Original article
Evaluation of concordance among three cardiac output measurement techniques in adult patients during cardiovascular surgery postoperative care
Evaluación de la concordancia de tres técnicas de medición del gasto cardiaco en pacientes adultos durante el postoperatorio de cirugía cardiaca
L. Muñoza,
, A. Velandiaa,b, L.E. Reyesc, I. Arevalo-Rodríguezd, C. Mejíae, D. Asprillae, D.V. Uribef, J.J. Arevalog
Autor para correspondencia
a Anestesiólogo Cardiovascular, Instructor Asociado, Anestesiología Cardiovascular, Fundación Universitaria de Ciencias de la Salud, Hospital San José, Calle 10, No. 18-75, Bogotá, Colombia
b Anestesiólogo Cardiovascular, Hospital Cardiovascular del Niño de Cundinamarca, Carrera 1E No. 31-58, Soacha, Colombia
c Anestesiólogo Cardiovascular, Jefe de Programa Anestesiología Cardiovascular, Fundación Universitaria de Ciencias de la Salud, Hospital San José, Calle 10 No. 18-75, Bogotá, Colombia
d Profesor Invitado, Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC), Facultad de Ciencias de la Salud Eugenio Espejo, Universidad Tecnológica Equinoccial, Ecuador
e Anestesiólogo, Fellow en Anestesiología Cardiovascular, Fundación Universitaria de Ciencias de la salud, Hospital San José, Calle 10, No. 18-75, Bogotá, Colombia
f Residente III año anestesiología, Fundación Universitaria de Ciencias de la Salud, Hospital San José, Calle 10, No. 18-75, Bogotá, Colombia
g M.D., M.Sc. Anestesiología y Reanimación, Fundación Universitaria de Ciencias de la Salud, Hospital San José, Calle 10, No. 18-75, Bogotá, Colombia
Leído
8667
Vecesse ha leído el artículo
3358
Total PDF
5309
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S021056911730219X" "issn" => "02105691" "doi" => "10.1016/j.medin.2017.08.001" "estado" => "S300" "fechaPublicacion" => "2017-12-01" "aid" => "1095" "copyright" => "Elsevier España, S.L.U. y SEMICYUC" "copyrightAnyo" => "2017" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Med Intensiva. 2017;41:539-45" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2805 "formatos" => array:3 [ "EPUB" => 216 "HTML" => 1806 "PDF" => 783 ] ] "Traduccion" => array:1 [ "en" => array:19 [ "pii" => "S2173572717301972" "issn" => "21735727" "doi" => "10.1016/j.medine.2017.08.010" "estado" => "S300" "fechaPublicacion" => "2017-12-01" "aid" => "1095" "copyright" => "Elsevier España, S.L.U. and SEMICYUC" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Med Intensiva. 2017;41:539-45" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1627 "formatos" => array:3 [ "EPUB" => 172 "HTML" => 899 "PDF" => 556 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Evaluation of concordance among three cardiac output measurement techniques in adult patients during cardiovascular surgery postoperative care" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "539" "paginaFinal" => "545" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación de la concordancia de tres técnicas de medición del gasto cardiaco en pacientes adultos durante el postoperatorio de cirugía cardiaca" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1207 "Ancho" => 1647 "Tamanyo" => 66173 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Bland–Altman limits of agreement – LVOT vs. mitral measurement.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Muñoz, A. Velandia, L.E. Reyes, I. Arevalo-Rodríguez, C. Mejía, D. Asprilla, D.V. Uribe, J.J. Arevalo" "autores" => array:8 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Muñoz" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Velandia" ] 2 => array:2 [ "nombre" => "L.E." "apellidos" => "Reyes" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Arevalo-Rodríguez" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Mejía" ] 5 => array:2 [ "nombre" => "D." "apellidos" => "Asprilla" ] 6 => array:2 [ "nombre" => "D.V." "apellidos" => "Uribe" ] 7 => array:2 [ "nombre" => "J.J." "apellidos" => "Arevalo" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S021056911730219X" "doi" => "10.1016/j.medin.2017.08.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021056911730219X?idApp=WMIE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572717301972?idApp=WMIE" "url" => "/21735727/0000004100000009/v1_201711250720/S2173572717301972/v1_201711250720/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0210569117301390" "issn" => "02105691" "doi" => "10.1016/j.medin.2017.03.005" "estado" => "S300" "fechaPublicacion" => "2017-12-01" "aid" => "1058" "copyright" => "Elsevier España, S.L.U. y SEMICYUC" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Intensiva. 2017;41:546-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2779 "formatos" => array:3 [ "EPUB" => 191 "HTML" => 1617 "PDF" => 971 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Point of view</span>" "titulo" => "Why did arterial pressure not increase after fluid administration?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "546" "paginaFinal" => "549" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿Por qué la presión arterial no aumentó después de la administración de líquidos?" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2881 "Ancho" => 3373 "Tamanyo" => 400918 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Rate of positive arterial pressure response after fluid administration.</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Proportion of pressure-responders (mean arterial pressure, MAP increase ≥10%) and preload-responders (cardiac output, CO increase ≥10%). A ventriculo-arterial coupling ratio 1:1 was assumed. So, for a CO increase of 10%, a MAP increase of 10% should be expected. Please, note that preload-responder and pressure-responder definitions could differ from that defined in the original publication.</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">References used for this illustration</span>:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><p id="par0090" class="elsevierStylePara elsevierViewall">Monge Garcia MI, Gil Cano A, Diaz Monrove JC. Arterial pressure changes during the Valsalva maneuver to predict fluid responsiveness in spontaneously breathing patients. Intensive Care Med. 2009;35(1):77–84.</p></li><li class="elsevierStyleListItem" id="lsti0010"><p id="par0095" class="elsevierStylePara elsevierViewall">Monge Garcia MI, Gil Cano A, Diaz Monrove JC. Brachial artery peak velocity variation to predict fluid responsiveness in mechanically ventilated patients. Crit Care. 2009;13(5):R142.</p></li><li class="elsevierStyleListItem" id="lsti0015"><p id="par0100" class="elsevierStylePara elsevierViewall">Monge Garcia MI, Gil Cano A, Gracia Romero M. Dynamic arterial elastance to predict arterial pressure response to volume loading in preload-dependent patients. Crit Care. 2011;15(1):R15.</p></li><li class="elsevierStyleListItem" id="lsti0020"><p id="par0105" class="elsevierStylePara elsevierViewall">Monge Garcia MI, Gil Cano A, Gracia Romero M, Monterroso Pintado R, Perez Madueno V, Diaz Monrove JC. Non-invasive assessment of fluid responsiveness by changes in partial end-tidal CO2 pressure during a passive leg-raising maneuver. Annals of Intensive Care. 2012;2:9.</p></li><li class="elsevierStyleListItem" id="lsti0025"><p id="par0110" class="elsevierStylePara elsevierViewall">Monge Garcia MI, Romero MG, Cano AG, Rhodes A, Grounds RM, Cecconi M. Impact of arterial load on the agreement between pulse pressure analysis and esophageal Doppler. Crit Care. 2013;17(3):R113.</p></li><li class="elsevierStyleListItem" id="lsti0030"><p id="par0115" class="elsevierStylePara elsevierViewall">Cecconi M, Monge Garcia MI, Gracia Romero M, Mellinghoff J, Caliandro F, Grounds RM, et al. The Use of Pulse Pressure Variation and Stroke Volume Variation in Spontaneously Breathing Patients to Assess Dynamic Arterial Elastance and to Predict Arterial Pressure Response to Fluid Administration. Anesth Analg. 2014;120(1):76–84.</p></li><li class="elsevierStyleListItem" id="lsti0035"><p id="par0120" class="elsevierStylePara elsevierViewall">Monge Garcia M, Gracia Romero M, Gil Cano A, Aya HD, Rhodes A, Grounds R, et al. Dynamic arterial elastance as a predictor of arterial pressure response to fluid administration: a validation study. Crit Care. 2014;18(6):626.</p></li><li class="elsevierStyleListItem" id="lsti0040"><p id="par0125" class="elsevierStylePara elsevierViewall">Monge Garcia MI, Guijo Gonzalez P, Gracia Romero M, Gil Cano A, Oscier C, Rhodes A, et al. Effects of fluid administration on arterial load in septic shock patients. Intensive Care Med. 2015;41(7):1247–55.</p></li></ul></p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.I. Monge García, H. Barrasa González" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M.I." "apellidos" => "Monge García" ] 1 => array:2 [ "nombre" => "H." "apellidos" => "Barrasa González" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173572717301960" "doi" => "10.1016/j.medine.2017.03.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572717301960?idApp=WMIE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569117301390?idApp=WMIE" "url" => "/02105691/0000004100000009/v1_201711250711/S0210569117301390/v1_201711250711/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0210569117300074" "issn" => "02105691" "doi" => "10.1016/j.medin.2016.10.016" "estado" => "S300" "fechaPublicacion" => "2017-12-01" "aid" => "1022" "copyright" => "Elsevier España, S.L.U. y SEMICYUC" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Med Intensiva. 2017;41:532-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 44324 "formatos" => array:3 [ "EPUB" => 457 "HTML" => 32742 "PDF" => 11125 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Predicción de hemorragia masiva. Índice de shock e índice de shock modificado" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "532" "paginaFinal" => "538" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prediction of massive bleeding. Shock index and modified shock index" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3061 "Ancho" => 2300 "Tamanyo" => 227550 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Flujo de pacientes incluidos en el estudio. Periodo 2014-1015.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L.J. Terceros-Almanza, C. García-Fuentes, S. Bermejo-Aznárez, I.J. Prieto-del Portillo, C. Mudarra-Reche, I. Sáez-de la Fuente, M. Chico-Fernández" "autores" => array:7 [ 0 => array:2 [ "nombre" => "L.J." "apellidos" => "Terceros-Almanza" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "García-Fuentes" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Bermejo-Aznárez" ] 3 => array:2 [ "nombre" => "I.J." "apellidos" => "Prieto-del Portillo" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Mudarra-Reche" ] 5 => array:2 [ "nombre" => "I." "apellidos" => "Sáez-de la Fuente" ] 6 => array:2 [ "nombre" => "M." "apellidos" => "Chico-Fernández" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S217357271730187X" "doi" => "10.1016/j.medine.2017.10.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357271730187X?idApp=WMIE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569117300074?idApp=WMIE" "url" => "/02105691/0000004100000009/v1_201711250711/S0210569117300074/v1_201711250711/es/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Evaluation of concordance among three cardiac output measurement techniques in adult patients during cardiovascular surgery postoperative care" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "539" "paginaFinal" => "545" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "L. Muñoz, A. Velandia, L.E. Reyes, I. Arevalo-Rodríguez, C. Mejía, D. Asprilla, D.V. Uribe, J.J. Arevalo" "autores" => array:8 [ 0 => array:4 [ "nombre" => "L." "apellidos" => "Muñoz" "email" => array:2 [ 0 => "lam24munoz78@gmail.com" 1 => "lamunoz@fucsalud.edu.co" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Velandia" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "L.E." "apellidos" => "Reyes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "I." "apellidos" => "Arevalo-Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "C." "apellidos" => "Mejía" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 5 => array:3 [ "nombre" => "D." "apellidos" => "Asprilla" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 6 => array:3 [ "nombre" => "D.V." "apellidos" => "Uribe" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] 7 => array:3 [ "nombre" => "J.J." "apellidos" => "Arevalo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff0035" ] ] ] ] "afiliaciones" => array:7 [ 0 => array:3 [ "entidad" => "Anestesiólogo Cardiovascular, Instructor Asociado, Anestesiología Cardiovascular, Fundación Universitaria de Ciencias de la Salud, Hospital San José, Calle 10, No. 18-75, Bogotá, Colombia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Anestesiólogo Cardiovascular, Hospital Cardiovascular del Niño de Cundinamarca, Carrera 1E No. 31-58, Soacha, Colombia" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Anestesiólogo Cardiovascular, Jefe de Programa Anestesiología Cardiovascular, Fundación Universitaria de Ciencias de la Salud, Hospital San José, Calle 10 No. 18-75, Bogotá, Colombia" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Profesor Invitado, Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC), Facultad de Ciencias de la Salud Eugenio Espejo, Universidad Tecnológica Equinoccial, Ecuador" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Anestesiólogo, Fellow en Anestesiología Cardiovascular, Fundación Universitaria de Ciencias de la salud, Hospital San José, Calle 10, No. 18-75, Bogotá, Colombia" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Residente III año anestesiología, Fundación Universitaria de Ciencias de la Salud, Hospital San José, Calle 10, No. 18-75, Bogotá, Colombia" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "M.D., M.Sc. Anestesiología y Reanimación, Fundación Universitaria de Ciencias de la Salud, Hospital San José, Calle 10, No. 18-75, Bogotá, Colombia" "etiqueta" => "g" "identificador" => "aff0035" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación de la concordancia de tres técnicas de medición del gasto cardiaco en pacientes adultos durante el postoperatorio de cirugía cardiaca" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1192 "Ancho" => 1638 "Tamanyo" => 72558 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Bland–Altman limits of agreement – thermodilution vs. mitral measurement.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Historically, cardiac output calculation for adults has been measured through thermodilution using a pulmonary artery catheter. This became the standard measurement method around 1970, and so it remained for more than ten years, until a high frequency of complications and/or misinterpreted data were associated to high mortality rates related to this technique.<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The first alternative to replace thermodilution was suggested by Dr. Parisi, who measured ventricle volume and ejection fraction using a two-dimensional transesophageal echocardiography (TEE).<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">1,3</span></a> Other methods have been proposed (e.g. arterial wave contour analysis, PiCCO, transpulmonar thermodilution, transpulmonary lithium dilution),<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">4</span></a> although they have shown questionable benefit during open-heart cardiovascular surgery.</p><p id="par0015" class="elsevierStylePara elsevierViewall">A recent promising possibility is TEE, which allows both cardiac structure and function evaluation during perioperative open-heart surgery. However, it requires training and certain skills to be learned by the operator in order to allow him or her to interpret different results adequately, and using them to guide management and improve care for a critically ill patient.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">5–7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Currently, TEE cardiac output monitoring is most commonly performed through a deep transgastric long axis view and aortic ring measurement (LVOT),<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">1</span></a> procedure that requires skills, and could be associated with gastrointestinal, bleeding and mortality risk, besides of increased costs.<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">8,9</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Considering potential risk and cost associated with aortic ring measurement, we propose an alternative method through TEE four chamber view, measuring flow across mitral annulus (MA).</p><p id="par0030" class="elsevierStylePara elsevierViewall">The main objective of this study is to evaluate concordance among three different cardiac output measurement methods including LVOT, MA and thermodilution.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Methods</span><p id="par0035" class="elsevierStylePara elsevierViewall">This is a concordance observational study, approved by the ethics committee. Enrolled patients were told before surgery about postoperative TEE hemodynamic data analysis study and gave informed consent. Twenty-five patients programmed to undergo cardiovascular procedures (myocardial revascularization, atrial septal defect closure, aortic or mitral valve replacement) in the Hospital Cardiovascular de Cundinamarca are included in the study. Cardiac output, systolic function and pulmonary pressure were measured immediately in the postoperative period. Those patients with esophageal diseases, prosthetic mitral or aortic valve insufficiency and those with atrial fibrillation history were excluded from the study.</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Perioperative management</span><p id="par0040" class="elsevierStylePara elsevierViewall">The following are simply monitored by means of a visuscope: pulse oximetry, capnography, invasive arterial blood pressure, esophageal thermometer, central catheter if the patient's condition warrants it, and pulmonary artery catheter to measure the cardiac output by thermodilution using the bolus thermodilution cold saline solution technique, and using the B650 and G Caresscape monitors from the 37B650-01 series. Transesophageal echocardiography probe was gently moved, and the following equipment was used: the Philips Sonos 7500 live 3D Echo and 5.0 and 6.5 MZ Omni-Plane Transducer, a one-meter long Hewlett Packard probe M-mode, two dimensional, color-flow Doppler echocardiography, pulsed wave and continuous Doppler, and harmonic imaging. The anesthetic technique and the use vasoconstrictors/inotropes were decided by the anesthesiologist in charge of the case.</p><p id="par0045" class="elsevierStylePara elsevierViewall">One cardiovascular anesthesiologist with training in TEE certified by the European Association of Cardiothoracic Anaesthesiologists (EACTA) performed all TEE cardiac output measurements during the immediate postoperative period (sternal closure), avoiding inotropic or vasopressor support during the study.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Measurement of cardiac output on the mitral annulus/left ventricle outflow tract</span><p id="par0050" class="elsevierStylePara elsevierViewall">All postoperative TEE cardiac output measures were done using the following formula; regardless the type of surgery performed considering clinical practice standards:</p><p id="par0055" class="elsevierStylePara elsevierViewall">The following formula was used for cardiac output measurement.<elsevierMultimedia ident="eq0005"></elsevierMultimedia>where Cardiac Output (CO)<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>Stroke Volume<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>Heart rate; Ejection fraction or Stroke volume (SV) or Flow<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>AT<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>VTI; Cross sectional area (AT)<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>D2<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>0.785 (cm<span class="elsevierStyleSup">2</span>); D2<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>mitral annulus or left ventricle outflow tract; VTI<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>velocity time integral (cm).</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Mitral annulus</span><p id="par0060" class="elsevierStylePara elsevierViewall">The probe is inserted at a depth of 28 – 30<span class="elsevierStyleHsp" style=""></span>cm and the mid esophageal four chamber window at zero degrees measures the cross-section of the mitral annulus, which was the result of measuring the diameter from edge to edge during the diastole at the moment when the mitral valves or prosthesis was at their maximum aperture. The probe's second speed was then used and it was multiplied by 0.785, which is a quarter of Pi (3.1416). This is undertaken on the assumption that the mitral annulus is circular and the cross section is constantly in diastole. The cardiac output was the product of the VTI for the diastolic mitral flow and this was measured with pulsed wave Doppler on the coaptation surface of the valve; color-flow images were used to keep the ultrasonic beam parallel to the mitral flow. The correction for the angle of incidence was taken into consideration for all the measurements and was less or equal to 20°. Three measurements were made consecutively, tracing was done manually, and the average was multiplied by the cross section of the mitral annulus: this gives the stroke volume that is subsequently multiplied by the heart rate.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Left ventricle outflow tract (LVOT)</span><p id="par0065" class="elsevierStylePara elsevierViewall">The cross section of the LVOT was measured in the mid-esophagus in the window on the aortic valve level on the longitudinal axis from 130 - 135°. LVOT was identified between 5<span class="elsevierStyleHsp" style=""></span>mm and 10<span class="elsevierStyleHsp" style=""></span>mm of the aortic ring and the diameter was measured from edge to edge during the diastole at the moment when the mitral valves or prosthesis was at its maximum aperture. The probe's second speed was then used and it was multiplied by 0.785, which is a quarter of Pi (3.1416).</p><p id="par0070" class="elsevierStylePara elsevierViewall">To measure the VTI, the probe was inserted between 45–50<span class="elsevierStyleHsp" style=""></span>cm and located in the deep transgastric window at zero degrees from the LVOT. Color-flow Doppler was used to keep the ultrasound beam parallel to the flow, the wave flow Doppler was positioned directly on the LVOT, 5<span class="elsevierStyleHsp" style=""></span>mm – 10<span class="elsevierStyleHsp" style=""></span>mm from the aortic ring, and the velocity time integral was manually traced. Three different samples were gathered and the average of the results was taken. This was then multiplied by the second speed of the cross section and then by 0.785, which corresponds to a quarter of Pi (3.1416). This result was in turn multiplied by the heart rate that could be measured at that particular moment.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Thermodilution</span><p id="par0075" class="elsevierStylePara elsevierViewall">With a maximum lapse of five minutes between echocardiographic measurements, the cardiac output measurement was taken by thermodilution using CVP from a pulmonary artery catheter, using the bolus thermodilution technique injecting 10 cc of cold saline solution. Three samples were taken and then a mean of the results was calculated, excluding those that were extreme (very high or very low). A second observer undertook this procedure who was not aware of the previous echocardiographic measurements.</p><p id="par0080" class="elsevierStylePara elsevierViewall">All the data from TEE and thermodilution measurements was registered along with demographic features, procedure type and EuroSCORE II.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Statistical analysis took into consideration patients’ demographic and clinical characteristics, which were summarized with their frequencies, central tendencies, and dispersion. To calculate the correlation between two cardiac output measuring methods, Lin's concordance correlation coefficient was used, as was the Bland–Altman limits of agreement after logarithmic transformation considering the possibility of scarcity of data and great variation of differences. The statistical analysis of the information was undertaken using Stata13.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Results</span><p id="par0090" class="elsevierStylePara elsevierViewall">The demographic characteristics of the 25 patients are outlined in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. The median age was 63 years (predominant age group: 51–64, 44%). The median ejection fraction was 35%; males were the prominent sex in the study (52%). The cardiac output measurement median by thermodilution was 3.25 liters/minute, while the cardiac output measurement median on the left ventricle outflow tract was 3.46 liters/minute, and on the mitral ring was 8.4 liters/minute (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The most common procedure undertaken was the valve replacement (48%). The majority of patients were in the group with the lowest ejection fraction that was less than 35% (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">On evaluating the concordance between the three measurements by means of Lin's concordance-correlation coefficient, we found that there was no concordance between the three measurements. Specifically, the thermodilution values differ from the values obtained from the mitral ring flow rate (Lin concordancev0.071; Confidence Interval 95%<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.009 to 0.151; Spearman's correlation<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.22) (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). In addition, the values that were obtained from the LVOT showed important discrepancies with those obtained by thermodilution (Lin concordance<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.232; Confidence Interval 95%<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.12 a 0.537; Spearman's correlation 0.28) (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). Due to scarcity of data and great variation of the differences, a logarithmic transformation of data was used to estimate the Bland–Altman limits of agreement. The average differences between the cardiac output values are more importantly marked in the comparison between thermodilution versus mitral annulus (DM<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.408; Bland–Altman Limits<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.809 to −0.007) (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) than the other echocardiographic findings (DM<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.007; Bland–Altman Limits<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.441 to 0.428) (<a class="elsevierStyleCrossRefs" href="#fig0015">Figs. 3–4</a>).</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Discussion</span><p id="par0105" class="elsevierStylePara elsevierViewall">Cardiac output calculation is routinely carried out by thermodilution, which presents widely disseminated and evaluated parameters.<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">1,8,11,12</span></a> Its invasiveness and related complications led the searching for alternative techniques with lower mortality and adverse events.</p><p id="par0110" class="elsevierStylePara elsevierViewall">Transesophageal echocardiography cardiac output measurement is an alternative in hemodynamic monitoring allowing guidance during these patients management according to cardiac output, stroke volume, preload, cardiac structure and function evaluation.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">7</span></a> Measurement can be taken through different routes, including pulmonary ring, aortic ring, mitral ring level, and on the LVOT with pulsed wave and continuous Doppler.<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">8,13–15</span></a> However, differences can be found among measured routes. LVOT correlates with thermodilution,<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">16</span></a> although its technical difficulty to align the transducer parallel in a deep transgastric window and the anteflexion that requires, is associated to increased mortality rate.<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">1,17,18</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Our study deals with this problem, obtaining an image by TEE on a window level with four chambers via the mid-esophagus at zero degrees on the mitral ring level, where the ultrasonic beam is aligned in parallel measuring the transmitral flow, calculating ring area diameter.</p><p id="par0120" class="elsevierStylePara elsevierViewall">However, the information obtained from 25 patients did not show concordance among three cardiac output measurements (thermodilution, MA and LVOT). Of the three measurements estimated, the closest were those that came from thermodilution with the flow through TSVI, showing a concordance between them but without being consistent for all the patients</p><p id="par0125" class="elsevierStylePara elsevierViewall">From our results, we cannot recommend thermodilution replacement by any of the other measurements derived from TEE. We can only suggest to monitor trends based on the initial value and during subsequent measurements, taking advantage of the complementary information that the TEE offers, which thermodilution alone does not.</p><p id="par0130" class="elsevierStylePara elsevierViewall">Our results are similar to those presented by Bettex et al. They found that cardiac output evaluation was 9.57 L/min (range of 6.4 – 12.5 L/min) compared with thermodilution.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">1</span></a> Likewise, Muhiudeen's study measured cardiac output by cross section diameter at a pulmonary ring level and found a modest correlation with thermodilution, but no correlation was found at the mitral ring level, as well as an important dispersion of the data close to zero (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.24).<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">13</span></a> Conversely, Cabrera et al. found a strong correlation between cardiac output measurement on the mitral ring level among Chilean population (Pearson's <span class="elsevierStyleItalic">R</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.92); however, this study measured an area on a transgastric level at zero degrees with a light anteflexion. This provided a transversal view of the mitral valve during ventricular diastole, which is calculated using a planimetric measurement under an elliptical model and not a circular one.<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">11,19,20</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Cabrera et al. suggested that mitral stenosis, severe mitral insufficiency or insufficiency in prosthetic valves could be a constraint for the application of this technique, including only patients undergoing myocardial revascularization. However, the authors of this study used a different technique for cross section measurement than they did when they measured the mitral ring by planimetric measurement in the transgastric window with a level of anteflexion, considering that cross section diameter measurement is a primary limitation for the mitral ring as it might overestimate cardiac output.</p><p id="par0140" class="elsevierStylePara elsevierViewall">Study strengths include that all three measurements were done in a similar way, with high quality windows, following the same steps, and with a difference of no more than five minutes between TEE and thermodilution measurements. Other hemodynamic influences were avoided, and similarity in demographic characteristics for ejection fraction and type of surgery were documented. In order to avoid possible bias, TEE results were kept apart from those from thermodilution.</p><p id="par0145" class="elsevierStylePara elsevierViewall">One of the limitations of this study was that the electrocardiogram was not available; therefore, it could not be included with the TEE image during the measurement at the precise moment of the rapid diastolic filling peak. This could generate an estimated variability of up to 12% in the mitral ring area size.<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">11,20</span></a> Also, the fact that the probe was not continuously available meant that the size of the sample could not be improved, being a small sample size another limitation of the present study. However, the sample obtained was sufficient to observe differences in concordance among measurement methods. We also note that thermodilution, as the standard practice, is susceptible to errors given that it is not the reference standard to measure cardiac output; It has been quantified that this process can overestimate the output by up to 15%.<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">1,5,6,21</span></a> It was, however, necessary to make the comparison with this measuring method, as it is the most commonly used for patients who undergo cardiac surgery.</p><p id="par0150" class="elsevierStylePara elsevierViewall">Studied population had a mean ejection fraction of 39.8% and was predominantly intermediate to high-risk patients according to EuroSCORE II. The former analysis being important, considering that myocardial wall movement abnormalities may alter up to 40% the two-dimensional volume evaluation, and may be related to a high degree of variability in the results.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">1</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">According to TEE calculations to estimate cardiac output, heart rate is an important determinant for variation. If tachycardia is present, a TEE-cardiac output measurement overestimation may happen. This consideration should be taken into account in patients with altered heart rate.</p><p id="par0160" class="elsevierStylePara elsevierViewall">Our findings showed that results on a mitral ring level are dispersed respect to thermodilution and LVOT; with a 5.8 L/min difference compared to thermodilution. However, during difficulties for catheter introduction, lack of training or when clinical conditions preclude TEE-transgastric window, MA four chamber method may offer a cardiac output estimation, information about left ventricle inflow related to ejection fraction deterioration and be monitored over time, compared with thermodilution and LVOT.</p><p id="par0165" class="elsevierStylePara elsevierViewall">Transesophageal echocardiography cardiac output measuring methods might be of complementary value during heart surgery, taken into account their limitations, during postoperative monitoring.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conflicts of interest</span><p id="par0170" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres945802" "titulo" => "Abstract" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec918447" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres945801" "titulo" => "Resumen" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivo" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec918446" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Perioperative management" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Measurement of cardiac output on the mitral annulus/left ventricle outflow tract" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Mitral annulus" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Left ventricle outflow tract (LVOT)" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Thermodilution" ] ] ] 6 => array:2 [ "identificador" => "sec0040" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0045" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0050" "titulo" => "Conflicts of interest" ] 9 => array:2 [ "identificador" => "xack319684" "titulo" => "Acknowledgements" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-01-15" "fechaAceptado" => "2017-08-10" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec918447" "palabras" => array:4 [ 0 => "Transesophageal echocardiography" 1 => "Cardiac output" 2 => "Thermodilution" 3 => "Cardiac surgery" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec918446" "palabras" => array:4 [ 0 => "Ecocardiografía transesofágica" 1 => "Gasto cardiaco" 2 => "Termodilución" 3 => "Cirugía cardiaca" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The standard method for cardiac output measuring is thermodilution although it is an invasive technique. Transesophageal Echocardiography (TEE) offers a dynamic and functional alternative to thermodilution.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Analyze concordance between two TEE methods and thermodilution for cardiac output assessment.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Observational concordance study in cardiovascular surgery patients that required pulmonary artery catheter. TEE cardiac output measurement at both mitral annulus (MA) and left ventricle outflow tract (LVOT) were performed. Results were compared with thermodilution. Correlation was evaluated by Lin's concordance correlation coefficient and Bland–Altman analysis. Statistical analysis was undertaken in STATA 13.0.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Twenty-five patients were enrolled. Fifty two percent of patients were male, median age and ejection fraction was 63 years and 35% respectively. Median thermodilution, LVOT and MA -measured cardiac output was 3.25 L/min, 3.46 L/min and 8.4 L/min respectively. Different values between thermodilution and MA measurements were found (Lin concordance<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.071; Confidence Interval 95%<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.009 to 0.151; Spearman's correlation<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.22) as values between thermodilution and LVOT (Lin concordance<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.232; Confidence Interval 95%<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.12 a 0.537; Spearman's correlation 0.28). Bland–Altman analysis showed greater difference between MA measurements and thermodilution (DM<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.408; Bland–Altman Limits<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.809 to −0.007), than the other echocardiographic findings (DM<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.007; Bland–Altman Limits<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.441 to 0.428).</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Results from cardiac output measurement by doppler and 2D-TEE on both MA and LVOT do not correlate with those obtained by thermodilution.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El cálculo del gasto cardiaco se realiza por termodilución, y su principal desventaja es el carácter invasivo. La ecocardiografía transesofágica (ETE) representa una alternativa dinámica y funcional a la termodilución.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Analizar la concordancia entre dos métodos de ETE y termodilución para la evaluación del gasto cardiaco.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional de concordancia en pacientes de cirugía cardiovascular con requerimiento de catéter de arteria pulmonar. Se realizó medición de gasto cardiaco por ETE en anillo mitral (AM) y en el tracto de salida del ventrículo izquierdo (TSVI). Los resultados se compararon con la termodilución. La concordancia fue evaluada por el coeficiente de correlación concordancia de Lin y analizada por el método de Bland-Altman. Los análisis estadísticos se realizaron en STATA 13.0.</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 25 pacientes. El 52% fueron hombres, con mediana de edad de 63<span class="elsevierStyleHsp" style=""></span>años y fracción de eyección del 35%. La mediana de gasto cardiaco por termodilución, AM y TSVI fue de 3,25, de 3,46 y de 8,4<span class="elsevierStyleHsp" style=""></span>L/min, respectivamente. Se encontraron diferentes valores entre termodilución y AM (concordancia de Lin<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,071; IC<span class="elsevierStyleHsp" style=""></span>95%: −0,009 a 0,151), así como entre termodilución y TSVI (concordancia de Lin<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,232; IC<span class="elsevierStyleHsp" style=""></span>95%: −0,12 a 0,537). El análisis de Bland-Altman muestra una diferencia entre la medición por AM y termodilución importante (DM<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0,408; Bland-Altman Limits<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0,809 a −0,007), así como entre las dos medidas por ETE (DM<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,007; Bland-Altman Limits<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0,441 a 0,428).</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusión</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Los resultados en la medición del gasto cardiaco por doppler y ETE bidimensional tanto a nivel del anillo mitral como del TSVI no son concordantes con la termodilución.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivo" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusión" ] ] ] ] "multimedia" => array:8 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 978 "Ancho" => 1668 "Tamanyo" => 65275 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Boxplot of the three cardiac output measurements.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1192 "Ancho" => 1638 "Tamanyo" => 72558 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Bland–Altman limits of agreement – thermodilution vs. mitral measurement.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1183 "Ancho" => 1608 "Tamanyo" => 69240 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Bland–Altman limits of agreement – thermodilution vs LVOT.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1207 "Ancho" => 1647 "Tamanyo" => 66173 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Bland–Altman limits of agreement – LVOT vs. mitral measurement.</p>" ] ] 4 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Note: C.O<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>cardiac output; LVOT<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>left ventricle outflow tract; L/Min<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>liters/minute.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patients’ characteristics \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Range \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Median \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P<span class="elsevierStyleInf">25</span>–P<span class="elsevierStyleInf">75</span> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20–79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56–69 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ejection fraction (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20–65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30–60 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C.O. thermodilution (L/min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.93–6.87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">3.25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.58–4.46 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C.O. mitral annulus (L/min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.01–19.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">8.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.81–12.52 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C.O. LVOT (L/min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.58–8.85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">3.46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.17–5.07 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Surface area (m<span class="elsevierStyleSup">2</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.32–2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">1.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.44–1.66 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">EuroSCORE II \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.22–19.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">4.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.5–8.19 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Heart rate (beats/min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">55–109 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">70–85 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1601459.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Demographic characteristics of the included patients.</p>" ] ] 5 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Relation between ejection fraction and EuroSCORE II.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">10</span></a></p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ejection fraction (EF) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span>° \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">% \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">EuroSCORE II \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span>° \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">% \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Normal EF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">50–75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Low (0–2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lower than normal EF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">36–49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Middle (3–5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Low EF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">High (>6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1601460.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Ejection fraction and EuroSCORE index II by ranges.</p>" ] ] 6 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Note: LVOT<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>left ventricle outflow tract.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Lin's concordance correlation coefficient \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Confidence interval<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Spearmans's Correlation \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Differences in measurements (standard deviation)<span class="elsevierStyleSup">c</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Bland–Altman Limits<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Thermodilution vs. LVOT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.232 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.127 to 0.537 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.007 (0.222) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−0.441 to 0.428 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Thermodilution vs. mitral valve \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.071 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.009 to 0.151 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.408 (0.205) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−0.809 to −0.007 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mitral valve vs. LVOT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.147 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.017 to 0.270 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.401 (0.210) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−0.011 to 0.813 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1601458.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">CI 95% under Z. transformation.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Data transformed under logarithmic transformation.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Concordance coefficients in the three cardiac output measurements.</p>" ] ] 7 => array:5 [ "identificador" => "eq0005" "tipo" => "MULTIMEDIAFORMULA" "mostrarFloat" => false "mostrarDisplay" => true "Formula" => array:1 [ "Quimica" => "TEE<span class="elsevierStyleHsp" style=""></span>cardiac<span class="elsevierStyleHsp" style=""></span>output<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>D2<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>0.785<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>VTI<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>FC<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>Liters/minute" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib0110" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transoesophageal echocardiography is unreliable for cardiac output assessment after cardiac surgery compared with thermodilution" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.A. Bettex" 1 => "V. Hinselmann" 2 => "J.P. Hellermann" 3 => "R. Jenni" 4 => "E.R. Schmid" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2044.2004.03928.x" "Revista" => array:6 [ "tituloSerie" => "Anaesthesia" "fecha" => "2004" "volumen" => "59" "paginaInicial" => "1184" "paginaFinal" => "1192" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15549977" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0115" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fisiología aplicada a la anestesiología" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Carrero-Cardenal" 1 => "J. Castillo Monsegur" 2 => "A. Villalonga Morales" 3 => "F.J. Tercero Marchin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "edicion" => "3rd ed." "fecha" => "2012" "editorial" => "Madrid" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0120" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Approaches to determination of left ventricular volume and ejection fraction by real-time two-dimensional echocardiography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.F. Parisi" 1 => "P.F. Moynihan" 2 => "C.L. Feldman" 3 => "E.D. Folland" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cardiol" "fecha" => "1979" "volumen" => "2" "paginaInicial" => "257" "paginaFinal" => "263" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/262574" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0125" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estimación del gasto cardíaco, utilidad en la práctica clínica. Monitorización disponible invasiva y no invasiva" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "X. García" 1 => "L. Mateu" 2 => "J. Maynar" 3 => "J. Mercadal" 4 => "A. Ochagavía" 5 => "A. Ferrandiz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.medin.2011.01.014" "Revista" => array:6 [ "tituloSerie" => "Med Intensiva" "fecha" => "2011" "volumen" => "35" "paginaInicial" => "552" "paginaFinal" => "561" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21411188" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0130" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Errors in the measurement of cardiac output by thermodilution" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Nishikawa" 1 => "S. Dohi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF03011312" "Revista" => array:6 [ "tituloSerie" => "Can J Anaesth" "fecha" => "1993" "volumen" => "40" "paginaInicial" => "142" "paginaFinal" => "153" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8443853" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0135" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thermodilution cardiac output: a critical analysis and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.M. Levett" 1 => "R.L. Replogle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Surg Res" "fecha" => "1979" "volumen" => "27" "paginaInicial" => "392" "paginaFinal" => "404" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/529796" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0140" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of transesophageal echocardiography in the intraoperative period" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "V. Gouveia" 1 => "P. Marcelino" 2 => "D.A. Reuter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Cardiol Rev" "fecha" => "2011" "volumen" => "7" "paginaInicial" => "184" "paginaFinal" => "196" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22758616" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0145" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiplane transesophageal echocardiographic Doppler imaging accurately determines cardiac output measurements in critically ill patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.S. Feinberg" 1 => "W.E. Hopkins" 2 => "V.G. Davila-Roman" 3 => "B. Barzilai" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1995" "volumen" => "107" "paginaInicial" => "769" "paginaFinal" => "773" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7874951" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0150" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. Sandham" 1 => "R.D. Hull" 2 => "R.F. Brant" 3 => "L. Knox" 4 => "G.F. Pineo" 5 => "C.J. Doig" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa021108" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2003" "volumen" => "348" "paginaInicial" => "5" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12510037" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0155" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictive value of the EuroSCORE model in cardiac surgery in our site" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Riera" 1 => "A. Carrillo" 2 => "J. Ibáñez" 3 => "J.I. Sáez de Ibarra" 4 => "M. Fiol" 5 => "O. Bonnin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Intensiva" "fecha" => "2007" "volumen" => "31" "paginaInicial" => "231" "paginaFinal" => "236" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17580013" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0160" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transoesophageal Doppler echocardiographic measurement of cardiac output by the mitral annulus method" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H. Shimamoto" 1 => "H. Kito" 2 => "K. Kawazoe" 3 => "T. Fujita" 4 => "Y. Shimamoto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br Heart J" "fecha" => "1992" "volumen" => "68" "paginaInicial" => "510" "paginaFinal" => "515" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1467040" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0165" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serious mechanical complications associated with pulmonary artery catheters in cardiovascular and thoracic surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Tenaa" 1 => "C. Gomar" 2 => "C. Roux" 3 => "J. Fontanals" 4 => "M.J. Jiménez" 5 => "I. Rovira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Anestesiol Reanim" "fecha" => "2008" "volumen" => "55" "paginaInicial" => "487" "paginaFinal" => "492" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18982786" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0170" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraoperative estimation of cardiac output by transesophageal pulsed Doppler echocardiography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I.A. Muhiudeen" 1 => "H.F. Kuecherer" 2 => "E. Lee" 3 => "M.K. Cahalan" 4 => "N.B. Schiller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "1991" "volumen" => "74" "paginaInicial" => "9" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1986664" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0175" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraoperative validation of mitral inflow determination by transesophageal echocardiography: comparison of single-plane, biplane and thermodilution techniques" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Pu" 1 => "B.P. Griffin" 2 => "P.M. Vandervoort" 3 => "D.Y. Leung" 4 => "D.M. Cosgrove" 5 => "J.D. Thomas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "1995" "volumen" => "26" "paginaInicial" => "1047" "paginaFinal" => "1053" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7560598" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0180" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A meta-analysis of studies using bias and precision statistics to compare cardiac output measurement techniques" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.A. Critchley" 1 => "J.A. Critchley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Monit Comput" "fecha" => "1999" "volumen" => "15" "paginaInicial" => "85" "paginaFinal" => "91" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12578081" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0185" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraoperative determination of cardiac output using multiplane transesophageal echocardiography: a comparison to thermodilution" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.C. Perrino" 1 => "S.N. Harris" 2 => "M.A. Luther" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "1998" "volumen" => "89" "paginaInicial" => "350" "paginaFinal" => "357" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9710392" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0190" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraoperative measurement of cardiac output by transesophageal echocardiography of transmitral flow" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.C. Cabrera Schulmeyer" 1 => "R.A. Vega Sepúlveda" 2 => "E.G. Santelices Cuevas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Anestesiol Reanim" "fecha" => "2004" "volumen" => "51" "paginaInicial" => "367" "paginaFinal" => "372" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15495634" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0195" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transesophageal echocardiography for the noncardiac surgical patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Rebel" 1 => "O. Klimkina" 2 => "Z.U. Hassan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.9738/CC61.1" "Revista" => array:6 [ "tituloSerie" => "Int Surg" "fecha" => "2012" "volumen" => "97" "paginaInicial" => "43" "paginaFinal" => "55" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23102000" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0200" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new technique for measurement of cardiac output by thermodilution in man" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "W. Ganz" 1 => "R. Donoso" 2 => "H.S. Marcus" 3 => "J.S. Forrester" 4 => "H.J. Swan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1971" "volumen" => "27" "paginaInicial" => "392" "paginaFinal" => "396" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4929422" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0205" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Size and motion of the mitral valve annulus in man I. A two-dimensional echocardiographic method and findings in normal subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.A. Ormiston" 1 => "P.M. Shah" 2 => "C. Tei" 3 => "M. Wong" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1981" "volumen" => "64" "paginaInicial" => "113" "paginaFinal" => "120" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7237707" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0210" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous thermodilution cardiac output: clinical validation against a reference technique of known accuracy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E.R. Schmid" 1 => "D. Schmidlin" 2 => "M. Tornic" 3 => "B. Seifert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Intensive Care Med" "fecha" => "1999" "volumen" => "25" "paginaInicial" => "166" "paginaFinal" => "172" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10193543" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack319684" "titulo" => "Acknowledgements" "texto" => "<p id="par0175" class="elsevierStylePara elsevierViewall">Special thanks is given to the Anesthesiology Department led by Dr. Jorge Córdoba, the Cardiology Department, Dr. Álvaro Rodríguez for his unconditional tutoring, to the Department of Epidemiology directed by Dr. Leonardo Cely, and especially to Dr. Leonidas Olaya who is Scientific Director of the Hospital Cardiovascular del Niño de Cundinamarca. He allowed us to undertake the study and offered us the possibility to pioneer many more studies in this institution that wholeheartedly supports the vulnerable population in our country – Colombia.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/02105691/0000004100000009/v1_201711250711/S021056911730219X/v1_201711250711/en/main.assets" "Apartado" => array:4 [ "identificador" => "18737" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02105691/0000004100000009/v1_201711250711/S021056911730219X/v1_201711250711/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021056911730219X?idApp=WMIE" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 5 | 7 | 12 |
| 2024 Octubre | 64 | 55 | 119 |
| 2024 Septiembre | 74 | 36 | 110 |
| 2024 Agosto | 81 | 47 | 128 |
| 2024 Julio | 94 | 40 | 134 |
| 2024 Junio | 89 | 86 | 175 |
| 2024 Mayo | 80 | 33 | 113 |
| 2024 Abril | 77 | 59 | 136 |
| 2024 Marzo | 60 | 28 | 88 |
| 2024 Febrero | 77 | 46 | 123 |
| 2024 Enero | 56 | 36 | 92 |
| 2023 Diciembre | 65 | 47 | 112 |
| 2023 Noviembre | 63 | 67 | 130 |
| 2023 Octubre | 54 | 35 | 89 |
| 2023 Septiembre | 50 | 39 | 89 |
| 2023 Agosto | 49 | 13 | 62 |
| 2023 Julio | 42 | 33 | 75 |
| 2023 Junio | 42 | 23 | 65 |
| 2023 Mayo | 54 | 42 | 96 |
| 2023 Abril | 45 | 33 | 78 |
| 2023 Marzo | 68 | 45 | 113 |
| 2023 Febrero | 76 | 39 | 115 |
| 2023 Enero | 34 | 24 | 58 |
| 2022 Diciembre | 81 | 52 | 133 |
| 2022 Noviembre | 62 | 58 | 120 |
| 2022 Octubre | 58 | 41 | 99 |
| 2022 Septiembre | 58 | 52 | 110 |
| 2022 Agosto | 48 | 44 | 92 |
| 2022 Julio | 64 | 49 | 113 |
| 2022 Junio | 62 | 45 | 107 |
| 2022 Mayo | 58 | 40 | 98 |
| 2022 Abril | 46 | 52 | 98 |
| 2022 Marzo | 73 | 68 | 141 |
| 2022 Febrero | 61 | 47 | 108 |
| 2022 Enero | 54 | 53 | 107 |
| 2021 Diciembre | 74 | 59 | 133 |
| 2021 Noviembre | 50 | 52 | 102 |
| 2021 Octubre | 61 | 80 | 141 |
| 2021 Septiembre | 48 | 44 | 92 |
| 2021 Agosto | 57 | 61 | 118 |
| 2021 Julio | 40 | 48 | 88 |
| 2021 Junio | 48 | 54 | 102 |
| 2021 Mayo | 53 | 77 | 130 |
| 2021 Abril | 120 | 109 | 229 |
| 2021 Marzo | 76 | 54 | 130 |
| 2021 Febrero | 57 | 43 | 100 |
| 2021 Enero | 61 | 43 | 104 |
| 2020 Diciembre | 57 | 32 | 89 |
| 2020 Noviembre | 55 | 31 | 86 |
| 2020 Octubre | 59 | 46 | 105 |
| 2020 Septiembre | 80 | 52 | 132 |
| 2020 Agosto | 72 | 23 | 95 |
| 2020 Julio | 56 | 39 | 95 |
| 2020 Junio | 64 | 38 | 102 |
| 2020 Mayo | 63 | 19 | 82 |
| 2020 Abril | 59 | 21 | 80 |
| 2020 Marzo | 44 | 23 | 67 |
| 2020 Febrero | 101 | 45 | 146 |
| 2020 Enero | 84 | 37 | 121 |
| 2019 Diciembre | 157 | 32 | 189 |
| 2019 Noviembre | 211 | 45 | 256 |
| 2019 Octubre | 218 | 38 | 256 |
| 2019 Septiembre | 118 | 34 | 152 |
| 2019 Agosto | 71 | 27 | 98 |
| 2019 Julio | 63 | 31 | 94 |
| 2019 Junio | 54 | 31 | 85 |
| 2019 Mayo | 77 | 50 | 127 |
| 2019 Abril | 48 | 30 | 78 |
| 2019 Marzo | 57 | 36 | 93 |
| 2019 Febrero | 48 | 41 | 89 |
| 2019 Enero | 45 | 40 | 85 |
| 2018 Diciembre | 50 | 31 | 81 |
| 2018 Noviembre | 85 | 100 | 185 |
| 2018 Octubre | 57 | 26 | 83 |
| 2018 Septiembre | 41 | 19 | 60 |
| 2018 Agosto | 33 | 14 | 47 |
| 2018 Julio | 44 | 17 | 61 |
| 2018 Junio | 53 | 21 | 74 |
| 2018 Mayo | 38 | 12 | 50 |
| 2018 Abril | 43 | 11 | 54 |
| 2018 Marzo | 12 | 7 | 19 |
| 2018 Febrero | 2 | 2 | 4 |
| 2018 Enero | 5 | 3 | 8 |
| 2017 Diciembre | 14 | 8 | 22 |
| 2017 Noviembre | 2 | 3 | 5 |
| 2017 Octubre | 0 | 5 | 5 |
Mostrar todo
