Journal Information
Share
Share
Download PDF
More article options
Visits
3
Original article
Available online 31 December 2024
Elastic static power, its correlation with acute respiratory distress syndrome severity: A Bayesian post-hoc analysis of the Mechanical Power Day cross-sectional trial
Poder elástico estático, su correlación con la severidad del SDRA: un análisis Bayesiano post-hoc del Mechanical Power Day
Visits
3
Aurio Fajardo-Campoverdia,
,1
, Alejandro González-Castrob,1, Vicent Modesto i Alapontc,1, Miguel Ibarra-Estradad,1, Carmen Chica-Mezae,1, Alberto Medinaf,1, Patricia Escudero-Achab, Denise Battaglinig, Patricia R.M. Roccoh, Chiara Robbag,i, Paolo Pelosig,i,2
a Universidad de la Frontera, Critical Care Unit, Hospital Biprovincial Quillota-Petorca, Quillota, Chile
b Intensive Care Service, Marqués de Valdecilla University Hospital, Santander, Spain
c Pediatric Intensive Care Unit, Hospital Universitari i Politècnic La Fe, Valencia, Spain
d Medicine of the Critically Ill, Civil Hospital Fray Antonio Alcalde and Instituto Jalisciense de Cancerología, Guadalajara, Mexico
e University of Rosario, Asociación Colombiana de Medicina Crítica y Cuidado Intensivo, Bogotá, Colombia
f Central University Hospital of Asturias, Oviedo, Spain
g IRCCS Policlinico San Martino, Genova, Italy
h Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
i Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy
Ver más
This item has received
Received 27 August 2024. Accepted 15 October 2024
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (3)
Show moreShow less
Tables (3)
Table 1. Description of different respiratory variables according to ARDS severity.
Table 2. Bayesian regression analysis of different respiratory power equations according to ARDS severity.
Table 3. Bayesian regression analysis of elastic static power components according to ARDS severity.
Show moreShow less
Abstract
Objective

The relationship between different power equations and the severity of acute respiratory distress syndrome (ARDS) remains unclear. This study aimed to evaluate various power equations: total mechanical power, total elastic power (comprising elastic static and elastic dynamic power), and resistive power, in a cohort of mechanically ventilated patients with and without ARDS. Bayesian analysis was employed to refine estimates and quantify uncertainty by incorporating a priori distributions.

Design

A Bayesian post-hoc analysis was conducted on data from the Mechanical Power Day study.

Setting

113 intensive care units across 15 countries and 4 continents.

Patients

Adults who received invasive mechanical ventilation in volume-controlled mode, with (mild and moderate/severe ARDS) and without ARDS.

Interventions

None.

Main variables of interest

ARDS, Elastic static power.

Results

Elastic static power was 5.8 J/min (BF: 0.3) in patients with mild ARDS and 7.4 J/min (BF: 0.9) in moderate/severe ARDS patients. Bayesian regression and modeling analysis revealed that elastic static power was independently correlated with mild (a posteriori Mean: 1.3; 95% Credible Interval [Cred. Interval]: 0.2–2.2) and moderate/severe ARDS (a posteriori Mean: 2.8; 95% Cred. Interval: 1.7–3.8) more strongly than other power equations.

Conclusions

Elastic static power was found to have the strongest correlation with ARDS severity among the power equations studied. Prospective studies are needed to further validate these findings.

Keywords:
Invasive mechanical ventilation
ARDS
Mechanical power
Elastic static power
VALI
PEEP
Abbreviations:
ABG
ARDS
BF
CEIC
Cred.Interval
ICU
MCMC
MH
PIPa
MPD
PEEP
Ppeak
Pplat
RR
SD
V′E
VALI
VT
Resumen
Objetivo

La relación entre diferentes ecuaciones de poder mecánico y la gravedad del síndrome de distrés respiratorio agudo (SDRA) no ha sido aclarada. El objetivo de este estudio fue evaluar distintas ecuaciones de poder: el poder mecánico total, el poder elástico total (que incluye: poder elástico estático y poder elástico dinámico) y el poder resistivo, en una cohorte de pacientes en ventilación mecánica, con y sin SDRA. Utilizamos análisis Bayesianos para refinar las estimaciones y cuantificar la incertidumbre mediante la incorporación de distribuciones a priori.

Diseño

Análisis Bayesiano post hoc de los datos del estudio Mechanical Power Day.

Ámbito

113 unidades de cuidados intensivos de 15 países y 4 continentes.

Pacientes

Adultos en ventilación mecánica invasiva en modo de volumen controlado, con (leve y moderado/severo) y sin SDRA.

Intervenciones

Ninguna.

Variables de interés principales

SDRA, Poder elástico estático.

Resultados

El poder elástico estático fue de 5,8 J/min (BF: 0,3) en pacientes con SDRA leve y de 7,4 J/min (BF: 0,9) en pacientes con SDRA moderado/grave. El análisis de regresión y modelización Bayesiana reveló que el poder elástico estático se correlacionó con el SDRA leve (media a posteriori: 1,3; intervalo de credibilidad [Int de Cred] del 95%: 0,2 a 2,2) y con el moderado/severo (media a posteriori: 2,8; Int de Cred del 95%: 1,7 a 3,8) con más fuerza que otras ecuaciones de poder analizadas.

Conclusiones

El poder elástico estático tenía la correlación más fuerte con la gravedad del SDRA entre las distintas ecuaciones de poder analizadas. Se necesitan estudios prospectivos para validar estos resultados.

Palabras clave:
Ventilación mecánica invasiva
SDRA
Poder mecánico
Poder elástico estático
VALI
PEEP

Article

These are the options to access the full texts of the publication Medicina Intensiva (English Edition)
Member
If you are a member of the Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias::
Go to the members area of the website of the SEMICYUC (www.semicyuc.org )and click the link to the magazine.
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Medicina Intensiva (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Email
Idiomas
Medicina Intensiva (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?