Scientific Letter
Three-stage treatment of late mediastinitis after implantation of left ventricular assist device
Tratamiento en tres fases de mediastinitis retardada después de implantación de un dispositivo para asistencia del ventrículo izquierdo
Leído
7654
Vecesse ha leído el artículo
3152
Total PDF
4502
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S0210569116000437" "issn" => "02105691" "doi" => "10.1016/j.medin.2016.01.005" "estado" => "S300" "fechaPublicacion" => "2016-11-01" "aid" => "889" "copyright" => "Elsevier España, S.L.U. y SEMICYUC" "copyrightAnyo" => "2016" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Med Intensiva. 2016;40:514-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2611 "formatos" => array:3 [ "EPUB" => 168 "HTML" => 1548 "PDF" => 895 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210569116000449" "issn" => "02105691" "doi" => "10.1016/j.medin.2016.01.006" "estado" => "S300" "fechaPublicacion" => "2016-11-01" "aid" => "890" "copyright" => "Elsevier España, S.L.U. y SEMICYUC" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Med Intensiva. 2016;40:516-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3694 "formatos" => array:3 [ "EPUB" => 193 "HTML" => 2472 "PDF" => 1029 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científica</span>" "titulo" => "Primer caso de shock séptico por <span class="elsevierStyleItalic">Streptococcus suis</span> de posible etiología alimentaria en España" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "516" "paginaFinal" => "518" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "First case in Spain of septic shock by <span class="elsevierStyleItalic">Streptococcus suis</span> possible food-borne" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. López-Mestanza, A. Bolaño-Navarro, A. Sánchez-Sánchez, C. Aldea-Mansilla" "autores" => array:4 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "López-Mestanza" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Bolaño-Navarro" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Sánchez-Sánchez" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Aldea-Mansilla" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569116000449?idApp=WMIE" "url" => "/02105691/0000004000000008/v1_201610200035/S0210569116000449/v1_201610200035/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210569116301462" "issn" => "02105691" "doi" => "10.1016/j.medin.2016.07.001" "estado" => "S300" "fechaPublicacion" => "2016-11-01" "aid" => "956" "copyright" => "Elsevier España, S.L.U. y SEMICYUC" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Intensiva. 2016;40:511-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4691 "formatos" => array:3 [ "EPUB" => 179 "HTML" => 3424 "PDF" => 1088 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Point of view</span>" "titulo" => "Care ethics. A new bioethical approach to humanize the ICU" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "511" "paginaFinal" => "513" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Ética del cuidado. Un nuevo enfoque bioético para humanizar la UCI" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Fernández-Truillo, H. Vallverdú-Cartié, B. Román-Maestre" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Fernández-Truillo" ] 1 => array:2 [ "nombre" => "H." "apellidos" => "Vallverdú-Cartié" ] 2 => array:2 [ "nombre" => "B." "apellidos" => "Román-Maestre" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569116301462?idApp=WMIE" "url" => "/02105691/0000004000000008/v1_201610200035/S0210569116301462/v1_201610200035/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Three-stage treatment of late mediastinitis after implantation of left ventricular assist device" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "514" "paginaFinal" => "516" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A.M. Scandroglio, E. Potapov, M. Pieri, G. Arlt, V. Falk, T. Krabatsch" "autores" => array:6 [ 0 => array:3 [ "nombre" => "A.M." "apellidos" => "Scandroglio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "E." "apellidos" => "Potapov" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:4 [ "nombre" => "M." "apellidos" => "Pieri" "email" => array:1 [ 0 => "pieri.marina@hsr.it" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 3 => array:3 [ "nombre" => "G." "apellidos" => "Arlt" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "V." "apellidos" => "Falk" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "T." "apellidos" => "Krabatsch" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department for Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamiento en tres fases de mediastinitis retardada después de implantación de un dispositivo para asistencia del ventrículo izquierdo" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1943 "Ancho" => 2688 "Tamanyo" => 292855 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Outline of the three-stage treatment.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Left ventricular assist device (LVAD) infection is a major cause of re-admission during long-term follow-up and is associated with very high morbidity and mortality. The VAD-related mediastinitis mortality rate is up to 70%.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">1–3</span></a> We describe successful three-stage treatment: 1st stage, explantation of the infected device and implantation of peripheral extracorporeal life support (ECLS), followed by surgical toilet of the infected mediastinum employing jet lavage and vacuum drainage; 2nd stage, mobilization of the great omentum and wrapping around the heart including apex; and 3rd stage, implantation of a new LVAD outside of mediastinum and explantation of ECLS (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">A 42-year-old man (175<span class="elsevierStyleHsp" style=""></span>cm and 110<span class="elsevierStyleHsp" style=""></span>kg-BSA 2.24<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>) with ischemic cardiomyopathy, type 2 diabetes mellitus, arterial hypertension, chronic renal failure (stage III), and paroxysmal atrial fibrillation was supported with Heart Mate III LVAD (Thoratec Corp, Pleasanton, CA) at Deutsches Herzzentrum Berlin.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Six months after hospital discharge, the patient presented with a subxyphoidal abscess and signs of systemic infection (white blood cells 12.6<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>/L, C reactive protein 24<span class="elsevierStyleHsp" style=""></span>mg/dl, procalcitonin 23.1 micrograms/L, and body temperature 38.9<span class="elsevierStyleHsp" style=""></span>°C). The exit site of the driveline was completely healed and free of infection. The thoracic CT scan revealed presternal collection of fluid with no evidence of intrathoracic involvement. Over 300<span class="elsevierStyleHsp" style=""></span>ml of purulence was evacuated during surgical drainage. The cable was involved in the abscess. Additionally, jet lavage was performed with 3 liters of warm 0.9% NaCl solution and a vacuum assisted closure (VAC) system was applied. Systemic antibiotics (fosfomycin and rifampicin) were administered to address methicillin-sensitive <span class="elsevierStyleItalic">Staphylococcus aureus</span> (MSSA) isolated from purulent drainage and blood samples obtained at hospital admission. The patient was extubated and orally fed. The dosage of the antimicrobic therapy was the maximal dose recommended according to the organ function throughout the whole clinical course.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient showed clinical improvement with reduction of infection markers and no fever, but, during 3rd VAC exchange, he presented continuous bleeding from the wound originating from the proximal part of the cable exiting. Loosening of the apical fixation ring connection was suspected. Ten days after hospital admission, re-sternotomy was performed. The apical cuff of the device was found to be partially detached from the apex causing bleeding. Macroscopic evidence of infection was found. Peripheral ECLS was implanted, including distal leg perfusion, and all the components of the LVAD were explanted. The apex of the heart was repaired with prolene sutures and a pericardial patch. In order to achieve full sterilization of the thorax, the sternum was left open and treated with repeated jet lavage and VAC. Systemic multidrug intravenous antibiotic therapy, including gentamicin, flucloxacillin, and linezolid, was administered for several weeks. Fourteen days after surgery limb ischemia occurred and required surgical treatment including thrombectomy and cannulation of the contralateral femoral artery. Already after few days after the first operation the wound samples were sterile in the absence of bacteremia, therefore, after 18 days of ECLS, omental flap plasty and sternal closure were performed.</p><p id="par0025" class="elsevierStylePara elsevierViewall">One week later and 27 days after removal of infected LVAD, with the patient breathing spontaneously on ECLS and without signs of systemic infection (white blood cells 7<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>/L, C reactive protein 16.6<span class="elsevierStyleHsp" style=""></span>mg/dl, procalcitonin 0.31 micrograms/L, and body temperature 37.3<span class="elsevierStyleHsp" style=""></span>°C) he underwent re-implantation of an LVAD (HVAD HeartWare International, Inc., Framingham, MA) from apex to descending aorta through left lateral thoracotomy, as described previously.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">4,5</span></a> The new driveline course does not intersect with the previous one and has a new exit site; in the same session the ECLS was explanted.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The postoperative course was complicated by pump thrombosis on day 7 with subsequent pump exchange as described,<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">6</span></a> and by groin infection treated with surgical revision and VAC therapy. The patient was stable, without signs of systemic infection and partially rehabilitated. Antibiotic therapy continued although blood cultures were negative, while intraoperative samples from the left groin identified <span class="elsevierStyleItalic">Candida glabrata</span> and <span class="elsevierStyleItalic">Klebsiella pneumonia</span>. According to the antibiogram, rifampicin and flucloxacillin were discontinued (total duration of therapy was 43 and 36 days, respectively), and caspofungin and ceftazidime were started. Unfortunately, after further 35 days of hospitalization the patient died due to sudden intracerebral bleeding.</p><p id="par0035" class="elsevierStylePara elsevierViewall">If the pump is infected, surgical cleaning of the mediastinum, debridement and vacuum treatment and, finally, transposition of the great omentum with wrapping around the pump have been successfully used in our institution and also described by other authors.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">7–10</span></a> Retention of potentially infected inflow or outflow cuffs could contribute to infection recurrence, and apex involvement with loosening of the fixation ring is still an unsolved problem. Severe pump infection may be controlled by device explantation if the cardiac function has fully recovered,<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">11,12</span></a> wrapping with the great omentum<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">7–10</span></a> or by pump exchange.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">13</span></a> However, in a devastating case of apex infection with bleeding, switching the inflow cannula from apex to left atrium is an option. In our case temporary implantation of the Berlin Heart Excor (Berlin Hear AG, Berlin, Germany) or Levitronix Centrimag (Levitronix, Framingham, MA) from left atrium to ascending aorta<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">14</span></a> would bring foreign material into the infected mediastinum. Connection to the descending aorta may lead to infection of the left pleural space precluding the implantation of the long-term pump through a left lateral thoracotomy. Therefore we decided to use peripheral ECLS to avoid opening the pleural space or introducing any additional cannula in or close to the infected situs. The thorax was free from any MCS components and the choice to leave it open allowed application of all topical treatments in addition to iv antimicrobic drugs.</p><p id="par0040" class="elsevierStylePara elsevierViewall">For ECLS, cannulation of the subclavian artery and jugular vein to allow better mobilization of the patient would also have been an option.</p><p id="par0045" class="elsevierStylePara elsevierViewall">It is important that the new pump does not come into contact with the previously infected tissue – in the present case the new pump was implanted, with new access to the thorax, 9 days after the omentum was wrapped around the sterile apex acting as a biological barrier to infection.</p><p id="par0050" class="elsevierStylePara elsevierViewall">In conclusion, pump infection with apex involvement is rare but can be disastrous. A staged surgical approach including complete removal of infected foreign material, sterilization of the wound by surgical debridement and VAC, closure of the wound with the highly immune competent great omentum and, finally, re-implantation of an LVAD outside the infected field may be effective.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interests and source of funding</span><p id="par0055" class="elsevierStylePara elsevierViewall">No conflicts of interest. The work was supported by departmental funds</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interests and source of funding" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1943 "Ancho" => 2688 "Tamanyo" => 292855 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Outline of the three-stage treatment.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib0075" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "International Society for Heart and Lung Transplantation. Working formulation for the standardization of definitions of infections in patients using ventricular assist devices" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.M. Hannan" 1 => "S. Husain" 2 => "F. Mattner" 3 => "L. Danziger-Isakov" 4 => "R.J. Drew" 5 => "G.R. Corey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.healun.2011.01.717" "Revista" => array:6 [ "tituloSerie" => "J Heart Lung Transplant" "fecha" => "2011" "volumen" => "30" "paginaInicial" => "375" "paginaFinal" => "384" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21419995" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0080" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Late-onset driveline infections: the Achilles’ heel of prolonged left ventricular assist device support" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Zierer" 1 => "S.J. Melby" 2 => "R.K. Voeller" 3 => "T.J. Guthrie" 4 => "G.A. Ewald" 5 => "K. Shelton" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.athoracsur.2007.03.085" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2007" "volumen" => "84" "paginaInicial" => "515" "paginaFinal" => "520" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17643627" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0085" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical Investigators. Results of the destination therapy post-food and drug administration approval study with a continuous flow left ventricular assist device: a prospective study using the INTERMACS registry (Interagency Registry for Mechanically Assisted Circulatory Support)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "U.P. Jorde" 1 => "S.S. Kushwaha" 2 => "A.J. Tatooles" 3 => "Y. Naka" 4 => "G. Bhat" 5 => "J.W. Long" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2014.01.053" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2014" "volumen" => "63" "paginaInicial" => "1751" "paginaFinal" => "1757" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24613333" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0090" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Different surgical strategies for implantation of continuous-flow VADs-Experience from Deutsches Herzzentrum Berlin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T. Krabatsch" 1 => "T. Drews" 2 => "E. Potapov" 3 => "Y. Weng" 4 => "M. Pasic" 5 => "R. Hezter" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3978/j.issn.2225-319X.2014.09.06" "Revista" => array:6 [ "tituloSerie" => "Ann Cardiothorac Surg" "fecha" => "2014" "volumen" => "3" "paginaInicial" => "472" "paginaFinal" => "474" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25452906" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0095" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Permanent mechanical circulatory support in patients of advance age" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.J. Jurmann" 1 => "Y. Weng" 2 => "T. Drews" 3 => "M. Pasic" 4 => "E. Henning" 5 => "R. Hetzer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejcts.2004.01.017" "Revista" => array:6 [ "tituloSerie" => "Eur J Cardiothorac Surg" "fecha" => "2004" "volumen" => "25" "paginaInicial" => "610" "paginaFinal" => "618" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15037280" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0100" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thrombosis and cable damage in the HeartWare pump: clinical decisions and surgical technique" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.V. Potapov" 1 => "A. Stepanenko" 2 => "F. Kaufmann" 3 => "E. Henning" 4 => "J. Vierecke" 5 => "E. Lehmkuhl" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MAT.0b013e31827c0d79" "Revista" => array:6 [ "tituloSerie" => "ASAIO J" "fecha" => "2013" "volumen" => "59" "paginaInicial" => "37" "paginaFinal" => "40" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23263342" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0105" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of deep sternal wound infection after permanent LVAD implantation using omental flap transposition" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Vierecke" 1 => "A. Stepanenko" 2 => "E. Potapov" 3 => "T. Krabatsch" 4 => "R. Hetzer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Thorac Cardiovasc Surg" "fecha" => "2010" "volumen" => "58" "paginaInicial" => "MP6" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0110" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Poststernotomy mediastinitis treated by transposition of the greater omentum" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Krabatsch" 1 => "R. Hetzer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Card Surg" "fecha" => "1995" "volumen" => "10" "paginaInicial" => "637" "paginaFinal" => "643" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8574022" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0115" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Omental flap for treatment of mediastinitis post-left ventricular assist device implantation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.E. Rodriguez" 1 => "B.A. Bruckner" 2 => "M. Loebe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Artif Org" "fecha" => "2013" "volumen" => "37" "paginaInicial" => "1081" "paginaFinal" => "1082" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0120" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Complex wound management in ventricular assist device (VAD) patients: the role of aggressive debridement and vascularized soft tissue coverage" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.A. Nelson" 1 => "O. Shaked" 2 => "J.P. Fischer" 3 => "M.N. Mirzabeigi" 4 => "S. Jandali" 5 => "S.J. Kovach" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/SAP.0000000000000228" "Revista" => array:7 [ "tituloSerie" => "Ann Plast Surg" "fecha" => "2014" "volumen" => "73" "numero" => "Suppl. 2" "paginaInicial" => "S165" "paginaFinal" => "S170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25393384" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0125" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "pii: S1053-2498(15)01379-0" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence and predictors of myocardial recovery on long-term left ventricular assist device support: Results from the united network for organ sharing database" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Pan" 1 => "B. Aksut" 2 => "O.E. Wever-Pinzon" 3 => "S.D. Rao" 4 => "A.P. Levin" 5 => "A.R. Garan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.healun.2015.08.004" "Revista" => array:6 [ "tituloSerie" => "J Heart Lung Transplant." "fecha" => "2015" "volumen" => "34" "paginaInicial" => "1624" "paginaFinal" => "1629" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26442678" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0130" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "First case in Spain of a permanent ventricular assist device: control in the intensive care unit" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.R. Koborzan" 1 => "D. Rodríguez-Castro" 2 => "M.L. Carrió" 3 => "H. Torrado" 4 => "E. Farrero" 5 => "J.L. Ventura" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.medin.2012.11.003" "Revista" => array:6 [ "tituloSerie" => "Med Intensiva" "fecha" => "2013" "volumen" => "37" "paginaInicial" => "618" "paginaFinal" => "619" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23290680" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0135" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Left ventricular assist device exchange for persistent infection: a case series and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.T. Levy" 1 => "Y. Guo" 2 => "J. Simkins" 3 => "Y.A. Puius" 4 => "V.A. Muggia" 5 => "D.J. Goldstein" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Transpl Infection Dis" "fecha" => "2014" "volumen" => "16" "paginaInicial" => "453" "paginaFinal" => "460" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0140" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exchange techniques for implatable ventricular assist devices" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "I.D. Gregoric" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "ASAIO J 2008" "fecha" => "2008" "volumen" => "54" "paginaInicial" => "14" "paginaFinal" => "19" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/02105691/0000004000000008/v1_201610200035/S0210569116000437/v1_201610200035/en/main.assets" "Apartado" => array:4 [ "identificador" => "19505" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Cartas Científicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02105691/0000004000000008/v1_201610200035/S0210569116000437/v1_201610200035/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569116000437?idApp=WMIE" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 5 | 11 | 16 |
| 2024 Octubre | 44 | 64 | 108 |
| 2024 Septiembre | 53 | 37 | 90 |
| 2024 Agosto | 59 | 41 | 100 |
| 2024 Julio | 45 | 25 | 70 |
| 2024 Junio | 67 | 68 | 135 |
| 2024 Mayo | 54 | 57 | 111 |
| 2024 Abril | 66 | 45 | 111 |
| 2024 Marzo | 48 | 33 | 81 |
| 2024 Febrero | 48 | 43 | 91 |
| 2024 Enero | 43 | 30 | 73 |
| 2023 Diciembre | 44 | 43 | 87 |
| 2023 Noviembre | 35 | 30 | 65 |
| 2023 Octubre | 53 | 41 | 94 |
| 2023 Septiembre | 42 | 47 | 89 |
| 2023 Agosto | 33 | 14 | 47 |
| 2023 Julio | 39 | 25 | 64 |
| 2023 Junio | 47 | 12 | 59 |
| 2023 Mayo | 51 | 38 | 89 |
| 2023 Abril | 54 | 20 | 74 |
| 2023 Marzo | 74 | 28 | 102 |
| 2023 Febrero | 75 | 29 | 104 |
| 2023 Enero | 37 | 33 | 70 |
| 2022 Diciembre | 68 | 34 | 102 |
| 2022 Noviembre | 63 | 34 | 97 |
| 2022 Octubre | 68 | 35 | 103 |
| 2022 Septiembre | 58 | 39 | 97 |
| 2022 Agosto | 54 | 56 | 110 |
| 2022 Julio | 47 | 49 | 96 |
| 2022 Junio | 47 | 40 | 87 |
| 2022 Mayo | 54 | 41 | 95 |
| 2022 Abril | 67 | 43 | 110 |
| 2022 Marzo | 83 | 50 | 133 |
| 2022 Febrero | 66 | 49 | 115 |
| 2022 Enero | 51 | 48 | 99 |
| 2021 Diciembre | 36 | 74 | 110 |
| 2021 Noviembre | 67 | 46 | 113 |
| 2021 Octubre | 74 | 84 | 158 |
| 2021 Septiembre | 50 | 52 | 102 |
| 2021 Agosto | 33 | 46 | 79 |
| 2021 Julio | 35 | 53 | 88 |
| 2021 Junio | 42 | 36 | 78 |
| 2021 Mayo | 51 | 46 | 97 |
| 2021 Abril | 129 | 142 | 271 |
| 2021 Marzo | 94 | 41 | 135 |
| 2021 Febrero | 61 | 46 | 107 |
| 2021 Enero | 50 | 28 | 78 |
| 2020 Diciembre | 58 | 17 | 75 |
| 2020 Noviembre | 31 | 24 | 55 |
| 2020 Octubre | 34 | 30 | 64 |
| 2020 Septiembre | 42 | 30 | 72 |
| 2020 Agosto | 34 | 18 | 52 |
| 2020 Julio | 43 | 25 | 68 |
| 2020 Junio | 20 | 12 | 32 |
| 2020 Mayo | 32 | 9 | 41 |
| 2020 Abril | 42 | 21 | 63 |
| 2020 Marzo | 24 | 25 | 49 |
| 2020 Febrero | 142 | 68 | 210 |
| 2020 Enero | 37 | 34 | 71 |
| 2019 Diciembre | 44 | 32 | 76 |
| 2019 Noviembre | 42 | 36 | 78 |
| 2019 Octubre | 43 | 27 | 70 |
| 2019 Septiembre | 56 | 26 | 82 |
| 2019 Agosto | 49 | 29 | 78 |
| 2019 Julio | 48 | 27 | 75 |
| 2019 Junio | 24 | 13 | 37 |
| 2019 Mayo | 51 | 30 | 81 |
| 2019 Abril | 29 | 15 | 44 |
| 2019 Marzo | 35 | 28 | 63 |
| 2019 Febrero | 33 | 35 | 68 |
| 2019 Enero | 71 | 41 | 112 |
| 2018 Diciembre | 50 | 46 | 96 |
| 2018 Noviembre | 61 | 104 | 165 |
| 2018 Octubre | 55 | 25 | 80 |
| 2018 Septiembre | 34 | 14 | 48 |
| 2018 Agosto | 21 | 12 | 33 |
| 2018 Julio | 35 | 15 | 50 |
| 2018 Junio | 39 | 9 | 48 |
| 2018 Mayo | 18 | 7 | 25 |
| 2018 Abril | 28 | 9 | 37 |
| 2018 Marzo | 27 | 9 | 36 |
| 2018 Febrero | 23 | 8 | 31 |
| 2018 Enero | 54 | 23 | 77 |
| 2017 Diciembre | 36 | 9 | 45 |
| 2017 Noviembre | 46 | 13 | 59 |
| 2017 Octubre | 33 | 13 | 46 |
| 2017 Septiembre | 31 | 11 | 42 |
| 2017 Agosto | 27 | 12 | 39 |
| 2017 Julio | 26 | 13 | 39 |
| 2017 Junio | 50 | 22 | 72 |
| 2017 Mayo | 50 | 27 | 77 |
| 2017 Abril | 52 | 31 | 83 |
| 2017 Marzo | 30 | 36 | 66 |
| 2017 Febrero | 32 | 0 | 32 |
| 2017 Enero | 2 | 0 | 2 |
| 2016 Diciembre | 2 | 2 | 4 |
| 2016 Noviembre | 10 | 1 | 11 |
| 2016 Octubre | 2 | 3 | 5 |
Mostrar todo
