbres.2012.06.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2013"
                        "volumen" => "49"
                        "paginaInicial" => "70"
                        "paginaFinal" => "78"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22939738"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Profilaxis antif&#250;ngica en el postoperatorio de trasplante de pulm&#243;n en Espa&#241;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Sacanell"
                            1 => "T&#46; Rey"
                            2 => "E&#46; Lopez"
                            3 => "R&#46; Vicente"
                            4 => "M&#46;A&#46; Ballesteros"
                            5 => "R&#46; Iranzo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2012"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prophylactic antifungal agents used after lung transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Marino"
                            1 => "J&#46;C&#46; Gallagher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1345/aph.1M377"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Pharmacother"
                        "fecha" => "2010"
                        "volumen" => "44"
                        "paginaInicial" => "546"
                        "paginaFinal" => "556"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20179260"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Vicente R&#44; Moreno I&#44; Soria A&#44; Ramos F&#44; Torregrosa S&#46; Oxigenador de membrana extracorp&#243;reo en el trasplante pulmonar Med Intensiva&#46; 2012&#46; 6 Oct&#46; Available online&#46;"
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
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Update in Intensive Care: Transplants
The impact of lung transplantation on ICU personnel
El impacto del trasplante pulmonar sobre el personal de la UCI
N. Masnoua,
Autor para correspondencia
nmasnou@vhebron.net

Corresponding author.
, J. Rellob
a Transplant Coordination Department, Vall d’Hebron University Hospital, Barcelona, Spain
b Critical Care Department, Vall d’Hebron University Hospital, CIBERES and VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">During recent months&#44; a series of up-dating articles about lung transplant published by members of PLUTO Network &#40;Postoperative Lung Transplant Network&#41; and Grupo de Trasplantes de SEMICYUC&#44; have appeared in Medicina Intensiva&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Even though lung transplant &#40;LT&#41; results have been improving over the last thirty years&#44; and it is accepted as a real therapeutic option for patients in end-stage disease&#44; some issues are still open&#46; Dr&#46; Rello&#39;s article lays down a challenge in terms of developing strategies to increase lung retrieval rates&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Generally speaking&#44; efficiency in lung retrieval is very poor&#44; due to the physiological changes deriving from brain death &#40;BD&#41; and difficulties in the management of potential donors&#46; Efficiency in lung harvesting is usually under 16&#37; of all potential donors&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> This is due to the fact that lung dysfunction is frequent in patients with severe brain damage&#59; between 15 and 20&#37; develop ALI&#47;SDRA&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This&#44; together with changes related to BD such as neurogenic oedema or related to base pathologies including pneumonia or bronchoaspiration&#44; explain the deterioration in oxygen exchange&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Different authors agree that having a specialized team for managing potential donors will result in more organs for transplant&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;6</span></a> Although there is no unique treatment model when talking about donor management&#44; there are different strategies called &#8220;protective strategies&#8221; related to the mechanical ventilation parameters which are widely accepted&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Some authors propose &#8220;aggressive&#8221; procurement such as the use of systematic bronchoscopy or recruitment manoeuvres with high or very high PEEP&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Scarcity of grafts for transplant is partially due to poor efficiency and the fact that there is no evidence supporting the ultra-strict accepted criteria&#46; Present expanded criteria includes&#58; age<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>55&#44; smoking antecedents&#44; abnormal chest X-ray &#40;unilateral&#58; for aspiration or trauma&#41;&#44; or even known positive sputum culture and the use of organs with Pa02<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>300<span class="elsevierStyleHsp" style=""></span>mmHg through recruitment manoeuvres or ex vivo perfusion&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Perhaps the moment has arrived to extend current criteria even further&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Another proposed strategy to increase the organ pool is the use of lungs from NHBD &#40;non heart-beating donors&#41;&#58; Maastricht type II &#40;uncontrolled donors&#41; and type III &#40;controlled&#41;&#44; although these represent a small percentage of transplanted lungs&#46; Results with organs proceeding from NHBD type II are acceptable related to mortality and survival rates&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Yet some other strategies are far removed from our desired intention&#44; for example&#44; the risky procedure of living lung donation&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Dr&#46; Masclans et al&#46;&#44; state in their special article<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> that whilst training for resident doctors in terms of organ donation is of good quality&#44; as courses are performed all over the country&#44; there is little or no emphasis at the level of immediate transplant post-operatory care&#44; management of immunosuppressant treatment and complications&#44; specifically linked to rejection and infection&#46; Bearing in mind that the current training plan dates back to 1996&#44; some degree of modernization should be considered&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Dr&#46; Masclans et al&#46; suggest that training in these increasingly complex areas could be useful for both resident doctors and indeed any doctors coming into contact with this type of patients&#46; To be familiar with the process will make dealing with this kind of patients easier&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Moving on to the main issues within the post-operatory period we find three related articles&#58; primary graft dysfunction &#40;PGD&#41;&#44; antibiotic prophylaxis&#47;infectious disease and advances in immunosuppression&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">PGD is a common postoperative complication&#59; between 15 and 20&#37; of patients will present some degree of dysfunction&#46; The Consensus Document of ISHLT in 2005<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> defines as a non cardiogenic pulmonary oedema less than 72<span class="elsevierStyleHsp" style=""></span>h of reperfusion and at the same time alterations of lung parenchyma&#46; The degree of PGD &#40;1-3&#41; correlated to the outcome and survival rates&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Treatment&#44; as referred to by Dr&#46; Su&#225;rez L&#243;pez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> should be underpinned from two perspectives&#58; &#40;1&#41; that of excellent donor management &#40;attempting to minimize the inflammatory response due to BD&#41; and avoidance of further complications&#44; where the awareness and dedication of intensive care doctors is indispensable&#46; &#40;2&#41; Managing the post-operative period so as to anticipate the following kinds of problems&#58; hemodynamic stabilization&#44; antibiotic prophylactic treatment&#44; individualization of immunosuppression&#44; taking into account the physiological condition of this type of patient&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Graft rejection is the next challenge to solve in LT&#46; An acceptable balance between immunosuppression and side effects is the sought-after end-point&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">We now know the different mechanisms involved in rejection&#46; Up till now we have only paid attention to the cellular rejection &#40;mediated by T cells&#41;&#46; Nowadays we also know that humoral rejection &#40;mediated by antibody&#8211;anti HLA&#41; influences the immediate and long term LT outcome&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">One of the difficulties in this field is the current impossibility of performing the cross-match before surgery in order to not only select the ideal match&#44; but also the amount of antigens carried by the transplanted graft&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">An excellent revision is performed by Dr&#46; J&#46;M&#46; Borro regarding the evolution of immune response mechanisms and the different therapeutic regimes currently in place&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> although the immunosuppressive regime in LT is far from being a uniform practice&#46; Induction treatment has increased in the last 8 years &#40;with polyclonal antilymphocyte globulins at the beginning&#44; converting to interleukin-2 receptor antagonists and alemtuzumab today&#41;&#46; Induction with IL-2R is correlated with better long term outcomes&#44; with a lower number of acute rejection episodes and delayed kidney lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> However&#44; in 2010&#44; only 50&#37; of patients had some type of induction representing a clear drop in this practice &#40;ISHLT 2012&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> The majority of immunosuppressive treatments include three drugs&#58; a calcineurin inhibitor&#44; an anti-proliferative drug and steroids&#46; In the long term immunosuppressive regime&#44; trends are more prone to maintain tacrolimus plus mycophenolic acid although there are other possibilities such as cyclosporine or azatioprine&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;17</span></a> Ideally&#44; the immunosuppressive regime should be tailored to each patient&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Whilst infection is relatively common in the post-operative period&#44; there is no consensus regarding the antibiotic prophylaxis&#46; The use of double or triple antibiotic therapy immediately after the surgery is common&#44; followed by the introduction of antifungals<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> and any cytomegalovirus &#40;CMV&#41; prophylaxis&#46; So far the length of treatment after LT has not been agreed upon&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Dr&#46; J&#46; Sacanell states&#44; as a result of a survey fulfilled for the seven active LT programs in Spain&#44; that the most frequent prophylactic antifungal used is inhaled amphotericin B&#44; which changes with the appearance of bronchospasms to a second line antifungal&#46; In that sense&#44; anidulafungin is used as a preferred second line treatment&#44; even though micafungin has provided greater efficiency against <span class="elsevierStyleItalic">Aspergillus</span> sp&#46; and <span class="elsevierStyleItalic">Candida</span> sp&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Finally&#44; a different approach is offered by Dr&#46; R&#46; Vicente et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> who considered the use of mechanical devices like extracorporeal membrane oxygenation &#40;ECMO&#41; which have created some expectation&#46; ECMO could be used &#40;and the results are acceptable&#41; as a bridge to transplant &#40;BTT&#41;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> in extremely ill patients who would otherwise die while awaiting a graft&#44; or even in conscious patients who are on waiting list&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> It is also used for management of primary graft dysfunction within the postoperative period&#44; allowing physicians to sustain treatment and offer the possibility of survival to some patients while the graft is recovering&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">It is important not to forget that LT is a relatively <span class="elsevierStyleItalic">new</span> field of transplant and consequently all technological and other advances are currently at the experimental stage&#46; Much work and effort is still required by all the professionals involved&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span></span>"
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        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:22 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung transplant&#58; an emerging challenge in the ICU"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Rello"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medin.2012.03.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2012"
                        "volumen" => "36"
                        "paginaInicial" => "504"
                        "paginaFinal" => "505"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22858072"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of a lung transplantation donor-management protocol on lung donation and recipient outcomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;F&#46; Angel"
                            1 => "D&#46;J&#46; Levine"
                            2 => "M&#46;I&#46; Restrepo"
                            3 => "S&#46; Johnson"
                            4 => "E&#46; Sako"
                            5 => "A&#46; Carpenter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200603-432OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2006"
                        "volumen" => "174"
                        "paginaInicial" => "710"
                        "paginaFinal" => "716"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16799075"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management to optimize organ procurement in brain dead donors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Mascia"
                            1 => "I&#46; Mastromauro"
                            2 => "S&#46; Viberti"
                            3 => "M&#46; Vincenzi"
                            4 => "M&#46; Zanello"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Minerva Anestesiol"
                        "fecha" => "2009"
                        "volumen" => "75"
                        "paginaInicial" => "125"
                        "paginaFinal" => "133"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18636057"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intensivist-led management of brain-dead donors is associated with an increase in organ recovery for transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Singbartl"
                            1 => "R&#46; Murugan"
                            2 => "A&#46;M&#46; Kaynar"
                            3 => "D&#46;W&#46; Crippen"
                            4 => "S&#46;A&#46; Tisherman"
                            5 => "K&#46; Shutterly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-6143.2011.03485"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Transplant"
                        "fecha" => "2011"
                        "volumen" => "11"
                        "paginaInicial" => "1517"
                        "paginaFinal" => "1521"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21449934"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aggressive management of lung donors classified as unacceptable&#58; excellent recipient survival one year after transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Straznicka"
                            1 => "D&#46;M&#46; Follette"
                            2 => "M&#46;D&#46; Eisner"
                            3 => "P&#46;F&#46; Roberts"
                            4 => "R&#46;L&#46; Menza"
                            5 => "W&#46;D&#46; Babcock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "2002"
                        "volumen" => "124"
                        "paginaInicial" => "250"
                        "paginaFinal" => "258"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12167784"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Achieving donor management goals before deceased donor procurement is associated with more organs transplanted per donor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46;J&#46; Malinoski"
                            1 => "M&#46;C&#46; Daly"
                            2 => "M&#46;S&#46; Patel"
                            3 => "C&#46; Oley-Graybill"
                            4 => "C&#46;E&#46; Foster"
                            5 => "A&#46; Salim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/TA.0b013e31822779e5"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2011"
                        "volumen" => "71"
                        "paginaInicial" => "990"
                        "paginaFinal" => "995"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21808207"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation&#58; a randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Mascia"
                            1 => "D&#46; Pasero"
                            2 => "A&#46;S&#46; Slutsky"
                            3 => "M&#46;J&#46; Arguis"
                            4 => "M&#46; Berardino"
                            5 => "S&#46; Grasso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2010.1796"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2010"
                        "volumen" => "304"
                        "paginaInicial" => "2620"
                        "paginaFinal" => "2627"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21156950"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aggressive lung donor management increases graft procurement without increasing renal graft loss after transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Mi&#241;ambres"
                            1 => "M&#46;A&#46; Ballesteros"
                            2 => "E&#46; Rodrigo"
                            3 => "A&#46; Garc&#237;a-Migu&#233;lez"
                            4 => "J&#46; Llorca"
                            5 => "J&#46;C&#46; Ruiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1399-0012.2012.01690.x"
                      "Revista" => array:2 [
                        "tituloSerie" => "Clin Transplant"
                        "fecha" => "2012"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung transplantation with uncontrolled non-heart-beating donor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46;A&#46; Mungu&#237;a-Canales"
                            1 => "J&#46;L&#46; Campo-Ca&#241;averal de la Cruz"
                            2 => "S&#46; Crowley-Carrasco"
                            3 => "D&#46; Lazo-P&#233;rez"
                            4 => "L&#46; Mac&#237;as-Sotuela"
                            5 => "A&#46; Varela-de Ugarte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cir Cir"
                        "fecha" => "2012"
                        "volumen" => "80"
                        "paginaInicial" => "86"
                        "paginaFinal" => "91"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22472160"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung procurement for transplantation&#58; new criteria for lung donor selection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;P&#46; Moretti"
                            1 => "C&#46; Betto"
                            2 => "M&#46; Gambacorta"
                            3 => "S&#46; Vesconi"
                            4 => "M&#46; Scalamogna"
                            5 => "E&#46;M&#46; Benazzi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.transproceed.2010.03.103"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplant Proc"
                        "fecha" => "2010"
                        "volumen" => "42"
                        "paginaInicial" => "1053"
                        "paginaFinal" => "1055"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20534222"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Objetivos docentes en la formaci&#243;n de m&#233;dicos residentes en trasplante de &#243;rganos s&#243;lidos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;R&#46; Masclans"
                            1 => "R&#46; Vicente"
                            2 => "M&#46;A&#46; Ballesteros"
                            3 => "J&#46; Sabater"
                            4 => "O&#46; Roca"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medin.2012.03.012"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2012"
                        "volumen" => "36"
                        "paginaInicial" => "584"
                        "paginaFinal" => "588"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22980670"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ISHLT Working Group on Primary Lung Graft Dysfunction&#46; Report of the ISHLT Working Group on Primary Lung Graft Dysfunction&#46; Part II&#46; Definition&#46; A consensus statement of the International Society for Heart and Lung Transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Christie"
                            1 => "M&#46; Carby"
                            2 => "R&#46; Bag"
                            3 => "P&#46; Corris"
                            4 => "M&#46; Hertz"
                            5 => "D&#46; Weill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.healun.2004.11.049"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Heart Lung Transplant"
                        "fecha" => "2005"
                        "volumen" => "24"
                        "paginaInicial" => "1454"
                        "paginaFinal" => "1459"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16210116"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ISHLT Working Group on Primary Lung Graft Dysfunction&#46; Report of the ISHLT Working Group on Primary Lung Graft Dysfunction&#46; Part V&#46; Predictors and outcomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;M&#46; Arcasoy"
                            1 => "A&#46; Fisher"
                            2 => "R&#46;R&#46; Hachem"
                            3 => "M&#46; Scavuzzo"
                            4 => "Ware LB"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.healun.2004.11.314"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Heart Lung Transplant"
                        "fecha" => "2005"
                        "volumen" => "24"
                        "paginaInicial" => "1483"
                        "paginaFinal" => "1488"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16210119"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disfunci&#243;n primaria del injerto tras el trasplante pulmonar"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46;J&#46; Su&#225;rez L&#243;pez"
                            1 => "E&#46; Mi&#241;ambres"
                            2 => "J&#46;C&#46; Robles Arista"
                            3 => "M&#46;A&#46; Ballesteros"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medin.2012.03.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2012"
                        "volumen" => "36"
                        "paginaInicial" => "506"
                        "paginaFinal" => "512"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22673134"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
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                      "titulo" => "Avances en la inmunosupresi&#243;n del trasplante pulmonar"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
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                    0 => array:2 [
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                ]
              ]
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                        0 => array:2 [
                          "etal" => true
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                            2 => "A&#46;Y&#46; Kucheryavaya"
                            3 => "P&#46; Aurora"
                            4 => "F&#46; Dobbels"
                            5 => "R&#46; Kirk"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "paginaFinal" => "1118"
                        "link" => array:1 [
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                  ]
                ]
              ]
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                      "titulo" => "Registro Espa&#241;ol de Trasplante Pulmonar&#58; primer informe de resultados &#40;2006&#8211;2010&#41;"
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                        0 => array:2 [
                          "etal" => true
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                            2 => "P&#46; Ussetti"
                            3 => "M&#46; Canela"
                            4 => "J&#46;M&#46; Borro"
                            5 => "M&#46; De La Torre"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
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                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2013"
                        "volumen" => "49"
                        "paginaInicial" => "70"
                        "paginaFinal" => "78"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22939738"
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                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "18"
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                    0 => array:2 [
                      "titulo" => "Profilaxis antif&#250;ngica en el postoperatorio de trasplante de pulm&#243;n en Espa&#241;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "T&#46; Rey"
                            2 => "E&#46; Lopez"
                            3 => "R&#46; Vicente"
                            4 => "M&#46;A&#46; Ballesteros"
                            5 => "R&#46; Iranzo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2012"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prophylactic antifungal agents used after lung transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Marino"
                            1 => "J&#46;C&#46; Gallagher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1345/aph.1M377"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Pharmacother"
                        "fecha" => "2010"
                        "volumen" => "44"
                        "paginaInicial" => "546"
                        "paginaFinal" => "556"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20179260"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                  "referenciaCompleta" => "Vicente R&#44; Moreno I&#44; Soria A&#44; Ramos F&#44; Torregrosa S&#46; Oxigenador de membrana extracorp&#243;reo en el trasplante pulmonar Med Intensiva&#46; 2012&#46; 6 Oct&#46; Available online&#46;"
                ]
              ]
            ]
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              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Primary lung transplantation after bridge with extracorporeal membrane oxygenation&#58; a plea for a shift in our paradigms for indications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Lang"
                            1 => "S&#46; Taghavi"
                            2 => "C&#46; Aigner"
                            3 => "F&#46; R&#233;nyi-V&#225;mos"
                            4 => "P&#46; Jaksch"
                            5 => "V&#46; Augustin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/TP.0b013e318246f8e1"
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                        "tituloSerie" => "Transplantation"
                        "fecha" => "2012"
                        "volumen" => "93"
                        "paginaInicial" => "729"
                        "paginaFinal" => "736"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22415051"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extracorporeal membrane oxygenation in awake patients as bridge to lung transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Fuehner"
                            1 => "C&#46; Kuehn"
                            2 => "J&#46; Hadem"
                            3 => "O&#46; Wiesner"
                            4 => "J&#46; Gottlieb"
                            5 => "I&#46; Tudorache"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201109-1599OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2012"
                        "volumen" => "185"
                        "paginaInicial" => "763"
                        "paginaFinal" => "768"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22268135"
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                      ]
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            ]
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ISSN: 02105691
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