Scientific Letter
Assessment of plasma endocan for the prediction of mortality in COVID-19 patients undergoing veno-venous ECMO: A pilot study
Evaluación del endocan para la predicción de la mortalidad en pacientes COVID-19 sometidos a ECMO veno-venosa: un estudio piloto
C. Levya,b,c,e, N. Dognona,b,c,e, S. Normandina,b,c,e, T. Duburcqa,b,c,e, A. Gaudeta,b,c,d,e,
, Lille Intensive Care COVID-19 group 1
Autor para correspondencia
a Department of Intensive Care Medicine, Critical Care Center, CHU Lille, F-59000 Lille, France
b University of Lille, U995-LIRIC-Lille Inflammation Research International Center, Lille, France
c CHU Lille, Immunology Institute, F-59000 Lille, France
d University Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité de Lille, F-59000 Lille, France
e University Lille, Inserm, U1285, CNRS, UMR 8576 - Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France
Lille Intensive Care COVID-19 group , Erika Parmentier-Decrucq, Julien Poissy, Sylvain Dubucquoi, Pauline Boddaert, Morgan Caplan, Julien Goutay, Arthur Durand, Benoit Graffin, Myrtille Gaudel, Charles Detollenaere, Ines Gueguen, Marine Van Ceunebroek, Romain Tortuyaux, Ouriel Saura, Ahmed El Kalioubie, Raphael Favory, Patrick Girardie, Marion Houard, Emmanuelle Jaillette..., Mercedes Jourdain, Geoffrey Ledoux, Daniel Mathieu, Anne Sophie Moreau, Saad Nseir, Thierry Onimus, Sebastien Preau, Laurent Robriquet, Anahita Rouze, Sophie Six, Jerome Soquet, Valentin Loobuyck, Agnes Mugnier, André VincentelliVer más
Leído
2134
Vecesse ha leído el artículo
728
Total PDF
1406
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S0210569122001073" "issn" => "02105691" "doi" => "10.1016/j.medin.2022.04.003" "estado" => "S300" "fechaPublicacion" => "2023-01-01" "aid" => "1788" "copyright" => "Elsevier España, S.L.U. y SEMICYUC" "copyrightAnyo" => "2022" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Med Intensiva. 2023;47:51-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:17 [ "pii" => "S0210569122002807" "issn" => "02105691" "doi" => "10.1016/j.medin.2022.07.006" "estado" => "S300" "fechaPublicacion" => "2023-01-01" "aid" => "1819" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Intensiva. 2023;47:55-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Antiseptic mouthwashes and mortality: look beyond chlorhexidine" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "55" "paginaFinal" => "56" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enjuagues bucales antisépticos y mortalidad: más allá de la clorhexidina" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Blot, M. Deschepper" "autores" => array:2 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Blot" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Deschepper" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569122002807?idApp=WMIE" "url" => "/02105691/0000004700000001/v1_202301030811/S0210569122002807/v1_202301030811/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210569122001565" "issn" => "02105691" "doi" => "10.1016/j.medin.2022.05.003" "estado" => "S300" "fechaPublicacion" => "2023-01-01" "aid" => "1796" "copyright" => "Elsevier España, S.L.U. y SEMICYUC" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Med Intensiva. 2023;47:48-51" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Myocardial injury as a prognostic factor in critically ill patients with severe SARS-Cov-2 pneumonia" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "48" "paginaFinal" => "51" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Daño miocárdico como factor pronóstico en neumonía grave por SARS-CoV-2" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1455 "Ancho" => 2341 "Tamanyo" => 131645 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Variables associated with 28-day mortality (logistic regression).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Villavicencio, X. Daniel, C. Ferré, M. Cartanyá, Á. Pobo, I. Oliva, M. Roure, J. Leache, M. Bodí" "autores" => array:9 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Villavicencio" ] 1 => array:2 [ "nombre" => "X." "apellidos" => "Daniel" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Ferré" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Cartanyá" ] 4 => array:2 [ "nombre" => "Á." "apellidos" => "Pobo" ] 5 => array:2 [ "nombre" => "I." "apellidos" => "Oliva" ] 6 => array:2 [ "nombre" => "M." "apellidos" => "Roure" ] 7 => array:2 [ "nombre" => "J." "apellidos" => "Leache" ] 8 => array:2 [ "nombre" => "M." "apellidos" => "Bodí" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569122001565?idApp=WMIE" "url" => "/02105691/0000004700000001/v1_202301030811/S0210569122001565/v1_202301030811/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Assessment of plasma endocan for the prediction of mortality in COVID-19 patients undergoing veno-venous ECMO: A pilot study" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "51" "paginaFinal" => "54" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "C. Levy, N. Dognon, S. Normandin, T. Duburcq, A. Gaudet" "autores" => array:6 [ 0 => array:3 [ "nombre" => "C." "apellidos" => "Levy" "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 1 => array:3 [ "nombre" => "N." "apellidos" => "Dognon" "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 2 => array:3 [ "nombre" => "S." "apellidos" => "Normandin" "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 3 => array:3 [ "nombre" => "T." "apellidos" => "Duburcq" "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 4 => array:4 [ "nombre" => "A." "apellidos" => "Gaudet" "email" => array:1 [ 0 => "alexandre.gaudet@chru-lille.fr" ] "referencia" => array:6 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 4 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] 5 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 5 => array:2 [ "colaborador" => "Lille Intensive Care COVID-19 group" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn0005" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Department of Intensive Care Medicine, Critical Care Center, CHU Lille, F-59000 Lille, France" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "University of Lille, U995-LIRIC-Lille Inflammation Research International Center, Lille, France" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "CHU Lille, Immunology Institute, F-59000 Lille, France" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "University Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité de Lille, F-59000 Lille, France" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "University Lille, Inserm, U1285, CNRS, UMR 8576 - Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] 1 => array:2 [ "autoresLista" => "Erika Parmentier-Decrucq, Julien Poissy, Sylvain Dubucquoi, Pauline Boddaert, Morgan Caplan, Julien Goutay, Arthur Durand, Benoit Graffin, Myrtille Gaudel, Charles Detollenaere, Ines Gueguen, Marine Van Ceunebroek, Romain Tortuyaux, Ouriel Saura, Ahmed El Kalioubie, Raphael Favory, Patrick Girardie, Marion Houard, Emmanuelle Jaillette, Mercedes Jourdain, Geoffrey Ledoux, Daniel Mathieu, Anne Sophie Moreau, Saad Nseir, Thierry Onimus, Sebastien Preau, Laurent Robriquet, Anahita Rouze, Sophie Six, Jerome Soquet, Valentin Loobuyck, Agnes Mugnier, André Vincentelli" "autores" => array:34 [ 0 => array:1 [ "colaborador" => "Lille Intensive Care COVID-19 group" ] 1 => array:2 [ "nombre" => "Erika" "apellidos" => "Parmentier-Decrucq" ] 2 => array:2 [ "nombre" => "Julien" "apellidos" => "Poissy" ] 3 => array:2 [ "nombre" => "Sylvain" "apellidos" => "Dubucquoi" ] 4 => array:2 [ "nombre" => "Pauline" "apellidos" => "Boddaert" ] 5 => array:2 [ "nombre" => "Morgan" "apellidos" => "Caplan" ] 6 => array:2 [ "nombre" => "Julien" "apellidos" => "Goutay" ] 7 => array:2 [ "nombre" => "Arthur" "apellidos" => "Durand" ] 8 => array:2 [ "nombre" => "Benoit" "apellidos" => "Graffin" ] 9 => array:2 [ "nombre" => "Myrtille" "apellidos" => "Gaudel" ] 10 => array:2 [ "nombre" => "Charles" "apellidos" => "Detollenaere" ] 11 => array:2 [ "nombre" => "Ines" "apellidos" => "Gueguen" ] 12 => array:2 [ "nombre" => "Marine Van" "apellidos" => "Ceunebroek" ] 13 => array:2 [ "nombre" => "Romain" "apellidos" => "Tortuyaux" ] 14 => array:2 [ "nombre" => "Ouriel" "apellidos" => "Saura" ] 15 => array:2 [ "nombre" => "Ahmed El" "apellidos" => "Kalioubie" ] 16 => array:2 [ "nombre" => "Raphael" "apellidos" => "Favory" ] 17 => array:2 [ "nombre" => "Patrick" "apellidos" => "Girardie" ] 18 => array:2 [ "nombre" => "Marion" "apellidos" => "Houard" ] 19 => array:2 [ "nombre" => "Emmanuelle" "apellidos" => "Jaillette" ] 20 => array:2 [ "nombre" => "Mercedes" "apellidos" => "Jourdain" ] 21 => array:2 [ "nombre" => "Geoffrey" "apellidos" => "Ledoux" ] 22 => array:2 [ "nombre" => "Daniel" "apellidos" => "Mathieu" ] 23 => array:2 [ "nombre" => "Anne Sophie" "apellidos" => "Moreau" ] 24 => array:2 [ "nombre" => "Saad" "apellidos" => "Nseir" ] 25 => array:2 [ "nombre" => "Thierry" "apellidos" => "Onimus" ] 26 => array:2 [ "nombre" => "Sebastien" "apellidos" => "Preau" ] 27 => array:2 [ "nombre" => "Laurent" "apellidos" => "Robriquet" ] 28 => array:2 [ "nombre" => "Anahita" "apellidos" => "Rouze" ] 29 => array:2 [ "nombre" => "Sophie" "apellidos" => "Six" ] 30 => array:2 [ "nombre" => "Jerome" "apellidos" => "Soquet" ] 31 => array:2 [ "nombre" => "Valentin" "apellidos" => "Loobuyck" ] 32 => array:2 [ "nombre" => "Agnes" "apellidos" => "Mugnier" ] 33 => array:2 [ "nombre" => "André" "apellidos" => "Vincentelli" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación del endocan para la predicción de la mortalidad en pacientes COVID-19 sometidos a ECMO veno-venosa: un estudio piloto" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1366 "Ancho" => 2502 "Tamanyo" => 207157 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Decision tree for prediction of survival on ICU discharge. Endocan<span class="elsevierStyleInf">D0</span>, endocan<span class="elsevierStyleInf">D7</span>, endocan<span class="elsevierStyleInf">D0–D7</span>, CRP<span class="elsevierStyleInf">D0</span>, CRP<span class="elsevierStyleInf">D7</span>, CRP<span class="elsevierStyleInf">D0–D7</span>, fibrinogen<span class="elsevierStyleInf">D0</span>, fibrinogen<span class="elsevierStyleInf">D7</span> and fibrinogen<span class="elsevierStyleInf">D0–D7</span> were tested as covariates for survival in ICU prediction model. D0: day of ECMO implantation. D7: day 7 following ECMO implantation; D0–D7: variation between D0 and D7, calculated as (value on D7<span class="elsevierStyleHsp" style=""></span>−<span class="elsevierStyleHsp" style=""></span>value on D0)/value on D0.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Patients with severe COVID-19 related acute respiratory distress syndrome (ARDS) may benefit from V-V ECMO support. However, this technique remains associated with frequent complications and high mortality.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> The early identification of patients with V-V ECMO who are likely to survive on ICU discharge therefore seems of major interest.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Endocan is a circulating proteoglycan secreted by the pulmonary vasculature under inflammatory conditions such as ARDS.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> Recent data suggest that monitoring of blood endocan during 1st week following intensive care unit (ICU) admission may correlate with the severity of ARDS in Covid-19.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Thus, we aimed in this study to assess whether plasma endocan measurements performed on the day of V-V ECMO implantation (D0) and repeated seven days later (D7) may be effective in predicting mortality on ICU discharge.</p><p id="par0020" class="elsevierStylePara elsevierViewall">This study was conducted in a 50-bed mixed ICU, from October 2020 to June 2021. We included all consecutive COVID-19 patients undergoing V-V ECMO implantation and with available results of plasma endocan measured on day of ECMO implantation.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Endocan was measured weekly on EDTA plasma in the central laboratory of our hospital using the ENDOMARK H1 ELISA kit (Biothelis, France) in COVID-19 patients admitted in our ICU as part as the routine assessment of prognosis in ARDS,<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">4–6</span></a> along with CRP and fibrinogen. This research was examined by our local IRB, and approved under the number HP 22/01. Because of the retrospective observational design, written informed consent was not required.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Patients’ characteristics were obtained at D0. We also retrospectively collected values on D0 and D7 for plasma endocan (endocan<span class="elsevierStyleInf">D0</span> and endocan<span class="elsevierStyleInf">D7</span>), CRP (CRP<span class="elsevierStyleInf">D0</span> and CRP<span class="elsevierStyleInf">D7</span>) and fibrinogen (fibrinogen<span class="elsevierStyleInf">D0</span> and fibrinogen<span class="elsevierStyleInf">D7</span>). Variations between D0 and D7 were respectively calculated for endocan (endocan<span class="elsevierStyleInf">D0–D7</span>), CRP (CRP<span class="elsevierStyleInf">D0–D7</span>) and fibrinogen (fibrinogen<span class="elsevierStyleInf">D0–D7</span>) as following: (value on D7<span class="elsevierStyleHsp" style=""></span>−<span class="elsevierStyleHsp" style=""></span>value on D0)/value on D0.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Categorical variables were expressed as numbers (percentages) and compared using Fisher's exact test, given small sample sizes. Skewed continuous variables were presented as median (interquartile range) and compared using Mann-Whitney U test.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Decision tree based on CART algorithm was generated using the <span class="elsevierStyleItalic">rpart</span> R package with default settings, using endocan<span class="elsevierStyleInf">D0</span>, endocan<span class="elsevierStyleInf">D7</span>, endocan<span class="elsevierStyleInf">D0–D7</span>, CRP<span class="elsevierStyleInf">D0</span>, CRP<span class="elsevierStyleInf">D7</span>, CRP<span class="elsevierStyleInf">D0–D7</span>, fibrinogen<span class="elsevierStyleInf">D0</span>, fibrinogen<span class="elsevierStyleInf">D7</span> and fibrinogen<span class="elsevierStyleInf">D0–D7</span> as covariates.</p><p id="par0045" class="elsevierStylePara elsevierViewall">All statistical tests were two-tailed, and <span class="elsevierStyleItalic">p</span> values <0.05 were considered statistically significant. Statistical analysis was performed using R version 3.6 (R foundation for statistical analysis, Austria).</p><p id="par0050" class="elsevierStylePara elsevierViewall">Eleven patients undergoing V-V ECMO implantation for COVID-19 related ARDS were included in this study, of whom 5 (45%) were discharged alive from ICU. All patients underwent invasive mechanical ventilation (MV) during their stay in ICU, although invasive MV was initiated right before ECMO implantation and maintained less than 24<span class="elsevierStyleHsp" style=""></span>h for 2 patients from the survivors group.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Compared to survivors, non-survivors had higher endocan<span class="elsevierStyleInf">D7</span> (median [IQR]<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>12.9 [6.1; 19]<span class="elsevierStyleHsp" style=""></span>ng/ml vs 4.3 [3.9; 5.6]<span class="elsevierStyleHsp" style=""></span>ng/ml; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.017), and greater increase in endocan<span class="elsevierStyleInf">D0–D7</span> (median [IQR]<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>208 [−1; +612] % vs −49 [−65; +52]%; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.03). Conversely, no difference was found between non-survivors and survivors for endocan<span class="elsevierStyleInf">D0</span> (median [IQR]<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4.7 [3; 5.7]<span class="elsevierStyleHsp" style=""></span>ng/ml vs 7.9 [3.8; 12.2]<span class="elsevierStyleHsp" style=""></span>ng/ml; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.25), CRP<span class="elsevierStyleInf">D0</span> (median [IQR]<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>94 [68; 200]<span class="elsevierStyleHsp" style=""></span>mg/l vs 118 [26; 150]<span class="elsevierStyleHsp" style=""></span>mg/l; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.66), CRP<span class="elsevierStyleInf">D7</span> (median [IQR]<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>68 [50; 77]<span class="elsevierStyleHsp" style=""></span>mg/l vs 39 [35; 123]<span class="elsevierStyleHsp" style=""></span>mg/l; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.41), CRP<span class="elsevierStyleInf">D0–D7</span> (median [IQR]<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−17 [−72; −5]% vs 4 [−75; +484]%; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.54), fibrinogen<span class="elsevierStyleInf">D0</span> (median [IQR]<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>7.1 [4.9; 8.1]<span class="elsevierStyleHsp" style=""></span>g/l vs 6.1 [3.9; 6.8]<span class="elsevierStyleHsp" style=""></span>g/l; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.33), fibrinogen<span class="elsevierStyleInf">D7</span> (median [IQR]<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5.1 [4.3; 5.6]<span class="elsevierStyleHsp" style=""></span>g/l vs 4.6 [2.7; 5.1]<span class="elsevierStyleHsp" style=""></span>g/l; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.23), and fibrinogen<span class="elsevierStyleInf">D0−D7</span> (median [IQR]<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−26 [−43; +9] % vs −28 [−50; +15]%; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">According to a decision tree based on a CART algorithm, a 2-nodes model combining endocan<span class="elsevierStyleInf">D0–D7</span> with static value of endocan<span class="elsevierStyleInf">D0</span> was able to correctly identify all survivors and non-survivors. Indeed, according to this decision tree, 3/3 patients with endocan<span class="elsevierStyleInf">D0−D7</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>−40% survived, while 4/4 patients with endocan<span class="elsevierStyleInf">D0−D7</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>120% died. Regarding patients with endocan<span class="elsevierStyleInf">D0−D7</span> in the gray zone ranging between −40% and +120%, 2/2 survivors had endocan<span class="elsevierStyleInf">D0</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>ng/ml, while 2/2 non-survivors had endocan<span class="elsevierStyleInf">D0</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>ng/ml (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). These cut-offs were inferred from the CART algorithm, and are not supported by any statistical test.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">We hereby report results from a pilot study exploring the potential usefulness of endocan in patients with Covid-19 related ARDS undergoing V-V ECMO. Compared to survivors, non-survivors from our cohort were older, with greater RESP scores and longer time from invasive MV to ECMO implantation, which was in line with previously published data.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Data from this pilot study suggest that among patients undergoing V-V ECMO for COVID-19 related ARDS, survival on ICU discharge would be associated with significant fall in plasma endocan measured 1 week after ECMO implantation. Indeed, subjects experiencing marked fall in plasma endocan were all discharged alive from ICU, while those with greatest rises did not survive. Further, it seems that patients with intermediate variations of plasma endocan might be segregated into 2 groups according to initial levels of plasma endocan: subjects with baseline values lower than 5<span class="elsevierStyleHsp" style=""></span>ng/ml who survived, in contrast with those exhibiting initial values higher than 5<span class="elsevierStyleHsp" style=""></span>ng/ml who were not discharged alive from ICU.</p><p id="par0075" class="elsevierStylePara elsevierViewall">These results are in line with previous data regarding the biological role of endocan in critically ill subjects. Indeed, secretion of endocan is upregulated by pro-inflammatory cytokines,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> and endocan has been widely reported as a marker of pulmonary endothelial stress.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> Furthermore, endocan is known as an inhibitor of leukocyte recruitment, therefore regulating lung inflammation.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a> Consistent data suggest that low circulating levels of endocan at the early phase of lung aggression, followed by secondary rise in its plasmatic values, would reflect insufficient initial protection against lung inflammation, being thus associated with poor outcomes.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">5,9–11</span></a> Interestingly, both patients from our cohort who underwent ECMO implantation with a duration of invasive MV<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>24<span class="elsevierStyleHsp" style=""></span>h experienced marked decreases of plasma endocan on D7, respectively found at −69% and −47%. Further studies are needed to investigate the significance of these results.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors’ contributions</span><p id="par0080" class="elsevierStylePara elsevierViewall">AT, SA and SBL designed the study. AT wrote the manuscript. FBL, CA, FD and YT contributed to data collection. SA and SBL participated in its critical revision. All authors read and approved the final manuscript.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0085" class="elsevierStylePara elsevierViewall">None declared.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflict of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors listed on this publication have no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Authors’ contributions" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Funding" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflict of interest" ] 3 => array:2 [ "identificador" => "xack644594" "titulo" => "Acknowledgements" ] 4 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">See <a class="elsevierStyleCrossRef" href="#sec0020">Appendix A</a> for the member of Lille Intensive Care COVID-19 group.</p>" "identificador" => "fn0005" ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0100" class="elsevierStylePara elsevierViewall">Erika Parmentier-Decrucq, Julien Poissy, Sylvain Dubucquoi, Pauline Boddaert, Morgan Caplan, Julien Goutay, Arthur Durand, Benoit Graffin, Myrtille Gaudel, Charles Detollenaere, Ines Gueguen, Marine Van Ceunebroek, Romain Tortuyaux, Ouriel Saura, Ahmed El Kalioubie, Raphael Favory, Patrick Girardie, Marion Houard, Emmanuelle Jaillette, Mercedes Jourdain, Geoffrey Ledoux, Daniel Mathieu, Anne Sophie Moreau, Saad Nseir, Thierry Onimus, Sebastien Preau, Laurent Robriquet, Anahita Rouze, Sophie Six, Jerome Soquet, Valentin Loobuyck, Agnes Mugnier, André Vincentelli.</p>" "etiqueta" => "Appendix A" "titulo" => "Lille Intensive Care COVID-19 group" "identificador" => "sec0020" ] ] ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1366 "Ancho" => 2502 "Tamanyo" => 207157 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Decision tree for prediction of survival on ICU discharge. Endocan<span class="elsevierStyleInf">D0</span>, endocan<span class="elsevierStyleInf">D7</span>, endocan<span class="elsevierStyleInf">D0–D7</span>, CRP<span class="elsevierStyleInf">D0</span>, CRP<span class="elsevierStyleInf">D7</span>, CRP<span class="elsevierStyleInf">D0–D7</span>, fibrinogen<span class="elsevierStyleInf">D0</span>, fibrinogen<span class="elsevierStyleInf">D7</span> and fibrinogen<span class="elsevierStyleInf">D0–D7</span> were tested as covariates for survival in ICU prediction model. D0: day of ECMO implantation. D7: day 7 following ECMO implantation; D0–D7: variation between D0 and D7, calculated as (value on D7<span class="elsevierStyleHsp" style=""></span>−<span class="elsevierStyleHsp" style=""></span>value on D0)/value on D0.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Data are presented as number (%) or median [IQR]. BMI: Body Mass Index; COPD: Chronic Obstructive Pulmonary Disease; D0: day of ECMO implantation; D7: day 7 following ECMO implantation; ECMO: Extra Corporeal Membrane Oxygenation; ICU: Intensive Care Unit; MV: Mechanical Ventilation; RESP: Respiratory Extracorporeal Membrane Oxygenation Survival Prediction; RPM: Rounds Per Minute; SOFA: Sequential Organ Failure Assessment; VAP: Ventilator Associated Pneumonia.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Survivors</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"><span class="elsevierStyleItalic">p</span> value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Yes (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>6) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Demographical data</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sex, male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 (80%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (83%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Age, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48 [33; 62] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57 (48; 63) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.43 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>BMI, kg/m<span class="elsevierStyleSup">2</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 [32; 40] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34 [28; 42] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.66 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Severity score on ECMO implantation</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SOFA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 [6; 13] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 [8; 11] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.93 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>RESP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 [−6; 2.5] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−4 [−6; −2] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.43 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Comorbidities</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes mellitus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (40%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (17%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.55 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Chronic respiratory failure \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>COPD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (33%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.45 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coronary disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (20%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (17%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Immunocompromised patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Characteristics of ECMO</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Time from onset of symptoms to ECMO, days \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 [10.5; 33.5] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 [13.5; 24] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.71 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Time from ICU admission to ECMO, days \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 [6; 28] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 [6; 17] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.58 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Time from invasive MV to ECMO, days \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 [0.5; 20] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.5 [3; 13] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.41 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Invasive MV initiated on the day of ECMO implantation and maintained for less than 24<span class="elsevierStyleHsp" style=""></span>h \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (40%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.18 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>RPM on day of ECMO implantation, ×1000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.9 [2.5; 4.6] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.7 [3.4; 4.1] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.93 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ECMO blood flow on day of ECMO implantation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.8 [3.9; 7.1] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.2 [4.6; 6.3] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.85 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Outcomes</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Duration of ECMO, days \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 [12; 34] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27 [19; 33] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Length of stay in hospital, days \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">53 [35; 79] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">36 [31; 49] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.31 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Length of invasive MV, days \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 [5; 43] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 [34; 48.5] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.25 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Biomarkers</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Endocan at D0, ng/ml \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.9 [3.8; 12.2] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.7 [3; 5.7] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.25 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Endocan at D7, ng/ml \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.3 [3.9; 5.6] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.9 [6.1; 19] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.017 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Variation of endocan between D0 and D7, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−49 [−65; 52] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">208 [−1; 612] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.03 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CRP at D0, mg/l \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">118 [26; 150] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">94 [68; 200] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.66 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CRP at D7, mg/l \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39 [35; 123] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">68 [50; 77] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.41 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Variation of CRP between D0 and D7, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 [−75; 484] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−17 [−72; −5] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.54 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fibrinogen at D0, g/l \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.1 [3.9; 6.8] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.1 [4.9; 8.1] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.33 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fibrinogen at D7, g/l \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.6 [2.7; 5.1] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.1 [4.3; 5.6] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.23 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Variation of fibrinogen between D0 and D7, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−28 [−50; 15] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−26 [−43; 9] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Characteristics of patients and biomarkers in survivors and non-survivors.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0060" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Ramanathan" 1 => "K. Shekar" 2 => "R.R. Ling" 3 => "R.P. Barbaro" 4 => "S.N. Wong" 5 => "C.S. Tan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Crit Care Lond Engl" "fecha" => "2021" "volumen" => "25" "paginaInicial" => "211" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0065" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endocan, sepsis, pneumonia, and acute respiratory distress syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N. De Freitas Caires" 1 => "A. Gaudet" 2 => "L. Portier" 3 => "A. Tsicopoulos" 4 => "D. Mathieu" 5 => "P. Lassalle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Crit Care Lond Engl" "fecha" => "2018" "volumen" => "22" "paginaInicial" => "280" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0070" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A high blood endocan profile during COVID-19 distinguishes moderate from severe acute respiratory distress syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T. Pascreau" 1 => "C. Tcherakian" 2 => "B. Zuber" 3 => "E. Farfour" 4 => "M. Vasse" 5 => "P. Lassalle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Crit Care Lond Engl" "fecha" => "2021" "volumen" => "25" "paginaInicial" => "166" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0075" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endocan levels in peripheral blood predict outcomes of acute respiratory distress syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Tang" 1 => "Y. Zhao" 2 => "D. Wang" 3 => "W. Deng" 4 => "C. Li" 5 => "Q. Li" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2014/625180" "Revista" => array:5 [ "tituloSerie" => "Mediators Inflamm" "fecha" => "2014" "volumen" => "2014" "paginaInicial" => "625180" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25132734" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0080" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endocan as an early biomarker of severity in patients with acute respiratory distress syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Orbegozo" 1 => "L. Rahmania" 2 => "M. Irazabal" 3 => "M. Mendoza" 4 => "F. Annoni" 5 => "D. De Backer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13613-017-0311-4" "Revista" => array:5 [ "tituloSerie" => "Ann Intensive Care" "fecha" => "2017" "volumen" => "7" "paginaInicial" => "93" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28884313" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0085" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiopoietin-2 levels as predictors of outcome in mechanically ventilated patients with acute respiratory distress syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Tsangaris" 1 => "A. Tsantes" 2 => "E. Vrigkou" 3 => "P. Kopterides" 4 => "A. Pelekanou" 5 => "K. Zerva" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2017/6758721" "Revista" => array:5 [ "tituloSerie" => "Dis Markers" "fecha" => "2017" "volumen" => "2017" "paginaInicial" => "6758721" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28947844" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0090" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Lassalle" 1 => "S. Molet" 2 => "A. Janin" 3 => "J.V. Heyden" 4 => "J. Tavernier" 5 => "W. Fiers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1074/jbc.271.34.20458" "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "1996" "volumen" => "271" "paginaInicial" => "20458" "paginaFinal" => "20464" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8702785" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0095" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endocan regulates acute lung inflammation through control of leukocyte diapedesis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Gaudet" 1 => "L. Portier" 2 => "M. Prin" 3 => "M.-C. Copin" 4 => "A. Tsicopoulos" 5 => "D. Mathieu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Appl Physiol Bethesda Md 1985" "fecha" => "2019" "volumen" => "127" "paginaInicial" => "668" "paginaFinal" => "678" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0100" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low endocan levels are predictive of Acute Respiratory Distress Syndrome in severe sepsis and septic shock" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Gaudet" 1 => "E. Parmentier" 2 => "S. Dubucquoi" 3 => "J. Poissy" 4 => "T. Duburcq" 5 => "P. Lassalle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jcrc.2018.06.018" "Revista" => array:6 [ "tituloSerie" => "J Crit Care" "fecha" => "2018" "volumen" => "47" "paginaInicial" => "121" "paginaFinal" => "126" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29957509" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0105" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Ioakeimidou" 1 => "E. Pagalou" 2 => "M. Kontogiorgi" 3 => "E. Antoniadou" 4 => "K. Kaziani" 5 => "K. Psaroulis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol" "fecha" => "2017" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0110" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The complex kinetics of blood endocan during the time course of sepsis and acute respiratory distress syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Gaudet" 1 => "E. Parmentier" 2 => "S. Dubucquoi" 3 => "J. Poissy" 4 => "T. Duburcq" 5 => "L. Portier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Crit Care Lond Engl" "fecha" => "2019" "volumen" => "23" "paginaInicial" => "86" ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack644594" "titulo" => "Acknowledgements" "texto" => "<p id="par0095" class="elsevierStylePara elsevierViewall">None.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/02105691/0000004700000001/v1_202301030811/S0210569122001073/v1_202301030811/en/main.assets" "Apartado" => array:4 [ "identificador" => "24372" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Cartas Científicas" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/02105691/0000004700000001/v1_202301030811/S0210569122001073/v1_202301030811/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569122001073?idApp=WMIE" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 4 | 8 | 12 |
| 2024 Octubre | 77 | 61 | 138 |
| 2024 Septiembre | 70 | 36 | 106 |
| 2024 Agosto | 81 | 37 | 118 |
| 2024 Julio | 59 | 34 | 93 |
| 2024 Junio | 56 | 42 | 98 |
| 2024 Mayo | 65 | 35 | 100 |
| 2024 Abril | 68 | 37 | 105 |
| 2024 Marzo | 68 | 31 | 99 |
| 2024 Febrero | 60 | 48 | 108 |
| 2024 Enero | 64 | 35 | 99 |
| 2023 Diciembre | 42 | 39 | 81 |
| 2023 Noviembre | 62 | 53 | 115 |
| 2023 Octubre | 51 | 44 | 95 |
| 2023 Septiembre | 58 | 42 | 100 |
| 2023 Agosto | 49 | 18 | 67 |
| 2023 Julio | 56 | 26 | 82 |
| 2023 Junio | 52 | 24 | 76 |
| 2023 Mayo | 60 | 38 | 98 |
| 2023 Abril | 59 | 25 | 84 |
| 2023 Marzo | 14 | 4 | 18 |
| 2023 Febrero | 1 | 0 | 1 |
| 2023 Enero | 31 | 6 | 37 |
| 2022 Diciembre | 27 | 0 | 27 |
| 2022 Noviembre | 36 | 0 | 36 |
| 2022 Octubre | 33 | 0 | 33 |
| 2022 Septiembre | 26 | 0 | 26 |
| 2022 Agosto | 21 | 0 | 21 |
| 2022 Julio | 30 | 0 | 30 |
| 2022 Junio | 25 | 3 | 28 |
| 2022 Mayo | 1 | 2 | 3 |
Mostrar todo
