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incluidas las terapias de soporte requeridas&#44; la proporci&#243;n de individuos que desarrollan enfermedades graves y la mortalidad intra-unidad de cuidados intensivos &#40;UCI&#41;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#8211;5</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Una evaluaci&#243;n de las caracter&#237;sticas&#44; los tratamientos empleados&#44; los resultados y la mortalidad de las dos enfermedades podr&#237;a utilizarse para mejores valoraciones pron&#243;sticas y planificaciones futuras en las unidades de cuidados intensivos<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">El objetivo del presente estudio fue comparar a la poblaci&#243;n ingresada por COVID-19 y la ingresada por la gripe durante la d&#233;cada 2009-2019 con el uso de datos de una unidad de cuidados intensivos en un hospital universitario de tercer nivel&#59; 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un volumen tidal &#40;VT&#41; significativamente m&#225;s bajo &#40;465 vs&#46; 495&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; y una presion positiva al final de la espiraci&#243;n &#40;PEEP&#41; m&#225;s alta &#40;11 vs&#46; 7&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Nuestro an&#225;lisis refleja un perfil de enfermos en edad&#44; sexo y comorbilidades similar en ambas infecciones&#46; Sin embargo&#44; podr&#237;a considerarse una diferente afecci&#243;n respiratoria en base al diferente porcentaje de enfermos que requiri&#243; ventilaci&#243;n mec&#225;nica&#44; a la diferente oxigenaci&#243;n de ingreso y los diferentes par&#225;metros ventilatorios requeridos&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">En este sentido&#44; aunque podr&#237;a considerarse un ingreso en UCI en diferentes momentos evolutivos para cada una de las infecciones&#44; diferentes autores apuntan que puede haber diferencias en el tipo de s&#237;ndrome de distr&#233;s respiratorio agudo &#40;SDRA&#41; en COVID-19<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a>&#46; De hecho&#44; estudios necr&#243;psicos revelan c&#243;mo la presencia de microtrombosis alveolar y la angiog&#233;nesis vascular es m&#225;s frecuente entre los pacientes con COVID-19 en comparaci&#243;n con los enfermos con gripe<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a>&#46; Sin embargo&#44; las caracter&#237;sticas histol&#243;gicas por COVID-19 parecen ser indistinguibles de otras causas de da&#241;o alveolar difuso<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Aunque estudios previos hab&#237;an encontrado mayor mortalidad en aquellos pacientes graves que desarrollaban SDRA por gripe en comparaci&#243;n con el SDRA secundario a COVID-19<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a>&#44; recientemente se han descrito peores resultados respiratorios y un mayor riesgo de mortalidad intrahospitalaria en los enfermos COVID-19&#44; independientemente de la edad&#44; el sexo y los &#237;ndices de gravedad de UCI<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Nuestro estudio presenta varias limitaciones&#58; es una serie relativamente peque&#241;a de pacientes procedentes de un solo hospital&#46; Existen las debilidades derivadas del largo periodo de tiempo de la serie de gripe&#46; Por otro lado&#44; en el grupo de enfermos COVID son resultados obtenidos en plena pandemia con saturaci&#243;n de los servicios y en ocasiones con personal m&#233;dico y de enfermer&#237;a frecuentemente no experto&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">De nuestros datos es posible concluir que las terapias y las caracter&#237;sticas analizadas en los enfermos con gripe y enfermos con COVID-19 difieren al ingreso en una UCI&#44; 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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">V&#46; de la gripen &#61; 142&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">144 &#40;69&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">HFNC al ingreso &#40;n &#91;&#37;&#93;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;16&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Fracaso HFNC &#40;n &#91;&#37;&#93;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77 &#40;54&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">130 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dec&#250;bito prono &#40;n &#91;&#37;&#93;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;10&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">122 &#40;48&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">ECMO &#40;n &#40;&#37;&#41;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;5&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Corticoides &#40;n &#91;&#37;&#93;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32 &#40;22&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">126 &#40;49&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Complicaciones desarrolladas durante el ingreso en UCI</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SDRA grave &#40;n &#91;&#37;&#93;&#41;<span class="elsevierStyleHsp" style=""></span>FRA &#40;n &#91;&#37;&#93;&#41;<span class="elsevierStyleHsp" style=""></span>Sobreinfecci&#243;n &#40;n &#91;&#37;&#93;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;12&#37;&#41;47 &#40;33&#37;&#41;37 &#40;26&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94 &#40;37&#37;&#41;60 &#40;23&#37;&#41;103 &#40;40&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;05&#60; 0&#44;05&#60; 0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">D&#237;as VM &#40;mediana &#91;p 25-75&#93;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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Comparación de las características de los pacientes con enfermedad por coronavirus tipo 2 y la gripe estacional ingresados en una unidad de cuidados intensivos
Comparison of the characteristics of patients with type 2 coronavirus disease and seasonal influenza admitted to an intensive care unit
A. González-Castro
Autor para correspondencia
e409@humv.es

Autor para correspondencia.
, A. Fernandez-Rodríguez, E. Cuenca Fito, B. Suberviola-Cañas, Y. Peñasco, J.C. Rodríguez-Borregán
Servicio de Medicina Intensiva, Hospital Universitario Marqués de Valdecilla, Santander, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Con frecuencia se ha comparado a la enfermedad por SARS-CoV-2 con la enfermedad por el virus de la gripe&#46; De hecho&#44; teniendo en cuenta su capacidad de propagaci&#243;n y las tasas relativamente bajas de letalidad notificadas inicialmente en China&#44; se pens&#243; que el SARS-CoV-2 era m&#225;s similar a la gripe que el SARS-CoV-1&#59; sin embargo&#44; es importante entender que la enfermedad por SARS-CoV-2 no es gripe<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Pocos estudios han comparado directamente las caracter&#237;sticas de los pacientes que requirieron ingreso en una unidad de cuidados intensivos en las epidemias de SARS-CoV-2 y de la gripe&#46; Es probable que existan diferencias importantes entre las dos infecciones virales respiratorias&#44; incluidas las terapias de soporte requeridas&#44; la proporci&#243;n de individuos que desarrollan enfermedades graves y la mortalidad intra-unidad de cuidados intensivos &#40;UCI&#41;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#8211;5</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Una evaluaci&#243;n de las caracter&#237;sticas&#44; los tratamientos empleados&#44; los resultados y la mortalidad de las dos enfermedades podr&#237;a utilizarse para mejores valoraciones pron&#243;sticas y planificaciones futuras en las unidades de cuidados intensivos<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">El objetivo del presente estudio fue comparar a la poblaci&#243;n ingresada por COVID-19 y la ingresada por la gripe durante la d&#233;cada 2009-2019 con el uso de datos de una unidad de cuidados intensivos en un hospital universitario de tercer nivel&#59; as&#237; como evaluar las diferencias en cuanto a factores de riesgo&#44; caracter&#237;sticas cl&#237;nicas&#44; tratamientos y resultados&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Se realiz&#243; un an&#225;lisis retrospectivo&#44; anal&#237;tico y comparativo entre los pacientes admitidos en la UCI con infecci&#243;n por gripe entre septiembre de 2009 y abril de 2019&#44; y pacientes ingresados por SARS-CoV-2 entre marzo y diciembre de 2020&#46; Para la realizaci&#243;n del an&#225;lisis se utilizaron sendos registros que previamente hab&#237;an recibido la aprobaci&#243;n del Comit&#233; de &#201;tica de Investigaci&#243;n local&#44; con la concesi&#243;n del consentimiento de los pacientes&#47;representante cuando fue requerida por dicho comit&#233;&#46; Los datos se muestran como n&#250;meros y porcentajes o medias y desviaci&#243;n est&#225;ndar&#46; Las variables cualitativas se compararon con la prueba &#967;<span class="elsevierStyleSup">2</span> y las cuantitativas con la t de student&#46; La significancia estad&#237;stica se fij&#243; en p<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Durante los periodos de tiempo estudiados&#44; ingresaron un total de 142 enfermos con infecci&#243;n por gripe y 256 con infecci&#243;n SARS-CoV-2&#46; No se encontraron diferencias significativas en cuanto a edad&#44; sexo o comorbilidades &#40;ver <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; La PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> al ingreso fue significativamente m&#225;s baja en pacientes SARS-CoV-2 &#40;144 vs&#46; 227&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; sin objetivar diferencias en la necesidad de VMI al ingreso &#40;primeras 24 horas de ingreso en UCI&#41;&#46; En los pacientes SARS-CoV-2 se emple&#243; un volumen tidal &#40;VT&#41; significativamente m&#225;s bajo &#40;465 vs&#46; 495&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; y una presion positiva al final de la espiraci&#243;n &#40;PEEP&#41; m&#225;s alta &#40;11 vs&#46; 7&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Nuestro an&#225;lisis refleja un perfil de enfermos en edad&#44; sexo y comorbilidades similar en ambas infecciones&#46; Sin embargo&#44; podr&#237;a considerarse una diferente afecci&#243;n respiratoria en base al diferente porcentaje de enfermos que requiri&#243; ventilaci&#243;n mec&#225;nica&#44; a la diferente oxigenaci&#243;n de ingreso y los diferentes par&#225;metros ventilatorios requeridos&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">En este sentido&#44; aunque podr&#237;a considerarse un ingreso en UCI en diferentes momentos evolutivos para cada una de las infecciones&#44; diferentes autores apuntan que puede haber diferencias en el tipo de s&#237;ndrome de distr&#233;s respiratorio agudo &#40;SDRA&#41; en COVID-19<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a>&#46; De hecho&#44; estudios necr&#243;psicos revelan c&#243;mo la presencia de microtrombosis alveolar y la angiog&#233;nesis vascular es m&#225;s frecuente entre los pacientes con COVID-19 en comparaci&#243;n con los enfermos con gripe<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a>&#46; Sin embargo&#44; las caracter&#237;sticas histol&#243;gicas por COVID-19 parecen ser indistinguibles de otras causas de da&#241;o alveolar difuso<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Aunque estudios previos hab&#237;an encontrado mayor mortalidad en aquellos pacientes graves que desarrollaban SDRA por gripe en comparaci&#243;n con el SDRA secundario a COVID-19<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a>&#44; recientemente se han descrito peores resultados respiratorios y un mayor riesgo de mortalidad intrahospitalaria en los enfermos COVID-19&#44; independientemente de la edad&#44; el sexo y los &#237;ndices de gravedad de UCI<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Nuestro estudio presenta varias limitaciones&#58; es una serie relativamente peque&#241;a de pacientes procedentes de un solo hospital&#46; Existen las debilidades derivadas del largo periodo de tiempo de la serie de gripe&#46; Por otro lado&#44; en el grupo de enfermos COVID son resultados obtenidos en plena pandemia con saturaci&#243;n de los servicios y en ocasiones con personal m&#233;dico y de enfermer&#237;a frecuentemente no experto&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">De nuestros datos es posible concluir que las terapias y las caracter&#237;sticas analizadas en los enfermos con gripe y enfermos con COVID-19 difieren al ingreso en una UCI&#44; 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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbilidades</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumadores &#40;n &#91;&#37;&#93;&#41;<span class="elsevierStyleHsp" style=""></span>HTA &#40;n &#91;&#37;&#93;&#41;<span class="elsevierStyleHsp" style=""></span>DM2 &#40;n &#91;&#37;&#93;&#41;<span class="elsevierStyleHsp" style=""></span>DLP &#40;n &#91;&#37;&#93;&#41;<span class="elsevierStyleHsp" style=""></span>Obesidad &#40;n &#91;&#37;&#93;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">HFNC al ingreso &#40;n &#91;&#37;&#93;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Fracaso HFNC &#40;n &#91;&#37;&#93;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">VMI al ingreso &#40;n &#91;&#37;&#93;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Dec&#250;bito prono &#40;n &#91;&#37;&#93;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">ECMO &#40;n &#40;&#37;&#41;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Corticoides &#40;n &#91;&#37;&#93;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t">126 &#40;49&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Complicaciones desarrolladas durante el ingreso en UCI</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">94 &#40;37&#37;&#41;60 &#40;23&#37;&#41;103 &#40;40&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">D&#237;as VM &#40;mediana &#91;p 25-75&#93;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;3-18&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;2-17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">D&#237;as de estancia UCI &#40;mediana &#91;p 25-75&#93;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;2-20&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;4-26&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Mortalidad intra-UCI &#40;n &#91;&#37;&#93;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;15&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56 &#40;22&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2866911.png"
              ]
            ]
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          "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Principales caracter&#237;sticas de las cohortes de pacientes ingresados en una unidad de cuidados intensivos por infecci&#243;n por el virus de la gripe y los enfermos ingresados por infecci&#243;n debida a SARS-CoV-2</p>"
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ISSN: 02105691
Idioma original: Español
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