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renal and hepatic functions were under normal parameters&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A lower respiratory tract infection was diagnosed and treated empirically with 40<span class="elsevierStyleHsp" style=""></span>mg&#47;day corticosteroids&#44; azytromicin&#44; ceftriaxone and cotrimoxazole&#46; Blood and sputum cultures&#44; typical and atypical pneumonia antigenurias &#40;urinary pneumococcal antigen detection&#41; and serologies were negative as well as HIV&#46; Antinuclear and antinuclear extractable auto-antibodies resulted negative&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">He developed a progressive severe respiratory insufficiency with increasing interstitial opacities in chest X-ray&#44; and the 7th day after admission he required intubation&#44; mechanical ventilation with an oxygen injection fraction of 1&#44; being transferred to the Intensive Care Unit&#46; Trans-thoracic echocardiography ruled out valvular alterations or decreased ventricular ejection fraction&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Suspecting lung interstitial pathology a biopsy by fibrobronchoscopy was performed and three metilprednisolone 1<span class="elsevierStyleHsp" style=""></span>g boluses were administered empirically&#46; The patient improved after 2 days and computerised tomography scanning &#40;CT scanning&#41; was performed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; showing diffuse acute pulmonary damage&#44; composed of ground glass areas associated to consolidation zones in inferior lobes&#44; mild pleural effusion and cystic images suggestive of emphysema&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Initial results from transbronchial biopsy showed absence of malignancy&#44; presence of widened septums due to fibrosis&#44; mild inflammatory component with a lymphocytic predominance&#44; and fribrin depots in the alveoli&#44; all being diagnostic of an acute organising pneumonia&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The patient kept diminishing oxygen demands and the 11th day after admission the final biopsy result showed presence of <span class="elsevierStyleItalic">P&#46; jirovecii</span>&#44; in spite of being treated with cotrimoxazole 800<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Control thoracic CT scanning was performed the 16th day since admission&#44; showing residual ground glass areas and a mild left pleural effusion&#46; The patient was extubated the 18th day after admission&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The patient was oriented as a non-cryptogenic organising pneumonia&#44; secondary to a <span class="elsevierStyleItalic">P&#46; jirovecii</span> infection&#46; He kept receiving 60<span class="elsevierStyleHsp" style=""></span>mg&#47;day of metilprednisolone for a month and later was tapered down gradually&#46; He also completed 3 weeks of treatment against the infection&#44; replacing cotrimoxazole for inhaled pentamidine due to hyperkalemia&#46; He completed a 6 month follow up&#44; with radiologic resolution of the infiltrates&#44; mild ventilatory obstruction and remaining clinically asymptomatic without treatment&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">In 1990&#44; Liote et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> described for the first time HIV patients suffering from <span class="elsevierStyleItalic">P&#46; jirovecii</span> infection who developed synchronically bronchiolitis obliterans&#44; nowadays known as OP&#44; that was thought to appear in context of a great inflammatory reaction induced by the infection&#46; Afterwards other authors described the same process in lung and liver transplanted subjects&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> The underlying pathogenic mechanism is still unknown but reports of <span class="elsevierStyleItalic">P&#46; jirovecii</span>-related type 1 pneumocytes related damage or proteolysis&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> as well as documentation of acute alveolar damage<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> in HIV patients&#44; 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Drug induced pulmonary damage was not considered responsible because it had been introduced 2 years before at low doses and biopsy did not match with toxicity&#46; The fact that the patient responded well and fast to high corticosteroid doses&#44; instead to cotrimoxazole and medium corticosteroid doses&#44; suggests that acute OP was the main responsible of the clinic&#46; Acute onset OP has been associated to a poor prognosis<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and high dose corticosteroids are the main treatment&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Diagnosis of OP includes systematic ruling out of other aetiologies and a corresponding biopsy&#46; Non-cryptogenic OP associated to <span class="elsevierStyleItalic">P&#46; jirovecii</span> infection has been described in some severely immunosuppressed patients&#46; In this report we describe the first case in a patient that does not meet those medical conditions&#46; High dose corticosteroids and specific antibiotics have shown to be a successful treatment for this patient&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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Scientific letter
An unusual case of organizing pneumonia and infection by P. jirovecii
Un caso inusual de neumonía organizada e infección por P. jirovecii
A. Fernández-Codinaa,
Autor para correspondencia
Andreu.fernandez@vhebron.net

Corresponding author.
, B. Caralt-Ramisab, J.R. Masclansb,d, M. Farréd, C. Bravoc, J. Rellob,d
a Internal Medicine Department, Autoimmune Diseases Unit, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain
b Critical Care Department, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain
c Pneumology Department, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain
d CIBERES, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Non-cryptogenic organising pneumonia &#40;OP&#41; secondary to a <span class="elsevierStyleItalic">Pneumocystis jirovecii</span> infection is a rare condition described in HIV &#40;human immunodeficiency virus&#41; infection&#44; lung and liver transplantation&#59; in this brief report we discuss the first clinical case in a patient not severely immunocompromised&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">He was a 63 year-old man who consulted our centre&#39;s Emergency Department referring a 2 month long history of progressive dyspnoea and purulent sputum&#44; oriented by general practitioner as an acute exacerbation of chronic bronchitis and treated with bronchodilators and amoxicillin-clavulanate&#46; Two weeks before consulting dyspnoea became severe&#46; Twenty-four hours before admission he referred fever &#40;38<span class="elsevierStyleHsp" style=""></span>&#176;C&#41; and left pleural chest pain&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">He was an active smoker &#40;45 packs&#47;year&#41;&#44; ex-alcoholic&#44; suffered from epilepsy well controlled with valproic acid for the last 2 years&#44; hemochromatosis without organic impairment&#44; an arytenoid carcinoma removed in 2009 endoscopically without relapse and a seronegative arthritis treated with methotrexate since 2009 with irregular medication intake &#40;white blood cell count two months before admission was 10&#44;200 leucocytes&#44; 8520 neutrophils&#44; 1560 lymphocytes&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">He had worked as a subway driver&#44; did not travel&#44; and neither had pets&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Initial tests performed in the Emergency Department were&#58; chest X-ray showing cardiomegaly&#59; blood testing showing 9400 leukocytes&#44; 8836 neutrophils&#44; 654 lymphocytes&#59; haemostasis&#44; renal and hepatic functions were under normal parameters&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A lower respiratory tract infection was diagnosed and treated empirically with 40<span class="elsevierStyleHsp" style=""></span>mg&#47;day corticosteroids&#44; azytromicin&#44; ceftriaxone and cotrimoxazole&#46; Blood and sputum cultures&#44; typical and atypical pneumonia antigenurias &#40;urinary pneumococcal antigen detection&#41; and serologies were negative as well as HIV&#46; Antinuclear and antinuclear extractable auto-antibodies resulted negative&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">He developed a progressive severe respiratory insufficiency with increasing interstitial opacities in chest X-ray&#44; and the 7th day after admission he required intubation&#44; mechanical ventilation with an oxygen injection fraction of 1&#44; being transferred to the Intensive Care Unit&#46; Trans-thoracic echocardiography ruled out valvular alterations or decreased ventricular ejection fraction&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Suspecting lung interstitial pathology a biopsy by fibrobronchoscopy was performed and three metilprednisolone 1<span class="elsevierStyleHsp" style=""></span>g boluses were administered empirically&#46; The patient improved after 2 days and computerised tomography scanning &#40;CT scanning&#41; was performed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; showing diffuse acute pulmonary damage&#44; composed of ground glass areas associated to consolidation zones in inferior lobes&#44; mild pleural effusion and cystic images suggestive of emphysema&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Initial results from transbronchial biopsy showed absence of malignancy&#44; presence of widened septums due to fibrosis&#44; mild inflammatory component with a lymphocytic predominance&#44; and fribrin depots in the alveoli&#44; all being diagnostic of an acute organising pneumonia&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The patient kept diminishing oxygen demands and the 11th day after admission the final biopsy result showed presence of <span class="elsevierStyleItalic">P&#46; jirovecii</span>&#44; in spite of being treated with cotrimoxazole 800<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Control thoracic CT scanning was performed the 16th day since admission&#44; showing residual ground glass areas and a mild left pleural effusion&#46; The patient was extubated the 18th day after admission&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The patient was oriented as a non-cryptogenic organising pneumonia&#44; secondary to a <span class="elsevierStyleItalic">P&#46; jirovecii</span> infection&#46; He kept receiving 60<span class="elsevierStyleHsp" style=""></span>mg&#47;day of metilprednisolone for a month and later was tapered down gradually&#46; He also completed 3 weeks of treatment against the infection&#44; replacing cotrimoxazole for inhaled pentamidine due to hyperkalemia&#46; He completed a 6 month follow up&#44; with radiologic resolution of the infiltrates&#44; mild ventilatory obstruction and remaining clinically asymptomatic without treatment&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">In 1990&#44; Liote et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> described for the first time HIV patients suffering from <span class="elsevierStyleItalic">P&#46; jirovecii</span> infection who developed synchronically bronchiolitis obliterans&#44; nowadays known as OP&#44; that was thought to appear in context of a great inflammatory reaction induced by the infection&#46; Afterwards other authors described the same process in lung and liver transplanted subjects&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> The underlying pathogenic mechanism is still unknown but reports of <span class="elsevierStyleItalic">P&#46; jirovecii</span>-related type 1 pneumocytes related damage or proteolysis&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> as well as documentation of acute alveolar damage<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> in HIV patients&#44; may show an important inflammatory background that could lead to the formation of the interstitial pneumonia architecture&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">OP is an exclusion diagnosis<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> and obtaining a biopsy specimen is mandatory&#46; This case report&#44; after ruling out HIV&#44; bacterial or viral agents different from <span class="elsevierStyleItalic">P&#46; jirovecii</span>&#59; collagen diseases or other interstitial entities&#44; could represent the first non-cryptogenic OP associated to <span class="elsevierStyleItalic">P&#46; jirovecii</span> pneumonia reported in a patient who does not meet the conditions described before in literature&#46; He had no lymphopenia&#44; and neither neutropenia in previous tests&#44; which are the best markers for immunosuppression due to methotrexate&#59; although immunosuppressor intake and the subject&#39;s previous medical history may raise reasonable doubts about a completely intact immune system function&#46; Drug induced pulmonary damage was not considered responsible because it had been introduced 2 years before at low doses and biopsy did not match with toxicity&#46; The fact that the patient responded well and fast to high corticosteroid doses&#44; instead to cotrimoxazole and medium corticosteroid doses&#44; suggests that acute OP was the main responsible of the clinic&#46; Acute onset OP has been associated to a poor prognosis<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and high dose corticosteroids are the main treatment&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Diagnosis of OP includes systematic ruling out of other aetiologies and a corresponding biopsy&#46; Non-cryptogenic OP associated to <span class="elsevierStyleItalic">P&#46; jirovecii</span> infection has been described in some severely immunosuppressed patients&#46; In this report we describe the first case in a patient that does not meet those medical conditions&#46; High dose corticosteroids and specific antibiotics have shown to be a successful treatment for this patient&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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2023 Marzo 79 45 124
2023 Febrero 58 56 114
2023 Enero 36 29 65
2022 Diciembre 74 42 116
2022 Noviembre 71 36 107
2022 Octubre 98 34 132
2022 Septiembre 125 54 179
2022 Agosto 90 42 132
2022 Julio 53 51 104
2022 Junio 50 30 80
2022 Mayo 76 56 132
2022 Abril 92 48 140
2022 Marzo 98 70 168
2022 Febrero 90 35 125
2022 Enero 99 35 134
2021 Diciembre 72 60 132
2021 Noviembre 104 40 144
2021 Octubre 146 74 220
2021 Septiembre 91 23 114
2021 Agosto 83 36 119
2021 Julio 70 42 112
2021 Junio 48 32 80
2021 Mayo 81 52 133
2021 Abril 155 80 235
2021 Marzo 126 16 142
2021 Febrero 113 35 148
2021 Enero 116 35 151
2020 Diciembre 76 19 95
2020 Noviembre 78 24 102
2020 Octubre 55 27 82
2020 Septiembre 48 25 73
2020 Agosto 59 24 83
2020 Julio 42 26 68
2020 Junio 42 20 62
2020 Mayo 52 16 68
2020 Abril 70 21 91
2020 Marzo 52 15 67
2020 Febrero 119 23 142
2020 Enero 71 27 98
2019 Diciembre 137 37 174
2019 Noviembre 128 31 159
2019 Octubre 132 27 159
2019 Septiembre 62 39 101
2019 Agosto 54 21 75
2019 Julio 48 25 73
2019 Junio 36 15 51
2019 Mayo 69 28 97
2019 Abril 29 27 56
2019 Marzo 32 26 58
2019 Febrero 37 23 60
2019 Enero 37 38 75
2018 Diciembre 53 29 82
2018 Noviembre 86 64 150
2018 Octubre 95 25 120
2018 Septiembre 45 15 60
2018 Agosto 26 10 36
2018 Julio 35 14 49
2018 Junio 42 15 57
2018 Mayo 34 3 37
2018 Abril 30 6 36
2018 Marzo 64 3 67
2018 Febrero 34 3 37
2018 Enero 40 16 56
2017 Diciembre 24 8 32
2017 Noviembre 27 11 38
2017 Octubre 27 3 30
2017 Septiembre 22 10 32
2017 Agosto 24 6 30
2017 Julio 21 7 28
2017 Junio 21 12 33
2017 Mayo 31 7 38
2017 Abril 20 5 25
2017 Marzo 26 4 30
2017 Febrero 20 14 34
2017 Enero 17 3 20
2016 Diciembre 30 8 38
2016 Noviembre 59 17 76
2016 Octubre 68 28 96
2016 Septiembre 61 20 81
2016 Agosto 21 9 30
2016 Julio 13 12 25
2016 Febrero 1 0 1
2015 Diciembre 4 0 4
2015 Julio 0 9 9
2014 Agosto 3 0 3
2014 Julio 4 0 4
2014 Junio 6 0 6
2014 Mayo 5 0 5
2014 Abril 2 0 2
2014 Marzo 21 12 33
2014 Febrero 20 5 25
2014 Enero 19 4 23
2013 Diciembre 17 4 21
2013 Noviembre 11 3 14
2013 Octubre 11 5 16
2013 Septiembre 13 4 17
2013 Agosto 15 2 17
2013 Julio 15 7 22
2013 Junio 10 3 13
2013 Mayo 6 3 9
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