Patrón hormonal hipofisario anterior y tiroideo en el paciente crítico

array:23 ["pii" => "S0210569100796112" "issn" => "02105691" "doi" => "10.1016/S0210-5691(00)79611-2" "estado" => "S300" "fechaPublicacion" => "2000-10-01" "aid" => "79611" "copyright" => "Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L." "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Med Intensiva. 2000;24:307-15" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5354 "formatos" => array:3 [ "EPUB" => 175 "HTML" => 971 "PDF" => 4208 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210569100796124" "issn" => "02105691" "doi" => "10.1016/S0210-5691(00)79612-4" "estado" => "S300" "fechaPublicacion" => "2000-10-01" "aid" => "79612" "copyright" => "Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Med Intensiva. 2000;24:316-20" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2304 "formatos" => array:3 [ "EPUB" => 190 "HTML" => 1044 "PDF" => 1070 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Plan de actuación conjunta en el infarto agudo de miocardio (PACIAM)" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "316" "paginaFinal" => "320" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Joint management plan of acute myocardial infarction" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.A. Arboleda Sánchez, R. Siendones Castillo, J.V. González Rodríguez, C. Romero Oloriz, C. Agüera Urbano, J.L. Marfil Robles, Ariam Grupo" "autores" => array:7 [ 0 => array:2 [ "nombre" => "J.A." "apellidos" => "Arboleda Sánchez" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Siendones Castillo" ] 2 => array:2 [ "nombre" => "J.V." "apellidos" => "González Rodríguez" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Romero Oloriz" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Agüera Urbano" ] 5 => array:2 [ "nombre" => "J.L." "apellidos" => "Marfil Robles" ] 6 => array:2 [ "nombre" => "Ariam" "apellidos" => "Grupo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796124?idApp=WMIE" "url" => "/02105691/0000002400000007/v1_201304241200/S0210569100796124/v1_201304241200/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210569100796100" "issn" => "02105691" "doi" => "10.1016/S0210-5691(00)79610-0" "estado" => "S300" "fechaPublicacion" => "2000-10-01" "aid" => "79610" "copyright" => "Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Med Intensiva. 2000;24:304-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3823 "formatos" => array:3 [ "EPUB" => 118 "HTML" => 925 "PDF" => 2780 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Extubación de pacientes neurocríticos con bajo nivel de conciencia. Un problema por resolver" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "304" "paginaFinal" => "306" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. Guerrero López, E. Fernández Mondéjar" "autores" => array:2 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Guerrero López" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Fernández Mondéjar" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796100?idApp=WMIE" "url" => "/02105691/0000002400000007/v1_201304241200/S0210569100796100/v1_201304241200/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Patrón hormonal hipofisario anterior y tiroideo en el paciente crítico" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "307" "paginaFinal" => "315" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "V. Gómez Tello" "autores" => array:1 [ 0 => array:3 [ "nombre" => "V." "apellidos" => "Gómez Tello" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "1" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Medicina Intensiva. Clínica Moncloa" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Dr. V. Gómez Tello.Unidad de Cuidados Intensivos. Clínica Moncloa. Av. Valladolid, 83. 28008 Madrid" ] ] ] 1 => array:3 [ "autoresLista" => "A. García De Lorenzo Y Mateos, J.M. Añón Elizalde, J. López Martínez" "autores" => array:3 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "García De Lorenzo Y Mateos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "J.M." "apellidos" => "Añón Elizalde" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "**" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "López Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "***" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Hospital Universitario La Paz. Madrid" "etiqueta" => "*" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital Virgen de la Luz. Cuenca" "etiqueta" => "**" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Hospital Severo Ochoa. Leganés. Madrid" "etiqueta" => "***" "identificador" => "aff0015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Anterior pituitary and thiroid hormonal pattern in the critically ill patients" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2000-02-07" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82364" "palabras" => array:4 [ 0 => "hormonas hipofisarias" 1 => "enfermedad crítica" 2 => "traumatismo" 3 => "traumatismo craneoencefálico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec82363" "palabras" => array:4 [ 0 => "Pituitary hormones" 1 => "critical illness" 2 => "trauma" 3 => "head injury" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "ObjetivoLa enfermedad crítica induce cambios extensos y complejos que involucran a los sistemas simpático-adrenal, al eje hipotálamo-hipofisario y a las glándulas tiroidea, adrenal y gonadal. En esta revisión sistemática, se evaluarán los resultados que diversos estudios han ofrecido sobre el perfil hormonal en pacientes críticos, su papel pronóstico, y las influencias que el momento evolutivo y determinadas intervenciones terapéuticas (sedación, analgesia, catecolaminas exógenas) ejercen sobre este patrón Fuente de datosBúsqueda en base de datos MEDLINE desde 1966 hasta 1999. Se empleó metodología booleana usando los términos hormonas hipofisarias (pituitary hormones), enfermedad crítica (critical illness), traumatismo (trauma), y traumatismo craneoencefálico (head injury) ResultadosSe seleccionaron por su relevancia 85 estudios ConclusionesNo se ha establecido un patrón hormonal característico en la enfermedad crítica, refiriendo patrones no ya faltos de homogeneidad sino absolutamente discrepantes. Ello es explicable por la diversidad de pacientes, métodos de medida y tipos de lesión estudiados. No obstante, parece existir una respuesta distinta según la lesión sea aguda o crónica, discutiéndose si las alteraciones encontradas son una respuesta proporcionada y adecuada al estrés agudo. En función de esta hipótesis, la suplementación hormonal, el efecto de las hormonas hipofisarias sobre la mortalidad y la modificación de factores terapéuticos que las influyen, podrían resultar discutibles" ] "en" => array:1 [ "resumen" => "ObjectiveThe Critical illness causes complex and wide changes in sympathetic nervous and endocrine systems. These variations have not been completely clarified. In this review, a great variety of studies about the pituitary hormonal pattern in trauma patients will be evaluated. Also, the influence of these hormones on outcome and their modification by the chronology of lesion and therapeutic maneuvers are considered Source of dataAppropriated studies were retrieved in MEDLINE database from 1966. Boolean strategy was applied using MESH terms as “pituitary hormones”, “trauma”, “critical illness” and “head injury” Results85 studies were selected due to their relevance ConclusionsIt is not possible to establish a characteristic hormonal pattern in Critical illness, because the results of these works are not only heterogeneous but also indeed discrepant. It is due to differences in design, sample, moment of study, methods of measurement, and type of Critical illness. Notwithstanding, a distinct response seems to be related with chronological aspects of the illness. It is possible that these alterations make up a proportional and proper response to acute stress. In agreement with this hypothesis, the supplementation of pituitary hormones, their relation with morbidity and mortality, and variation in therapeutic agents would be questionable" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:85 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endocrine Response after Brain Injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Chioléro" 1 => "J.P. Revelly" 2 => "T. Lemarchand-Béraud" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Yearbook of Intensive Care and Emergency Medicine" "paginaInicial" => "588" "paginaFinal" => "596" "serieFecha" => "1993" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The hypothalamus-pituitary axis in septic shock" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Annane" 1 => "E. Bellisant" 2 => "P.E. Bollaert" 3 => "I. Auriant" 4 => "D. Ghez" 5 => "J.C. Raphael" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "British Journal of Intensive Care" "fecha" => "1996" "volumen" => "6" "paginaInicial" => "260" "paginaFinal" => "266" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyroid and thymic endocrine function and survival in severely traumatized patients with or without head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Mocchegiani" 1 => "R. Imberti" 2 => "D. Testasecca" 3 => "M. Zandri" 4 => "L. Santarelli" 5 => "N. Fabris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Intensive Care Med" "fecha" => "1995" "volumen" => "21" "paginaInicial" => "334" "paginaFinal" => "341" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7650256" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "y Grupo de Trabajo de Metabolismo y Nutrición. Respuesta a la agresión: valoración e implicaciones terapéuticas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. García de Lorenzo" 1 => "C. Ortiz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Medicina Intensiva" "fecha" => "1997" "volumen" => "21" "paginaInicial" => "13" "paginaFinal" => "28" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute and prolonged critical illness are two distinct neuroendocrine paradigms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.H. Van den Berghe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Vehr K Acad Genesskd Belg" "fecha" => "1998" "volumen" => "60" "paginaInicial" => "487" "paginaFinal" => "518" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alterations in thyroid function in patients with systemic illness: The “euthiroid sick syndrome”" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Wartofsky" 1 => "K.D. Burman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/edrv-3-2-164" "Revista" => array:6 [ "tituloSerie" => "Endocr Rev" "fecha" => "1982" "volumen" => "3" "paginaInicial" => "164" "paginaFinal" => "217" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6806085" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Post-traumatic hypopituitarism. Six cases and a review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "O.M. Edwards" 1 => "J.D.A. Clark" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Medicine" "fecha" => "1980" "volumen" => "65" "paginaInicial" => "281" "paginaFinal" => "290" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3018425" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Traumatic Infarction of anterior lobe of pituitary gland" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.M. Daniel" 1 => "M.M.L. Prichard" 2 => "C.S. Treip" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "1959" "volumen" => "II" "paginaInicial" => "81" "paginaFinal" => "84" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypothalamic lesions following close head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Crompton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Brain" "fecha" => "1971" "volumen" => "94" "paginaInicial" => "165" "paginaFinal" => "172" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5552160" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypopituitarism and artificial ventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.G. Barber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Endocrinol (Copenh" "fecha" => "1979" "volumen" => "90" "paginaInicial" => "211" "paginaFinal" => "216" "itemHostRev" => array:3 [ "pii" => "S0161642010001314" "estado" => "S300" "issn" => "01616420" ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroendocrinology of prolonged critical illness: effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone secretagogues" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Van den Berghe" 1 => "F. De Zegher" 2 => "R.C. Baxter" 3 => "J.D. Veldhuis" 4 => "P. Wouters" 5 => "M. Schetz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem.83.2.4575" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1998" "volumen" => "83" "paginaInicial" => "309" "paginaFinal" => "319" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9467533" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Suprahypophyseal hypogonadism and hypothyroidism during prolonged coma after head trauma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Rudman" 1 => "A.S. Fleischer" 2 => "M.H. Kutner" 3 => "J.F. Raggio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jclinepi.2015.01.026" "Revista" => array:6 [ "tituloSerie" => "JCE&M" "fecha" => "1977" "volumen" => "45" "paginaInicial" => "747" "paginaFinal" => "754" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25777627" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyrotropin releasing hormone provocative release of prolactin and thyrotropin in acute head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Matsuura" 1 => "S. Nakazawa" 2 => "I. Wakabayashi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "1985" "volumen" => "16" "paginaInicial" => "791" "paginaFinal" => "795" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3925367" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alterations in hypothalamic function following thermal injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Wilmore" 1 => "T. Orcutt" 2 => "A. Mason" 3 => "B.A. Pruitt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "1975" "volumen" => "15" "paginaInicial" => "697" "paginaFinal" => "703" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1152091" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prolactin corticotrophin and gonadotropin concentrations following thermal injury in adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Brizio-Molteni" 1 => "A. Molteni" 2 => "R. Warpeha" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "1984" "volumen" => "24" "paginaInicial" => "1" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6319728" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma pituitary hormone levels in severe trauma with or without head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Chioléro" 1 => "T.H. Lemarchand" 2 => "Y. Schutz" 3 => "N. Tribolet" 4 => "J.P. Felber" 5 => "J. Freeman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "1988" "volumen" => "28" "paginaInicial" => "1368" "paginaFinal" => "1374" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3418763" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pituitary hormone response to head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.R. King" 1 => "H.C. Knowles" 2 => "R.L. Mclaurin" 3 => "J. Brielmaier" 4 => "G. Perisutti" 5 => "V.K. Piziak" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "1981" "volumen" => "9" "paginaInicial" => "229" "paginaFinal" => "235" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6795524" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroendocrinethyroid responses after trauma: does head injury make any difference" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. García de Lorenzo" 1 => "J.M. Añón" 2 => "J. López Martinez" 3 => "J. Peláez" 4 => "M. Sisón" 5 => "M. Sánchez Castilla" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Crit Care Med" "fecha" => "1996" "volumen" => "25" "paginaInicial" => "132" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anterior pituitary and thyroid response after trauma. Modifying factors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. García de Lorenzo" 1 => "J. López Martínez" 2 => "J.M. Añón" 3 => "M. Sánchez Castilla" 4 => "D. Díaz Díaz" 5 => "C. Vaquero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Intensive Care Med" "fecha" => "1997" "volumen" => "23" "paginaInicial" => "188" "paginaFinal" => "235" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A molecular basis for bi-directional communication between the immune and neuroendocrine systems" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.E. Blalock" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Physiol Rev" "fecha" => "1989" "volumen" => "69" "paginaInicial" => "1" "paginaFinal" => "32" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2536183" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of brain monoamines and histamine in regulation of anterior pituitary secretion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.I. Weiner" 1 => "W.F. Ganong" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Physiol Rev" "fecha" => "1978" "volumen" => "58" "paginaInicial" => "905" "paginaFinal" => "976" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/212770" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypercortisolism in septic shock is not suppressible by dexamethasone infusion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Perrot" 1 => "A. Bonneton" 2 => "H. Dechaud" 3 => "J. Motin" 4 => "M. Pugeat" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "1993" "volumen" => "21" "paginaInicial" => "396" "paginaFinal" => "401" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8440110" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Temperature-induced down regulation of the glucocorticoid receptor in peripheral blood mononuclear leukocytes in patients with sepsis and septic shock" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.J. Molijn" 1 => "J.W. Koper" 2 => "C.J.C. Van Uffelen" 3 => "F.H. de Jong" 4 => "A.O. Brinkmann" 5 => "H.A. Bruining" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Endocrinol" "fecha" => "1995" "volumen" => "43" "paginaInicial" => "197" "paginaFinal" => "203" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effects of endotoxin on neuroendocrin axis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. Navarra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Curr Opinion Endocrinol Diabetes" "fecha" => "1995" "volumen" => "2" "paginaInicial" => "127" "paginaFinal" => "133" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The hypothalamic-pituitary-adrenal axis in critical illnes: response to dexamethasone and corticotropin-releasing hormone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Reincke" 1 => "B. Allolio" 2 => "G. Würth" 3 => "W. Winkelmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem.77.1.8392081" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1993" "volumen" => "77" "paginaInicial" => "151" "paginaFinal" => "156" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8392081" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dissociation of plasma adrenocorticotropin and cortisol levels in critically ill patients: possible role of endothelin and atrial natriuretic hormone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I. Vermes" 1 => "A. Vbeishuizen" 2 => "R.M. Hampsink" 3 => "C. Haanen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem.80.4.7714094" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1995" "volumen" => "80" "paginaInicial" => "1238" "paginaFinal" => "1242" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7714094" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of surgical operation on growth hormone levels in plasma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.D. Wrigth" 1 => "I.D.A. Johnston" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Surgery" "fecha" => "1975" "volumen" => "77" "paginaInicial" => "479" "paginaFinal" => "486" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1145426" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Altered growth hormone homeostasis during acute bacterial sepsis in the rhesus monkey" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Rayfield" 1 => "T.D. George" 2 => "W.R. Beisel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem-38-5-746" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1974" "volumen" => "38" "paginaInicial" => "746" "paginaFinal" => "754" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4150927" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The sepsis-glucose intolerance riddle: A hormonal explanation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.S. Dahn" 1 => "D.L. Bouwman" 2 => "J.R. Kirkpatrick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Surgery" "fecha" => "1979" "volumen" => "86" "paginaInicial" => "423" "paginaFinal" => "428" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/473028" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sepsis, glucoseintolerance and protein malnutrition: A metabolic paradox" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.S. Dahn" 1 => "J.R. Kirkpatrick" 2 => "D.L. Bouwman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Arch Surg" "fecha" => "1980" "volumen" => "115" "paginaInicial" => "1415" "paginaFinal" => "1418" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6778457" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0161642010001338" "estado" => "S300" "issn" => "01616420" ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endocrine mediators of metabolism associated with injury and sepsis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.S. Dahn" 1 => "L.A. Jacobs" 2 => "M.P. Lange" 3 => "S. Smith" 4 => "R.A. Mitchell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "JPEN" "fecha" => "1986" "volumen" => "10" "paginaInicial" => "253" "paginaFinal" => "257" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Decreased growth hormone levels in the catabolic phase of severe injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Jeevanandan" 1 => "L. Ramias" 2 => "R.F. Shamos" 3 => "W.R. Schiller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Surgery" "fecha" => "1992" "volumen" => "111" "paginaInicial" => "495" "paginaFinal" => "502" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1598669" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of IGFs in catabolism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Botfield" 1 => "J. Ross" 2 => "C.J. Hinds" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Baillieres Clin Endocrinol Metab" "fecha" => "1997" "volumen" => "11" "paginaInicial" => "679" "paginaFinal" => "697" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9589777" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Positive nitrogen balance with human growth hormone and hypocaloric intravenous feeding" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.K. Manson" 1 => "D.W. Wilmore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Surgery" "fecha" => "1986" "volumen" => "100" "paginaInicial" => "188" "paginaFinal" => "197" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3090723" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enhancement of protein synthesis efficiency in parenterally fed trauma victims by adjuvant recombinant human growth hormone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.R. Peterson" 1 => "N.J. Holaday" 2 => "M. Jeevanandan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "1994" "volumen" => "36" "paginaInicial" => "726" "paginaFinal" => "733" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8189476" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improvement of septic syndrome after administration of recombinant human growth hormone (rhGH)?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Gottardis" 1 => "A. Benzer" 2 => "W. Koller" 3 => "T.J. Luger" 4 => "F. Pühringer" 5 => "J. Hackl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "1991" "volumen" => "31" "paginaInicial" => "81" "paginaFinal" => "86" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1986138" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of growth hormone in patients receiving total parenteral nutrition following major gastrointestinal surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Vara-Thorbeck" 1 => "J.A. Guerrero" 2 => "M.E. Ruiz-Requena" 3 => "J. Capitán" 4 => "M. Rodríguez" 5 => "J. Rosell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hepatogastroenterology" "fecha" => "1992" "volumen" => "39" "paginaInicial" => "270" "paginaFinal" => "272" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1505903" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low-dose Growth hormone and hypocaloric nutrition attenuate the protein-catabolic response after major operation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Z.M. Jiang" 1 => "G.Z. He" 2 => "S.Y. Zhang" 3 => "X.R. Wang" 4 => "N.F. Yang" 5 => "Y. Zhu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Surg" "fecha" => "1989" "volumen" => "210" "paginaInicial" => "513" "paginaFinal" => "525" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2802836" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of recombinant human Insulin-like growth factor I and early total parenteral nutrition on immune depression following severe head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.A. Kudsk" 1 => "C. Mowatt-Larssen" 2 => "J. Bukar" 3 => "T. Fabian" 4 => "S. Oellerich" 5 => "D.L. Dent" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Surg" "fecha" => "1994" "volumen" => "129" "paginaInicial" => "66" "paginaFinal" => "71" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8279942" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The somatotropic axis in critical illness: effect of continuous growth hormone (GH)-releasing hormone and GH-releasing peptide 2 infusion" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Van den Berghe" 1 => "F. De Zegher" 2 => "J.D. Veldhuis" 3 => "P. Wouters" 4 => "M. Awouters" 5 => "W. Verbruggen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem.82.2.3736" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1997" "volumen" => "82" "paginaInicial" => "590" "paginaFinal" => "599" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9024260" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased survival after major thermal injury: the effect of growth hormone therapy in adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Knox" 1 => "R. Demling" 2 => "D. Wilmore" 3 => "P. Sarraf" 4 => "A. Santos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "1995" "volumen" => "39" "paginaInicial" => "526" "paginaFinal" => "530" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7473919" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of human growth hormone combined with nutrititional support in a critical care unit" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T.R. Ziegler" 1 => "L.S. Young" 2 => "E. Ferrari-Baliviera" 3 => "R.H. Demling" 4 => "D.W. Wilmore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "JPEN" "fecha" => "1990" "volumen" => "14" "paginaInicial" => "574" "paginaFinal" => "581" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased mortality associated with growth hormone treatment in critically ill adults" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Takala" 1 => "E. Ruokonen" 2 => "N.R. Webster" 3 => "M.S. Nielsen" 4 => "D.F. Zandstra" 5 => "G. Vundelincks" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199909093411102" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med" "fecha" => "1999" "volumen" => "341" "paginaInicial" => "785" "paginaFinal" => "792" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10477776" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0161642010005075" "estado" => "S300" "issn" => "01616420" ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Growth hormone therapy in critically ill patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Demling" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199909093411110" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1999" "volumen" => "341" "paginaInicial" => "837" "paginaFinal" => "839" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10490384" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of growth hormone in the septic, trauma and surgical patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.A. Desai" 1 => "D.O. Jacobs" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Growth hormone in ciritcal illness" "paginaInicial" => "119" "paginaFinal" => "140" "serieFecha" => "1996" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of recombinant human growth hormone on catabolic hormones and free fatty acids following thermal injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.Y. Flemming" 1 => "R.L. Rutan" 2 => "R.E. Jahoor" 3 => "R.R. Wolfe" 4 => "D.N. Herndon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "1992" "volumen" => "32" "paginaInicial" => "698" "paginaFinal" => "702" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1613829" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trauma and thermal injury: comparison of hemostatic and cytokine chagnesin the acute phase of injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Kowal-Vern" 1 => "M.M. Sharp-Pucci" 2 => "J.M. Walenga" 3 => "D.J. Dries" 4 => "R.L. Gamelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "1998" "volumen" => "44" "paginaInicial" => "325" "paginaFinal" => "329" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9498505" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pituitary-testicular axis dysfunction in burned med" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.V. Vogel" 1 => "G.T. Peake" 2 => "R.T. Rada" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem-60-4-658" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1985" "volumen" => "60" "paginaInicial" => "658" "paginaFinal" => "665" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4038713" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reproductive axis suppression in acute illness is related to disease severity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.I. Spratt" 1 => "P. Cox" 2 => "J. Orav" 3 => "J. Moloney" 4 => "T. Bigos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem.76.6.8501163" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1993" "volumen" => "76" "paginaInicial" => "1548" "paginaFinal" => "1554" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8501163" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of epinephrine on testosterone production" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Levin" 1 => "C.V. Lloyd" 2 => "J. Lobostsky" 3 => "E.H. Friedrich" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Endocrinol (Copenh" "fecha" => "1967" "volumen" => "55" "paginaInicial" => "184" "paginaFinal" => "190" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morphine exerts testosterone-like effects in the hypothalamus of the castrated male rat" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T.J. Cicero" 1 => "E.R. Meyer" 2 => "S.M. Gabriel" 3 => "R.D. Bell" 4 => "C.E. Wilcox" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Brain Res" "fecha" => "1980" "volumen" => "202" "paginaInicial" => "151" "paginaFinal" => "156" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7427731" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0260" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transient hypogonadotropic hypogonadism caused by critical illness" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.D. Woolf" 1 => "R.W. Hamill" 2 => "J.V. McDonald" 3 => "L.A. Lee" 4 => "M. Kelly" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem-60-3-444" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1985" "volumen" => "60" "paginaInicial" => "444" "paginaFinal" => "450" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3919042" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prolactin: a novel and safe immunomodulating hormone for the treatment of immunodepression following severe hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Zellweger" 1 => "M.W. Wichman" 2 => "A. Ayala" 3 => "C.M. DeMaso" 4 => "I.H. Chaudry" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1006/jsre.1996.0222" "Revista" => array:6 [ "tituloSerie" => "J Surg Res" "fecha" => "1996" "volumen" => "63" "paginaInicial" => "53" "paginaFinal" => "58" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8661172" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metoclopramide: a novel and safe immunomodulating agent for restoring the depressed macrophage immune function after hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Zellweger" 1 => "M.W. Wichmann" 2 => "A. Ayala" 3 => "I.H. Chaudry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "1998" "volumen" => "44" "paginaInicial" => "70" "paginaFinal" => "77" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9464751" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypothalamic-pituitary axis dysfunction in critically ill patients with a low free thyroxine index" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.I. Mechanick" 1 => "H.S. Sacks" 2 => "R.H. Cobin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF03348002" "Revista" => array:6 [ "tituloSerie" => "J Endocrinol Invest" "fecha" => "1997" "volumen" => "20" "paginaInicial" => "462" "paginaFinal" => "470" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9364249" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anterior pituitary function during critical illness and dopamine treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Van den Berghe" 1 => "F. De Zegher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "1996" "volumen" => "24" "paginaInicial" => "1580" "paginaFinal" => "1590" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8797634" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0285" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impaired thyroxine and 3,5,3’-triiodothyronine handling by rat hepatocytes in the presence of serum of serum of patients with nonthyroidal illness" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.A. Vos" 1 => "M. De Jong" 2 => "B.F. Bernard" 3 => "R. Docter" 4 => "E.P. Krenning" 5 => "G. Hennemann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem.80.12.8530634" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1995" "volumen" => "80" "paginaInicial" => "2.364" "paginaFinal" => "2.370" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8530634" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0290" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin 1 beta, tumor necrosis factor-alpha and interlukin 6 decreasee nuclear thyroid hormone receptor capacity in a liver cell line" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Wolf" 1 => "N. Hansen" 2 => "H. Greten" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Endocrinol" "fecha" => "1994" "volumen" => "131" "paginaInicial" => "307" "paginaFinal" => "312" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7921216" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0295" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Activation of the hypothalamolppituitary-adrenal axis in response to septic or non-septic diseases-implications for the euthyroid sick syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H. Mönig" 1 => "T. Arendt" 2 => "M. Meyer" 3 => "B. Kloehn Bewig" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Intensive Care Med" "fecha" => "1999" "volumen" => "25" "paginaInicial" => "1.402" "paginaFinal" => "1.406" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10660852" "web" => "Medline" ] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0300" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impaired secretion of TSH in critically ill patients with `low T4-syndrome´" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H. Vierhapper" 1 => "A. Laggner" 2 => "W. Waldhäusl" 3 => "B. Grubeck-Loeebenstein" 4 => "G. Kleinberger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Endocrinol" "fecha" => "1982" "volumen" => "101" "paginaInicial" => "542" "paginaFinal" => "549" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6818804" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0305" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pituitary-Thyroid axis in critical illness" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Faber" 1 => "C. Kierkegaard" 2 => "B. Rasussen" 3 => "H. Westh" 4 => "M. Busch-Sorensen" 5 => "I.W. Jensen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem-65-2-315" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1987" "volumen" => "65" "paginaInicial" => "315" "paginaFinal" => "320" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3597710" "web" => "Medline" ] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0310" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyrotropin-releasing hormone in critical illness: From a dopamine-dependent test to a strategy for increasing low serum triiodothyronine, prolactin, and growth hormone concentrations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Van den Berghe" 1 => "F. de Zegher" 2 => "D. Vlasselaers" 3 => "M. Schetz" 4 => "C. Verwaest" 5 => "P. Ferdinande" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Crit Care Med" "fecha" => "1996" "volumen" => "24" "paginaInicial" => "590" "paginaFinal" => "595" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8612408" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0002939410001558" "estado" => "S300" "issn" => "00029394" ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0315" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyroid test abnormalities in traumatic brain injury: Correlation with neurologic impairment and sympathetic nervous system activation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Woolf" 1 => "L. Lee" 2 => "R. Hamill" 3 => "J.V. Mac Donald" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1988" "volumen" => "84" "paginaInicial" => "201" "paginaFinal" => "258" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3407649" "web" => "Medline" ] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0320" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyrotropin concentration predicts outcome in critical illness" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.M. Rothwell" 1 => "Z.F. Udwadia" 2 => "P.G. Lawler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anaesthesia" "fecha" => "1993" "volumen" => "48" "paginaInicial" => "373" "paginaFinal" => "376" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8317642" "web" => "Medline" ] ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0325" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of thyroid hormone on metabolic adaptation to fasting" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "W.J. Carter" 1 => "K.M. SHakir" 2 => "S. Hodges" 3 => "F.H. Faas" 4 => "J.O. Wynn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Metabolism" "fecha" => "1975" "volumen" => "24" "paginaInicial" => "1.177" "paginaFinal" => "1.183" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1196134" "web" => "Medline" ] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0330" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relations between the selenium status and the low T3 syndrome after major trauma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.M. Berger" 1 => "T. Lemarchand-Béraud" 2 => "C. Cavadini" 3 => "R. Chioléro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Intensive Care Med" "fecha" => "1996" "volumen" => "22" "paginaInicial" => "575" "paginaFinal" => "581" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8814474" "web" => "Medline" ] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0335" "etiqueta" => "67." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Decreased extrathyroidal triiiodothyronine production in nonthyroidal illness. Benefit or harm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.D. Utiger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Am J Med" "fecha" => "1980" "volumen" => "69" "paginaInicial" => "807" "paginaFinal" => "810" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7446544" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0161642009007386" "estado" => "S300" "issn" => "01616420" ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib0340" "etiqueta" => "68." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cathecolamine and thyroid hormones in traumatic injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.G. Ziegler" 1 => "E.C. Morrissey" 2 => "L.F. Marshall" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "1990" "volumen" => "18" "paginaInicial" => "253" "paginaFinal" => "258" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2302947" "web" => "Medline" ] ] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib0345" "etiqueta" => "69." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.A. Brent" 1 => "J.M. Hershman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem-63-1-1" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1986" "volumen" => "63" "paginaInicial" => "1" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3011834" "web" => "Medline" ] ] ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib0350" "etiqueta" => "70." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular effects of intravenous triiodothyronine in patients undergoing coronary artery bypass grafting. A randomized, double-blind, placebo-controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Bennet-Guerrero" 1 => "J.L. Jiménez" 2 => "W.D. White" 3 => "E.B. D’Amico" 4 => "B.I. Baldwin" 5 => "D.A. Schwinn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1996" "volumen" => "275" "paginaInicial" => "687" "paginaFinal" => "692" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8594265" "web" => "Medline" ] ] ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib0355" "etiqueta" => "71." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A senescent pattern of pituitary function during critical illness and dopamine treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Van den Berghe" 1 => "F. De Zegher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Verh K Acad Geneeskd Belg" "fecha" => "1996" "volumen" => "58" "paginaInicial" => "383" "paginaFinal" => "411" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8956555" "web" => "Medline" ] ] ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib0360" "etiqueta" => "72." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain opiates and neuroendocrine function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Grossman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Endocrinol Metab" "fecha" => "1983" "volumen" => "12" "paginaInicial" => "725" "paginaFinal" => "746" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6323067" …1 ] ] ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib0365" "etiqueta" => "73." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The behavior of GH and somatomedin C following anesthesia induction with propofol in comparison with diazepam and thiopental" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anasth Intensivther Notfallmed" "fecha" => "1989" "volumen" => "24" "paginaInicial" => "226" "paginaFinal" => "230" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib0370" "etiqueta" => "74." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma cortisol, prolactin and thyroxine levels related to midazolam anaesthesia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Med Hung" "fecha" => "1986" "volumen" => "43" "paginaInicial" => "283" "paginaFinal" => "289" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib0375" "etiqueta" => "75." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyroid function in severely traumatized patients with or without head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Endocrinol (Copenh" "fecha" => "1988" "volumen" => "117" "paginaInicial" => "80" "paginaFinal" => "86" ] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib0380" "etiqueta" => "76." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship of altered thyroid hormone indices to survival in nonthyroidal illnesses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Endocrinol" "fecha" => "1982" "volumen" => "16" "paginaInicial" => "565" "paginaFinal" => "574" ] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib0385" "etiqueta" => "77." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Do Thyroid function tests independently predict survival in the critically ill?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/thy.1992.2.119" "Revista" => array:6 [ "tituloSerie" => "Thyroid" "fecha" => "1992" "volumen" => "2" "paginaInicial" => "119" "paginaFinal" => "123" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib0390" "etiqueta" => "78." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship of admission thyroid function tests to outcome in critical illness" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anaesthesia" "fecha" => "1995" "volumen" => "50" "paginaInicial" => "1.022" "paginaFinal" => "1.025" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 78 => array:3 [ "identificador" => "bib0395" "etiqueta" => "79." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence and prognostic relevance of sick euthyroid syndrome in a medical intensive care unit" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Acad Med Singapore" "fecha" => "1995" "volumen" => "24" "paginaInicial" => "802" "paginaFinal" => "806" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 79 => array:3 [ "identificador" => "bib0400" "etiqueta" => "80." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pituitary-thyroid function in patients with septic shock and its relation with outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Med Res" "fecha" => "1997" "volumen" => "11" "paginaInicial" => "477" "paginaFinal" => "482" "itemHostRev" => array:3 [ "pii" => "S0161642008009706" "estado" => "S300" "issn" => "01616420" ] ] ] ] ] ] ] 80 => array:3 [ "identificador" => "bib0405" "etiqueta" => "81." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Free thriyodotironine in sera of acutely ill general medical patients. A prognostic indicator" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "1992" "volumen" => "38" "paginaInicial" => "414" "paginaFinal" => "415" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 81 => array:3 [ "identificador" => "bib0410" "etiqueta" => "82." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma pituitary hormone levels in severe trauma with or without head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Trauma" "fecha" => "1991" "volumen" => "17" "paginaInicial" => "25" "paginaFinal" => "29" ] ] ] ] ] ] 82 => array:3 [ "identificador" => "bib0415" "etiqueta" => "83." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Provocative hypothalamopituitary axis tests in severe head injury: Correlation with severity and prognosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "1998" "volumen" => "26" "paginaInicial" => "1.419" "paginaFinal" => "1.426" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 83 => array:3 [ "identificador" => "bib0420" "etiqueta" => "84." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Propofol 2%: Effect on lipids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "1997" "volumen" => "25" "paginaInicial" => "1.976" "paginaFinal" => "1.981" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 84 => array:3 [ "identificador" => "bib0425" "etiqueta" => "85." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hormonal dysregulations in severe burns" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Burns" "fecha" => "1984" "volumen" => "10" "paginaInicial" => "257" "paginaFinal" => "263" "itemHostRev" => array:3 [ "pii" => "S0002939408006594" "estado" => "S300" "issn" => "00029394" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02105691/0000002400000007/v1_201304241200/S0210569100796112/v1_201304241200/es/main.assets" "Apartado" => array:4 [ "identificador" => "436" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Revisiones" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02105691/0000002400000007/v1_201304241200/S0210569100796112/v1_201304241200/es/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796112?idApp=WMIE"]

Estadísticas

Anterior pituitary and thiroid hormonal pattern in the critically ill patients

V. Gómez Tello1

Servicio de Medicina Intensiva. Clínica Moncloa

A. García De Lorenzo Y Mateos*, J.M. Añón Elizalde**, J. López Martínez***

* Hospital Universitario La Paz. Madrid

** Hospital Virgen de la Luz. Cuenca

*** Hospital Severo Ochoa. Leganés. Madrid

Leído

11285

Veces
se ha leído el artículo

8509

Total PDF

2776

Total HTML

Compartir estadísticas

 array:23 [
  "pii" => "S0210569100796112"
  "issn" => "02105691"
  "doi" => "10.1016/S0210-5691(00)79611-2"
  "estado" => "S300"
  "fechaPublicacion" => "2000-10-01"
  "aid" => "79611"
  "copyright" => "Sociedad Espa&#241;ola de Medicina Intensiva&#44; Critica y Unidades Coronarias &#40;SEMICYUC&#41; and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
  "copyrightAnyo" => "2000"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "rev"
  "cita" => "Med Intensiva. 2000;24:307-15"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5354
    "formatos" => array:3 [
      "EPUB" => 175
      "HTML" => 971
      "PDF" => 4208
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0210569100796124"
    "issn" => "02105691"
    "doi" => "10.1016/S0210-5691(00)79612-4"
    "estado" => "S300"
    "fechaPublicacion" => "2000-10-01"
    "aid" => "79612"
    "copyright" => "Sociedad Espa&#241;ola de Medicina Intensiva&#44; Critica y Unidades Coronarias &#40;SEMICYUC&#41; and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Med Intensiva. 2000;24:316-20"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2304
      "formatos" => array:3 [
        "EPUB" => 190
        "HTML" => 1044
        "PDF" => 1070
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Plan de actuaci&#243;n conjunta en el infarto agudo de miocardio &#40;PACIAM&#41;"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "316"
          "paginaFinal" => "320"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Joint management plan of acute myocardial infarction"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46;A&#46; Arboleda S&#225;nchez, R&#46; Siendones Castillo, J&#46;V&#46; Gonz&#225;lez Rodr&#237;guez, C&#46; Romero Oloriz, C&#46; Ag&#252;era Urbano, J&#46;L&#46; Marfil Robles, Ariam Grupo"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "J&#46;A&#46;"
              "apellidos" => "Arboleda S&#225;nchez"
            ]
            1 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Siendones Castillo"
            ]
            2 => array:2 [
              "nombre" => "J&#46;V&#46;"
              "apellidos" => "Gonz&#225;lez Rodr&#237;guez"
            ]
            3 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Romero Oloriz"
            ]
            4 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Ag&#252;era Urbano"
            ]
            5 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "Marfil Robles"
            ]
            6 => array:2 [
              "nombre" => "Ariam"
              "apellidos" => "Grupo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796124?idApp=WMIE"
    "url" => "/02105691/0000002400000007/v1_201304241200/S0210569100796124/v1_201304241200/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0210569100796100"
    "issn" => "02105691"
    "doi" => "10.1016/S0210-5691(00)79610-0"
    "estado" => "S300"
    "fechaPublicacion" => "2000-10-01"
    "aid" => "79610"
    "copyright" => "Sociedad Espa&#241;ola de Medicina Intensiva&#44; Critica y Unidades Coronarias &#40;SEMICYUC&#41; and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Med Intensiva. 2000;24:304-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3823
      "formatos" => array:3 [
        "EPUB" => 118
        "HTML" => 925
        "PDF" => 2780
      ]
    ]
    "es" => array:7 [
      "idiomaDefecto" => true
      "titulo" => "Extubaci&#243;n de pacientes neurocr&#237;ticos con bajo nivel de conciencia&#46; Un problema por resolver"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "304"
          "paginaFinal" => "306"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "F&#46; Guerrero L&#243;pez, E&#46; Fern&#225;ndez Mond&#233;jar"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Guerrero L&#243;pez"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Fern&#225;ndez Mond&#233;jar"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796100?idApp=WMIE"
    "url" => "/02105691/0000002400000007/v1_201304241200/S0210569100796100/v1_201304241200/es/main.assets"
  ]
  "es" => array:13 [
    "idiomaDefecto" => true
    "titulo" => "Patr&#243;n hormonal hipofisario anterior y tiroideo en el paciente cr&#237;tico"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "307"
        "paginaFinal" => "315"
      ]
    ]
    "autores" => array:2 [
      0 => array:4 [
        "autoresLista" => "V&#46; G&#243;mez Tello"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "V&#46;"
            "apellidos" => "G&#243;mez Tello"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Medicina Intensiva&#46; Cl&#237;nica Moncloa"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "1"
            "correspondencia" => "Correspondencia&#58; Dr&#46; V&#46; G&#243;mez Tello&#46;Unidad de Cuidados Intensivos&#46; Cl&#237;nica Moncloa&#46; Av&#46; Valladolid&#44; 83&#46; 28008 Madrid"
          ]
        ]
      ]
      1 => array:3 [
        "autoresLista" => "A&#46; Garc&#237;a De Lorenzo Y Mateos, J&#46;M&#46; A&#241;&#243;n Elizalde, J&#46; L&#243;pez Mart&#237;nez"
        "autores" => array:3 [
          0 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Garc&#237;a De Lorenzo Y Mateos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "J&#46;M&#46;"
            "apellidos" => "A&#241;&#243;n Elizalde"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;&#42;</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "L&#243;pez Mart&#237;nez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;&#42;&#42;</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Hospital Universitario La Paz&#46; Madrid"
            "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Hospital Virgen de la Luz&#46; Cuenca"
            "etiqueta" => "<span class="elsevierStyleSup">&#42;&#42;</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Hospital Severo Ochoa&#46; Legan&#233;s&#46; Madrid"
            "etiqueta" => "<span class="elsevierStyleSup">&#42;&#42;&#42;</span>"
            "identificador" => "aff0015"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Anterior pituitary and thiroid hormonal pattern in the critically ill patients"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaAceptado" => "2000-02-07"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec82364"
          "palabras" => array:4 [
            0 => "hormonas hipofisarias"
            1 => "enfermedad cr&#237;tica"
            2 => "traumatismo"
            3 => "traumatismo craneoencef&#225;lico"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec82363"
          "palabras" => array:4 [
            0 => "Pituitary hormones"
            1 => "critical illness"
            2 => "trauma"
            3 => "head injury"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La enfermedad cr&#237;tica induce cambios extensos y complejos que involucran a los sistemas simp&#225;tico-adrenal&#44; al eje hipot&#225;lamo-hipofisario y a las gl&#225;ndulas tiroidea&#44; adrenal y gonadal&#46; En esta revisi&#243;n sistem&#225;tica&#44; se evaluar&#225;n los resultados que diversos estudios han ofrecido sobre el perfil hormonal en pacientes cr&#237;ticos&#44; su papel pron&#243;stico&#44; y las influencias que el momento evolutivo y determinadas intervenciones terap&#233;uticas &#40;sedaci&#243;n&#44; analgesia&#44; catecolaminas ex&#243;genas&#41; ejercen sobre este patr&#243;n</p> <span class="elsevierStyleSectionTitle">Fuente de datos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">B&#250;squeda en base de datos MEDLINE desde 1966 hasta 1999&#46; Se emple&#243; metodolog&#237;a booleana usando los t&#233;rminos hormonas hipofisarias &#40;pituitary hormones&#41;&#44; enfermedad cr&#237;tica &#40;critical illness&#41;&#44; traumatismo &#40;trauma&#41;&#44; y traumatismo craneoencef&#225;lico &#40;head injury&#41;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron por su relevancia 85 estudios</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">No se ha establecido un patr&#243;n hormonal caracter&#237;stico en la enfermedad cr&#237;tica&#44; refiriendo patrones no ya faltos de homogeneidad sino absolutamente discrepantes&#46; Ello es explicable por la diversidad de pacientes&#44; m&#233;todos de medida y tipos de lesi&#243;n estudiados&#46; No obstante&#44; parece existir una respuesta distinta seg&#250;n la lesi&#243;n sea aguda o cr&#243;nica&#44; discuti&#233;ndose si las alteraciones encontradas son una respuesta proporcionada y adecuada al estr&#233;s agudo&#46; En funci&#243;n de esta hip&#243;tesis&#44; la suplementaci&#243;n hormonal&#44; el efecto de las hormonas hipofisarias sobre la mortalidad y la modificaci&#243;n de factores terap&#233;uticos que las influyen&#44; podr&#237;an resultar discutibles</p>"
      ]
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The Critical illness causes complex and wide changes in sympathetic nervous and endocrine systems&#46; These variations have not been completely clarified&#46; In this review&#44; a great variety of studies about the pituitary hormonal pattern in trauma patients will be evaluated&#46; Also&#44; the influence of these hormones on outcome and their modification by the chronology of lesion and therapeutic maneuvers are considered</p> <span class="elsevierStyleSectionTitle">Source of data</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Appropriated studies were retrieved in MEDLINE database from 1966&#46; Boolean strategy was applied using MESH terms as &#8220;pituitary hormones&#8221;&#44; &#8220;trauma&#8221;&#44; &#8220;critical illness&#8221; and &#8220;head injury&#8221;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">85 studies were selected due to their relevance</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">It is not possible to establish a characteristic hormonal pattern in Critical illness&#44; because the results of these works are not only heterogeneous but also indeed discrepant&#46; It is due to differences in design&#44; sample&#44; moment of study&#44; methods of measurement&#44; and type of Critical illness&#46; Notwithstanding&#44; a distinct response seems to be related with chronological aspects of the illness&#46; It is possible that these alterations make up a proportional and proper response to acute stress&#46; In agreement with this hypothesis&#44; the supplementation of pituitary hormones&#44; their relation with morbidity and mortality&#44; and variation in therapeutic agents would be questionable</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:85 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endocrine Response after Brain Injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Chiol&#233;ro"
                            1 => "J&#46;P&#46; Revelly"
                            2 => "T&#46; Lemarchand-B&#233;raud"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Yearbook of Intensive Care and Emergency Medicine"
                        "paginaInicial" => "588"
                        "paginaFinal" => "596"
                        "serieFecha" => "1993"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The hypothalamus-pituitary axis in septic shock"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Annane"
                            1 => "E&#46; Bellisant"
                            2 => "P&#46;E&#46; Bollaert"
                            3 => "I&#46; Auriant"
                            4 => "D&#46; Ghez"
                            5 => "J&#46;C&#46; Raphael"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "British Journal of Intensive Care"
                        "fecha" => "1996"
                        "volumen" => "6"
                        "paginaInicial" => "260"
                        "paginaFinal" => "266"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thyroid and thymic endocrine function and survival in severely traumatized patients with or without head injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46; Mocchegiani"
                            1 => "R&#46; Imberti"
                            2 => "D&#46; Testasecca"
                            3 => "M&#46; Zandri"
                            4 => "L&#46; Santarelli"
                            5 => "N&#46; Fabris"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "1995"
                        "volumen" => "21"
                        "paginaInicial" => "334"
                        "paginaFinal" => "341"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7650256"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "y Grupo de Trabajo de Metabolismo y Nutrici&#243;n&#46; Respuesta a la agresi&#243;n&#58; valoraci&#243;n e implicaciones terap&#233;uticas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Garc&#237;a de Lorenzo"
                            1 => "C&#46; Ortiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicina Intensiva"
                        "fecha" => "1997"
                        "volumen" => "21"
                        "paginaInicial" => "13"
                        "paginaFinal" => "28"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute and prolonged critical illness are two distinct neuroendocrine paradigms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;H&#46; Van den Berghe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Vehr K Acad Genesskd Belg"
                        "fecha" => "1998"
                        "volumen" => "60"
                        "paginaInicial" => "487"
                        "paginaFinal" => "518"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alterations in thyroid function in patients with systemic illness&#58; The &#8220;euthiroid sick syndrome&#8221;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Wartofsky"
                            1 => "K&#46;D&#46; Burman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/edrv-3-2-164"
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocr Rev"
                        "fecha" => "1982"
                        "volumen" => "3"
                        "paginaInicial" => "164"
                        "paginaFinal" => "217"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6806085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Post-traumatic hypopituitarism&#46; Six cases and a review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46;M&#46; Edwards"
                            1 => "J&#46;D&#46;A&#46; Clark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Medicine"
                        "fecha" => "1980"
                        "volumen" => "65"
                        "paginaInicial" => "281"
                        "paginaFinal" => "290"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3018425"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Traumatic Infarction of anterior lobe of pituitary gland"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;M&#46; Daniel"
                            1 => "M&#46;M&#46;L&#46; Prichard"
                            2 => "C&#46;S&#46; Treip"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1959"
                        "volumen" => "II"
                        "paginaInicial" => "81"
                        "paginaFinal" => "84"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypothalamic lesions following close head injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Crompton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Brain"
                        "fecha" => "1971"
                        "volumen" => "94"
                        "paginaInicial" => "165"
                        "paginaFinal" => "172"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5552160"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypopituitarism and artificial ventilation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;G&#46; Barber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Endocrinol &#40;Copenh"
                        "fecha" => "1979"
                        "volumen" => "90"
                        "paginaInicial" => "211"
                        "paginaFinal" => "216"
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642010001314"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neuroendocrinology of prolonged critical illness&#58; effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone secretagogues"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Van den Berghe"
                            1 => "F&#46; De Zegher"
                            2 => "R&#46;C&#46; Baxter"
                            3 => "J&#46;D&#46; Veldhuis"
                            4 => "P&#46; Wouters"
                            5 => "M&#46; Schetz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.83.2.4575"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1998"
                        "volumen" => "83"
                        "paginaInicial" => "309"
                        "paginaFinal" => "319"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9467533"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Suprahypophyseal hypogonadism and hypothyroidism during prolonged coma after head trauma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Rudman"
                            1 => "A&#46;S&#46; Fleischer"
                            2 => "M&#46;H&#46; Kutner"
                            3 => "J&#46;F&#46; Raggio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jclinepi.2015.01.026"
                      "Revista" => array:6 [
                        "tituloSerie" => "JCE&#38;M"
                        "fecha" => "1977"
                        "volumen" => "45"
                        "paginaInicial" => "747"
                        "paginaFinal" => "754"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25777627"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thyrotropin releasing hormone provocative release of prolactin and thyrotropin in acute head injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Matsuura"
                            1 => "S&#46; Nakazawa"
                            2 => "I&#46; Wakabayashi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1985"
                        "volumen" => "16"
                        "paginaInicial" => "791"
                        "paginaFinal" => "795"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3925367"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alterations in hypothalamic function following thermal injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Wilmore"
                            1 => "T&#46; Orcutt"
                            2 => "A&#46; Mason"
                            3 => "B&#46;A&#46; Pruitt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1975"
                        "volumen" => "15"
                        "paginaInicial" => "697"
                        "paginaFinal" => "703"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1152091"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prolactin corticotrophin and gonadotropin concentrations following thermal injury in adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Brizio-Molteni"
                            1 => "A&#46; Molteni"
                            2 => "R&#46; Warpeha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1984"
                        "volumen" => "24"
                        "paginaInicial" => "1"
                        "paginaFinal" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6319728"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasma pituitary hormone levels in severe trauma with or without head injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Chiol&#233;ro"
                            1 => "T&#46;H&#46; Lemarchand"
                            2 => "Y&#46; Schutz"
                            3 => "N&#46; Tribolet"
                            4 => "J&#46;P&#46; Felber"
                            5 => "J&#46; Freeman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1988"
                        "volumen" => "28"
                        "paginaInicial" => "1368"
                        "paginaFinal" => "1374"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3418763"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pituitary hormone response to head injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;R&#46; King"
                            1 => "H&#46;C&#46; Knowles"
                            2 => "R&#46;L&#46; Mclaurin"
                            3 => "J&#46; Brielmaier"
                            4 => "G&#46; Perisutti"
                            5 => "V&#46;K&#46; Piziak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1981"
                        "volumen" => "9"
                        "paginaInicial" => "229"
                        "paginaFinal" => "235"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6795524"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neuroendocrinethyroid responses after trauma&#58; does head injury make any difference"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Garc&#237;a de Lorenzo"
                            1 => "J&#46;M&#46; A&#241;&#243;n"
                            2 => "J&#46; L&#243;pez Martinez"
                            3 => "J&#46; Pel&#225;ez"
                            4 => "M&#46; Sis&#243;n"
                            5 => "M&#46; S&#225;nchez Castilla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "1996"
                        "volumen" => "25"
                        "paginaInicial" => "132"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anterior pituitary and thyroid response after trauma&#46; Modifying factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Garc&#237;a de Lorenzo"
                            1 => "J&#46; L&#243;pez Mart&#237;nez"
                            2 => "J&#46;M&#46; A&#241;&#243;n"
                            3 => "M&#46; S&#225;nchez Castilla"
                            4 => "D&#46; D&#237;az D&#237;az"
                            5 => "C&#46; Vaquero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "1997"
                        "volumen" => "23"
                        "paginaInicial" => "188"
                        "paginaFinal" => "235"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A molecular basis for bi-directional communication between the immune and neuroendocrine systems"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;E&#46; Blalock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Physiol Rev"
                        "fecha" => "1989"
                        "volumen" => "69"
                        "paginaInicial" => "1"
                        "paginaFinal" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2536183"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of brain monoamines and histamine in regulation of anterior pituitary secretion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;I&#46; Weiner"
                            1 => "W&#46;F&#46; Ganong"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Physiol Rev"
                        "fecha" => "1978"
                        "volumen" => "58"
                        "paginaInicial" => "905"
                        "paginaFinal" => "976"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/212770"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypercortisolism in septic shock is not suppressible by dexamethasone infusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Perrot"
                            1 => "A&#46; Bonneton"
                            2 => "H&#46; Dechaud"
                            3 => "J&#46; Motin"
                            4 => "M&#46; Pugeat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "1993"
                        "volumen" => "21"
                        "paginaInicial" => "396"
                        "paginaFinal" => "401"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8440110"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Temperature-induced down regulation of the glucocorticoid receptor in peripheral blood mononuclear leukocytes in patients with sepsis and septic shock"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;J&#46; Molijn"
                            1 => "J&#46;W&#46; Koper"
                            2 => "C&#46;J&#46;C&#46; Van Uffelen"
                            3 => "F&#46;H&#46; de Jong"
                            4 => "A&#46;O&#46; Brinkmann"
                            5 => "H&#46;A&#46; Bruining"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol"
                        "fecha" => "1995"
                        "volumen" => "43"
                        "paginaInicial" => "197"
                        "paginaFinal" => "203"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effects of endotoxin on neuroendocrin axis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Navarra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Opinion Endocrinol Diabetes"
                        "fecha" => "1995"
                        "volumen" => "2"
                        "paginaInicial" => "127"
                        "paginaFinal" => "133"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The hypothalamic-pituitary-adrenal axis in critical illnes&#58; response to dexamethasone and corticotropin-releasing hormone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Reincke"
                            1 => "B&#46; Allolio"
                            2 => "G&#46; W&#252;rth"
                            3 => "W&#46; Winkelmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.77.1.8392081"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1993"
                        "volumen" => "77"
                        "paginaInicial" => "151"
                        "paginaFinal" => "156"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8392081"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dissociation of plasma adrenocorticotropin and cortisol levels in critically ill patients&#58; possible role of endothelin and atrial natriuretic hormone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Vermes"
                            1 => "A&#46; Vbeishuizen"
                            2 => "R&#46;M&#46; Hampsink"
                            3 => "C&#46; Haanen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.80.4.7714094"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1995"
                        "volumen" => "80"
                        "paginaInicial" => "1238"
                        "paginaFinal" => "1242"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7714094"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of surgical operation on growth hormone levels in plasma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;D&#46; Wrigth"
                            1 => "I&#46;D&#46;A&#46; Johnston"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surgery"
                        "fecha" => "1975"
                        "volumen" => "77"
                        "paginaInicial" => "479"
                        "paginaFinal" => "486"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1145426"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Altered growth hormone homeostasis during acute bacterial sepsis in the rhesus monkey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Rayfield"
                            1 => "T&#46;D&#46; George"
                            2 => "W&#46;R&#46; Beisel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem-38-5-746"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1974"
                        "volumen" => "38"
                        "paginaInicial" => "746"
                        "paginaFinal" => "754"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4150927"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The sepsis-glucose intolerance riddle&#58; A hormonal explanation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;S&#46; Dahn"
                            1 => "D&#46;L&#46; Bouwman"
                            2 => "J&#46;R&#46; Kirkpatrick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surgery"
                        "fecha" => "1979"
                        "volumen" => "86"
                        "paginaInicial" => "423"
                        "paginaFinal" => "428"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/473028"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sepsis&#44; glucoseintolerance and protein malnutrition&#58; A metabolic paradox"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;S&#46; Dahn"
                            1 => "J&#46;R&#46; Kirkpatrick"
                            2 => "D&#46;L&#46; Bouwman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Arch Surg"
                        "fecha" => "1980"
                        "volumen" => "115"
                        "paginaInicial" => "1415"
                        "paginaFinal" => "1418"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6778457"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642010001338"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endocrine mediators of metabolism associated with injury and sepsis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;S&#46; Dahn"
                            1 => "L&#46;A&#46; Jacobs"
                            2 => "M&#46;P&#46; Lange"
                            3 => "S&#46; Smith"
                            4 => "R&#46;A&#46; Mitchell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "JPEN"
                        "fecha" => "1986"
                        "volumen" => "10"
                        "paginaInicial" => "253"
                        "paginaFinal" => "257"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Decreased growth hormone levels in the catabolic phase of severe injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Jeevanandan"
                            1 => "L&#46; Ramias"
                            2 => "R&#46;F&#46; Shamos"
                            3 => "W&#46;R&#46; Schiller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surgery"
                        "fecha" => "1992"
                        "volumen" => "111"
                        "paginaInicial" => "495"
                        "paginaFinal" => "502"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1598669"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of IGFs in catabolism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Botfield"
                            1 => "J&#46; Ross"
                            2 => "C&#46;J&#46; Hinds"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Baillieres Clin Endocrinol Metab"
                        "fecha" => "1997"
                        "volumen" => "11"
                        "paginaInicial" => "679"
                        "paginaFinal" => "697"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9589777"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Positive nitrogen balance with human growth hormone and hypocaloric intravenous feeding"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;K&#46; Manson"
                            1 => "D&#46;W&#46; Wilmore"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surgery"
                        "fecha" => "1986"
                        "volumen" => "100"
                        "paginaInicial" => "188"
                        "paginaFinal" => "197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3090723"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enhancement of protein synthesis efficiency in parenterally fed trauma victims by adjuvant recombinant human growth hormone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;R&#46; Peterson"
                            1 => "N&#46;J&#46; Holaday"
                            2 => "M&#46; Jeevanandan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1994"
                        "volumen" => "36"
                        "paginaInicial" => "726"
                        "paginaFinal" => "733"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8189476"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improvement of septic syndrome after administration of recombinant human growth hormone &#40;rhGH&#41;&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Gottardis"
                            1 => "A&#46; Benzer"
                            2 => "W&#46; Koller"
                            3 => "T&#46;J&#46; Luger"
                            4 => "F&#46; P&#252;hringer"
                            5 => "J&#46; Hackl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1991"
                        "volumen" => "31"
                        "paginaInicial" => "81"
                        "paginaFinal" => "86"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1986138"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of growth hormone in patients receiving total parenteral nutrition following major gastrointestinal surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Vara-Thorbeck"
                            1 => "J&#46;A&#46; Guerrero"
                            2 => "M&#46;E&#46; Ruiz-Requena"
                            3 => "J&#46; Capit&#225;n"
                            4 => "M&#46; Rodr&#237;guez"
                            5 => "J&#46; Rosell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepatogastroenterology"
                        "fecha" => "1992"
                        "volumen" => "39"
                        "paginaInicial" => "270"
                        "paginaFinal" => "272"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1505903"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low-dose Growth hormone and hypocaloric nutrition attenuate the protein-catabolic response after major operation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Z&#46;M&#46; Jiang"
                            1 => "G&#46;Z&#46; He"
                            2 => "S&#46;Y&#46; Zhang"
                            3 => "X&#46;R&#46; Wang"
                            4 => "N&#46;F&#46; Yang"
                            5 => "Y&#46; Zhu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Surg"
                        "fecha" => "1989"
                        "volumen" => "210"
                        "paginaInicial" => "513"
                        "paginaFinal" => "525"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2802836"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of recombinant human Insulin-like growth factor I and early total parenteral nutrition on immune depression following severe head injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;A&#46; Kudsk"
                            1 => "C&#46; Mowatt-Larssen"
                            2 => "J&#46; Bukar"
                            3 => "T&#46; Fabian"
                            4 => "S&#46; Oellerich"
                            5 => "D&#46;L&#46; Dent"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Surg"
                        "fecha" => "1994"
                        "volumen" => "129"
                        "paginaInicial" => "66"
                        "paginaFinal" => "71"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8279942"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The somatotropic axis in critical illness&#58; effect of continuous growth hormone &#40;GH&#41;-releasing hormone and GH-releasing peptide 2 infusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Van den Berghe"
                            1 => "F&#46; De Zegher"
                            2 => "J&#46;D&#46; Veldhuis"
                            3 => "P&#46; Wouters"
                            4 => "M&#46; Awouters"
                            5 => "W&#46; Verbruggen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.82.2.3736"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1997"
                        "volumen" => "82"
                        "paginaInicial" => "590"
                        "paginaFinal" => "599"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9024260"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib205"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased survival after major thermal injury&#58; the effect of growth hormone therapy in adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Knox"
                            1 => "R&#46; Demling"
                            2 => "D&#46; Wilmore"
                            3 => "P&#46; Sarraf"
                            4 => "A&#46; Santos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1995"
                        "volumen" => "39"
                        "paginaInicial" => "526"
                        "paginaFinal" => "530"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7473919"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib210"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of human growth hormone combined with nutrititional support in a critical care unit"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46;R&#46; Ziegler"
                            1 => "L&#46;S&#46; Young"
                            2 => "E&#46; Ferrari-Baliviera"
                            3 => "R&#46;H&#46; Demling"
                            4 => "D&#46;W&#46; Wilmore"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "JPEN"
                        "fecha" => "1990"
                        "volumen" => "14"
                        "paginaInicial" => "574"
                        "paginaFinal" => "581"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib215"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased mortality associated with growth hormone treatment in critically ill adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Takala"
                            1 => "E&#46; Ruokonen"
                            2 => "N&#46;R&#46; Webster"
                            3 => "M&#46;S&#46; Nielsen"
                            4 => "D&#46;F&#46; Zandstra"
                            5 => "G&#46; Vundelincks"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199909093411102"
                      "Revista" => array:7 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1999"
                        "volumen" => "341"
                        "paginaInicial" => "785"
                        "paginaFinal" => "792"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10477776"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642010005075"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib220"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth hormone therapy in critically ill patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Demling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199909093411110"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1999"
                        "volumen" => "341"
                        "paginaInicial" => "837"
                        "paginaFinal" => "839"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10490384"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of growth hormone in the septic&#44; trauma and surgical patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;A&#46; Desai"
                            1 => "D&#46;O&#46; Jacobs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Growth hormone in ciritcal illness"
                        "paginaInicial" => "119"
                        "paginaFinal" => "140"
                        "serieFecha" => "1996"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of recombinant human growth hormone on catabolic hormones and free fatty acids following thermal injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;Y&#46; Flemming"
                            1 => "R&#46;L&#46; Rutan"
                            2 => "R&#46;E&#46; Jahoor"
                            3 => "R&#46;R&#46; Wolfe"
                            4 => "D&#46;N&#46; Herndon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1992"
                        "volumen" => "32"
                        "paginaInicial" => "698"
                        "paginaFinal" => "702"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1613829"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "47&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trauma and thermal injury&#58; comparison of hemostatic and cytokine chagnesin the acute phase of injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Kowal-Vern"
                            1 => "M&#46;M&#46; Sharp-Pucci"
                            2 => "J&#46;M&#46; Walenga"
                            3 => "D&#46;J&#46; Dries"
                            4 => "R&#46;L&#46; Gamelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1998"
                        "volumen" => "44"
                        "paginaInicial" => "325"
                        "paginaFinal" => "329"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9498505"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pituitary-testicular axis dysfunction in burned med"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;V&#46; Vogel"
                            1 => "G&#46;T&#46; Peake"
                            2 => "R&#46;T&#46; Rada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem-60-4-658"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1985"
                        "volumen" => "60"
                        "paginaInicial" => "658"
                        "paginaFinal" => "665"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4038713"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "49&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reproductive axis suppression in acute illness is related to disease severity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;I&#46; Spratt"
                            1 => "P&#46; Cox"
                            2 => "J&#46; Orav"
                            3 => "J&#46; Moloney"
                            4 => "T&#46; Bigos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.76.6.8501163"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1993"
                        "volumen" => "76"
                        "paginaInicial" => "1548"
                        "paginaFinal" => "1554"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8501163"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "50&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of epinephrine on testosterone production"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Levin"
                            1 => "C&#46;V&#46; Lloyd"
                            2 => "J&#46; Lobostsky"
                            3 => "E&#46;H&#46; Friedrich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Endocrinol &#40;Copenh"
                        "fecha" => "1967"
                        "volumen" => "55"
                        "paginaInicial" => "184"
                        "paginaFinal" => "190"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "51&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Morphine exerts testosterone-like effects in the hypothalamus of the castrated male rat"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46;J&#46; Cicero"
                            1 => "E&#46;R&#46; Meyer"
                            2 => "S&#46;M&#46; Gabriel"
                            3 => "R&#46;D&#46; Bell"
                            4 => "C&#46;E&#46; Wilcox"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Brain Res"
                        "fecha" => "1980"
                        "volumen" => "202"
                        "paginaInicial" => "151"
                        "paginaFinal" => "156"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7427731"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "52&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transient hypogonadotropic hypogonadism caused by critical illness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;D&#46; Woolf"
                            1 => "R&#46;W&#46; Hamill"
                            2 => "J&#46;V&#46; McDonald"
                            3 => "L&#46;A&#46; Lee"
                            4 => "M&#46; Kelly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem-60-3-444"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1985"
                        "volumen" => "60"
                        "paginaInicial" => "444"
                        "paginaFinal" => "450"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3919042"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "53&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prolactin&#58; a novel and safe immunomodulating hormone for the treatment of immunodepression following severe hemorrhage"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Zellweger"
                            1 => "M&#46;W&#46; Wichman"
                            2 => "A&#46; Ayala"
                            3 => "C&#46;M&#46; DeMaso"
                            4 => "I&#46;H&#46; Chaudry"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1006/jsre.1996.0222"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Surg Res"
                        "fecha" => "1996"
                        "volumen" => "63"
                        "paginaInicial" => "53"
                        "paginaFinal" => "58"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8661172"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "54&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metoclopramide&#58; a novel and safe immunomodulating agent for restoring the depressed macrophage immune function after hemorrhage"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Zellweger"
                            1 => "M&#46;W&#46; Wichmann"
                            2 => "A&#46; Ayala"
                            3 => "I&#46;H&#46; Chaudry"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1998"
                        "volumen" => "44"
                        "paginaInicial" => "70"
                        "paginaFinal" => "77"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9464751"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "55&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypothalamic-pituitary axis dysfunction in critically ill patients with a low free thyroxine index"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;I&#46; Mechanick"
                            1 => "H&#46;S&#46; Sacks"
                            2 => "R&#46;H&#46; Cobin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF03348002"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Endocrinol Invest"
                        "fecha" => "1997"
                        "volumen" => "20"
                        "paginaInicial" => "462"
                        "paginaFinal" => "470"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9364249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "56&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anterior pituitary function during critical illness and dopamine treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Van den Berghe"
                            1 => "F&#46; De Zegher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "1996"
                        "volumen" => "24"
                        "paginaInicial" => "1580"
                        "paginaFinal" => "1590"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8797634"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "57&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impaired thyroxine and 3&#44;5&#44;3&#8217;-triiodothyronine handling by rat hepatocytes in the presence of serum of serum of patients with nonthyroidal illness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46;A&#46; Vos"
                            1 => "M&#46; De Jong"
                            2 => "B&#46;F&#46; Bernard"
                            3 => "R&#46; Docter"
                            4 => "E&#46;P&#46; Krenning"
                            5 => "G&#46; Hennemann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.80.12.8530634"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1995"
                        "volumen" => "80"
                        "paginaInicial" => "2&#46;364"
                        "paginaFinal" => "2&#46;370"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8530634"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "58&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin 1 beta&#44; tumor necrosis factor-alpha and interlukin 6 decreasee nuclear thyroid hormone receptor capacity in a liver cell line"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Wolf"
                            1 => "N&#46; Hansen"
                            2 => "H&#46; Greten"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Endocrinol"
                        "fecha" => "1994"
                        "volumen" => "131"
                        "paginaInicial" => "307"
                        "paginaFinal" => "312"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7921216"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "59&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activation of the hypothalamolppituitary-adrenal axis in response to septic or non-septic diseases-implications for the euthyroid sick syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46; M&#246;nig"
                            1 => "T&#46; Arendt"
                            2 => "M&#46; Meyer"
                            3 => "B&#46; Kloehn Bewig"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "1999"
                        "volumen" => "25"
                        "paginaInicial" => "1&#46;402"
                        "paginaFinal" => "1&#46;406"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10660852"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "60&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impaired secretion of TSH in critically ill patients with &#96;low T4-syndrome&#180;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46; Vierhapper"
                            1 => "A&#46; Laggner"
                            2 => "W&#46; Waldh&#228;usl"
                            3 => "B&#46; Grubeck-Loeebenstein"
                            4 => "G&#46; Kleinberger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Endocrinol"
                        "fecha" => "1982"
                        "volumen" => "101"
                        "paginaInicial" => "542"
                        "paginaFinal" => "549"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6818804"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "61&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pituitary-Thyroid axis in critical illness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Faber"
                            1 => "C&#46; Kierkegaard"
                            2 => "B&#46; Rasussen"
                            3 => "H&#46; Westh"
                            4 => "M&#46; Busch-Sorensen"
                            5 => "I&#46;W&#46; Jensen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem-65-2-315"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1987"
                        "volumen" => "65"
                        "paginaInicial" => "315"
                        "paginaFinal" => "320"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3597710"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "62&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thyrotropin-releasing hormone in critical illness&#58; From a dopamine-dependent test to a strategy for increasing low serum triiodothyronine&#44; prolactin&#44; and growth hormone concentrations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Van den Berghe"
                            1 => "F&#46; de Zegher"
                            2 => "D&#46; Vlasselaers"
                            3 => "M&#46; Schetz"
                            4 => "C&#46; Verwaest"
                            5 => "P&#46; Ferdinande"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "1996"
                        "volumen" => "24"
                        "paginaInicial" => "590"
                        "paginaFinal" => "595"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8612408"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939410001558"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "63&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thyroid test abnormalities in traumatic brain injury&#58; Correlation with neurologic impairment and sympathetic nervous system activation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Woolf"
                            1 => "L&#46; Lee"
                            2 => "R&#46; Hamill"
                            3 => "J&#46;V&#46; Mac Donald"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1988"
                        "volumen" => "84"
                        "paginaInicial" => "201"
                        "paginaFinal" => "258"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3407649"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "64&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thyrotropin concentration predicts outcome in critical illness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;M&#46; Rothwell"
                            1 => "Z&#46;F&#46; Udwadia"
                            2 => "P&#46;G&#46; Lawler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Anaesthesia"
                        "fecha" => "1993"
                        "volumen" => "48"
                        "paginaInicial" => "373"
                        "paginaFinal" => "376"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8317642"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "65&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of thyroid hormone on metabolic adaptation to fasting"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "W&#46;J&#46; Carter"
                            1 => "K&#46;M&#46; SHakir"
                            2 => "S&#46; Hodges"
                            3 => "F&#46;H&#46; Faas"
                            4 => "J&#46;O&#46; Wynn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Metabolism"
                        "fecha" => "1975"
                        "volumen" => "24"
                        "paginaInicial" => "1&#46;177"
                        "paginaFinal" => "1&#46;183"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1196134"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "66&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relations between the selenium status and the low T3 syndrome after major trauma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;M&#46; Berger"
                            1 => "T&#46; Lemarchand-B&#233;raud"
                            2 => "C&#46; Cavadini"
                            3 => "R&#46; Chiol&#233;ro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "1996"
                        "volumen" => "22"
                        "paginaInicial" => "575"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8814474"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "67&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Decreased extrathyroidal triiiodothyronine production in nonthyroidal illness&#46; Benefit or harm"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;D&#46; Utiger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1980"
                        "volumen" => "69"
                        "paginaInicial" => "807"
                        "paginaFinal" => "810"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7446544"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642009007386"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "68&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cathecolamine and thyroid hormones in traumatic injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;G&#46; Ziegler"
                            1 => "E&#46;C&#46; Morrissey"
                            2 => "L&#46;F&#46; Marshall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "1990"
                        "volumen" => "18"
                        "paginaInicial" => "253"
                        "paginaFinal" => "258"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2302947"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "69&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46;A&#46; Brent"
                            1 => "J&#46;M&#46; Hershman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem-63-1-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1986"
                        "volumen" => "63"
                        "paginaInicial" => "1"
                        "paginaFinal" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3011834"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "70&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular effects of intravenous triiodothyronine in patients undergoing coronary artery bypass grafting&#46; A randomized&#44; double-blind&#44; placebo-controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46; Bennet-Guerrero"
                            1 => "J&#46;L&#46; Jim&#233;nez"
                            2 => "W&#46;D&#46; White"
                            3 => "E&#46;B&#46; D&#8217;Amico"
                            4 => "B&#46;I&#46; Baldwin"
                            5 => "D&#46;A&#46; Schwinn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1996"
                        "volumen" => "275"
                        "paginaInicial" => "687"
                        "paginaFinal" => "692"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8594265"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "71&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A senescent pattern of pituitary function during critical illness and dopamine treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Van den Berghe"
                            1 => "F&#46; De Zegher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Verh K Acad Geneeskd Belg"
                        "fecha" => "1996"
                        "volumen" => "58"
                        "paginaInicial" => "383"
                        "paginaFinal" => "411"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8956555"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            71 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "72&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Brain opiates and neuroendocrine function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Grossman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Endocrinol Metab"
                        "fecha" => "1983"
                        "volumen" => "12"
                        "paginaInicial" => "725"
                        "paginaFinal" => "746"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6323067"
                             …1
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            72 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "73&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The behavior of GH and somatomedin C following anesthesia induction with propofol in comparison with diazepam and thiopental"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Anasth Intensivther Notfallmed"
                        "fecha" => "1989"
                        "volumen" => "24"
                        "paginaInicial" => "226"
                        "paginaFinal" => "230"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            73 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "74&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasma cortisol&#44; prolactin and thyroxine levels related to midazolam anaesthesia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Med Hung"
                        "fecha" => "1986"
                        "volumen" => "43"
                        "paginaInicial" => "283"
                        "paginaFinal" => "289"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            74 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "75&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thyroid function in severely traumatized patients with or without head injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Endocrinol &#40;Copenh"
                        "fecha" => "1988"
                        "volumen" => "117"
                        "paginaInicial" => "80"
                        "paginaFinal" => "86"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            75 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "76&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship of altered thyroid hormone indices to survival in nonthyroidal illnesses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol"
                        "fecha" => "1982"
                        "volumen" => "16"
                        "paginaInicial" => "565"
                        "paginaFinal" => "574"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            76 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "77&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Do Thyroid function tests independently predict survival in the critically ill&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/thy.1992.2.119"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thyroid"
                        "fecha" => "1992"
                        "volumen" => "2"
                        "paginaInicial" => "119"
                        "paginaFinal" => "123"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            77 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "78&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship of admission thyroid function tests to outcome in critical illness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Anaesthesia"
                        "fecha" => "1995"
                        "volumen" => "50"
                        "paginaInicial" => "1&#46;022"
                        "paginaFinal" => "1&#46;025"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            78 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "79&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence and prognostic relevance of sick euthyroid syndrome in a medical intensive care unit"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Acad Med Singapore"
                        "fecha" => "1995"
                        "volumen" => "24"
                        "paginaInicial" => "802"
                        "paginaFinal" => "806"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            79 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "80&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pituitary-thyroid function in patients with septic shock and its relation with outcome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Med Res"
                        "fecha" => "1997"
                        "volumen" => "11"
                        "paginaInicial" => "477"
                        "paginaFinal" => "482"
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642008009706"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            80 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "81&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Free thriyodotironine in sera of acutely ill general medical patients&#46; A prognostic indicator"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chem"
                        "fecha" => "1992"
                        "volumen" => "38"
                        "paginaInicial" => "414"
                        "paginaFinal" => "415"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            81 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "82&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasma pituitary hormone levels in severe trauma with or without head injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1991"
                        "volumen" => "17"
                        "paginaInicial" => "25"
                        "paginaFinal" => "29"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            82 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "83&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Provocative hypothalamopituitary axis tests in severe head injury&#58; Correlation with severity and prognosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "1998"
                        "volumen" => "26"
                        "paginaInicial" => "1&#46;419"
                        "paginaFinal" => "1&#46;426"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            83 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "84&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Propofol 2&#37;&#58; Effect on lipids"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "1997"
                        "volumen" => "25"
                        "paginaInicial" => "1&#46;976"
                        "paginaFinal" => "1&#46;981"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            84 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "85&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hormonal dysregulations in severe burns"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Burns"
                        "fecha" => "1984"
                        "volumen" => "10"
                        "paginaInicial" => "257"
                        "paginaFinal" => "263"
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939408006594"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/02105691/0000002400000007/v1_201304241200/S0210569100796112/v1_201304241200/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "436"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Revisiones"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02105691/0000002400000007/v1_201304241200/S0210569100796112/v1_201304241200/es/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796112?idApp=WMIE"
]

Información del artículo

ISSN: 02105691
Idioma original: Español

DOI:10.1016/S0210-5691(00)79611-2

Datos actualizados diariamente

año/Mes	Html	Pdf	Total

2024 Noviembre	9	14	23
2024 Octubre	41	99	140
2024 Septiembre	43	52	95
2024 Agosto	44	77	121
2024 Julio	33	66	99
2024 Junio	31	54	85
2024 Mayo	29	45	74
2024 Abril	26	71	97
2024 Marzo	36	66	102
2024 Febrero	32	68	100
2024 Enero	30	55	85
2023 Diciembre	28	53	81
2023 Noviembre	25	46	71
2023 Octubre	25	54	79
2023 Septiembre	21	52	73
2023 Agosto	20	36	56
2023 Julio	28	46	74
2023 Junio	27	37	64
2023 Mayo	20	32	52
2023 Abril	19	34	53
2023 Marzo	26	65	91
2023 Febrero	19	55	74
2023 Enero	19	58	77
2022 Diciembre	28	85	113
2022 Noviembre	33	74	107
2022 Octubre	28	63	91
2022 Septiembre	40	92	132
2022 Agosto	27	103	130
2022 Julio	22	74	96
2022 Junio	27	50	77
2022 Mayo	33	100	133
2022 Abril	44	104	148
2022 Marzo	41	103	144
2022 Febrero	32	93	125
2022 Enero	27	102	129
2021 Diciembre	34	56	90
2021 Noviembre	31	105	136
2021 Octubre	42	117	159
2021 Septiembre	36	115	151
2021 Agosto	25	162	187
2021 Julio	28	98	126
2021 Junio	22	107	129
2021 Mayo	44	124	168
2021 Abril	54	184	238
2021 Marzo	66	92	158
2021 Febrero	61	88	149
2021 Enero	58	99	157
2020 Diciembre	30	79	109
2020 Noviembre	37	62	99
2020 Octubre	23	51	74
2020 Septiembre	16	52	68
2020 Agosto	32	57	89
2020 Julio	19	64	83
2020 Junio	37	53	90
2020 Mayo	39	52	91
2020 Abril	28	78	106
2020 Marzo	18	84	102
2020 Febrero	27	180	207
2020 Enero	30	127	157
2019 Diciembre	30	134	164
2019 Noviembre	29	142	171
2019 Octubre	17	147	164
2019 Septiembre	21	155	176
2019 Agosto	37	139	176
2019 Julio	18	97	115
2019 Junio	23	104	127
2019 Mayo	46	272	318
2019 Abril	12	176	188
2019 Marzo	10	172	182
2019 Febrero	11	164	175
2019 Enero	15	123	138
2018 Diciembre	16	62	78
2018 Noviembre	73	136	209
2018 Octubre	25	80	105
2018 Septiembre	12	65	77
2018 Agosto	13	80	93
2018 Julio	11	57	68
2018 Junio	14	57	71
2018 Mayo	6	41	47
2018 Abril	10	53	63
2018 Marzo	12	48	60
2018 Febrero	5	48	53
2018 Enero	10	65	75
2017 Diciembre	12	61	73
2017 Noviembre	10	49	59
2017 Octubre	10	70	80
2017 Septiembre	13	71	84
2017 Agosto	7	82	89
2017 Julio	12	83	95
2017 Junio	19	94	113
2017 Mayo	17	77	94
2017 Abril	24	90	114
2017 Marzo	11	107	118
2017 Febrero	14	124	138
2017 Enero	15	39	54
2016 Diciembre	30	35	65
2016 Noviembre	41	70	111
2016 Octubre	49	49	98
2016 Septiembre	52	89	141
2016 Agosto	76	91	167
2016 Julio	38	47	85

Mostrar todo

Indexada en:

Síguenos:

Suscribirse:

Estadísticas

Indexada en:

Síguenos:

Suscribirse:

Estadísticas

Suscríbase a la newsletter