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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se efect&#250;a una revisi&#243;n de las caracter&#237;sticas y significado de la respuesta inflamatoria&#46; Se describen las reacciones programadas que se desencadenan cuando la respuesta inflamatoria se generaliza y se analizan los mecanismos de puesta en marcha y finalizaci&#243;n del proceso&#46;</p> <span class="elsevierStyleSectionTitle">Material</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Revisi&#243;n bibliogr&#225;fica de los estudios recogidos en Medline&#46;</p> <span class="elsevierStyleSectionTitle">Resumen de la revisi&#243;n</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Tras la agresi&#243;n se desencadena una serie de respuestas org&#225;nicas programadas que tienden a limitar el cuadro inflamatorio&#46; La p&#233;rdida del control local induce una respuesta inflamatoria generalizada&#44; r&#225;pida y ampliada&#44; controlada humoral y celularmente &#40;complemento&#44; cininas&#44; coagulaci&#243;n y cascada fibrinol&#237;tica&#41; y desencadenada por la activaci&#243;n conjunta de fagocitos y c&#233;lulas endoteliales&#46; Si esta respuesta inflamatoria no es adecuadamente modulada&#44; se origina un sindrome inflamatorio sist&#233;mico&#44; que puede alterar el metabolismo intermediario y el funcionalismo de los diferentes &#243;rganos&#46; Se describe el complejo entramado de los mediadores de la inflamaci&#243;n&#44; as&#237; como sus relaciones con la respuesta neuroendocrina y con la respuesta de fase aguda&#46; Se pasa revista a los mecanismos que ponen en marcha la respuesta inflamatoria y a los sistemas org&#225;nicos establecidos para su modulaci&#243;n o contrarregulaci&#243;n&#46; Se concluye en la necesidad de sistematizar el estudio de las diferentes respuestas a la inflamaci&#243;n&#44; con fines pron&#243;sticos y terap&#233;uticos&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Inflammatory response characteristics and significance are reviewed&#46; The programmed reactions which are displayed when the reactions is widespread and those mechanisms involved in its onset and ending are analysed&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Systematic review of Medline&#8217;s bibliography&#46;</p> <span class="elsevierStyleSectionTitle">Review&#8217;s summary</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">When injury ensues&#44; there are several programmed reactions displayed which tend to restrict the inflammatory reaction&#46; When local control is overwhelmed&#44; a quick and generalized reaction promoted by the joint activation of phagocytes and endotelial cells and under humoral and cellular control &#40;complement&#44; citokynes&#44; clotting and fibrinolysis&#41; takes place&#46; As long as this inflammatory reaction is not adequately suppressed&#44; a systemic inflammatory syndrome ensues which may disturb the intermediate metabolism and several organ function&#46; Inflammatory mediators are described&#44; as well as their role in the neuroendocrine and in the acute phase reaction&#46; Mechanisms involved in the onset of the inflammatory reaction and its up or downregulation are reviewd&#46; To sum up&#44; we stress the need of systematic approaches to study the different reactions to inflammation if we try to achieve improvements in prognosis and therapy&#46;</p>"
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                        "paginaInicial" => "45"
                        "paginaFinal" => "48"
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                        "paginaFinal" => "33"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8001382"
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Respuesta inflamatoria sistémica: fisiopatología y mediadores
Systemic inflammatory response: pathophysiology and mediators
A. García de lorenzo y mateos*,1, J. López martínez**, M. Ssánchez castilla***
* Servicio de Medicina Intensiva. Hospital Universitario La Paz
** Unidad de Cuidados Intensivos
*** Servicio de Anestesia y Reanimación. Hospital Severo Ochoa. Leganés. Madrid
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                        "paginaInicial" => "920"
                        "paginaFinal" => "935"
                        "link" => array:1 [
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                        "paginaFinal" => "172"
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                          0 => array:2 [
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                        "paginaFinal" => "48"
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                        "paginaFinal" => "33"
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                          0 => array:2 [
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                            "web" => "Medline"
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                            "web" => "Medline"
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ISSN: 02105691
Idioma original: Español
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