Respuesta inflamatoria sistémica: fisiopatología y mediadores
Systemic inflammatory response: pathophysiology and mediators
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"apellidos" => "García de lorenzo y mateos" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "López martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Ssánchez castilla" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Intensiva. Hospital Universitario La Paz" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Cuidados Intensivos" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Anestesia y Reanimación. Hospital Severo Ochoa. Leganés. Madrid" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Dr. A. García de Lorenzo y Mateos. Servicio de Medicina Intensiva. Hospital Universitario La Paz. Paseo de la Castellana 261. 28046 Madrid" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Systemic inflammatory response: pathophysiology and mediators" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2000-03-05" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82372" "palabras" => array:4 [ 0 => "inflamación" 1 => "Sirs" 2 => "citocinas" 3 => "mediadores inflamatorios" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec82371" "palabras" => array:4 [ 0 => "Inflammation" 1 => "Sirs" 2 => "citokines" 3 => "inflammatory mediators" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se efectúa una revisión de las características y significado de la respuesta inflamatoria. Se describen las reacciones programadas que se desencadenan cuando la respuesta inflamatoria se generaliza y se analizan los mecanismos de puesta en marcha y finalización del proceso.</p> <span class="elsevierStyleSectionTitle">Material</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Revisión bibliográfica de los estudios recogidos en Medline.</p> <span class="elsevierStyleSectionTitle">Resumen de la revisión</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Tras la agresión se desencadena una serie de respuestas orgánicas programadas que tienden a limitar el cuadro inflamatorio. La pérdida del control local induce una respuesta inflamatoria generalizada, rápida y ampliada, controlada humoral y celularmente (complemento, cininas, coagulación y cascada fibrinolítica) y desencadenada por la activación conjunta de fagocitos y células endoteliales. Si esta respuesta inflamatoria no es adecuadamente modulada, se origina un sindrome inflamatorio sistémico, que puede alterar el metabolismo intermediario y el funcionalismo de los diferentes órganos. Se describe el complejo entramado de los mediadores de la inflamación, así como sus relaciones con la respuesta neuroendocrina y con la respuesta de fase aguda. Se pasa revista a los mecanismos que ponen en marcha la respuesta inflamatoria y a los sistemas orgánicos establecidos para su modulación o contrarregulación. Se concluye en la necesidad de sistematizar el estudio de las diferentes respuestas a la inflamación, con fines pronósticos y terapéuticos.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Inflammatory response characteristics and significance are reviewed. The programmed reactions which are displayed when the reactions is widespread and those mechanisms involved in its onset and ending are analysed.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Systematic review of Medline’s bibliography.</p> <span class="elsevierStyleSectionTitle">Review’s summary</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">When injury ensues, there are several programmed reactions displayed which tend to restrict the inflammatory reaction. When local control is overwhelmed, a quick and generalized reaction promoted by the joint activation of phagocytes and endotelial cells and under humoral and cellular control (complement, citokynes, clotting and fibrinolysis) takes place. As long as this inflammatory reaction is not adequately suppressed, a systemic inflammatory syndrome ensues which may disturb the intermediate metabolism and several organ function. Inflammatory mediators are described, as well as their role in the neuroendocrine and in the acute phase reaction. Mechanisms involved in the onset of the inflammatory reaction and its up or downregulation are reviewd. To sum up, we stress the need of systematic approaches to study the different reactions to inflammation if we try to achieve improvements in prognosis and therapy.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:35 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 193 | 249 | 442 |
| 2024 Octubre | 1881 | 2598 | 4479 |
| 2024 Septiembre | 1652 | 2223 | 3875 |
| 2024 Agosto | 1360 | 2460 | 3820 |
| 2024 Julio | 974 | 1240 | 2214 |
| 2024 Junio | 835 | 1471 | 2306 |
| 2024 Mayo | 1187 | 2236 | 3423 |
| 2024 Abril | 1355 | 2685 | 4040 |
| 2024 Marzo | 1415 | 2661 | 4076 |
| 2024 Febrero | 1776 | 2859 | 4635 |
| 2024 Enero | 1499 | 1877 | 3376 |
| 2023 Diciembre | 1015 | 1038 | 2053 |
| 2023 Noviembre | 1396 | 2251 | 3647 |
| 2023 Octubre | 1630 | 2802 | 4432 |
| 2023 Septiembre | 1636 | 3352 | 4988 |
| 2023 Agosto | 1371 | 2736 | 4107 |
| 2023 Julio | 587 | 1413 | 2000 |
| 2023 Junio | 511 | 1489 | 2000 |
| 2023 Mayo | 99 | 896 | 995 |
| 2023 Abril | 648 | 2239 | 2887 |
| 2023 Marzo | 1229 | 7399 | 8628 |
| 2023 Febrero | 1498 | 6365 | 7863 |
| 2023 Enero | 856 | 3445 | 4301 |
| 2022 Diciembre | 333 | 2018 | 2351 |
| 2022 Noviembre | 841 | 5499 | 6340 |
| 2022 Octubre | 1000 | 5413 | 6413 |
| 2022 Septiembre | 1107 | 8458 | 9565 |
| 2022 Agosto | 666 | 6090 | 6756 |
| 2022 Julio | 441 | 3001 | 3442 |
| 2022 Junio | 476 | 3131 | 3607 |
| 2022 Mayo | 630 | 4357 | 4987 |
| 2022 Abril | 688 | 4506 | 5194 |
| 2022 Marzo | 911 | 5599 | 6510 |
| 2022 Febrero | 761 | 4848 | 5609 |
| 2022 Enero | 549 | 3040 | 3589 |
| 2021 Diciembre | 353 | 2156 | 2509 |
| 2021 Noviembre | 566 | 3495 | 4061 |
| 2021 Octubre | 643 | 3775 | 4418 |
| 2021 Septiembre | 612 | 5130 | 5742 |
| 2021 Agosto | 570 | 4204 | 4774 |
| 2021 Julio | 436 | 2294 | 2730 |
| 2021 Junio | 537 | 3567 | 4104 |
| 2021 Mayo | 652 | 4480 | 5132 |
| 2021 Abril | 1437 | 8655 | 10092 |
| 2021 Marzo | 1242 | 6526 | 7768 |
| 2021 Febrero | 1071 | 8300 | 9371 |
| 2021 Enero | 584 | 5580 | 6164 |
| 2020 Diciembre | 484 | 4397 | 4881 |
| 2020 Noviembre | 712 | 6241 | 6953 |
| 2020 Octubre | 662 | 6468 | 7130 |
| 2020 Septiembre | 762 | 9769 | 10531 |
| 2020 Agosto | 602 | 6492 | 7094 |
| 2020 Julio | 888 | 5525 | 6413 |
| 2020 Junio | 911 | 7077 | 7988 |
| 2020 Mayo | 690 | 9909 | 10599 |
| 2020 Abril | 643 | 11464 | 12107 |
| 2020 Marzo | 300 | 6276 | 6576 |
| 2020 Febrero | 462 | 11147 | 11609 |
| 2020 Enero | 303 | 7312 | 7615 |
| 2019 Diciembre | 234 | 4784 | 5018 |
| 2019 Noviembre | 481 | 9978 | 10459 |
| 2019 Octubre | 393 | 12575 | 12968 |
| 2019 Septiembre | 447 | 15044 | 15491 |
| 2019 Agosto | 239 | 12122 | 12361 |
| 2019 Julio | 159 | 6491 | 6650 |
| 2019 Junio | 119 | 7502 | 7621 |
| 2019 Mayo | 174 | 11855 | 12029 |
| 2019 Abril | 91 | 11323 | 11414 |
| 2019 Marzo | 99 | 13060 | 13159 |
| 2019 Febrero | 103 | 10490 | 10593 |
| 2019 Enero | 65 | 5196 | 5261 |
| 2018 Diciembre | 106 | 2370 | 2476 |
| 2018 Noviembre | 121 | 3705 | 3826 |
| 2018 Octubre | 40 | 2066 | 2106 |
| 2018 Septiembre | 44 | 1871 | 1915 |
| 2018 Agosto | 38 | 1623 | 1661 |
| 2018 Julio | 39 | 867 | 906 |
| 2018 Junio | 25 | 856 | 881 |
| 2018 Mayo | 18 | 752 | 770 |
| 2018 Abril | 33 | 1458 | 1491 |
| 2018 Marzo | 38 | 1567 | 1605 |
| 2018 Febrero | 33 | 1668 | 1701 |
| 2018 Enero | 11 | 1015 | 1026 |
| 2017 Diciembre | 12 | 527 | 539 |
| 2017 Noviembre | 18 | 1264 | 1282 |
| 2017 Octubre | 19 | 1353 | 1372 |
| 2017 Septiembre | 22 | 1586 | 1608 |
| 2017 Agosto | 9 | 1364 | 1373 |
| 2017 Julio | 20 | 665 | 685 |
| 2017 Junio | 24 | 1151 | 1175 |
| 2017 Mayo | 24 | 1070 | 1094 |
| 2017 Abril | 28 | 1344 | 1372 |
| 2017 Marzo | 12 | 1674 | 1686 |
| 2017 Febrero | 11 | 1496 | 1507 |
| 2017 Enero | 11 | 841 | 852 |
| 2016 Diciembre | 33 | 589 | 622 |
| 2016 Noviembre | 48 | 1058 | 1106 |
| 2016 Octubre | 49 | 1220 | 1269 |
| 2016 Septiembre | 783 | 2281 | 3064 |
| 2016 Agosto | 1582 | 2182 | 3764 |
| 2016 Julio | 459 | 1013 | 1472 |
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