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with fraction of inspired oxygen &#40;FiO<span class="elsevierStyleInf">2</span>&#41; greater than 70&#37;&#44; was even lower than the recommendations of low PEEP level group in ALVEOLI study&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">2</span></a> This argument regarding PEEP level is not exclusive for patients with ARDS but this parameter is controversial in other situations such as surgical patients or patients with exacerbations of chronic obstructive pulmonary disease &#40;COPD&#41;&#44; both to set FiO<span class="elsevierStyleInf">2</span> and to improve patient&#8211;ventilator interaction&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">It is demonstrated that the use of lung protective ventilation strategies improve the outcome of patients with ARDS and there is broad consensus in using a limited tidal volume and a limited lung pressure&#44; as well as using PEEP levels higher than those used &#40;and still being used&#41; in routine clinical practice&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">4&#44;5</span></a> However&#44; there is no consensus regarding the appropriate strategy to select a PEEP level in each patient&#44; so that different strategies are used with different purposes&#44; what&#44; at the moment&#44; could be the two basic strategies&#58; optimal PEEP determination depending on pulmonary mechanics of each patient or PEEP level adjustment depending on the quotient PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Recently&#44; we have learned that in order to set tidal volume and PEEP level we have to keep in mind hemodynamics and pulmonary mechanics monitorization in patients with ARDS&#44; so what is important to set ventilatory parameters is knowing lung recruitment capacity &#40;to avoid atelectrauma&#41; and keep the balance with an adequate tidal volume &#40;to avoid overstretching phenomena&#41;&#46; Undoubtedly&#44; adequate balance between lung recruitment and overstretching improves not only lung function but also cardiac function in patients with ARDS&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In a meta-analysis conducted by our group analyzing the effect of high PEEP versus conventional PEEP in ARDS&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">7</span></a> we have already described that the use of high PEEP was not associated to increase mortality&#46; However&#44; if we consider only those studies in which high PEEP level is selected depending on the pulmonary mechanics characteristics&#44; obtained by performing pressure-volume curves&#44; the use of a high PEEP level was associated with a significant reduction in mortality &#40;RR 0&#46;59&#44; 95&#37; CI 0&#46;43&#8211;0&#46;82&#41; and the incidence of barotrauma &#40;RR 0&#46;24&#44; 95&#37; CI 0&#46;09&#8211;0&#46;70&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Recently Amaro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a> have published the Driving Pressure Concept&#46; Driving pressure could be the most important force in mechanical ventilation&#44; it is the ratio as an index indicating the &#8220;functional&#8221; size of the lung an would provide a better predictor of outcomes in patients with ARDS than volume tidal alone&#46; This ratio &#40;&#916;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Volume tidal&#47;static compliance&#41;&#44; can be routinely calculated for patients who are not making inspiratory efforts as the plateau pressure minus PEEP&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Pintado et al&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a> published a randomized study comparing a lung protective ventilation strategy with two types of setting PEEP level in 70 patients with ARDS&#58; 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vs&#46; 21&#37;&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">This issue of &#8220;Medicina Intensiva&#8221; journal&#44;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">10</span></a> presents a post hoc analysis of this study which included patients with severe ARDS according to Berlin consensus conference criteria&#44; reporting that in severe ARDS patients&#44; they found more organ dysfunction-free days at 28 days &#40;12&#46;83<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;70 vs&#46; 3&#46;09<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;23&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41; and a trend toward lower 28-days mortality when PEEP was applied according to best static compliance &#40;33&#46;3&#37; vs&#46; 72&#46;7&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;16&#41;&#46; In patients with moderate ARDS&#44; they did not find those effects&#46; An important limitation of this study is the sample size&#44; this could explain some of the negatives results&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">A very interesting finding of this study is that patients randomized to compliance-guided PEEP adjustment group had a strong trend to lower driving pressure mainly at the beginning of the evolution of the disease&#46; This finding was very similar regardless of severity of ARDS&#46; Recently&#44; Amato et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a> performed a multilevel mediation analysis with nine previous randomized trials on patients with ARDS to examine if the driving pressure &#40;VT&#47;respiratory-system compliance&#41; was an independent variable associated with survival&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The authors of the study declare its limitations&#44; originated mainly its post hoc analysis of a randomized trial with a low number of patients&#44; however it is useful to create a hypothesis of great interest to justify conducting a multicenter clinical trial to resolve definitely the important question &#8220;What PEEP level should I use in my patient&#63;&#8221;&#44; meanwhile&#44; from the respiration physiology perspective&#44; PEEP optimization based on clinical situation and lung mechanics in each individual case might be the best option&#44; perhaps making use of bedside imaging techniques as ultrasound or electrical impedance tomography &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#44; although it is not the easiest one at the routine clinical practice&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">As we have seen in PROSEVA study<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a> regarding the use of prone-position during ventilation&#44; the biggest benefit of this physiologic approach might lie in its specific use in high risk patients who need an individualized treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical disclosures</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Protection of human and animal subjects</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Confidentiality of data</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Right to privacy and informed consent</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span></span>"
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Editorial
What PEEP level should I use in my patient?
¿Qué nivel de PEEP debería utilizar en mi paciente?
F. Gordoa,b,
Autor para correspondencia
fgordo5@gmail.com

Corresponding author.
, I. Conejoa
a Servicio de Medicina Intensiva, Hospital Universitario del Henares, Coslada, Madrid, Spain
b Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">What PEEP level should I use in my patient&#63; This is a question we ask ourselves everyday in clinical practice when we are dealing with mechanical ventilation in the intensive care unit &#40;ICU&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Nowadays this question does not have a unique answer&#44; which causes an important variability in clinical practice&#46; Recent studies in patients with ARDS &#40;Acute respiratory distress syndrome&#41; present this variability as well as non-compliance of clinical practice guidelines recommendations&#46; For example&#44; in LUNG-SAFE<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">1</span></a> study only 53&#37; of ARDS patients were ventilated with tidal volume less than 7<span class="elsevierStyleHsp" style=""></span>ml&#47;kg while PEEP level used in these patients&#44; with fraction of inspired oxygen &#40;FiO<span class="elsevierStyleInf">2</span>&#41; greater than 70&#37;&#44; was even lower than the recommendations of low PEEP level group in ALVEOLI study&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">2</span></a> This argument regarding PEEP level is not exclusive for patients with ARDS but this parameter is controversial in other situations such as surgical patients or patients with exacerbations of chronic obstructive pulmonary disease &#40;COPD&#41;&#44; both to set FiO<span class="elsevierStyleInf">2</span> and to improve patient&#8211;ventilator interaction&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">It is demonstrated that the use of lung protective ventilation strategies improve the outcome of patients with ARDS and there is broad consensus in using a limited tidal volume and a limited lung pressure&#44; as well as using PEEP levels higher than those used &#40;and still being used&#41; in routine clinical practice&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">4&#44;5</span></a> However&#44; there is no consensus regarding the appropriate strategy to select a PEEP level in each patient&#44; so that different strategies are used with different purposes&#44; what&#44; at the moment&#44; could be the two basic strategies&#58; optimal PEEP determination depending on pulmonary mechanics of each patient or PEEP level adjustment depending on the quotient PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Recently&#44; we have learned that in order to set tidal volume and PEEP level we have to keep in mind hemodynamics and pulmonary mechanics monitorization in patients with ARDS&#44; so what is important to set ventilatory parameters is knowing lung recruitment capacity &#40;to avoid atelectrauma&#41; and keep the balance with an adequate tidal volume &#40;to avoid overstretching phenomena&#41;&#46; Undoubtedly&#44; adequate balance between lung recruitment and overstretching improves not only lung function but also cardiac function in patients with ARDS&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In a meta-analysis conducted by our group analyzing the effect of high PEEP versus conventional PEEP in ARDS&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">7</span></a> we have already described that the use of high PEEP was not associated to increase mortality&#46; However&#44; if we consider only those studies in which high PEEP level is selected depending on the pulmonary mechanics characteristics&#44; obtained by performing pressure-volume curves&#44; the use of a high PEEP level was associated with a significant reduction in mortality &#40;RR 0&#46;59&#44; 95&#37; CI 0&#46;43&#8211;0&#46;82&#41; and the incidence of barotrauma &#40;RR 0&#46;24&#44; 95&#37; CI 0&#46;09&#8211;0&#46;70&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Recently Amaro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a> have published the Driving Pressure Concept&#46; Driving pressure could be the most important force in mechanical ventilation&#44; it is the ratio as an index indicating the &#8220;functional&#8221; size of the lung an would provide a better predictor of outcomes in patients with ARDS than volume tidal alone&#46; This ratio &#40;&#916;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Volume tidal&#47;static compliance&#41;&#44; can be routinely calculated for patients who are not making inspiratory efforts as the plateau pressure minus PEEP&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Pintado et al&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a> published a randomized study comparing a lung protective ventilation strategy with two types of setting PEEP level in 70 patients with ARDS&#58; based on PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> or based on pulmonary mechanics&#44; searching for the best pulmonary compliance point&#46; Main results have shown the group selected based on compliance had more organ dysfunction-free days &#40;median 6 vs&#46; 20&#46;5 days&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41;&#44; more days without respiratory failure &#40;7&#46;5 vs&#46; 14&#46;5 days&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#41;&#44; and more days without hemodynamic failure &#40;16 vs&#46; 22 days&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46; There was nonsignificant reduction in mortality at 28 days &#40;39&#37; vs&#46; 21&#37;&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">This issue of &#8220;Medicina Intensiva&#8221; journal&#44;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">10</span></a> presents a post hoc analysis of this study which included patients with severe ARDS according to Berlin consensus conference criteria&#44; reporting that in severe ARDS patients&#44; they found more organ dysfunction-free days at 28 days &#40;12&#46;83<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;70 vs&#46; 3&#46;09<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;23&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41; and a trend toward lower 28-days mortality when PEEP was applied according to best static compliance &#40;33&#46;3&#37; vs&#46; 72&#46;7&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;16&#41;&#46; In patients with moderate ARDS&#44; they did not find those effects&#46; An important limitation of this study is the sample size&#44; this could explain some of the negatives results&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">A very interesting finding of this study is that patients randomized to compliance-guided PEEP adjustment group had a strong trend to lower driving pressure mainly at the beginning of the evolution of the disease&#46; This finding was very similar regardless of severity of ARDS&#46; Recently&#44; Amato et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a> performed a multilevel mediation analysis with nine previous randomized trials on patients with ARDS to examine if the driving pressure &#40;VT&#47;respiratory-system compliance&#41; was an independent variable associated with survival&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The authors of the study declare its limitations&#44; originated mainly its post hoc analysis of a randomized trial with a low number of patients&#44; however it is useful to create a hypothesis of great interest to justify conducting a multicenter clinical trial to resolve definitely the important question &#8220;What PEEP level should I use in my patient&#63;&#8221;&#44; meanwhile&#44; from the respiration physiology perspective&#44; PEEP optimization based on clinical situation and lung mechanics in each individual case might be the best option&#44; perhaps making use of bedside imaging techniques as ultrasound or electrical impedance tomography &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#44; although it is not the easiest one at the routine clinical practice&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">As we have seen in PROSEVA study<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a> regarding the use of prone-position during ventilation&#44; the biggest benefit of this physiologic approach might lie in its specific use in high risk patients who need an individualized treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical disclosures</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Protection of human and animal subjects</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Confidentiality of data</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Right to privacy and informed consent</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span></span>"
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