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Llaurado-Serra, M. Ulldemolins, R. Güell-Baró, B. Coloma-Gómez, X. Alabart-Lorenzo, A. López-Gil, M. Bodí, A. Rodriguez, M.F. Jiménez-Herrera" "autores" => array:10 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Llaurado-Serra" "email" => array:1 [ 0 => "mireiallaurado@gmail.com" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M." 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"apellidos" => "Jiménez-Herrera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 9 => array:2 [ "colaborador" => "on behalf of the CAPCRI Study Investigators" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">◊</span>" "identificador" => "fn1" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Institut d’investigació Sanitària Pere Virgili, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Intensive Care Unit, University Hospital Joan XXIII, Tarragona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Nursing Department, Universitat Rovira i Virgili, Tarragona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Critical Care Department, Sabadell Hospital, University Institute Parc Taulí – Universitat Autònoma de Barcelona (UAB), Sabadell Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Fundació Clínic per la Recerca Biomèdica – Universitat de Barcelona (UB), Barcelona, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Medical school, Universitat Rovira i Virgili, Tarragona, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación del cumplimiento de la elevación de la cabecera de la cama en pacientes críticamente enfermos sometidos a ventilación mecánica en una unidad de cuidados intensivos polivalente" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 628 "Ancho" => 1000 "Tamanyo" => 87883 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Device used for the measurement of the head-of-bed elevation and technique for the measurement of the backrest elevation (Bosch<span class="elsevierStyleSup">®</span> GLM 80).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Background</span><p id="par0005" class="elsevierStylePara elsevierViewall">Semi-recumbent position is defined as head-of-bed elevation (HOBE) from 30 to 45°, and is recommended for the prevention of Ventilator-Associated Pneumonia (VAP) in all international guidelines.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–6</span></a> However, despite the broad recommendation of the use of HOBE for the prevention of VAP, evidence supporting this measure is limited.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7–10</span></a></p><p id="par0195" class="elsevierStylePara elsevierViewall">The first study supporting HOBE was published in 1992 by Torres et al.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and reported that 45° HOBE significantly decreased the incidence of broncoaspiration when compared to supine position at 0°. Later, a randomized controlled trial comparing backrest patients positioned at 45° with patients positioned at 0° found a 76% decrease in VAP incidence in the 45° group.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> On the one hand, only these two randomized trials have prospectively demonstrated the effectiveness of HOBE at 45° for VAP prevention. On the other hand, other studies with more realistic control groups, such as HOBE of 25° or 10°, did not find any significant differences in VAP incidence compared to the 45° group.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,11</span></a> Regarding observational studies, a multivariate logistic regression analysis showed that keeping patients on at least 30° during the first 24<span class="elsevierStyleHsp" style=""></span>h of mechanical ventilation (MV) was independently associated with lower VAP incidence and mortality.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Due to lack of conclusive evidence supporting HOBE, the European Society of Intensive Care Medicine (ESICM) recommends elevating the head-of-bed from 20 to 45°, preferably >30°, unless it interferes with patient care or wishes.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0200" class="elsevierStylePara elsevierViewall">However, compliance is a factor that may limit the effectiveness of this recommendation. In fact, a common issue in all of the previously mentioned studies is low compliance<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10,11</span></a> or even non-report of compliance.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7–9</span></a> For instance, in the study performed by Van Nieuwenhoven et al., the patients were positioned to 45° or 10° and compliance was monitored continuously. The investigators found that the group at 45° did not achieve this position for 85% of the time, being the median HOBE (M-HOBE) 28°.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Studies particularly focusing on compliance have found that M-HOBE ranges from 19.2° to 28°<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13–15</span></a> and that HOBE compliance is below the optimal value, from 22.3% to 40.9%.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15–18</span></a></p><p id="par0205" class="elsevierStylePara elsevierViewall">Many strategies have been described that aim to increase compliance to HOBE, such as training sessions,<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16,19</span></a> devices to remind staff of the importance of the HOBE<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> and even considering HOBE a clinical monitoring parameter.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21,22</span></a> However, maintaining patients positioned at 30–45° still seems challenging.</p><p id="par0210" class="elsevierStylePara elsevierViewall">Some studies evaluated the main factors associated with low compliance and concluded that airway device type, nursing shift, nursing experience, enteral nutrition, weaning and haemodynamic status of the patients were factors associated with low compliance.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14,15,17,18</span></a></p><p id="par0215" class="elsevierStylePara elsevierViewall">Most of the studies that evaluated HOBE compliance were performed during a 7-days period, regardless of whether they evaluated or not the relationship between HOBE and VAP.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,13,15,18,23</span></a> For the assessment of compliance during longer periods of time, self-reported checklists may be regarded as an alternative as they might be easier to implement compared to direct observation. Checklists have been demonstrated to be useful in improving adherence to patient's care<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> and might have an impact in patient outcomes.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> However, the effectiveness of this measuring technique has not been yet evaluated for HOBE compliance. The aim of the present study was to assess the real HOBE compliance in a 14-bed Intensive Care Unit (ICU), to compare direct-observation with self-reported compliance using a daily checklist (checklist-reported) and to identify the factors that might influence HOBE compliance.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Patients and methods</span><p id="par0035" class="elsevierStylePara elsevierViewall">A prospective, observational study was performed in a 14-bed polyvalent ICU, in a tertiary hospital. Study was undertaken from January 2012 to March 2013, during four time periods of one month in length each. HOBE was recorded from all patients requiring MV with no absolute contraindications for HOBE. Absolute contraindications for HOBE were pelvic fracture, suspected or confirmed spinal injury and anti-Trendelemburg and prone positioning. Study investigators registered HOBE three times daily (once per nursing shift), when the nurse was not in the patient room. For each nursing shift there were two study investigators responsible for data collection. The first evaluation period was over January 2012 [(Blinded period (BP)], where HOBE was audited without the awareness of the nursing staff in order to minimize the Hawthorne effect.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> To achieve this blinding, data were collected during the nurses’ break time. At the end of the BP, an intervention was implemented to all the health care workers. It consisted of presenting (1) the results of the BP evaluation, mainly median-HOBE (M-HOBE, (°) and HOBE compliance (%), and (2) the research project and the rationale for implementing HOBE. Afterwards, HOBE evaluation was continued using the methodology described above for another month [period 1 (P1)]. The follow-up observations were performed six and 12 months after BP, corresponding to P2 and P3 respectively.</p><p id="par0220" class="elsevierStylePara elsevierViewall">Variables recorded for each measurement were: degrees of HOBE, airway device type (endotracheal tube (ET) or tracheostomy), type of bed (with or without HOBE measuring device), day of the week (weekday or weekend), nursing shift (day, evening or night) and checklist-reported compliance. The ICU has two types of beds, 7 beds with HOBE measuring device (Hill-Room Total Care<span class="elsevierStyleSup">®</span>) and 7 beds without the device. The device available to measure the HOBE consists of a protractor with a small sphere inside. This bed has no alarm but the angle of elevation can be monitored continuously in an approximate manner.</p><p id="par0225" class="elsevierStylePara elsevierViewall">Direct-observation compliance was defined as HOBE between 30.0° and 45.0°. Data were collected as observations rather than as individual patients.</p><p id="par0230" class="elsevierStylePara elsevierViewall">The study investigators measured HOBE when patients were not undergoing clinical procedures in order to avoid position changes that may affect reliability of the data. HOBE was assessed at the mattress’ base of the bed, always using the same device (BOSCH GLM80<span class="elsevierStyleSup">®</span>) regardless of bed type (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). All the study investigators were properly trained by the principal investigator.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0235" class="elsevierStylePara elsevierViewall">For comparing direct-observation with self-reported compliance, a checklist that included several VAP preventive measures was used, including HOBE between 30.0° and 45.0°. In the study unit, this checklist has been used routinely during three years before the onset of the study, and consists of 5 evidence-based interventions for VAP prevention, including HOBE. This checklist was completed at the end of every working shift. For each marked item, it was assumed that the intervention had been performed during the whole time period. In the present study, checklist-reported compliance was defined as whether or not the nurse marked in the checklist the accomplishment of HOBE recommendation during her working shift.</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Ethical considerations</span><p id="par0060" class="elsevierStylePara elsevierViewall">The study was designed according to the ethical standards stated in the Helsinki Declaration and following the good clinical practices and it was approved by the local ethics committee. The informed consent was waived for all study subjects.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Data analysis</span><p id="par0065" class="elsevierStylePara elsevierViewall">Statistical analysis was performed using SPSS v15 for Windows (SPSS Inc., Chicago, USA). Results are expressed as absolute and relative frequencies for categorical variables and as medians with percentiles 25–75 (IQR 25–75) for continuous variables. U-Mann Whitney test was used for non-normally distributed variables, and Chi-square test was used for categorical variables. ANOVA analysis was performed to compare HOBE compliance across the four periods. A multivariate logistic regression model was developed in order to identify the factors independently associated with HOBE compliance. The variables were included in the multivariate analysis if they were significant in the univariate analysis (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05). The logistic regression models were assessed for goodness of fit using the method of Hosmer and Lemeshow.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> The significance level for all the analyses was defined as <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05.</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><p id="par0070" class="elsevierStylePara elsevierViewall">From a total of 3254 possible observations, 2639 observations were obtained (81.1%). Of these, 557 were obtained during BP, 773 during P1, 590 during P2 and 719 during P3 (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The remaining 18.9% observations were not obtained due to absence of study investigators or too high workload during some shifts.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0240" class="elsevierStylePara elsevierViewall">Overall compliance was 24.0% with a M-HOBE of 24.0° (IQR 18.8–30.0). During the BP, M-HOBE was 21.1° (IQR 16.3°–25.4°) with a compliance of 13.8%. During P1 M-HOBE increased to 24.3° (IQR 18.8°–30.2°) (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001), with a compliance of 25.5% (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001). During P2 M-HOBE was 24.4° (IQR 18.9°–29.6°) and compliance was 22.7%. Finally, during P3 M-HOBE was 26.7° (IQR 21.3°–32.6°) with a compliance of 31.4%.</p><p id="par0245" class="elsevierStylePara elsevierViewall">When comparing BP, P1, P2 and P3, significant differences were found among periods for M-HOBE and HOBE compliance, except for P1 versus P2. ANOVA showed statistical significance when comparing M-HOBE across the study periods (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> and <a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0250" class="elsevierStylePara elsevierViewall">When comparing HOBE compliance by direct-observation with self-reported compliance using the checklist, 50–60% differences were observed. Checklist-reported compliance was 89.2% (BP), 86.0% (P1), 86.4% (P2) and 90.7% (P3) while direct-observation compliance was 13.8%, 25.5%, 22.7% and 31.4% respectively (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001).</p><p id="par0255" class="elsevierStylePara elsevierViewall">Factors associated with an increased HOBE compliance differed depending on the periods in the bivariate analysis. During BP only the shift had an influence on HOBE compliance, being higher during night shift (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001). During P2, morning shift and presence of ET were associated with higher HOBE compliance (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05). During P3, morning shift and bed without HOBE measuring device were associated with an increased HOBE compliance (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05 and <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001 respectively) (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). When considering data as a whole, bivariate analysis found that morning shift, presence of ET and bed without HOBE measuring device were associated with an increased HOBE compliance (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05).</p><p id="par0260" class="elsevierStylePara elsevierViewall">Factors associated with an increase of M-HOBE also differed according to the different study periods. Nursing shift was associated with increased M-HOBE, although it changed through study periods (night shift in BP, and morning shift in P2 and P3) (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05); the presence of ET was associated with higher M-HOBE in all periods except P3 (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05); the presence of bed without HOBE measuring device was associated with a higher M-HOBE in all periods except P2 (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). When considering data as a whole, morning shift, presence of ET and bed without HOBE measuring device were associated with higher M-HOBE (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05).</p><p id="par0265" class="elsevierStylePara elsevierViewall">The multivariate logistic regression model identified presence of tracheostomy (OR 0.69, IC95% (0.57–0.85) <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001), afternoon shift (OR 0.77 IC95% (0.63–0.94) <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.01) and the presence of HOBE measuring device (OR 0.78 IC95% (0.67–0.94) <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.01) as the factors independently associated with lower HOBE compliance (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0105" class="elsevierStylePara elsevierViewall">The present study reports the evaluation of M-HOBE and HOBE compliance during the longest follow-up period in the literature. Moreover, it is the first study that compares direct-observation compliance with checklist-reported compliance. As a summary, compliance lower than 35% was found during the study period, as well as a very significant gap between checklist-reported and direct observation compliance. Moreover, the presence of beds with a HOBE measuring device was not associated to higher compliances.</p><p id="par0270" class="elsevierStylePara elsevierViewall">Our results are in accordance with others reported in the literature that have found a range of M-HOBE of 19.2°–28°<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13–15</span></a> as well as low compliances (<40%).<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15–18</span></a> Importantly, we found an improvement of HOBE compliance and M-HOBE after an educational intervention, which was statistically significant and was maintained over time. Similar improvements have been reported in other studies with shorter follow-up times. However, in most of them results were not sustained over time.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16,19,22,23</span></a></p><p id="par0275" class="elsevierStylePara elsevierViewall">Regarding checklist-reported and direct-observation compliance, we found a 50–60% difference, which was an unexpected finding. Since HOBE compliance was introduced as a part of the checklist 3 years before the study was performed, this self-reporting tool had been routinely used in every shift by the nursing staff of the study unit. Checklists implementation has been proven to be useful for avoiding human errors and improving patients’ outcomes and safety.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">25,28</span></a> However, checklists used for prolonged periods of time may turn them into a routine tool, failing in its intended purpose. Investigators hypothesize that this may have happened in this study. Published findings regarding hand hygiene compliance found similar results when comparing compliance estimation methods.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> They reported that self-reported compliance and self-administered checklists importantly overestimated hand hygiene compliance, which also happened in our study. For this reason, we believe that checklists are not the optimal method for improving compliance of measures that have to be implemented continuously such as HOBE, and we would recommend complementing them with random audits and feedback of the results to the clinical staff in order to encourage compliance optimization.</p><p id="par0280" class="elsevierStylePara elsevierViewall">When analysing HOBE compliance and M-HOBE, we found that the presence of ET was associated with an increase in M-HOBE and HOBE compliance, which is in accordance with other studies.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> Variations in sickness severity along ICU stay may explain this finding. Tracheostomy is normally performed after a prolonged period of MV, once vital signs are stable. Stabilization may lead to prioritization of nursing attention to other areas of patient care other than backrest position measurement, such as patient's comfort or weaning.</p><p id="par0285" class="elsevierStylePara elsevierViewall">We also found an influence of nursing shifts in M-HOBE and HOBE compliance, although it differed from period to period. During BP and P1, the night shift exhibited the highest M-HOBE, while morning shift was the highest during P2 and P3. We attribute this finding to a new protocol that has been implemented in our unit for improving patient's safety that includes HOBE compliance evaluation. The protocol is only performed during the morning shift and started after P1; hence we believe that this might have influenced the increase in HOBE compliance and M-HOBE during morning shifts observed in P2 and P3.</p><p id="par0290" class="elsevierStylePara elsevierViewall">Surprisingly, and contrary to the existing evidence,<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23,30</span></a> we found that patients in beds without a HOBE measuring device had higher backrest elevation than the ones lying on beds with HOBE measuring device. Moreover, absence of HOBE measuring device was independently associated with HOBE compliance in the multivariate logistic regression analysis. When confronted with these results, staff nurses pointed out that visual perception of the beds with the device was somehow higher compared to the ones without it. Multiple explanations might have contributed to this observation bias, such as the pillow, the mattress type, obesity or abdominal perimeter; however, most of them are beyond the investigators control.</p><p id="par0295" class="elsevierStylePara elsevierViewall">We expected to find lower HOBE compliance during weekends compared to weekdays. Frequently, higher percentages of unexperienced nurses work during weekends, and Vinagre et al.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> reported that experience has an impact on HOBE compliance. However, we did not find significant differences in HOBE compliance between weekdays and weekends, but it is unknown whether differences in experience were present across these two periods, as experience was not recorded during the present study.</p><p id="par0300" class="elsevierStylePara elsevierViewall">We acknowledge that our study has several limitations. We included observations rather than patients; therefore we could not assess the impact of HOBE in VAP prevention. The compliance of the HOBE could be overestimated due to the punctual observation of the HOBE as has been demonstrated by Wolken et al. rather than continuous evaluation.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Moreover, the number of variables studied was limited, and 18.9% of the measures could not be recorded unfortunately due to the lack/unavailability of study investigators during certain periods. Variables related to the nurse responsible for the patient, such as reasons for not following HOBE recommendations, could not be obtained due to the blinded fashion of the study. The blinded fashion also limited very importantly the number of variables that could be evaluated, as data collection was quick for not raising nurse's awareness. Moreover, this study is a single centre study, what limits the representativeness of the results. However, among our strengths we include the blinded observation to clinical staff, the comparison between checklist-reported compliance and direct-observation compliance and the one-year period follow-up.</p><p id="par0305" class="elsevierStylePara elsevierViewall">According to our results, HOBE compliance is below optimal values and the use of checklist does not reflect the reality. Regarding risk factors for non-compliance, extra efforts are required in the nursing management of tracheostomized patients and in the correct HOBE visual perception by the nurse. The nursing shift should be also considered as an influencing factor and further analyzed to avoid differences in HOBE compliance.</p><p id="par0310" class="elsevierStylePara elsevierViewall">In conclusion, we found an increase in M-HOBE and HOBE compliance after a formative session that remained for a year of follow-up. Checklist-reported compliance is not a good indicator for the evaluation of the HOBE compliance and is associated with important overestimation. Patients with ET had higher backrest elevation and HOBE compliance. The presence of beds with a HOBE measuring device was associated with neither an increased compliance nor M-HOBE. Nursing shift also had an influence in the HOBE compliance and M-HOBE but it changed over the time.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Authorship</span><p id="par0315" class="elsevierStylePara elsevierViewall">All the authors have contributed actively in the data collection and have critically reviewed and approved the manuscript, Maria Jiménez and Alejandro Rodriguez have contributed to the data analysis, and Mireia Llaurado has participated in all the procedures, analysis and manuscript writing.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Financial support and previous diffusion of the results</span><p id="par0320" class="elsevierStylePara elsevierViewall">Presented partially in the “Annual National Congress of the Spanish Society of Intensive and Critical Care Nursing”, 2013 and “Annual Congress of the European Society of Intensive Care Medicine”, 2013.</p><p id="par0325" class="elsevierStylePara elsevierViewall">Partially funded by the Research grant “<span class="elsevierStyleGrantSponsor" id="gs1">Premio H.U. Marqués de Valdecilla, de investigación en enfermería</span>”.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conflicts of interest</span><p id="par0155" class="elsevierStylePara elsevierViewall">All the authors declare to have no conflicts of interest with the present manuscript.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:3 [ "identificador" => "xres534792" "titulo" => "Abstract" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Design and setting" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Patients" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Intervention and variables" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Results" ] 5 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec555082" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres534793" "titulo" => "Resumen" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 1 => array:2 [ "identificador" => "abst0040" "titulo" => "Diseño y ámbito" ] 2 => array:2 [ "identificador" => "abst0045" "titulo" => "Pacientes" ] 3 => array:2 [ "identificador" => "abst0050" "titulo" => "Intervención y variables" ] 4 => array:2 [ "identificador" => "abst0055" "titulo" => "Resultados" ] 5 => array:2 [ "identificador" => "abst0060" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec555081" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Background" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Patients and methods" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Ethical considerations" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Data analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0050" "titulo" => "Authorship" ] 9 => array:2 [ "identificador" => "sec0055" "titulo" => "Financial support and previous diffusion of the results" ] 10 => array:2 [ "identificador" => "sec0035" "titulo" => "Conflicts of interest" ] 11 => array:2 [ "identificador" => "xack181481" "titulo" => "Acknowledgements" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-06-01" "fechaAceptado" => "2014-07-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec555082" "palabras" => array:3 [ 0 => "Patient positioning" 1 => "Head-of-bed elevation" 2 => "Clinical practice based evidence" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec555081" "palabras" => array:3 [ 0 => "Colocación del paciente" 1 => "Elevación del cabezal de la cama" 2 => "Práctica clínica basada en la evidencia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To evaluate head-of-bed elevation (HOBE) compliance in mechanically ventilated (MV) patients during different time periods, in order to identify factors that may influence compliance and to compare direct-observation compliance with checklist-reported compliance.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design and setting</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A prospective observational study was carried out in a polyvalent Intensive Care Unit.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Patients</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">All consecutive patients with MV and no contraindication for semi-recumbency were studied.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Intervention and variables</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">HOBE was observed during four periods of one month each for one year, the first period being blinded. HOBE was measured with an electronic device three times daily. Main variables were HOBE, type of airway device, type of bed, nursing shift, day of the week and checklist-reported compliance. No patient characteristics were collected.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Results</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">During the four periods, 2639 observations were collected. Global HOBE compliance was 24.0%, and the median angle head-of-bed elevation (M-HOBE) was 24.0° (IQR 18.8–30.0). HOBE compliance and M-HOBE by periods were as follows: blinded period: 13.8% and 21.1° (IQR 16.3–24.4); period 1: 25.5% and 24.3° (IQR 18.8–30.2); period 2: 22.7% and 24.4° (IQR 18.9–29.6); and period 3: 31.4% and 26.7° (IQR 21.3–32.6) (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001). An overestimation of 50–60% was found when comparing self-reported compliance using a checklist versus direct-observation compliance (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001).</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Multivariate logistic regression analysis found the presence of an endotracheal tube (ET) and bed without HOBE measuring device to be independently associated to greater compliance (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05).</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Although compliance increased significantly during the study period, it was still not optimal. Checklist-reported compliance significantly overestimated HOBE compliance. The presence of an ET and a bed without HOBE measuring device was associated to greater compliance.</p></span>" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Design and setting" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Patients" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Intervention and variables" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Results" ] 5 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Evaluar el cumplimiento de la elevación de la cabecera de la cama (ECC) en pacientes atendidos con ventilación mecánica (MV) durante distintos periodos de tiempo con el fin de identificar los factores que pueden influir sobre el cumplimiento y comparar el cumplimiento evaluado mediante observación directa con el cumplimiento evaluado mediante lista de verificación.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Diseño y ámbito</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se llevó a cabo un estudio observacional y prospectivo en una unidad de cuidados intensivos polivalente.</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Pacientes</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Se estudió a todos los pacientes consecutivos atendidos con MV y en los que no estaba contraindicada la reclinación parcial.</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Intervención y variables</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Se observó la ECC durante 4 periodos de un mes a lo largo de un año, el primero de ellos con enmascaramiento. Se midió la ECC mediante un dispositivo electrónico 3 veces al día. Las variables principales fueron ECC, tipo de dispositivo para las vías respiratorias, tipo de cama, turno de enfermería, día de la semana y cumplimiento notificado mediante lista de verificación. No se recopilaron las características de los pacientes.</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Resultados</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Se recopilaron 2.639 observaciones durante los 4 periodos. La tasa global de cumplimiento con la ECC fue del 24.0%, mientras que la mediana del ángulo de elevación de la cabecera de la cama (M-ECC) fue de 24.0° (IQR 18.8–30.0). El cumplimiento con la ECC y la M-ECC por cada periodo fue: periodo con enmascaramiento: 13.8% y 21.1° (IQR 16.3–24.4); periodo 1: 25.5% y 24.3° (IQR 18.8–30.2); periodo 2: 22.7% y 24.4° (IQR 18.9–29.6); y periodo 3: 31.4% y 26.7° (IQR 21.3–32.6) (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001). Se observó una sobreestimación del 50–60% al comparar el cumplimiento autoevaluado por medio de una lista de verificación frente al cumplimiento evaluado mediante observación directa (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001).</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Un análisis de regresión logística multivariante concluyó que la presencia de un tubo endotraqueal (TE) y de una cama sin dispositivo de medición de ECC se asociaban de manera independiente a un mayor cumplimiento (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05).</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conclusiones</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Si bien el cumplimiento aumentó de manera significativa durante el periodo del estudio, seguía sin ser el óptimo. El cumplimiento evaluado mediante lista de verificación sobreestimó de manera significativa el cumplimiento de la ECC. La presencia de un TE y una cama sin dispositivo de medición de ECC se asociaba a un mayor cumplimiento.</p></span>" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 1 => array:2 [ "identificador" => "abst0040" "titulo" => "Diseño y ámbito" ] 2 => array:2 [ "identificador" => "abst0045" "titulo" => "Pacientes" ] 3 => array:2 [ "identificador" => "abst0050" "titulo" => "Intervención y variables" ] 4 => array:2 [ "identificador" => "abst0055" "titulo" => "Resultados" ] 5 => array:2 [ "identificador" => "abst0060" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "◊" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please see Appendix for list of the CAPCRI study investigators.</p>" "identificador" => "fn1" ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0190" class="elsevierStylePara elsevierViewall">Mireia Llauradó-Serra; Rosa Güell-Baró; Barbara Coloma-Gómez; Luz María Vallejo-Henao; Soledad Molina-Ramos; Laura Bordonado-Pérez; Maria Luisa Fortes-Del Valle; Margarita Peralvo-Bernat; Judith Mariné-Vidal; Yolanda Alabart-Segura; Sonia Hidalgo-Margalef; Carmen Portal-Porcel; Xavier Alabart-Lorenzo; Ascensión López-Gil.</p>" "etiqueta" => "Appendix A" "titulo" => "List of the CAPCRI study investigators" "identificador" => "sec0045" ] ] ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 628 "Ancho" => 1000 "Tamanyo" => 87883 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Device used for the measurement of the head-of-bed elevation and technique for the measurement of the backrest elevation (Bosch<span class="elsevierStyleSup">®</span> GLM 80).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1633 "Ancho" => 2476 "Tamanyo" => 228965 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Diagram of the study sample.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1753 "Ancho" => 2524 "Tamanyo" => 198479 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Head-of-bed elevation compliance according to the different variables evaluated over the periods.</p>" ] ] 3 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Each symbol represents the M-HOBE of each period where significant differences were found compared to another one.<span class="elsevierStyleSup">α</span>vs<span class="elsevierStyleSup">αα</span><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05, <span class="elsevierStyleSup">α</span>vs<span class="elsevierStyleSup">ααα</span><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05, <span class="elsevierStyleSup">α</span>vs<span class="elsevierStyleSup">αααα</span><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001, *vs*** <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001, **vs*** <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05/<span class="elsevierStyleSup">+</span>vs<span class="elsevierStyleSup">++</span><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001/<span class="elsevierStyleSup">¡</span>vs<span class="elsevierStyleSup">¡¡</span><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001/<span class="elsevierStyleSup">¿</span>vs<span class="elsevierStyleSup">¿¿</span><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05/<span class="elsevierStyleSup">$</span>vs<span class="elsevierStyleSup">$$</span><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05/<span class="elsevierStyleSup">#</span>vs<span class="elsevierStyleSup">##</span><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05, <span class="elsevierStyleSup">#</span>vs<span class="elsevierStyleSup">###</span><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001/<span class="elsevierStyleSup">@</span>vs<span class="elsevierStyleSup">@@</span><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001/<span class="elsevierStyleSup">&</span>vs<span class="elsevierStyleSup">&&</span><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05/<span class="elsevierStyleSup">€</span>vs<span class="elsevierStyleSup">€€</span><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001. The rest of the comparisons were not significant. M-HOBE<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>median of head-of-bed elevation; IQR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>interquartile range.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Baseline period [median (IQR 25–75)]<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>557 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Period 1 [median (IQR 25–75)]<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>773 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Period 2 [median (IQR 25–75)]<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>590 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Period 3 [median (IQR 25–75)]<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>719 \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Overall</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21.1° (16.3–25.4)<span class="elsevierStyleSup">α</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.3° (18.8–30.2)<span class="elsevierStyleSup">αα</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.4° (18.9–29.6) <span class="elsevierStyleSup">ααα</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.7° (21.3–32.6) <span class="elsevierStyleSup">αααα</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Working shift</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Morning \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20.3° (15.3–24.4)* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.7 (19.1–30.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.6 (21.3–30.6)<span class="elsevierStyleSup">#</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27.7 (22.4–33.8)<span class="elsevierStyleSup">&</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Evening \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20.6° (16.8–23.7)** \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.6 (19.1–30.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.2 (18.4–28.8)<span class="elsevierStyleSup">##</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.5 (21.4–32.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Night \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22.8 (17.0–30.0)*** \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.5 (18.6–30.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.0 (17.5–28.3)<span class="elsevierStyleSup">###</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25.3 (20.1–31.5)<span class="elsevierStyleSup">&&</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Day of the week</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Weekday \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20.8 (16.3–25.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.4 (18.8–30.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.4 (18.9–29.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27.0 (21.2–32.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Weekend \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21.4 (15.3–27.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.0 (19.7–30.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.7 (19.1–30.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.0 (21.3–32.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Airway device type</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Endotracheal tube \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21.6 (17.5–26.8)<span class="elsevierStyleSup">+</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.8 (19.1–31.0)<span class="elsevierStyleSup">¿</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25.6 (20.3–30.2)<span class="elsevierStyleSup">@</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.8 (21.2–32.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Tracheostomy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18.7 (13.9–24.2)<span class="elsevierStyleSup">++</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.1 (18.3–29.3)<span class="elsevierStyleSup">¿¿</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22.1 (17.8–27.6)<span class="elsevierStyleSup">@@</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.4 (21.5–32.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Type of bed</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Without HOBE measurement device \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21.7 (18.1–25.4)<span class="elsevierStyleSup">¡</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.8 (20.3–30.5)<span class="elsevierStyleSup">$</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.6 (19.9–29.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29.2 (23.0–35.7)<span class="elsevierStyleSup">€</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>With HOBE measurement device \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19.7 (14.6–25.6)<span class="elsevierStyleSup">¡¡</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.0 (17.8–30.0)<span class="elsevierStyleSup">$$</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.1 (18.4–29.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25.2 (20.2–30.5)<span class="elsevierStyleSup">€€</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab859604.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">M-HOBE during study periods, overall and by evaluated variables.</p>" ] ] 4 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">HOBE: head-of-bed elevation.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Odds ratio \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Confidence interval 95% \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Presence of tracheostomy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.693 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.567–0.848 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Bed with HOBE measuring device \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.785 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.656–0.940 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Evening shift \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.768 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.629–0.939 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab859603.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Variables independently associated with HOBE compliance in patients with mechanical ventilation (multivariate logistic regression model).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "American Thoracic S" 1 => "Infectious Diseases Society of A" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200405-644ST" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2005" "volumen" => "171" "paginaInicial" => "388" "paginaFinal" => "416" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15699079" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence-based clinical practice guideline for the prevention of 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Cimiotti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nurs Meas" "fecha" => "2004" "volumen" => "12" "paginaInicial" => "77" "paginaFinal" => "85" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15916321" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A bedside placard significantly increases compliance with head of the bed elevation in the intensive care unit: a pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Y. Sasabuchi" 1 => "M. Sanui" 2 => "T. Onuma" 3 => "T. Shimozono" 4 => "A.T. Lefor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anaesth Intensive Care" "fecha" => "2012" "volumen" => "40" "paginaInicial" => "731" "paginaFinal" => "732" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22813518" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack181481" "titulo" => "Acknowledgements" "texto" => "<p id="par0185" class="elsevierStylePara elsevierViewall">We want to thank all the nurses from the ICU for their collaboration in the study, and especially Dr Alberto Sandiumenge, Dr Christer Axelsson and Ms Elsa Afonso for their help in the critical review of the manuscript and English improvement.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/02105691/0000003900000006/v1_201507210015/S0210569114002071/v1_201507210015/en/main.assets" "Apartado" => array:4 [ "identificador" => "18737" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02105691/0000003900000006/v1_201507210015/S0210569114002071/v1_201507210015/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569114002071?idApp=WMIE" ]
año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 16 | 13 | 29 |
2024 Octubre | 79 | 99 | 178 |
2024 Septiembre | 71 | 76 | 147 |
2024 Agosto | 98 | 84 | 182 |
2024 Julio | 67 | 64 | 131 |
2024 Junio | 78 | 81 | 159 |
2024 Mayo | 69 | 68 | 137 |
2024 Abril | 87 | 67 | 154 |
2024 Marzo | 63 | 39 | 102 |
2024 Febrero | 57 | 42 | 99 |
2024 Enero | 75 | 37 | 112 |
2023 Diciembre | 47 | 49 | 96 |
2023 Noviembre | 87 | 44 | 131 |
2023 Octubre | 49 | 42 | 91 |
2023 Septiembre | 54 | 49 | 103 |
2023 Agosto | 45 | 32 | 77 |
2023 Julio | 58 | 37 | 95 |
2023 Junio | 48 | 35 | 83 |
2023 Mayo | 74 | 47 | 121 |
2023 Abril | 47 | 55 | 102 |
2023 Marzo | 123 | 54 | 177 |
2023 Febrero | 80 | 57 | 137 |
2023 Enero | 79 | 43 | 122 |
2022 Diciembre | 63 | 49 | 112 |
2022 Noviembre | 93 | 52 | 145 |
2022 Octubre | 75 | 50 | 125 |
2022 Septiembre | 81 | 46 | 127 |
2022 Agosto | 80 | 61 | 141 |
2022 Julio | 81 | 60 | 141 |
2022 Junio | 82 | 40 | 122 |
2022 Mayo | 94 | 59 | 153 |
2022 Abril | 129 | 47 | 176 |
2022 Marzo | 185 | 74 | 259 |
2022 Febrero | 151 | 35 | 186 |
2022 Enero | 157 | 44 | 201 |
2021 Diciembre | 114 | 60 | 174 |
2021 Noviembre | 125 | 75 | 200 |
2021 Octubre | 145 | 80 | 225 |
2021 Septiembre | 90 | 45 | 135 |
2021 Agosto | 95 | 45 | 140 |
2021 Julio | 62 | 44 | 106 |
2021 Junio | 74 | 51 | 125 |
2021 Mayo | 100 | 49 | 149 |
2021 Abril | 183 | 104 | 287 |
2021 Marzo | 138 | 33 | 171 |
2021 Febrero | 193 | 34 | 227 |
2021 Enero | 89 | 27 | 116 |
2020 Diciembre | 69 | 13 | 82 |
2020 Noviembre | 83 | 24 | 107 |
2020 Octubre | 91 | 37 | 128 |
2020 Septiembre | 101 | 37 | 138 |
2020 Agosto | 102 | 28 | 130 |
2020 Julio | 86 | 37 | 123 |
2020 Junio | 82 | 38 | 120 |
2020 Mayo | 76 | 21 | 97 |
2020 Abril | 92 | 42 | 134 |
2020 Marzo | 60 | 35 | 95 |
2020 Febrero | 170 | 86 | 256 |
2020 Enero | 73 | 34 | 107 |
2019 Diciembre | 193 | 33 | 226 |
2019 Noviembre | 320 | 41 | 361 |
2019 Octubre | 280 | 33 | 313 |
2019 Septiembre | 92 | 51 | 143 |
2019 Agosto | 85 | 48 | 133 |
2019 Julio | 70 | 35 | 105 |
2019 Junio | 65 | 56 | 121 |
2019 Mayo | 105 | 41 | 146 |
2019 Abril | 96 | 40 | 136 |
2019 Marzo | 78 | 39 | 117 |
2019 Febrero | 60 | 50 | 110 |
2019 Enero | 84 | 52 | 136 |
2018 Diciembre | 142 | 56 | 198 |
2018 Noviembre | 249 | 90 | 339 |
2018 Octubre | 231 | 38 | 269 |
2018 Septiembre | 86 | 16 | 102 |
2018 Agosto | 43 | 23 | 66 |
2018 Julio | 56 | 18 | 74 |
2018 Junio | 59 | 13 | 72 |
2018 Mayo | 31 | 10 | 41 |
2018 Abril | 106 | 20 | 126 |
2018 Marzo | 111 | 11 | 122 |
2018 Febrero | 97 | 13 | 110 |
2018 Enero | 122 | 23 | 145 |
2017 Diciembre | 67 | 14 | 81 |
2017 Noviembre | 58 | 12 | 70 |
2017 Octubre | 55 | 10 | 65 |
2017 Septiembre | 58 | 12 | 70 |
2017 Agosto | 48 | 13 | 61 |
2017 Julio | 964 | 18 | 982 |
2017 Junio | 55 | 15 | 70 |
2017 Mayo | 80 | 21 | 101 |
2017 Abril | 69 | 26 | 95 |
2017 Marzo | 49 | 19 | 68 |
2017 Febrero | 68 | 6 | 74 |
2017 Enero | 26 | 7 | 33 |
2016 Diciembre | 60 | 22 | 82 |
2016 Noviembre | 74 | 26 | 100 |
2016 Octubre | 113 | 41 | 154 |
2016 Septiembre | 75 | 20 | 95 |
2016 Agosto | 38 | 17 | 55 |
2016 Julio | 20 | 21 | 41 |
2016 Mayo | 1 | 0 | 1 |
2016 Abril | 2 | 0 | 2 |
2016 Febrero | 1 | 0 | 1 |
2016 Enero | 1 | 0 | 1 |
2015 Noviembre | 1 | 0 | 1 |