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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The management of critically ill burn patients is challenging&#46; These patients have to be managed in specialized centers&#44; where the expertise of physicians and nursing personnel guarantees the best treatment&#46; Mortality of burn patients has improved over the past decades due to a better understanding of burn shock pathophysiology&#44; optimal surgical management&#44; infection control and nutritional support&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">1</span></a> Indeed&#44; a more aggressive resuscitation&#44; early excision and grafting&#44; the judicious use of topical antibiotics&#44; and the provision of an adequate calorie and protein intake are key to attain best survival results&#46; General advances in critical care have also to be implemented&#44; including protective ventilation&#44; glycemic control&#44; selective decontamination of the digestive tract&#44; and implementation of sedation protocols&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Editors of <span class="elsevierStyleItalic">Medicina Intensiva</span> have made the keen decision to support the publication of a series of five review articles updating current management of critically ill burned patients&#44; covering areas such as initial treatment&#44; resuscitation&#44; infection control&#44; surgery and current guidelines and evidence-based burn care&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The framework for an appropriate comprehension of current burn care has to include basic knowledge on advances on the physiological bases of resuscitation&#44; as will be discussed in detail in the present series&#46; Burn patients develop shock immediately after trauma&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">2&#8211;5</span></a> Shock is characterized by severe tissue hypoperfusion&#46; Despite the presence of shock&#44; blood pressure is often not low due to intense vasoconstriction of the cardiovascular system&#46; The intense systemic catecholamine surge increases blood pressure &#40;increased afterload&#41; that compromises cardiac function&#46; Hypovolemia is determined by intracellular fluid shifts and loss of plasma volume due to the release of inflammatory mediators and subsequent increased capillary permeability&#46; Understanding that the major cardiovascular disturbance in burn shock is hypovolemia is crucial for the success of resuscitation&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">6&#8211;8</span></a> We have shown that 90&#37; of patients admitted to the Burn ICU are successfully resuscitated following this principle&#44; only by the administration of crystalloids and&#44; in some cases&#44; colloids in the form of albumin&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">It is important to note that immediately after trauma there is decreased cardiac output and a marker increase in systemic vascular resistance &#40;<span class="elsevierStyleItalic">ebb</span> phase&#41; that evolves over the first 72<span class="elsevierStyleHsp" style=""></span>h of resuscitation toward a state of systemic vasodilation and increased cardiac output&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">5</span></a> Thus the typical vasodilatory state characteristic of distributive shock ensues only 2&#8211;3 days after resuscitation is initiated&#44; being the initial state characterized by hypovolemic shock&#46; Low cardiac output is the combined result of decreased plasma volume &#40;low preload&#41;&#44; increased afterload&#44; and decreased contractility&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Patients with burns of more than 20&#37; total body surface area &#40;TBSA&#41; need resuscitation&#46; However we have found that elderly patients with burns as small as 10&#37; TBSA are admitted to the floor without resuscitation only to require days later ICU admission because of hypotension and renal failure&#46; Thus&#44; the need for resuscitation in the context of significant intravascular fluid deficit should not be ignored even for small burns&#44; particularly in the elderly&#46; Under-resuscitation leads to persistent tissue hypoxia&#44; metabolic acidosis&#44; shock and renal failure&#46; The risk of over resuscitation&#44; leading to excessive edema formation and limb&#44; abdominal and orbital compartment syndromes&#44; has recently been pointed out&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The pathophysiology of the burn injured gravitates around the open wound&#44; which perpetuates the state of hypercatabolism&#44; immunodeficiency and risk of infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">9&#44;10</span></a> Thus advances that allow burn wound closure in a short period of time are needed&#44; as will be reviewed in the current series&#46; The standard surgical treatment rests on only two principles&#58; removal of burned skin and coverage of the burn wound in the shorter period of time possible&#46; Delayed burn wound closure is associated with increased risk of infection&#44; higher mortality and worse esthetic and functional results&#46; Split-thickness skin autografts are used for burn wound closure&#46; Normal skin is taken from unaffected areas &#40;donor site&#41; and used to cover the excised wound&#46; However&#44; closure takes time&#44; and donor sites may not be available to cover the burn wound in cases of extensive burns&#46; In these cases&#44; autografts from the patients keratinocytes obtained from a small biopsy can be used with reasonable success&#44;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">11&#8211;13</span></a> but cell expansion takes 3&#8211;4 weeks before keratinocytes are ready to use&#46; Thus&#44; advances to obtain permanent coverage in a short period of time are needed&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Cell based therapies using progenitor cells is a new option aimed at improving time to healing&#46; Mesenchymal stem cells &#40;MSC&#41; from the bone marrow have been successfully used to treat burns experimentally and in human subjects&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">14&#8211;16</span></a> However&#44; the use of autologous &#40;from the same patient&#41; MSC as a therapy for burns is also associated with a delay of several weeks required for cell isolation and expansion in culture&#46; However&#44; allogeneic &#40;from a different individual&#41; MSC&#44; already expanded and ready to use&#44; will circumvent the problem of the time required for cell expansion before use&#44; and can be available for treatment in the early stages after injury&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">17&#44;18</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">These series are completed by discussion on initial treatment&#44; infection control and evidence-based burn care&#46; Indeed&#44; knowledge on the initial management of burn injury is pertinent for any critical care physician&#46; Early management principles are only related to airway management &#40;consider intubation in cases with facial burns&#44; burns in an enclosed space&#44; or large burns&#41;&#44; and initiation of fluid resuscitation&#46; Consideration of these principles suffices to keep the patient alive until the patient is taken to a specialized center&#46; Infection control by the use of bacteriological surveillance cultures&#44; use of selective digestive decontamination to prevent secondary endogenous infections&#44;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">19&#44;20</span></a> and early antibiotic treatment when infection is suspected&#44; is crucial in later stages after injury&#44; as most patients who do not survive die in the context of multiorgan failure associated with sepsis&#46; Finally&#44; burn care has been traditionally based on expert opinion and evidence based guidelines and clinical trials were lacking&#46; 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Special article
Update in the management of critically ill burned patients
Actualización sobre el tratamiento de enfermos quemados críticos
J.A. Lorentea,b,c,
Corresponding author
, R. Amaya-Villard,e
a Cuidados intensivos, Hospital Universitario de Getafe, Madrid, Spain
b CIBER de Enfermedades Respiratorias, Madrid, Spain
c Universidad Europea, Madrid, Spain
d Cuidados intensivos, Hospital Universitario Virgen del Rocío, Sevilla, Spain
e Instituto de Biomedicina de Sevilla (IBIS)/CSIC, Universidad de Sevilla, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The management of critically ill burn patients is challenging&#46; These patients have to be managed in specialized centers&#44; where the expertise of physicians and nursing personnel guarantees the best treatment&#46; Mortality of burn patients has improved over the past decades due to a better understanding of burn shock pathophysiology&#44; optimal surgical management&#44; infection control and nutritional support&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">1</span></a> Indeed&#44; a more aggressive resuscitation&#44; early excision and grafting&#44; the judicious use of topical antibiotics&#44; and the provision of an adequate calorie and protein intake are key to attain best survival results&#46; General advances in critical care have also to be implemented&#44; including protective ventilation&#44; glycemic control&#44; selective decontamination of the digestive tract&#44; and implementation of sedation protocols&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Editors of <span class="elsevierStyleItalic">Medicina Intensiva</span> have made the keen decision to support the publication of a series of five review articles updating current management of critically ill burned patients&#44; covering areas such as initial treatment&#44; resuscitation&#44; infection control&#44; surgery and current guidelines and evidence-based burn care&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The framework for an appropriate comprehension of current burn care has to include basic knowledge on advances on the physiological bases of resuscitation&#44; as will be discussed in detail in the present series&#46; Burn patients develop shock immediately after trauma&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">2&#8211;5</span></a> Shock is characterized by severe tissue hypoperfusion&#46; Despite the presence of shock&#44; blood pressure is often not low due to intense vasoconstriction of the cardiovascular system&#46; The intense systemic catecholamine surge increases blood pressure &#40;increased afterload&#41; that compromises cardiac function&#46; Hypovolemia is determined by intracellular fluid shifts and loss of plasma volume due to the release of inflammatory mediators and subsequent increased capillary permeability&#46; Understanding that the major cardiovascular disturbance in burn shock is hypovolemia is crucial for the success of resuscitation&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">6&#8211;8</span></a> We have shown that 90&#37; of patients admitted to the Burn ICU are successfully resuscitated following this principle&#44; only by the administration of crystalloids and&#44; in some cases&#44; colloids in the form of albumin&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">It is important to note that immediately after trauma there is decreased cardiac output and a marker increase in systemic vascular resistance &#40;<span class="elsevierStyleItalic">ebb</span> phase&#41; that evolves over the first 72<span class="elsevierStyleHsp" style=""></span>h of resuscitation toward a state of systemic vasodilation and increased cardiac output&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">5</span></a> Thus the typical vasodilatory state characteristic of distributive shock ensues only 2&#8211;3 days after resuscitation is initiated&#44; being the initial state characterized by hypovolemic shock&#46; Low cardiac output is the combined result of decreased plasma volume &#40;low preload&#41;&#44; increased afterload&#44; and decreased contractility&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Patients with burns of more than 20&#37; total body surface area &#40;TBSA&#41; need resuscitation&#46; However we have found that elderly patients with burns as small as 10&#37; TBSA are admitted to the floor without resuscitation only to require days later ICU admission because of hypotension and renal failure&#46; Thus&#44; the need for resuscitation in the context of significant intravascular fluid deficit should not be ignored even for small burns&#44; particularly in the elderly&#46; Under-resuscitation leads to persistent tissue hypoxia&#44; metabolic acidosis&#44; shock and renal failure&#46; The risk of over resuscitation&#44; leading to excessive edema formation and limb&#44; abdominal and orbital compartment syndromes&#44; has recently been pointed out&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The pathophysiology of the burn injured gravitates around the open wound&#44; which perpetuates the state of hypercatabolism&#44; immunodeficiency and risk of infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">9&#44;10</span></a> Thus advances that allow burn wound closure in a short period of time are needed&#44; as will be reviewed in the current series&#46; The standard surgical treatment rests on only two principles&#58; removal of burned skin and coverage of the burn wound in the shorter period of time possible&#46; Delayed burn wound closure is associated with increased risk of infection&#44; higher mortality and worse esthetic and functional results&#46; Split-thickness skin autografts are used for burn wound closure&#46; Normal skin is taken from unaffected areas &#40;donor site&#41; and used to cover the excised wound&#46; However&#44; closure takes time&#44; and donor sites may not be available to cover the burn wound in cases of extensive burns&#46; In these cases&#44; autografts from the patients keratinocytes obtained from a small biopsy can be used with reasonable success&#44;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">11&#8211;13</span></a> but cell expansion takes 3&#8211;4 weeks before keratinocytes are ready to use&#46; Thus&#44; advances to obtain permanent coverage in a short period of time are needed&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Cell based therapies using progenitor cells is a new option aimed at improving time to healing&#46; Mesenchymal stem cells &#40;MSC&#41; from the bone marrow have been successfully used to treat burns experimentally and in human subjects&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">14&#8211;16</span></a> However&#44; the use of autologous &#40;from the same patient&#41; MSC as a therapy for burns is also associated with a delay of several weeks required for cell isolation and expansion in culture&#46; However&#44; allogeneic &#40;from a different individual&#41; MSC&#44; already expanded and ready to use&#44; will circumvent the problem of the time required for cell expansion before use&#44; and can be available for treatment in the early stages after injury&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">17&#44;18</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">These series are completed by discussion on initial treatment&#44; infection control and evidence-based burn care&#46; Indeed&#44; knowledge on the initial management of burn injury is pertinent for any critical care physician&#46; Early management principles are only related to airway management &#40;consider intubation in cases with facial burns&#44; burns in an enclosed space&#44; or large burns&#41;&#44; and initiation of fluid resuscitation&#46; Consideration of these principles suffices to keep the patient alive until the patient is taken to a specialized center&#46; Infection control by the use of bacteriological surveillance cultures&#44; use of selective digestive decontamination to prevent secondary endogenous infections&#44;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">19&#44;20</span></a> and early antibiotic treatment when infection is suspected&#44; is crucial in later stages after injury&#44; as most patients who do not survive die in the context of multiorgan failure associated with sepsis&#46; Finally&#44; burn care has been traditionally based on expert opinion and evidence based guidelines and clinical trials were lacking&#46; 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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El manejo de enfermos quemados cr&#237;ticos supone un gran reto para el cl&#237;nico&#46; Estos pacientes han de ser tratados en centros especializados&#44; donde la experiencia del personal m&#233;dico y de enfermer&#237;a garantiza el mejor tratamiento&#46; El pron&#243;stico de los enfermos quemados ha mejorado durante las &#250;ltimas d&#233;cadas debido a una mejor comprensi&#243;n de la fisiopatolog&#237;a del shock y a un mejor tratamiento quir&#250;rgico&#44; de la infecci&#243;n y soporte nutricional&#46; La reanimaci&#243;n intensiva&#44; el tratamiento quir&#250;rgico m&#225;s puntual&#44; el uso juicioso del tratamiento t&#243;pico antimicrobiano y el aporte de la cantidad de nutrientes necesaria son aspectos clave para conseguir los mejores resultados&#46; Tambi&#233;n han de implementarse los avances generales en la medicina intensiva&#44; como son la ventilaci&#243;n mec&#225;nica protectora&#44; el control de la glucemia&#44; la descontaminaci&#243;n digestiva selectiva y el uso de protocolos de sedaci&#243;n&#46;</p></span>"
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