array:23 [
  "pii" => "S0210569118302778"
  "issn" => "02105691"
  "doi" => "10.1016/j.medin.2018.09.015"
  "estado" => "S300"
  "fechaPublicacion" => "2019-11-01"
  "aid" => "1282"
  "copyright" => "Elsevier España, S.L.U. y SEMICYUC"
  "copyrightAnyo" => "2018"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Med Intensiva. 2019;43:510-2"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 107
    "formatos" => array:3 [
      "EPUB" => 16
      "HTML" => 49
      "PDF" => 42
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0210569119300178"
    "issn" => "02105691"
    "doi" => "10.1016/j.medin.2019.01.001"
    "estado" => "S300"
    "fechaPublicacion" => "2019-11-01"
    "aid" => "1305"
    "copyright" => "Elsevier España, S.L.U. y SEMICYUC"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Med Intensiva. 2019;43:513"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 294
      "formatos" => array:3 [
        "EPUB" => 12
        "HTML" => 232
        "PDF" => 50
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
      "titulo" => "Ingenier&#237;a de materiales&#44; <span class="elsevierStyleItalic">mechanical power&#44;</span> ventilaci&#243;n protectora y una de paraca&#237;das"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "513"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Materials engineering&#44; mechanical power&#44; protective ventilation and a parachute"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Escudero-Acha, A&#46; Gonz&#225;lez-Castro, Y&#46; Pe&#241;asco, M&#46; Feo-Gonzalez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Escudero-Acha"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Gonz&#225;lez-Castro"
            ]
            2 => array:2 [
              "nombre" => "Y&#46;"
              "apellidos" => "Pe&#241;asco"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Feo-Gonzalez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2173572719301456"
        "doi" => "10.1016/j.medine.2019.01.008"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572719301456?idApp=WMIE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569119300178?idApp=WMIE"
    "url" => "/02105691/0000004300000008/v1_201910220814/S0210569119300178/v1_201910220814/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0210569118302699"
    "issn" => "02105691"
    "doi" => "10.1016/j.medin.2018.09.007"
    "estado" => "S300"
    "fechaPublicacion" => "2019-11-01"
    "aid" => "1274"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; y SEMICYUC"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Med Intensiva. 2019;43:509-10"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 114
      "formatos" => array:3 [
        "EPUB" => 17
        "HTML" => 47
        "PDF" => 50
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
      "titulo" => "Severity scores should incorporate limitations on life support for predicting mortality"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "509"
          "paginaFinal" => "510"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Las puntuaciones de intensidad deber&#237;an incorporar las limitaciones del soporte vital para predecir la mortalidad"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1398
              "Ancho" => 2078
              "Tamanyo" => 125291
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Comparison of observed and predicted hospital mortality in patients according to the existence or not of limitations of life-support on ICU admission&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rafael Fernandez, Lara Ventura, Caroline Macharete, Ignacio Catalan, Silvia Cano, Josep-Maria Alcoverro, Carles Subira, Jaume Masclans, Gina Rognoni, Olga Rubio"
          "autores" => array:10 [
            0 => array:2 [
              "nombre" => "Rafael"
              "apellidos" => "Fernandez"
            ]
            1 => array:2 [
              "nombre" => "Lara"
              "apellidos" => "Ventura"
            ]
            2 => array:2 [
              "nombre" => "Caroline"
              "apellidos" => "Macharete"
            ]
            3 => array:2 [
              "nombre" => "Ignacio"
              "apellidos" => "Catalan"
            ]
            4 => array:2 [
              "nombre" => "Silvia"
              "apellidos" => "Cano"
            ]
            5 => array:2 [
              "nombre" => "Josep-Maria"
              "apellidos" => "Alcoverro"
            ]
            6 => array:2 [
              "nombre" => "Carles"
              "apellidos" => "Subira"
            ]
            7 => array:2 [
              "nombre" => "Jaume"
              "apellidos" => "Masclans"
            ]
            8 => array:2 [
              "nombre" => "Gina"
              "apellidos" => "Rognoni"
            ]
            9 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Rubio"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569118302699?idApp=WMIE"
    "url" => "/02105691/0000004300000008/v1_201910220814/S0210569118302699/v1_201910220814/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
    "titulo" => "Lymphopenic hospital acquired sepsis &#40;L-HAS&#41;&#58; An immunological phenotype conferring higher risk of mortality"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "510"
        "paginaFinal" => "512"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46; L&#243;pez-Mestanza, D&#46; Andaluz-Ojeda, J&#46;R&#46; G&#243;mez-L&#243;pez, J&#46;F&#46; Bermejo-Mart&#237;n"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "C&#46;"
            "apellidos" => "L&#243;pez-Mestanza"
            "email" => array:1 [
              0 => "xtina.lopez.mestanza@hotmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Andaluz-Ojeda"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;R&#46;"
            "apellidos" => "G&#243;mez-L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "J&#46;F&#46;"
            "apellidos" => "Bermejo-Mart&#237;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "BIO SEPSIS &#40;Group of Biomedical Research in Sepsis&#41;&#44; Hospital Cl&#237;nico Universitario de Valladolid&#44; SACYL&#44; Valladolid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Critical Care Medicine Service&#44; Hospital Cl&#237;nico Universitario de Valladolid&#44; Valladolid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "General Surgery Service&#44; Hospital de Medina del Campo&#44; SACYL&#44; Medina del Campo-Valladolid&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Sepsis nosocomial linfop&#233;nica&#58; un fenotipo inmunol&#243;gico que confiere un mayor riesgo de mortalidad"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1386
            "Ancho" => 1583
            "Tamanyo" => 63336
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier survival curve&#46; Groups were compared by the log rank test &#40;Mantel&#8211;Henzel&#41;&#46; Circulating Lymphocyte Count &#40;CLC&#41; at HAS diagnosis were divided in two groups&#44; &#8804;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span> and greater&#46; Time was censored at 90 days following HAS diagnosis&#46; Cum&#58; cumulative&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The clinical profile of Hospital Acquired Sepsis &#40;HAS&#41; is poorly known&#46; In a recent work&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> we found that patients suffering from HAS show many of the risk factors associated with cardiovascular disease and cancer&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Lymphopenia is a frequent finding in sepsis patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#8211;4</span></a> Sepsis affects the immune system by directly altering the lifespan&#44; production and function of the effector cells responsible for homeostasis&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Lymphopenia is also found in other severe infections like pneumonia needing of hospitalization&#44; and it is associated to an increased risk of mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The impact of lymphocyte counts on the prognosis of patients with HAS is unknown&#46; The objective of the present study was to evaluate the association between lymphocyte counts and mortality risk of the patients suffering from HAS&#46; The predictive ability of the other leukocyte subpopulations was also assessed&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The study was approved by the Clinical Research and Ethics Committee of our hospital&#46; Informed consent was waived due to the observational nature of the study&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A total of 196 patients were included in the study&#46; Hospital and 90 days mortality was 45&#46;4&#37;&#46; The median age of HAS patients was of 73 years &#40;IQR&#58; 68&#46;1&#8211;71&#46;4&#41;&#44; with 68&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>134&#41; of them being male&#46; Some serious comorbidities were&#58; cardiac disease 63&#46;8&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>125&#41;&#44; cancer 34&#46;2&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>67&#41;&#44; chronic kidney disease 19&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>38&#41;&#44; immunosuppression 17&#46;9&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>35&#41; and chronic hepatic disease 6&#46;1&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#41; &#40;Supplementary Table 1&#41;&#46; Sepsis with organ failure &#40;severe sepsis&#47;septic shock&#41; was present in 146 patients &#40;74&#46;5&#37;&#41; with 75 of these patients dying during the first 90 days&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">HAS emerged 10 days following hospital admission in median &#40;IQR&#44; 11&#46;4&#8211;14&#46;5&#41;&#46; The most frequent source of infection was the respiratory tract &#40;29&#46;1&#37;&#41;&#44; followed by bacteraemia &#40;25&#37;&#41; &#40;Supplementary Table 1&#41;&#46; Microorganisms were isolated in one hundred and fifty patients &#40;76&#46;5&#37;&#41;&#46; Gram negative bacteria were the most common microorganisms &#40;58&#46;6&#37;&#41;&#44; followed by Gram positive cocci &#40;46&#46;0&#37;&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We collected leukocyte subpopulations counts at hospital admission and also at HAS diagnosis&#46; Patients with HAS showed a significant increase in the median values of neutrophil counts from admission to diagnosis&#58; &#40;5&#46;3 &#91;4&#46;00&#8211;7&#46;4&#93;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>&#47;mm<span class="elsevierStyleSup">3</span>&#41; <span class="elsevierStyleItalic">vs</span> &#40;10&#46;9 &#91;6&#46;5&#8211;17&#46;0&#93;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>&#47;mm<span class="elsevierStyleSup">3</span>&#41; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#46; On the contrary&#44; median values of eosinophil and lymphocyte counts decreased from admission to diagnosis&#58; &#40;0&#46;11 &#91;0&#46;04&#8211;0&#46;22&#93;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>&#47;mm<span class="elsevierStyleSup">3</span>&#41; <span class="elsevierStyleItalic">vs</span> &#40;0&#46;02 &#91;0&#46;00&#8211;0&#46;11&#93;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>&#47;mm<span class="elsevierStyleSup">3</span>&#41; for eosinophils and &#40;1&#46;6 &#91;1&#46;0&#8211;2&#46;3&#93;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>0<span class="elsevierStyleSup">3</span>&#47;mm<span class="elsevierStyleSup">3</span>&#41; <span class="elsevierStyleItalic">vs</span> &#40;0&#46;8 &#91;0&#46;4&#8211;1&#46;3&#93;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>&#47;mm<span class="elsevierStyleSup">3</span>&#93;&#41; for lymphocytes &#40;with differences yielding a <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001 in both cases&#41;&#46; Median values of monocytes and basophil counts did not change in a significant manner between both moments&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Median values of lymphocytes at HAS diagnosis were higher in survivors than in non survivors&#46; Survivors showed also higher median values of eosinophils at HAS diagnosis than non survivors&#46; On the contrary&#44; monocyte&#44; basophil and neutrophil counts did not show differences between both groups &#40;Supplementary Table 1&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Lymphocytes and eosinophil counts at HAS diagnosis showed significant AUCs for identifying survivors at hospital discharge &#40;Supplementary Fig&#46; 1&#41;&#44; with an &#40;AUC &#91;CI95&#37;&#93;&#44; <span class="elsevierStyleItalic">p</span>&#41; of &#40;0&#46;59 &#91;0&#46;59&#8211;0&#46;67&#93;&#44; 0&#46;042&#41; and &#40;0&#46;60 &#91;0&#46;52&#8211;0&#46;68&#93;&#44; 0&#46;023&#41; respectively&#46; Other leukocyte subtypes failed to discriminate survivors from non survivors&#46; The optimal operating point &#40;OOP&#41; was calculated for those leukocyte subpopulations showing an AUC <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05 as previously described<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> for distinguishing between both kinds of patients in the AUC analysis was 775<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> for lymphocytes and 13<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> for eosinophils&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Categorical variables were created based on the OOPs and the resulting variables for lymphocyte and eosinophil counts were evaluated for hospital mortality prediction using multivariate analysis adjusting by the potential confounding factors selected in the univariate analysis&#58; &#91;Age&#40;years&#41;&#93;&#44; &#91;Sex&#40;male&#41;&#93;&#44; &#91;&#8220;Sepsis code&#8221; implemented&#93;&#44; &#91;antecedent of vascular disease&#93;&#44; &#91;antecedent of cancer&#93;&#44; &#91;antecedent of chronic kidney disease&#93;&#44; &#91;sepsis with organ failure&#93;&#44; &#91;more than one episode of sepsis during hospital admission&#93;&#44; &#91;surgical intervention&#93; and &#91;time &#40;days&#41; from admission to sepsis diagnosis&#93;&#46; The presence of a lymphocyte count &#8804;775<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> at diagnosis of HAS was an independent predictor of mortality in the multivariate analysis&#58; &#40;1&#46;98 &#91;1&#46;00&#8211;3&#46;92&#93;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;049&#41; &#40;OR 1&#46;98 &#91;CI 95&#37; 1&#46;00&#8211;3&#46;92&#93;&#44; <span class="elsevierStyleItalic">p</span> &#61; 0&#46;049&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; In turn&#44; showing a eosinophil count &#8804;13<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> at diagnosis of HAS conferred a non-significant higher risk of mortality &#40;1&#46;87 &#91;0&#46;95&#8211;3&#46;70&#93;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;072&#41;&#46; Finally&#44; the Kaplan&#8211;Meier curves at 90 days following diagnosis of HAS showed that patients with &#8804;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span> died earlier &#40;media 48&#46;6 days &#91;40&#46;3&#8211;56&#46;8&#93;&#41; than patients with &#62;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span> &#40;media 60&#46;5 &#91;53&#46;1&#8211;67&#46;9&#93;&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;030 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">HAS was characterized by a significant increase in the blood counts of the paradigmatic cell representing innate immunity&#44; the neutrophil&#44; accompanied by a decrease in the prototypic cell of the adaptive immunity&#44; the lymphocyte&#46; Neutrophil count expansion could represent a kind of compensatory mechanism responding to the decrease in the lymphocyte counts&#44; which precedes the emergence of HAS&#46; The significant decrease in lymphocyte counts found from admission to diagnosis of HAS cannot be explained by hemodilution due to fluid administration&#44; since counts of the other leukocyte subsets were not affected&#46; In consequence&#44; this is the first report providing evidence that sepsis does induce diminution of lymphocyte counts in blood&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Early identification of patients at risk of death is a crucial step in the clinical management of sepsis&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;10</span></a> In this regard&#44; this study provides a cut-off value for lymphocyte counts &#40;&#8804;775<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span>&#41; which is useful for the early identification of those patients at higher risk of mortality&#44; independently of their accompanying co-morbidities &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Also we repeat analysis excluding immunosuppressed patients and we found that those patients with &#8804;775 lymphocytes&#47;mm<span class="elsevierStyleSup">3</span> continue presenting higher risk to mortality&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Lymphocyte counting is a simple and inexpensive test&#44; widely available in most hospital settings&#46; In our study&#44; the eosinophil count at diagnosis of HAS conferred a nonsignificant higher risk of mortality&#46; Some limitations of our work were its retrospective nature&#44; the absence of some variables like the albumin levels or severity scores like SOFA or APACHE&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; lymphopenic HAS &#40;L-HAS&#41; &#40;&#8804;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span>&#41; constitutes a particular immunological phenotype of the disease conferring a two-fold increase in the risk of hospital mortality&#46; Patients with L-HAS deserve special care and close monitoring of vital signs&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">None&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0080" class="elsevierStylePara elsevierViewall">This research did not received any specific grant from funding agencies in the public&#44; commercial or not-for-profit sectors&#46; Salaries from the authors are paid by the &#8220;Consejer&#237;a de Sanidad de Castilla y Le&#243;n&#44; Spain&#8221;&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:3 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflict of interest"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Funding"
        ]
        2 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005"><span class="elsevierStyleItalic">Institution where the work was done</span>&#58; Hospital Cl&#237;nico Universitario de Valladolid&#44; Av&#46; Ram&#243;n y Cajal&#44; 3&#44; 47003&#44; Valladolid&#44; Spain&#46;</p>"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0090" class="elsevierStylePara elsevierViewall">The following are the supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0020"
          ]
        ]
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1386
            "Ancho" => 1583
            "Tamanyo" => 63336
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier survival curve&#46; Groups were compared by the log rank test &#40;Mantel&#8211;Henzel&#41;&#46; Circulating Lymphocyte Count &#40;CLC&#41; at HAS diagnosis were divided in two groups&#44; &#8804;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span> and greater&#46; Time was censored at 90 days following HAS diagnosis&#46; Cum&#58; cumulative&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">OR&#58; odds ratio&#59; CI&#58; confidence interval&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Hospital mortality</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;034&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#46;002&#8211;1&#46;067&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;040&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sex &#40;male&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;067&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#46;978&#8211;4&#46;369&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;057&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8220;Sepsis Code&#8221; implemented&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;583&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#46;294&#8211;1&#46;157&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;123&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vascular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;419&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#46;650&#8211;3&#46;096&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;380&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cancer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;385&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#46;680&#8211;2&#46;818&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;369&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chronic kidney disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;693&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#46;713&#8211;4&#46;021&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;233&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sepsis with organ failure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;687&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#46;889&#8211;11&#46;629&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">More than one episode of sepsis during hospital admission&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;346&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#46;529&#8211;7&#46;324&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Time &#40;days&#41; from admission to sepsis diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;036&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#46;000&#8211;1&#46;074&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;050&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Surgical intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;316&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#46;144&#8211;0&#46;696&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8804;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;983&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#46;004&#8211;3&#46;919&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;049&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2149228.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multivariate regression analysis to predict hospital mortality risk in patients with &#8804;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span> at diagnosis of HAS&#46;</p>"
        ]
      ]
      2 => array:5 [
        "identificador" => "upi0005"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc1.pdf"
          "ficheroTamanyo" => 86921
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical factors influencing mortality risk in hospital-acquired sepsis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; L&#243;pez-Mestanza"
                            1 => "D&#46; Andaluz-Ojeda"
                            2 => "J&#46;R&#46; G&#243;mez-L&#243;pez"
                            3 => "J&#46;F&#46; Bermejo-Mart&#237;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jhin.2017.08.022"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hosp Infect"
                        "fecha" => "2018"
                        "volumen" => "98"
                        "paginaInicial" => "194"
                        "paginaFinal" => "201"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28882641"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunosuppression in patients who die of sepsis and multiple organ failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;S&#46; Boomer"
                            1 => "K&#46; To"
                            2 => "K&#46;C&#46; Chang"
                            3 => "O&#46; Takasu"
                            4 => "D&#46;F&#46; Osborne"
                            5 => "A&#46;H&#46; Walton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2011.1829"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2011"
                        "volumen" => "306"
                        "paginaInicial" => "2594"
                        "paginaFinal" => "2605"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22187279"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Persistent lymphopenia after diagnosis of sepsis predicts mortality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;M&#46; Drewry"
                            1 => "N&#46; Samra"
                            2 => "L&#46;P&#46; Skrupky"
                            3 => "B&#46;M&#46; Fuller"
                            4 => "S&#46;M&#46; Compton"
                            5 => "R&#46;S&#46; Hotchkiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Shock Augusta Ga"
                        "fecha" => "2014"
                        "volumen" => "42"
                        "paginaInicial" => "383"
                        "paginaFinal" => "391"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Severe lymphopenia is associated with elevated plasma interleukin-15 levels and increased mortality during severe sepsis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;-P&#46; Chung"
                            1 => "H&#46;-T&#46; Chang"
                            2 => "S&#46;-C&#46; Lo"
                            3 => "L&#46;-Y&#46; Chang"
                            4 => "S&#46;-Y&#46; Lin"
                            5 => "A&#46; Cheng"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Shock Augusta Ga"
                        "fecha" => "2015"
                        "volumen" => "43"
                        "paginaInicial" => "569"
                        "paginaFinal" => "575"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sepsis-induced immune dysfunction&#58; can immune therapies reduce mortality&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;J&#46; Delano"
                            1 => "P&#46;A&#46; Ward"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI82224"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "2016"
                        "volumen" => "126"
                        "paginaInicial" => "23"
                        "paginaFinal" => "31"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26727230"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lymphopenic community acquired pneumonia &#40;L-CAP&#41;&#44; an immunological phenotype associated with higher risk of mortality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;F&#46; Bermejo-Martin"
                            1 => "C&#46; Cilloniz"
                            2 => "R&#46; Mendez"
                            3 => "R&#46; Almansa"
                            4 => "A&#46; Gabarrus"
                            5 => "A&#46; Ceccato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ebiom.2017.09.023"
                      "Revista" => array:6 [
                        "tituloSerie" => "EBioMedicine"
                        "fecha" => "2017"
                        "volumen" => "24"
                        "paginaInicial" => "231"
                        "paginaFinal" => "236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28958655"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quantification of immune dysregulation by next-generation polymerase chain reaction to improve sepsis diagnosis in surgical patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Almansa"
                            1 => "A&#46; Ortega"
                            2 => "A&#46; &#193;vila-Alonso"
                            3 => "M&#46; Heredia-Rodr&#237;guez"
                            4 => "S&#46; Mart&#237;n"
                            5 => "D&#46; Benavides"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.sla.0000165196.32207.dd"
                      "Revista" => array:3 [
                        "tituloSerie" => "Ann Surg"
                        "fecha" => "2017"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15912052"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consensus document &#40;SEMES-SEMICYUC&#41; recommendations for the initial and multidisciplinary diagnostic management of severe sepsis in the hospital emergency departments"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Leon Gil"
                            1 => "L&#46; Garcia-Castrillo Riesgo"
                            2 => "M&#46; Moya Mir"
                            3 => "A&#46; Artigas Raventos"
                            4 => "M&#46; Borges Sa"
                            5 => "F&#46;J&#46; Candel Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2007"
                        "volumen" => "31"
                        "paginaInicial" => "375"
                        "paginaFinal" => "387"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17942061"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;F&#46; Gaieski"
                            1 => "M&#46;E&#46; Mikkelsen"
                            2 => "R&#46;A&#46; Band"
                            3 => "J&#46;M&#46; Pines"
                            4 => "R&#46; Massone"
                            5 => "F&#46;F&#46; Furia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CCM.0b013e3181cc4824"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2010"
                        "volumen" => "38"
                        "paginaInicial" => "1045"
                        "paginaFinal" => "1053"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20048677"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reductions in sepsis mortality and costs after design and implementation of a nurse-based early recognition and response program"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;L&#46; Jones"
                            1 => "C&#46;M&#46; Ashton"
                            2 => "L&#46; Kiehne"
                            3 => "E&#46; Gigliotti"
                            4 => "C&#46; Bell-Gordon"
                            5 => "M&#46; Disbot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Jt Comm J Qual Patient Saf Jt Comm Resour"
                        "fecha" => "2015"
                        "volumen" => "41"
                        "paginaInicial" => "483"
                        "paginaFinal" => "491"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/02105691/0000004300000008/v1_201910220814/S0210569118302778/v1_201910220814/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "53"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Cartas cient&#237;ficas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02105691/0000004300000008/v1_201910220814/S0210569118302778/v1_201910220814/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569118302778?idApp=WMIE"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Scientific Letter
Lymphopenic hospital acquired sepsis (L-HAS): An immunological phenotype conferring higher risk of mortality
Sepsis nosocomial linfopénica: un fenotipo inmunológico que confiere un mayor riesgo de mortalidad
C. López-Mestanzaa,
Autor para correspondencia
, D. Andaluz-Ojedab, J.R. Gómez-Lópezc, J.F. Bermejo-Martína
a BIO SEPSIS (Group of Biomedical Research in Sepsis), Hospital Clínico Universitario de Valladolid, SACYL, Valladolid, Spain
b Critical Care Medicine Service, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
c General Surgery Service, Hospital de Medina del Campo, SACYL, Medina del Campo-Valladolid, Spain
Leído
4514
Veces
se ha leído el artículo
1947
Total PDF
2567
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S0210569118302778"
  "issn" => "02105691"
  "doi" => "10.1016/j.medin.2018.09.015"
  "estado" => "S300"
  "fechaPublicacion" => "2019-11-01"
  "aid" => "1282"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; y SEMICYUC"
  "copyrightAnyo" => "2018"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Med Intensiva. 2019;43:510-2"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 107
    "formatos" => array:3 [
      "EPUB" => 16
      "HTML" => 49
      "PDF" => 42
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0210569119300178"
    "issn" => "02105691"
    "doi" => "10.1016/j.medin.2019.01.001"
    "estado" => "S300"
    "fechaPublicacion" => "2019-11-01"
    "aid" => "1305"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; y SEMICYUC"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Med Intensiva. 2019;43:513"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 294
      "formatos" => array:3 [
        "EPUB" => 12
        "HTML" => 232
        "PDF" => 50
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
      "titulo" => "Ingenier&#237;a de materiales&#44; <span class="elsevierStyleItalic">mechanical power&#44;</span> ventilaci&#243;n protectora y una de paraca&#237;das"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "513"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Materials engineering&#44; mechanical power&#44; protective ventilation and a parachute"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Escudero-Acha, A&#46; Gonz&#225;lez-Castro, Y&#46; Pe&#241;asco, M&#46; Feo-Gonzalez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Escudero-Acha"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Gonz&#225;lez-Castro"
            ]
            2 => array:2 [
              "nombre" => "Y&#46;"
              "apellidos" => "Pe&#241;asco"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Feo-Gonzalez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2173572719301456"
        "doi" => "10.1016/j.medine.2019.01.008"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572719301456?idApp=WMIE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569119300178?idApp=WMIE"
    "url" => "/02105691/0000004300000008/v1_201910220814/S0210569119300178/v1_201910220814/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0210569118302699"
    "issn" => "02105691"
    "doi" => "10.1016/j.medin.2018.09.007"
    "estado" => "S300"
    "fechaPublicacion" => "2019-11-01"
    "aid" => "1274"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; y SEMICYUC"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Med Intensiva. 2019;43:509-10"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 114
      "formatos" => array:3 [
        "EPUB" => 17
        "HTML" => 47
        "PDF" => 50
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
      "titulo" => "Severity scores should incorporate limitations on life support for predicting mortality"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "509"
          "paginaFinal" => "510"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Las puntuaciones de intensidad deber&#237;an incorporar las limitaciones del soporte vital para predecir la mortalidad"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1398
              "Ancho" => 2078
              "Tamanyo" => 125291
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Comparison of observed and predicted hospital mortality in patients according to the existence or not of limitations of life-support on ICU admission&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rafael Fernandez, Lara Ventura, Caroline Macharete, Ignacio Catalan, Silvia Cano, Josep-Maria Alcoverro, Carles Subira, Jaume Masclans, Gina Rognoni, Olga Rubio"
          "autores" => array:10 [
            0 => array:2 [
              "nombre" => "Rafael"
              "apellidos" => "Fernandez"
            ]
            1 => array:2 [
              "nombre" => "Lara"
              "apellidos" => "Ventura"
            ]
            2 => array:2 [
              "nombre" => "Caroline"
              "apellidos" => "Macharete"
            ]
            3 => array:2 [
              "nombre" => "Ignacio"
              "apellidos" => "Catalan"
            ]
            4 => array:2 [
              "nombre" => "Silvia"
              "apellidos" => "Cano"
            ]
            5 => array:2 [
              "nombre" => "Josep-Maria"
              "apellidos" => "Alcoverro"
            ]
            6 => array:2 [
              "nombre" => "Carles"
              "apellidos" => "Subira"
            ]
            7 => array:2 [
              "nombre" => "Jaume"
              "apellidos" => "Masclans"
            ]
            8 => array:2 [
              "nombre" => "Gina"
              "apellidos" => "Rognoni"
            ]
            9 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Rubio"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569118302699?idApp=WMIE"
    "url" => "/02105691/0000004300000008/v1_201910220814/S0210569118302699/v1_201910220814/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
    "titulo" => "Lymphopenic hospital acquired sepsis &#40;L-HAS&#41;&#58; An immunological phenotype conferring higher risk of mortality"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "510"
        "paginaFinal" => "512"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46; L&#243;pez-Mestanza, D&#46; Andaluz-Ojeda, J&#46;R&#46; G&#243;mez-L&#243;pez, J&#46;F&#46; Bermejo-Mart&#237;n"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "C&#46;"
            "apellidos" => "L&#243;pez-Mestanza"
            "email" => array:1 [
              0 => "xtina.lopez.mestanza@hotmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Andaluz-Ojeda"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;R&#46;"
            "apellidos" => "G&#243;mez-L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "J&#46;F&#46;"
            "apellidos" => "Bermejo-Mart&#237;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "BIO SEPSIS &#40;Group of Biomedical Research in Sepsis&#41;&#44; Hospital Cl&#237;nico Universitario de Valladolid&#44; SACYL&#44; Valladolid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Critical Care Medicine Service&#44; Hospital Cl&#237;nico Universitario de Valladolid&#44; Valladolid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "General Surgery Service&#44; Hospital de Medina del Campo&#44; SACYL&#44; Medina del Campo-Valladolid&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Sepsis nosocomial linfop&#233;nica&#58; un fenotipo inmunol&#243;gico que confiere un mayor riesgo de mortalidad"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1386
            "Ancho" => 1583
            "Tamanyo" => 63336
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier survival curve&#46; Groups were compared by the log rank test &#40;Mantel&#8211;Henzel&#41;&#46; Circulating Lymphocyte Count &#40;CLC&#41; at HAS diagnosis were divided in two groups&#44; &#8804;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span> and greater&#46; Time was censored at 90 days following HAS diagnosis&#46; Cum&#58; cumulative&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The clinical profile of Hospital Acquired Sepsis &#40;HAS&#41; is poorly known&#46; In a recent work&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> we found that patients suffering from HAS show many of the risk factors associated with cardiovascular disease and cancer&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Lymphopenia is a frequent finding in sepsis patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#8211;4</span></a> Sepsis affects the immune system by directly altering the lifespan&#44; production and function of the effector cells responsible for homeostasis&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Lymphopenia is also found in other severe infections like pneumonia needing of hospitalization&#44; and it is associated to an increased risk of mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The impact of lymphocyte counts on the prognosis of patients with HAS is unknown&#46; The objective of the present study was to evaluate the association between lymphocyte counts and mortality risk of the patients suffering from HAS&#46; The predictive ability of the other leukocyte subpopulations was also assessed&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The study was approved by the Clinical Research and Ethics Committee of our hospital&#46; Informed consent was waived due to the observational nature of the study&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A total of 196 patients were included in the study&#46; Hospital and 90 days mortality was 45&#46;4&#37;&#46; The median age of HAS patients was of 73 years &#40;IQR&#58; 68&#46;1&#8211;71&#46;4&#41;&#44; with 68&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>134&#41; of them being male&#46; Some serious comorbidities were&#58; cardiac disease 63&#46;8&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>125&#41;&#44; cancer 34&#46;2&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>67&#41;&#44; chronic kidney disease 19&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>38&#41;&#44; immunosuppression 17&#46;9&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>35&#41; and chronic hepatic disease 6&#46;1&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#41; &#40;Supplementary Table 1&#41;&#46; Sepsis with organ failure &#40;severe sepsis&#47;septic shock&#41; was present in 146 patients &#40;74&#46;5&#37;&#41; with 75 of these patients dying during the first 90 days&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">HAS emerged 10 days following hospital admission in median &#40;IQR&#44; 11&#46;4&#8211;14&#46;5&#41;&#46; The most frequent source of infection was the respiratory tract &#40;29&#46;1&#37;&#41;&#44; followed by bacteraemia &#40;25&#37;&#41; &#40;Supplementary Table 1&#41;&#46; Microorganisms were isolated in one hundred and fifty patients &#40;76&#46;5&#37;&#41;&#46; Gram negative bacteria were the most common microorganisms &#40;58&#46;6&#37;&#41;&#44; followed by Gram positive cocci &#40;46&#46;0&#37;&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We collected leukocyte subpopulations counts at hospital admission and also at HAS diagnosis&#46; Patients with HAS showed a significant increase in the median values of neutrophil counts from admission to diagnosis&#58; &#40;5&#46;3 &#91;4&#46;00&#8211;7&#46;4&#93;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>&#47;mm<span class="elsevierStyleSup">3</span>&#41; <span class="elsevierStyleItalic">vs</span> &#40;10&#46;9 &#91;6&#46;5&#8211;17&#46;0&#93;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>&#47;mm<span class="elsevierStyleSup">3</span>&#41; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#46; On the contrary&#44; median values of eosinophil and lymphocyte counts decreased from admission to diagnosis&#58; &#40;0&#46;11 &#91;0&#46;04&#8211;0&#46;22&#93;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>&#47;mm<span class="elsevierStyleSup">3</span>&#41; <span class="elsevierStyleItalic">vs</span> &#40;0&#46;02 &#91;0&#46;00&#8211;0&#46;11&#93;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>&#47;mm<span class="elsevierStyleSup">3</span>&#41; for eosinophils and &#40;1&#46;6 &#91;1&#46;0&#8211;2&#46;3&#93;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>0<span class="elsevierStyleSup">3</span>&#47;mm<span class="elsevierStyleSup">3</span>&#41; <span class="elsevierStyleItalic">vs</span> &#40;0&#46;8 &#91;0&#46;4&#8211;1&#46;3&#93;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>&#47;mm<span class="elsevierStyleSup">3</span>&#93;&#41; for lymphocytes &#40;with differences yielding a <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001 in both cases&#41;&#46; Median values of monocytes and basophil counts did not change in a significant manner between both moments&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Median values of lymphocytes at HAS diagnosis were higher in survivors than in non survivors&#46; Survivors showed also higher median values of eosinophils at HAS diagnosis than non survivors&#46; On the contrary&#44; monocyte&#44; basophil and neutrophil counts did not show differences between both groups &#40;Supplementary Table 1&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Lymphocytes and eosinophil counts at HAS diagnosis showed significant AUCs for identifying survivors at hospital discharge &#40;Supplementary Fig&#46; 1&#41;&#44; with an &#40;AUC &#91;CI95&#37;&#93;&#44; <span class="elsevierStyleItalic">p</span>&#41; of &#40;0&#46;59 &#91;0&#46;59&#8211;0&#46;67&#93;&#44; 0&#46;042&#41; and &#40;0&#46;60 &#91;0&#46;52&#8211;0&#46;68&#93;&#44; 0&#46;023&#41; respectively&#46; Other leukocyte subtypes failed to discriminate survivors from non survivors&#46; The optimal operating point &#40;OOP&#41; was calculated for those leukocyte subpopulations showing an AUC <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05 as previously described<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> for distinguishing between both kinds of patients in the AUC analysis was 775<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> for lymphocytes and 13<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> for eosinophils&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Categorical variables were created based on the OOPs and the resulting variables for lymphocyte and eosinophil counts were evaluated for hospital mortality prediction using multivariate analysis adjusting by the potential confounding factors selected in the univariate analysis&#58; &#91;Age&#40;years&#41;&#93;&#44; &#91;Sex&#40;male&#41;&#93;&#44; &#91;&#8220;Sepsis code&#8221; implemented&#93;&#44; &#91;antecedent of vascular disease&#93;&#44; &#91;antecedent of cancer&#93;&#44; &#91;antecedent of chronic kidney disease&#93;&#44; &#91;sepsis with organ failure&#93;&#44; &#91;more than one episode of sepsis during hospital admission&#93;&#44; &#91;surgical intervention&#93; and &#91;time &#40;days&#41; from admission to sepsis diagnosis&#93;&#46; The presence of a lymphocyte count &#8804;775<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> at diagnosis of HAS was an independent predictor of mortality in the multivariate analysis&#58; &#40;1&#46;98 &#91;1&#46;00&#8211;3&#46;92&#93;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;049&#41; &#40;OR 1&#46;98 &#91;CI 95&#37; 1&#46;00&#8211;3&#46;92&#93;&#44; <span class="elsevierStyleItalic">p</span> &#61; 0&#46;049&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; In turn&#44; showing a eosinophil count &#8804;13<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span> at diagnosis of HAS conferred a non-significant higher risk of mortality &#40;1&#46;87 &#91;0&#46;95&#8211;3&#46;70&#93;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;072&#41;&#46; Finally&#44; the Kaplan&#8211;Meier curves at 90 days following diagnosis of HAS showed that patients with &#8804;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span> died earlier &#40;media 48&#46;6 days &#91;40&#46;3&#8211;56&#46;8&#93;&#41; than patients with &#62;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span> &#40;media 60&#46;5 &#91;53&#46;1&#8211;67&#46;9&#93;&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;030 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">HAS was characterized by a significant increase in the blood counts of the paradigmatic cell representing innate immunity&#44; the neutrophil&#44; accompanied by a decrease in the prototypic cell of the adaptive immunity&#44; the lymphocyte&#46; Neutrophil count expansion could represent a kind of compensatory mechanism responding to the decrease in the lymphocyte counts&#44; which precedes the emergence of HAS&#46; The significant decrease in lymphocyte counts found from admission to diagnosis of HAS cannot be explained by hemodilution due to fluid administration&#44; since counts of the other leukocyte subsets were not affected&#46; In consequence&#44; this is the first report providing evidence that sepsis does induce diminution of lymphocyte counts in blood&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Early identification of patients at risk of death is a crucial step in the clinical management of sepsis&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;10</span></a> In this regard&#44; this study provides a cut-off value for lymphocyte counts &#40;&#8804;775<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span>&#41; which is useful for the early identification of those patients at higher risk of mortality&#44; independently of their accompanying co-morbidities &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Also we repeat analysis excluding immunosuppressed patients and we found that those patients with &#8804;775 lymphocytes&#47;mm<span class="elsevierStyleSup">3</span> continue presenting higher risk to mortality&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Lymphocyte counting is a simple and inexpensive test&#44; widely available in most hospital settings&#46; In our study&#44; the eosinophil count at diagnosis of HAS conferred a nonsignificant higher risk of mortality&#46; Some limitations of our work were its retrospective nature&#44; the absence of some variables like the albumin levels or severity scores like SOFA or APACHE&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; lymphopenic HAS &#40;L-HAS&#41; &#40;&#8804;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span>&#41; constitutes a particular immunological phenotype of the disease conferring a two-fold increase in the risk of hospital mortality&#46; Patients with L-HAS deserve special care and close monitoring of vital signs&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">None&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0080" class="elsevierStylePara elsevierViewall">This research did not received any specific grant from funding agencies in the public&#44; commercial or not-for-profit sectors&#46; Salaries from the authors are paid by the &#8220;Consejer&#237;a de Sanidad de Castilla y Le&#243;n&#44; Spain&#8221;&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:3 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflict of interest"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Funding"
        ]
        2 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005"><span class="elsevierStyleItalic">Institution where the work was done</span>&#58; Hospital Cl&#237;nico Universitario de Valladolid&#44; Av&#46; Ram&#243;n y Cajal&#44; 3&#44; 47003&#44; Valladolid&#44; Spain&#46;</p>"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0090" class="elsevierStylePara elsevierViewall">The following are the supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0020"
          ]
        ]
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1386
            "Ancho" => 1583
            "Tamanyo" => 63336
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier survival curve&#46; Groups were compared by the log rank test &#40;Mantel&#8211;Henzel&#41;&#46; Circulating Lymphocyte Count &#40;CLC&#41; at HAS diagnosis were divided in two groups&#44; &#8804;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span> and greater&#46; Time was censored at 90 days following HAS diagnosis&#46; Cum&#58; cumulative&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">OR&#58; odds ratio&#59; CI&#58; confidence interval&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Hospital mortality</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;034&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#46;002&#8211;1&#46;067&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;040&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sex &#40;male&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;067&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#46;978&#8211;4&#46;369&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;057&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8220;Sepsis Code&#8221; implemented&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;583&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#46;294&#8211;1&#46;157&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;123&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vascular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;419&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#46;650&#8211;3&#46;096&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;380&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cancer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;385&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#46;680&#8211;2&#46;818&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;369&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chronic kidney disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;693&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#46;713&#8211;4&#46;021&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;233&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sepsis with organ failure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;687&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#46;889&#8211;11&#46;629&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">More than one episode of sepsis during hospital admission&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;346&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#46;529&#8211;7&#46;324&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Time &#40;days&#41; from admission to sepsis diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;036&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#46;000&#8211;1&#46;074&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;050&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Surgical intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;316&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#46;144&#8211;0&#46;696&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8804;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;983&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#46;004&#8211;3&#46;919&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;049&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2149228.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multivariate regression analysis to predict hospital mortality risk in patients with &#8804;775<span class="elsevierStyleHsp" style=""></span>lymphocytes&#47;mm<span class="elsevierStyleSup">3</span> at diagnosis of HAS&#46;</p>"
        ]
      ]
      2 => array:5 [
        "identificador" => "upi0005"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc1.pdf"
          "ficheroTamanyo" => 86921
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical factors influencing mortality risk in hospital-acquired sepsis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; L&#243;pez-Mestanza"
                            1 => "D&#46; Andaluz-Ojeda"
                            2 => "J&#46;R&#46; G&#243;mez-L&#243;pez"
                            3 => "J&#46;F&#46; Bermejo-Mart&#237;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jhin.2017.08.022"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hosp Infect"
                        "fecha" => "2018"
                        "volumen" => "98"
                        "paginaInicial" => "194"
                        "paginaFinal" => "201"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28882641"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunosuppression in patients who die of sepsis and multiple organ failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;S&#46; Boomer"
                            1 => "K&#46; To"
                            2 => "K&#46;C&#46; Chang"
                            3 => "O&#46; Takasu"
                            4 => "D&#46;F&#46; Osborne"
                            5 => "A&#46;H&#46; Walton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2011.1829"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2011"
                        "volumen" => "306"
                        "paginaInicial" => "2594"
                        "paginaFinal" => "2605"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22187279"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Persistent lymphopenia after diagnosis of sepsis predicts mortality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;M&#46; Drewry"
                            1 => "N&#46; Samra"
                            2 => "L&#46;P&#46; Skrupky"
                            3 => "B&#46;M&#46; Fuller"
                            4 => "S&#46;M&#46; Compton"
                            5 => "R&#46;S&#46; Hotchkiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Shock Augusta Ga"
                        "fecha" => "2014"
                        "volumen" => "42"
                        "paginaInicial" => "383"
                        "paginaFinal" => "391"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Severe lymphopenia is associated with elevated plasma interleukin-15 levels and increased mortality during severe sepsis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;-P&#46; Chung"
                            1 => "H&#46;-T&#46; Chang"
                            2 => "S&#46;-C&#46; Lo"
                            3 => "L&#46;-Y&#46; Chang"
                            4 => "S&#46;-Y&#46; Lin"
                            5 => "A&#46; Cheng"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Shock Augusta Ga"
                        "fecha" => "2015"
                        "volumen" => "43"
                        "paginaInicial" => "569"
                        "paginaFinal" => "575"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sepsis-induced immune dysfunction&#58; can immune therapies reduce mortality&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;J&#46; Delano"
                            1 => "P&#46;A&#46; Ward"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI82224"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "2016"
                        "volumen" => "126"
                        "paginaInicial" => "23"
                        "paginaFinal" => "31"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26727230"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lymphopenic community acquired pneumonia &#40;L-CAP&#41;&#44; an immunological phenotype associated with higher risk of mortality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;F&#46; Bermejo-Martin"
                            1 => "C&#46; Cilloniz"
                            2 => "R&#46; Mendez"
                            3 => "R&#46; Almansa"
                            4 => "A&#46; Gabarrus"
                            5 => "A&#46; Ceccato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ebiom.2017.09.023"
                      "Revista" => array:6 [
                        "tituloSerie" => "EBioMedicine"
                        "fecha" => "2017"
                        "volumen" => "24"
                        "paginaInicial" => "231"
                        "paginaFinal" => "236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28958655"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quantification of immune dysregulation by next-generation polymerase chain reaction to improve sepsis diagnosis in surgical patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Almansa"
                            1 => "A&#46; Ortega"
                            2 => "A&#46; &#193;vila-Alonso"
                            3 => "M&#46; Heredia-Rodr&#237;guez"
                            4 => "S&#46; Mart&#237;n"
                            5 => "D&#46; Benavides"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.sla.0000165196.32207.dd"
                      "Revista" => array:3 [
                        "tituloSerie" => "Ann Surg"
                        "fecha" => "2017"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15912052"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consensus document &#40;SEMES-SEMICYUC&#41; recommendations for the initial and multidisciplinary diagnostic management of severe sepsis in the hospital emergency departments"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Leon Gil"
                            1 => "L&#46; Garcia-Castrillo Riesgo"
                            2 => "M&#46; Moya Mir"
                            3 => "A&#46; Artigas Raventos"
                            4 => "M&#46; Borges Sa"
                            5 => "F&#46;J&#46; Candel Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2007"
                        "volumen" => "31"
                        "paginaInicial" => "375"
                        "paginaFinal" => "387"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17942061"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;F&#46; Gaieski"
                            1 => "M&#46;E&#46; Mikkelsen"
                            2 => "R&#46;A&#46; Band"
                            3 => "J&#46;M&#46; Pines"
                            4 => "R&#46; Massone"
                            5 => "F&#46;F&#46; Furia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CCM.0b013e3181cc4824"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2010"
                        "volumen" => "38"
                        "paginaInicial" => "1045"
                        "paginaFinal" => "1053"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20048677"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reductions in sepsis mortality and costs after design and implementation of a nurse-based early recognition and response program"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;L&#46; Jones"
                            1 => "C&#46;M&#46; Ashton"
                            2 => "L&#46; Kiehne"
                            3 => "E&#46; Gigliotti"
                            4 => "C&#46; Bell-Gordon"
                            5 => "M&#46; Disbot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Jt Comm J Qual Patient Saf Jt Comm Resour"
                        "fecha" => "2015"
                        "volumen" => "41"
                        "paginaInicial" => "483"
                        "paginaFinal" => "491"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/02105691/0000004300000008/v1_201910220814/S0210569118302778/v1_201910220814/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "53"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Cartas cient&#237;ficas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02105691/0000004300000008/v1_201910220814/S0210569118302778/v1_201910220814/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569118302778?idApp=WMIE"
]
Información del artículo
ISSN: 02105691
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 7 11 18
2024 Octubre 49 72 121
2024 Septiembre 48 41 89
2024 Agosto 40 26 66
2024 Julio 49 41 90
2024 Junio 58 57 115
2024 Mayo 50 39 89
2024 Abril 46 49 95
2024 Marzo 45 26 71
2024 Febrero 36 43 79
2024 Enero 38 32 70
2023 Diciembre 26 34 60
2023 Noviembre 51 61 112
2023 Octubre 39 26 65
2023 Septiembre 42 37 79
2023 Agosto 36 16 52
2023 Julio 41 23 64
2023 Junio 28 16 44
2023 Mayo 46 36 82
2023 Abril 29 21 50
2023 Marzo 45 36 81
2023 Febrero 51 29 80
2023 Enero 32 20 52
2022 Diciembre 80 37 117
2022 Noviembre 50 33 83
2022 Octubre 56 35 91
2022 Septiembre 46 36 82
2022 Agosto 42 44 86
2022 Julio 41 49 90
2022 Junio 34 41 75
2022 Mayo 50 48 98
2022 Abril 42 27 69
2022 Marzo 48 40 88
2022 Febrero 48 35 83
2022 Enero 40 42 82
2021 Diciembre 40 52 92
2021 Noviembre 45 38 83
2021 Octubre 58 70 128
2021 Septiembre 27 36 63
2021 Agosto 30 37 67
2021 Julio 24 35 59
2021 Junio 43 30 73
2021 Mayo 52 54 106
2021 Abril 102 118 220
2021 Marzo 97 21 118
2021 Febrero 82 24 106
2021 Enero 75 19 94
2020 Diciembre 77 10 87
2020 Noviembre 34 17 51
2020 Octubre 19 15 34
2020 Septiembre 0 0 0
2020 Julio 28 17 45
2020 Junio 43 19 62
2020 Mayo 35 10 45
2020 Abril 42 7 49
2020 Marzo 32 10 42
2020 Febrero 41 21 62
2020 Enero 0 0 0
2019 Diciembre 4 0 4
2019 Noviembre 5 4 9
2019 Octubre 3 0 3
2019 Septiembre 2 2 4
2019 Julio 0 2 2
2019 Junio 0 0 0
2019 Mayo 0 2 2
2019 Abril 0 5 5
2019 Marzo 0 4 4
2019 Febrero 0 1 1
2019 Enero 0 2 2
2018 Diciembre 9 4 13
2018 Noviembre 9 2 11
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Medicina Intensiva
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?