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En el ensayo cl&#237;nico MIRACL<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> se aleatorizaron 3&#46;086 pacientes para iniciar el tratamiento con 80<span class="elsevierStyleHsp" style=""></span>mg de atorvastatina o placebo entre las 24<span class="elsevierStyleHsp" style=""></span>h y los 4 d&#237;as tras el inicio de un s&#237;ndrome coronario agudo &#40;SCA&#41;&#46; En el seguimiento al cuarto mes se comprob&#243; una reducci&#243;n del 16&#37; de las variables principales &#40;muerte&#44; IM&#44; necesidad de reanimaci&#243;n cardiopulmonar&#44; isquemia mioc&#225;rdica recurrente que precisara hospitalizaci&#243;n&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;048&#41;&#44; y reducciones del 26&#37; de la recurrencia anginosa y del 50&#37; de la incidencia de ictus&#46; En los ensayos Florida<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> y A-to-Z<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> no se encontraron beneficios en cuanto a mortalidad&#46; 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y obtuvieron una odds ratio &#40;OR&#41; de 0&#44;8 para la recurrencia anginosa&#44; sin efectos sobre la mortalidad&#46; Hulten et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> analizaron 13 ensayos cl&#237;nicos con poblaciones muy heterog&#233;neas&#44; englobando un total de 17&#46;963 pacientes&#44; y detectaron disminuci&#243;n de la mortalidad y de los eventos cardiovasculares tras la administraci&#243;n de estatinas &#40;hazard ratio&#44; 0&#44;81&#58; IC intervalo de confianza al 95&#37; &#91;IC 95&#37;&#93;&#44; 0&#44;77-0&#44;87&#41;&#59; siendo esta m&#225;s significativa entre el 4&#176; y 12&#176; mes&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Los datos m&#225;s relevantes provienen actualmente de registros&#46; Fonarow et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> en el <span class="elsevierStyleItalic">National Registry of Myocardial Infarction</span> &#40;NRMI&#41;&#44; encontraron un claro beneficio de la administraci&#243;n precoz de estatinas&#46; En el registro GRACE<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&#44; los pacientes tratados con estatinas tuvieron un hazard ratio de 0&#44;87 para muerte intrahospitalaria&#44; reinfarto o ictus&#46; Similares resultados se obtuvieron en el registro AMIS Plus<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&#59; ambos observaron que los pacientes tratados previamente con estatinas eran menos propensos para tener un IM con elevaci&#243;n del segmento ST al ingreso en unidad de cuidados intensivos &#40;UCI&#41;&#47;unidad coronaria &#40;UC&#41;&#46; El <span class="elsevierStyleItalic">Euro Heart Survey</span><a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> tambi&#233;n report&#243; una tasa muy baja de mortalidad asociada a la administraci&#243;n de estatinas &#40;hazard ratio 0&#44;34&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Parece por tanto que la administraci&#243;n precoz de estatinas en los pacientes con IM podr&#237;a reducir la mortalidad de estos&#44; afirmaci&#243;n que podr&#237;a crear mucha controversia dado que las poblaciones estudiadas&#44; momento de administraci&#243;n y metodolog&#237;a empleada fueron muy heterog&#233;neos&#46; La mayor parte de los estudios publicados hasta la fecha usaron una variable combinada para medir la eficacia&#44; o incluso incluyeron pacientes con SCA &#40;combinando IM y angina inestable&#41;&#46; Esta heterogeneidad hace dif&#237;cil determinar el verdadero efecto de la administraci&#243;n de estatinas en la fase precoz del IM&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Nuestra hip&#243;tesis es que la administraci&#243;n precoz de estatinas podr&#237;a reducir la mortalidad&#44; la incidencia de shock cardiog&#233;nico y de arritmias letales en los pacientes con IM&#46; Adem&#225;s&#44; creemos que la administraci&#243;n conjunta de betabloqueantes&#44; inhibidores de la enzima convertidora de angiotensina &#40;IECA&#41; y estatinas podr&#237;a tener un efecto beneficioso&#44; coadyuvante&#46; El objetivo de este estudio es evaluar los efectos de la administraci&#243;n de estatinas en los pacientes con IM&#44; durante su ingreso en la UCI o en la UC&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">M&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Tipo de estudio&#58; el registro ARIAM</span><p id="par0035" class="elsevierStylePara elsevierViewall">Se realiz&#243; un estudio de cohortes observacional basado en un registro con inclusi&#243;n prospectiva y an&#225;lisis retrospectivo del registro ARIAM<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#8211;17</span></a>&#46; El periodo de estudio fue desde enero de 1999 hasta diciembre de 2008&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Variables estudiadas</span><p id="par0040" class="elsevierStylePara elsevierViewall">En este estudio los pacientes seleccionados fueron aquellos diagnosticados de IM o angina inestable que fueron ingresados en UCI&#47;UC&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">El IM se defini&#243; con los criterios cl&#237;nicos tradicionales de dolor tor&#225;cico prolongado &#40;duraci&#243;n superior a los 20<span class="elsevierStyleHsp" style=""></span>min&#41;&#44; con cambios t&#237;picos en el electrocardiograma&#44; y elevaci&#243;n de los marcadores de da&#241;o mioc&#225;rdico &#40;creatinfosfocinasa y&#47;o troponina&#41;&#46; El tratamiento administrado en cada caso&#44; incluyendo la trombolisis&#44; fue responsabilidad del m&#233;dico que lo asisti&#243; bas&#225;ndose en los criterios aceptados en el momento en el que se realiz&#243; el estudio&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">El tratamiento con estatinas de forma precoz se defini&#243; como su administraci&#243;n durante las primeras 24<span class="elsevierStyleHsp" style=""></span>h del IM&#46; La mortalidad se estudi&#243; al alta de UCI&#47;UC y a los 60 d&#237;as&#46; Se estudiaron los siguientes par&#225;metros&#58; 1&#41; factores de riesgo cardiovascular&#44; 2&#41; peor clase funcional &#40;clase Killip&#41; desde las &#225;reas de emergencia hasta el alta de UCI&#47;UC&#44; 3&#41; mortalidad&#44; 4&#41; complicaciones&#44; y 5&#41; tratamiento recibido&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Las arritmias se definieron como letales&#44; aquellas que cursaron en forma de taquicardia ventricular sostenida o fibrilaci&#243;n ventricular&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Se cre&#243; una nueva variable en los pacientes que recibieron simult&#225;neamente tratamiento con betabloqueantes&#44; IECA y estatinas durante el ingreso en UCI&#47;UC&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Criterios de exclusi&#243;n</span><p id="par0065" class="elsevierStylePara elsevierViewall">Los pacientes en los que no figuraba en el registro cumplimentaci&#243;n alguna sobre la toma de medicaci&#243;n en UCI fueron excluidos&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Objetivos</span><p id="par0070" class="elsevierStylePara elsevierViewall">Este estudio tuvo los siguientes objetivos&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#41;</span><p id="par0075" class="elsevierStylePara elsevierViewall">Estudiar la administraci&#243;n de estatinas durante el ingreso en UCI&#47;UC&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#41;</span><p id="par0080" class="elsevierStylePara elsevierViewall">Evaluar los factores asociados con la administraci&#243;n de estatinas&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#41;</span><p id="par0085" class="elsevierStylePara elsevierViewall">Evaluar si la administraci&#243;n de estatinas durante las primeras 24<span class="elsevierStyleHsp" style=""></span>h del IM se comportaba como un factor protector frente a la mortalidad&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#41;</span><p id="par0090" class="elsevierStylePara elsevierViewall">Evaluar si la administraci&#243;n de estatinas durante el ingreso en UCI&#47;UC se comport&#243; como un factor protector contra el desarrollo de shock cardiog&#233;nico y arritmias letales&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5&#41;</span><p id="par0095" class="elsevierStylePara elsevierViewall">Estudiar en los pacientes con IM que se trataban previamente con estatinas los efectos en la mortalidad durante su ingreso en UCI&#47;UC de la continuaci&#243;n o interrupci&#243;n de dicho tratamiento y&#44; en los pacientes que no tomaban estatinas&#44; su repercusi&#243;n en la mortalidad en UCI&#47;UC del inicio del tratamiento&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">6&#41;</span><p id="par0100" class="elsevierStylePara elsevierViewall">Evaluar los efectos en la mortalidad del tratamiento simult&#225;neo con betabloqueantes&#44; IECA y estatinas&#46;</p></li></ul></p><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">An&#225;lisis estad&#237;stico</span><p id="par0105" class="elsevierStylePara elsevierViewall">El an&#225;lisis estad&#237;stico fue realizado con la versi&#243;n espa&#241;ola del paquete estad&#237;stico SPSS v&#46;15 &#40;SPSS Inc&#46;&#44; Chicago&#44; Illinois&#44; EE&#46; UU&#46;&#41; y el paquete estad&#237;stico R&#46;2&#46;9&#44;1 &#40;GNU System&#44; Free Software Foundation&#44; Boston&#44; Massachusetts 02110-1301&#44; EE&#46; UU&#46;&#41;&#46; El an&#225;lisis univariante se emple&#243; para encontrar asociaciones o diferencias entre los siguientes grupos&#58; 1&#41; administraci&#243;n de estatinas y 2&#41; no administraci&#243;n de estatinas&#46; Este an&#225;lisis se realiz&#243; utilizando el test ANOVA para estudiar las variables cuantitativas&#44; tras evaluar la homogeneidad de la varianza empleando los test de Levene&#44; &#967;<span class="elsevierStyleSup">2</span> de Pearson y de Fisher&#46; El an&#225;lisis multivariante se realiz&#243; para evaluar cada uno de los objetivos planteados en el estudio&#44; por lo que se obtuvieron 5 modelos&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">En el an&#225;lisis multivariante se incluyeron todas las variables que presentaron diferencias estad&#237;sticamente significativas o que fueron cl&#236;nicamente relevantes&#46; Se calcularon las OR con sus IC 95&#37; para cada variable independiente en el an&#225;lisis multivariante&#46; Este an&#225;lisis se realiz&#243; mediante regression log&#237;stica binaria con inclusion de las distintas variables independientes&#46; La bondad del ajuste y su calibraci&#243;n fueron establecidas usando el test de Hosmer-Lemeshow&#46; Se evaluaron la presencia de posibles variables confusoras y la interacci&#243;n entre las variables independientes&#46; Se defini&#243; como variable confusora aquella que produc&#237;a un cambio del 20&#37; en el valor &#171;&#946;&#187; en el an&#225;lisis multivariante o en el valor estad&#237;stico de Mantel-Haenszel en el modelo bivariante&#46; Adem&#225;s&#44; se realiz&#243; un estudio de validaci&#243;n del an&#225;lisis multivariante empleando &#233;l &#225;rea bajo la curva ROC&#46; Los datos num&#233;ricos se expresaron como la media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>desviaci&#243;n est&#225;ndar&#46; Las variables cualitativas se expresaron en n&#250;meros absolutos y porcentajes&#46; Se consider&#243; estad&#237;sticamente significativo un valor de p de menos de 0&#44;05&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Como este estudio se bas&#243; en un registro&#44; tiene sus limitaciones&#44; por lo que se realiz&#243; un an&#225;lisis de propensi&#243;n para evitar la posibilidad de sesgos y variables confusoras&#46; Posteriormente se aplic&#243; la t&#233;cnica de matching&#44; con estratificaci&#243;n en 5 subgrupos&#46; Adem&#225;s&#44; la propensi&#243;n se introdujo como una nueva variable dentro del an&#225;lisis multivariante&#44; para obtener un estimador m&#225;s fiable y v&#225;lido de la magnitud de la asociaci&#243;n entre el tratamiento con estatinas y los diferentes eventos cardiovasculares &#40;mortalidad&#44; shock cardiog&#233;nico y arritmias letales&#41;&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Resultados</span><p id="par0120" class="elsevierStylePara elsevierViewall">Durante el estudio se reclutaron a 36&#46;842 pacientes con IM que ingresaron en UCI&#47;UC&#46; El an&#225;lisis multivariante se hizo con 32&#46;906 pacientes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#44; habiendo 3&#46;936 pacientes excluidos &#40;10&#44;7&#37;&#41;&#44; cuyos tratamientos no estaban cumplimentados en el registro&#46; El tratamiento con estatinas durante el ingreso en UCI&#47;UC era conocido en 25&#46;380 pacientes&#44; de los cuales 5&#46;965 &#40;23&#44;5&#37;&#41; lo tomaban previamente&#46; De estos&#44; 4&#46;508 &#40;76&#44;4&#37;&#41; recibieron tratamiento precoz con estatinas y mantuvieron dicho tratamiento durante su ingreso en UCI&#47;UC&#46; Las tasas crudas de mortalidad fueron del 3&#44;3&#37; en los pacientes que continuaron el tratamiento y del 13&#44;7&#37; en quienes se interrumpi&#243; el tratamiento &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; La continuidad precoz del tratamiento con estatinas durante el ingreso en UCI&#47;UC se comport&#243; como un factor protector contra mortalidad &#40;OR 0&#44;556&#59; IC 95&#37; 0&#44;412-0&#44;752&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">Un total de 19&#46;415 pacientes no tomaban previamente estatinas&#59; 10&#46;245 de estos pacientes &#40;52&#44;8&#37;&#41; iniciaron el tratamiento de forma precoz&#46; Las tasas crudas de mortalidad fueron del 2&#44;9&#37; en los pacientes que iniciaron el tratamiento y del 12&#44;3&#37; en aquellos que no lo hicieron &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; El tratamiento precoz con estatinas tambi&#233;n fue un factor protector contra mortalidad en esta poblaci&#243;n &#40;OR ajustada 0&#44;603&#59; IC 95&#37; 0&#44;505-0&#44;720&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; Mediante an&#225;lisis de propensi&#243;n este tratamiento continuaba siendo factor de protector contra mortalidad &#40;OR 0&#44;642&#59; IC 95&#37; 0&#44;544-0&#44;757&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">El an&#225;lisis multivariante mostr&#243; que el tratamiento precoz con estatinas era un factor protector contra mortalidad&#44; con una OR ajustada de 0&#44;480 &#40;IC 95&#37; 0&#44;408-0&#44;564&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46; La administraci&#243;n de estatinas aument&#243; progresiva y significativamente durante el trascurso del estudio&#44; desde un 7&#44;1&#37; en 1998 hasta un 89&#44;1&#37; en 2008 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46; Los pacientes que recibieron estatinas fueron m&#225;s j&#243;venes&#44; con poca comorbilidad y sol&#237;an estar en tratamiento con betabloqueantes&#44; IECA&#44; trombolisis&#44; e incluso intervencionismo coronario percut&#225;neo&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">La mortalidad media fue del 8&#44;2&#37;&#59; por subgrupos&#44; la mortalidad fue del 3&#44;0&#37; en los pacientes tratados con estatinas y del 13&#44;2&#37; en los pacientes sin estatinas &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; El an&#225;lisis de propensi&#243;n tambi&#233;n mostr&#243; una reducci&#243;n de la mortalidad&#44; con una OR ajustada de 0&#44;518 &#40;IC 95&#37; 0&#44;447-0&#44;601&#41;&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">La mortalidad acumulada fue del 9&#44;8&#37;&#46; La tasa de mortalidad cruda para los pacientes tratados con estatinas fue del 3&#44;7&#37;&#44; mientras que fue del 13&#44;7&#37; en los pacientes que no fueron tratados con estatinas &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; La administraci&#243;n precoz de estatinas se comport&#243; como un factor protector contra mortalidad en el an&#225;lisis multivariante&#44; realizando regresi&#243;n log&#237;stica binaria &#40;OR ajustada 0&#44;604&#59; IC 95&#37; 0&#44;379-0&#44;963&#41; y an&#225;lisis de propensi&#243;n &#40;OR ajustada 0&#44;476&#59; IC 95&#37; 0&#44;297-0&#44;762&#41;&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">La administraci&#243;n precoz de estatinas tambi&#233;n se comport&#243; como un factor protector frente a la incidencia de shock cardiog&#233;nico &#40;OR ajustada 0&#44;409&#59; IC 95&#37; 00&#44;370-0&#44;452&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46; Utilizando an&#225;lisis de propensi&#243;n&#44; la OR ajustada fue de 0&#44;562 &#40;IC 95&#37; 0&#44;414-0&#44;768&#41;&#46; Del mismo modo&#44; tambi&#233;n demostr&#243; ser factor protector frente al desarrollo de arritmias letales &#40;OR ajustada 0&#44;600&#59; IC 95&#37; 0&#44;526-0&#44;685&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a>&#41;&#46; Utilizando an&#225;lisis de propensi&#243;n&#44; la OR ajustada fue de 0&#44;686 &#40;IC 95&#37; 0&#44;621-0&#44;759&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0150" class="elsevierStylePara elsevierViewall">En los pacientes que tomaron sin&#233;rgicamente la triple terapia betabloqueantes&#44; IECA y estatinas &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#46;555&#41;&#44; se observ&#243; una OR menor que de forma separada para mortalidad &#40;OR ajustada 0&#44;397&#59; IC 95&#37; 0&#44;295-0&#44;535&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">tabla 6</a>&#41;&#46; Mediante an&#225;lisis de propensi&#243;n&#44; la OR fue de 0&#44;471 &#40;IC 95&#37; 0&#44;376-0&#44;591&#41;&#44; menor que para cada f&#225;rmaco de forma aislada&#46;</p><elsevierMultimedia ident="tbl0030"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Discusi&#243;n</span><p id="par0155" class="elsevierStylePara elsevierViewall">Los resultados obtenidos soportan la posible existencia de un claro beneficio del tratamiento con estatinas si es administrado de forma precoz en el IM&#46; Estos resultados concuerdan con los obtenidos en otros registros cl&#237;nicos&#44; que reportaron reducci&#243;n de la mortalidad<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;18&#44;19</span></a> o incluso de variables combinadas de eventos cardiovasculares<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&#46; Como en la mayor&#237;a de los registros&#44; los grupos tratados y no tratados con estatinas fueron heterog&#233;neos&#44; un hecho que es evidente porque no se aleatorizaron&#46; En este estudio&#44; las estatinas tambi&#233;n fueron administradas en una poblaci&#243;n heterog&#233;nea y esto podr&#237;a explicar la marcada diferencia entre las distintas tasas de mortalidad cruda observadas&#46; A pesar de esto&#44; y como demuestran nuestros resultados&#44; todos los estudios que realizaron regresi&#243;n log&#237;stica y an&#225;lisis de propensi&#243;n mostraron un claro y relativamente constante beneficio a favor de la administraci&#243;n precoz de estatinas&#46; Estos an&#225;lisis podr&#237;an tener una fuerte relaci&#243;n causa-efecto&#44; concuerdan con los resultados de los ensayos cl&#237;nicos MIRACL<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> y Prove-IT-TIMI 22<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#44; y sugieren que el tratamiento con estatinas debe administrase precozmente en el IM&#46; En los ensayos cl&#237;nicos A-to-Z<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#44; Florida<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> y PACT<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>&#44; los resultados desfavorables &#40;ausencia de eficacia&#41; no fueron relacionados con ausencia de seguridad en la administraci&#243;n de estatinas&#44; y esto puede ser explicado porque la potencia para encontrar una reducci&#243;n en la mortalidad o de la variable combinada fue insuficiente&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Un hallazgo importante que coincide con los resultados de los estudios NRMI<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> y PRISM<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> es que tanto la combinaci&#243;n del tratamiento con estatinas como el inicio precoz durante el IM se comportaron como factores protectores&#44; mientras que la interrupci&#243;n del tratamiento se relacion&#243; con un aumento en la mortalidad significativo<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;18&#8211;20</span></a>&#46; Esto nos hace considerar la necesidad de no interrumpir el tratamiento con estatinas durante la fase aguda del IM&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Los efectos por los que las estatinas podr&#237;an causar una reducci&#243;n precoz de la mortalidad son ampliamente conocidos<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&#44; particularmente la reducci&#243;n que hemos detectado en el desarrollo de shock cardiog&#233;nico o arritmias letales&#44; hallazgos similares a los obtenidos en el registro NRMI<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&#46; Resulta interesante que&#44; a pesar de no existir gu&#237;as cl&#237;nicas establecidas&#44; pueda observarse que m&#225;s del 50&#37; de los pacientes de varios registros internacionales reciben estatinas en la fase aguda del SCA&#44; y que la frecuencia de esta administraci&#243;n ha sido particularmente alta en los &#250;ltimos a&#241;os&#46; Otro aspecto interesante que ha sido analizado en este estudio es el posible efecto positivo de la combinaci&#243;n de estatinas con betabloqueantes e IECA&#44; que podr&#237;a relacionarse con un efecto sin&#233;rgico de los 3 f&#225;rmacos&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Limitaciones</span><p id="par0170" class="elsevierStylePara elsevierViewall">Este estudio fue realizado a partir de un registro cl&#237;nico &#40;ARIAM&#41;&#46; Este registro no se dise&#241;&#243; espec&#237;ficamente para evaluar la administraci&#243;n de estatinas&#44; lo que explica la ausencia de ciertas variables que podr&#237;an haber enriquecido el estudio&#44; tales como el momento exacto de administraci&#243;n &#40;aunque s&#237; se especifica si fue en las primeras 24<span class="elsevierStyleHsp" style=""></span>h o con posterioridad&#41;&#44; la estatina utilizada y su dosificaci&#243;n&#46; Tampoco se tuvieron en cuenta a los pacientes que no ingresaron en UCI&#47;UC&#44; ya que no figuran en el registro&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">El seguimiento no se pudo realizar en algunos pacientes&#46; En la mayor parte de los casos&#44; solo conocemos la mortalidad al alta de UCI&#47;UC&#46; Adem&#225;s&#44; como no se trata de un ensayo cl&#237;nico&#44; no hubo aleatorizaci&#243;n&#46; Aunque el an&#225;lisis de propensi&#243;n se asocia habitualmente con ciertas limitaciones&#44; como la necesidad de un volumen muestral amplio o la existencia de covariables que no han sido recopiladas&#44; estas limitaciones se minimizaron en este estudio debido a las caracter&#237;sticas del registro ARIAM&#46; Aunque la precisi&#243;n de este m&#233;todo no puede compararse con la de un estudio aleatorizado&#44; sus resultados consiguen una buena aproximaci&#243;n a la que se obtendr&#237;an con estos&#46; Sin embargo&#44; este estudio observacional no puede excluir factores de confusi&#243;n cl&#237;nicos y hospitalarios&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Como la mayor mortalidad de los pacientes con IM que ingresaron en UCI&#47;UC se produce durante las primeras 24<span class="elsevierStyleHsp" style=""></span>h de hospitalizaci&#243;n&#44; probablemente se genere un sesgo en la evaluaci&#243;n de la efectividad del tratamiento&#46; Teniendo esto en cuenta&#44; se condujo un nuevo estudio seleccionando 30&#46;153 pacientes &#40;81&#44;84&#37;&#41; que permanecieron en UCI&#47;UC durante un periodo mayor de 24<span class="elsevierStyleHsp" style=""></span>h&#46; Los resultados mantienen la afirmaci&#243;n del efecto protector del tratamiento con estatinas&#44; con una OR 0&#44;666 &#40;IC 95&#37; 0&#44;573-0&#44;785&#41; frente a mortalidad&#59; 0&#44;801 &#40;IC 95&#37; 0&#44;702-0&#44;930&#41; frente a la incidencia de shock cardiog&#233;nico&#44; y 0&#44;845 &#40;IC 95&#37; 0&#44;751-0&#44;951&#41; contra arritmias letales&#46; La OR para un efecto combinado de la triple terapia estatinas&#44; betabloqueantes e IECA fue 0&#44;497 &#40;IC 95&#37; 0&#44;381-0&#44;647&#41;&#46; En esta poblaci&#243;n tambi&#233;n estudiamos a 4&#46;584 pacientes que previamente estaban siendo tratados con estatinas&#44; obteniendo una OR 0&#44;644 &#40;IC 95&#37; 0&#44;451-0&#44;920&#41; contra mortalidad&#59; y a 14&#46;774 pacientes que no tomaban previamente estatinas&#44; con una OR 0&#44;636 &#40;IC 95&#37; 0&#44;516-0&#44;783&#41;&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Conclusiones</span><p id="par0185" class="elsevierStylePara elsevierViewall">Este an&#225;lisis proporciona nueva evidencia para soportar la hip&#243;tesis de que las estatinas suponen un efecto cardioprotector directo cuando son administradas de forma precoz en contexto de un IM&#46; Adem&#225;s&#44; la interrupci&#243;n de su administraci&#243;n podr&#237;a incrementar la mortalidad&#46; Sin embargo&#44; se necesitan nuevos ensayos cl&#237;nicos para confirmar estos hallazgos&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Adendum</span><p id="par0190" class="elsevierStylePara elsevierViewall">Parte de los datos aportados en este manuscrito han sido publicados como tesis doctoral<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">Trabajo realizado bajo el apoyo del PAI CTS-606 y dedicado a la memoria de D&#46; Juan Jos&#233; Rodr&#237;guez Garc&#237;a&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Conflicto de intereses</span><p id="par0195" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
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        0 => array:2 [
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          "titulo" => array:9 [
            0 => "Resumen"
            1 => "Objetivos"
            2 => "Dise&#241;o"
            3 => "&#193;mbito"
            4 => "Pacientes o participantes"
            5 => "Intervenciones"
            6 => "Variables de inter&#233;s principales"
            7 => "Resultados"
            8 => "Conclusiones"
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec284786"
          "titulo" => "Palabras clave"
        ]
        2 => array:2 [
          "identificador" => "xres301719"
          "titulo" => array:9 [
            0 => "Abstract"
            1 => "Objectives"
            2 => "Design"
            3 => "Setting"
            4 => "Patients or participants"
            5 => "Interventions"
            6 => "Main variables"
            7 => "Results"
            8 => "Conclusions"
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec284785"
          "titulo" => "Keywords"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introducci&#243;n"
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        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "M&#233;todos"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Tipo de estudio&#58; el registro ARIAM"
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            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Variables estudiadas"
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            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Criterios de exclusi&#243;n"
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          "identificador" => "sec0030"
          "titulo" => "Objetivos"
          "secciones" => array:1 [
            0 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "An&#225;lisis estad&#237;stico"
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        7 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Resultados"
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        8 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Discusi&#243;n"
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        9 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Limitaciones"
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        10 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Conclusiones"
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          "identificador" => "sec0060"
          "titulo" => "Adendum"
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        12 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conflicto de intereses"
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        13 => array:1 [
          "titulo" => "Bibliograf&#237;a"
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      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2012-07-02"
    "fechaAceptado" => "2012-12-08"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec284786"
          "palabras" => array:5 [
            0 => "Estatinas"
            1 => "Trombolisis"
            2 => "Mortalidad"
            3 => "Infarto de miocardio"
            4 => "An&#225;lisis de propensi&#243;n"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec284785"
          "palabras" => array:5 [
            0 => "Statins"
            1 => "Thrombolysis"
            2 => "Mortality"
            3 => "Myocardial infarction"
            4 => "Propensity score analysis"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluar el efecto de la administraci&#243;n precoz de estatinas durante la fase aguda del infarto de miocardio &#40;IM&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Dise&#241;o</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio de cohortes retrospectivo&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">&#193;mbito</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nacional&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Pacientes o participantes</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Pacientes incluidos en el registro ARIAM desde enero de 1999 hasta diciembre de 2008 con diagn&#243;stico de IM&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Intervenciones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Ninguna&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0035">Variables de inter&#233;s principales</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se utilizaron an&#225;lisis de regresi&#243;n log&#237;stica y de propensi&#243;n para determinar si la administraci&#243;n de estatinas&#44; durante las primeras 24<span class="elsevierStyleHsp" style=""></span>h del IM&#44; se comportaba como un factor protector frente a&#58; 1&#41; la mortalidad&#44; 2&#41; la incidencia de arritmias letales o 3&#41; el shock cardiog&#233;nico&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 36&#46;842 pacientes en el estudio&#46; En un 50&#44;2&#37; de los pacientes las estatinas se administraron de forma precoz&#46; Su administraci&#243;n se asoci&#243; a pacientes m&#225;s j&#243;venes&#44; con dislipidemia previa conocida&#44; obesidad&#44; antecedentes personales de cardiopat&#237;a isqu&#233;mica&#44; insuficiencia cardiaca&#44; presencia de taquicardia sinusal&#44; uso de betabloqueantes&#44; inhibidores de la enzima convertidora de angiotensina&#44; trombolisis e intervencionismo coronario percut&#225;neo&#46; La mortalidad fue del 8&#44;2&#37; &#40;13&#44;2&#37; sin estatinas vs&#46; 3&#37; con estatinas&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; El an&#225;lisis multivariante demostr&#243; que la administraci&#243;n de estatinas actu&#243; como factor protector frente a la mortalidad &#40;OR ajustada 0&#44;518&#59; IC 95&#37; 0&#44;447-0&#44;601&#41;&#46; La continuaci&#243;n de la administraci&#243;n de estatinas se asoci&#243; con una reducci&#243;n en la mortalidad &#40;OR ajustada 0&#44;597&#59; IC 95&#37; 0&#44;449-0&#44;798&#41;&#44; y el inicio del tratamiento fue un factor protector frente a la mortalidad &#40;OR ajustada 0&#44;642&#59; IC 95&#37; 0&#44;544-0&#44;757&#41;&#46; El tratamiento con estatinas tambi&#233;n fue factor protector contra la incidencia de arritmias letales y shock cardiog&#233;nico&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estos resultados sugieren que el tratamiento precoz con estatinas en los pacientes con IM se asocia con una reducci&#243;n de la mortalidad&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0055">Objectives</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">To evaluate the effects of the early administration of statins during acute myocardial infarction &#40;MI&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0060">Design</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">A retrospective cohort study was carried out&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0065">Setting</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">National &#40;Spain&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0070">Patients or participants</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Patients included in the ARIAM registry from January 1999 to December 2008 with a diagnosis of MI&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0075">Interventions</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">None&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0080">Main variables</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">We used logistic regression analysis and propensity scoring to determine whether the administration of statins during the first 24<span class="elsevierStyleHsp" style=""></span>h of MI acts as a protective factor against&#58; 1&#41; mortality&#44; 2&#41; the incidence of lethal arrhythmias&#44; or 3&#41; cardiogenic shock&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">A total of 36 842 patients were included in the study&#46; Statins were administered early in 50&#46;2&#37; of the patients&#46; Statin administration was associated with younger patients with known previous dyslipidemia&#44; obesity&#44; a history of ischemic heart disease&#44; heart failure&#44; presence of sinus tachycardia&#44; use of beta-blockers&#44; angiotensin-converting enzyme inhibitors&#44; thrombolysis and percutaneous coronary intervention&#46; Mortality was 8&#46;2&#37; &#40;13&#46;2&#37; without statin versus 3&#37; with statin&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; Multivariate analysis demonstrated that statin administration acted as a protective factor against mortality &#40;adjusted OR 0&#46;518&#44; 95&#37;CI 0&#46;447 to 0&#46;601&#41;&#46; Continued use of statins was associated with a reduction in mortality &#40;adjusted OR 0&#46;597&#44; 95&#37;CI 0&#46;449 to 0&#46;798&#41;&#44; and the start of treatment was a protective factor against mortality &#40;adjusted OR 0&#46;642&#44; 95&#37;CI 0&#46;544 -0&#46;757&#41;&#46; Statin therapy also exerted a protective effect against the incidence of lethal arrhythmias and cardiogenic shock&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0090">Conclusions</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">These results suggest that early treatment with statins in patients with MI is associated with reduced mortality&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Los investigadores participantes en el Grupo ARIM est&#225;n referidos en <span class="elsevierStyleInterRef" id="intr0005" href="http://www.ariam.net/">www&#46;arIM&#46;net</span>&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Parte de los datos aportados en este manuscrito han sido publicados como tesis doctoral&#46;</p>"
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          "es" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Diagrama de flujo de los resultados de este estudio&#44; mostrando la mortalidad de los distintos subgrupos creados&#46;</p>"
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          "es" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Frecuencia de la administraci&#243;n de estatinas durante la fase aguda del IM desde enero de 1998 hasta diciembre de 2008&#44; tanto en los pacientes con SCA en tratamiento previamente con estatinas como en aquellos que no se trataban&#46; Marcados con flechas&#44; las fechas de los estudios m&#225;s relevantes que demostraron efectos beneficiosos de las estatinas en el SCA&#46;</p>"
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          "leyenda" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">IM&#58; infarto de miocardio&#59; IC&#58; intervalo de confianza&#59; OR&#58; odds ratio&#59; UC&#58; unidad coronaria&#59; UCI&#58; unidad de cuidados intensivos&#46;</p><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">La continuaci&#243;n del tratamiento con estatinas se comport&#243; como un factor protector contra la mortalidad &#40;OR 0&#44;556&#59; IC 95&#37; 0&#44;412-0&#44;752&#41;&#46; El an&#225;lisis se realiz&#243; con regresi&#243;n log&#237;stica binaria y en &#233;l se incluyeron 5&#46;430 pacientes &#40;535 p&#233;rdidas -9&#37;-&#41;&#46; Cox y R<span class="elsevierStyleSup">2</span> Snell<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;123&#59; R<span class="elsevierStyleSup">2</span> Nagelkerke<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;362&#46; Test de Hosmer-Lemeshow<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;779&#46; &#193;rea bajo la curva ROC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;890 &#40;IC 95&#37; 0&#44;871-0&#44;909&#41;&#46;</p>"
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                  \t\t\t\t">1&#44;053&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diabetes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;048&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;348&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Killip 1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Killip 2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#44;431&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">IM con bloqueo de rama izquierda&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;178&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM no especificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#44;310&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Estatinas</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;752</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Constante&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab445106.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis multivariante de la mortalidad en tre los pacientes que tomaban estatinas antes de su ingreso en UCI&#47;UC</p>"
        ]
      ]
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        "identificador" => "tbl0010"
        "etiqueta" => "Tabla 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
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          "leyenda" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">IM&#58; infarto de miocardio&#59; IC&#58; intervalo de confianza&#59; IECA&#58; inhibidores de la enzima convertidora de angiotensina&#59; OR&#58; odds ratio&#59; UC&#58; unidad coronaria&#59; UCI&#58; unidad de cuidados intensivos&#46;</p><p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">El inicio precoz del tratamiento con estatinas fue factor protector frente a mortalidad &#40;OR ajustada 0&#44;603&#59; IC 95&#37; 0&#44;505-0&#44;720&#41;&#46; An&#225;lisis realizado con cero p&#233;rdidas&#46; An&#225;lisis de Cox y R<span class="elsevierStyleSup">2</span> Snell<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;381&#59; R<span class="elsevierStyleSup">2</span> Nagelkerke<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;289&#46; Test de Hosmer-Lemeshow<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;214&#46; &#193;rea bajo la curva ROC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;882 &#40;IC 95&#37; 0&#44;871-0&#44;893&#41;&#46;</p>"
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM no Q&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;521&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;435&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;624&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM con bloqueo de rama izqueirda&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;132&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;749&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;514&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;091&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM no especificado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;583&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;411&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;828&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Estatinas</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;000</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;603</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;505</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;720</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Constante&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  """
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          "es" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis multivariate de la mortalidad entre los pacientes que no estaban en tratamiento con estatinas antes del ingreso en UCI&#47;UC</p>"
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          "leyenda" => "<p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">IM&#58; infarto de miocardio&#59; IC&#58; Intervalo de confianza&#59; ICP&#58; intervencionismo coronario percut&#225;neo&#59; IECA&#58; inhibidores de la enzima convertidora de angiotensina&#59; OR&#58; odds ratio&#46;</p><p id="spar0135" class="elsevierStyleSimplePara elsevierViewall">El an&#225;lisis multivariante fue realizado con 32&#46;906 pacientes &#40;con 3&#46;936 p&#233;rdidas -10&#44;7&#37;-&#41;&#46; Este an&#225;lisis demostr&#243; que el tratamiento precoz con estatinas durante el ingreso en UCI&#47;UC actu&#243; como factor protector contra la mortalidad &#40;OR ajustada 0&#44;480&#44; IC 95&#37; 0&#44;408-0&#44;564&#41;&#44; con un coeficiente de Hosmer-Lemeshow de 0&#44;993&#46; La tasa media de clasificaci&#243;n fue 94&#44;1&#37;&#46; &#193;rea bajo la curva ROC 0&#44;896 &#40;IC 95&#37; 0&#44;889-0&#44;902&#41;&#46;</p>"
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                  \t\t\t\t\tvoid\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " colspan="2" align="center" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">IC 95&#37; para OR</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Bajo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Alto&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Edad&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;042&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#44;058&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tabaquismo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;006&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;759&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;624&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;923&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diabetes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;011&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;215&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;047&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;411&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Killip 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Killip 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;080&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;548&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;723&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Killip 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;399&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;232&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;825&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Killip 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#44;759&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;031&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;027&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;035&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ICP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;640&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;401&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;921&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo femenino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;322&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;203&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;452&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diabetes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;300&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;189&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;421&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM previo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;478&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;333&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;639&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IECA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;516&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;471&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;565&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Estatinas</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;000</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;409</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;370</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;452</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Betabloqueantes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;381&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;342&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;425&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM anterior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM inferior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;651&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;590&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;718&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM lateral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;322&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;123&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;557&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM combinado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;023&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;530&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;307&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;916&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM en otras localizaciones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;698&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;589&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;828&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM Q&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM no Q&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;498&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;446&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;557&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM con bloqueo de rama izquierda&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;768&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM no especificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Isquemia vascular perif&#233;rica previa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;475&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Constante&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;044&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                  \t\t\t\t  " colspan="2" align="center" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Bajo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;488</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coronariopat&#237;a previa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Tratamiento previo con antiarr&#237;tmicos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Killip 1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Killip 2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Killip 3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;414&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;024&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;878&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Killip 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t">Bloqueo A-V de alto grado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM anterior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM inferior&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;753&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;656&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;864&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM lateral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;438&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;096&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;869&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;384&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM combinado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;490&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;333&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;722&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM en otras localizaciones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;109&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;867&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;729&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;032&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IECA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;792&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;699&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;897&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">ICP&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;450&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0155" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis multivariante para evaluar la probabilidad de aparici&#243;n de arritmias letales</p>"
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          "leyenda" => "<p id="spar0175" class="elsevierStyleSimplePara elsevierViewall">IM&#58; infarto de miocardio&#59; IC&#58; intervalo de confianza&#59; IECA&#58; inhibidores de la enzima convertidora de angiotensina&#59; OR&#58; odds ratio&#46;</p><p id="spar0180" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis realizado con cero p&#233;rdidas&#46; Cox y R<span class="elsevierStyleSup">2</span> Snell<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;158&#59; R<span class="elsevierStyleSup">2</span> Nagelkerke<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;394&#46; Test de Hosmer-Lemeshow<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;680&#46; &#193;rea bajo la curva ROC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;882 &#40;IC 95&#37; 0&#44;840-0&#44;902&#41;&#46;</p>"
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Edad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;050&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;042&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;058&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fumador-a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;716&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;588&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;872&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antecedentes familiares de patolog&#237;a cardiovascular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;580&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;405&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;831&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presi&#243;n arterial sist&#243;lica alterada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;024&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;994&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;990&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;999&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Frecuencia cardiaca alterada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Killip 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Killip 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;788&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;283&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;405&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Killip 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;614&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;526&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;963&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Killip 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#46;404&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#46;517&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#46;093&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM anterior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM inferior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;517&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;438&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;609&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM lateral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;267&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;172&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;886&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;550&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM combinado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;368&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;165&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;820&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM de otras localizaciones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;535&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;331&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;865&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM Q&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM no Q&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;419&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;324&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;542&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM con bloqueo de rama izquierda&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;862&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">1&#44;064&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;529&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;140&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IM no especificado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;464&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;822&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;486&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#44;389&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Constante&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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          "es" => "<p id="spar0170" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis multivariante de la mortalidad para evaluar si el tratamiento combinado betabloqueantes-IECA-estatinas ten&#237;a menor OR que cada tratamiento de forma independiente</p>"
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              "identificador" => "bib0005"
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                    0 => array:2 [
                      "titulo" => "Executive Summary of the Third Report of the National Cholesterol Education Program &#40;NCEP&#41; Expert Panel onDdetection&#44; Evaluation And Treatment of High Blood Cholesterol In Adults &#40;Adult Treatment Panel III&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Expert Panel onDdetection&#44; Evaluation&#44; And Treatment of High Blood Cholesterol In Adults"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11368702"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Quantifying effect of statins on low density lipoprotein cholesterol&#44; ischaemic heart disease&#44; and stroke&#58; systematic review and meta-analysis&#46; Law MR&#44; Wald NJ&#44; Rudnicka AR&#46; BMJ&#46; 2003&#59;326&#58;1407-1408"
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                      "Revista" => array:6 [
                        "tituloSerie" => "Vasc Med"
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                        "paginaInicial" => "289"
                        "paginaFinal" => "290"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15125495"
                            "web" => "Medline"
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                      "doi" => "10.1001/archinte.164.13.1427"
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                  "contribucion" => array:1 [
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                      "titulo" => "Efficacy and safety of cholesterol-lowering treatment&#58; prospective meta-analysis of data from 90&#44;056 participants in 14 randomised trials of statins"
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                      "titulo" => "Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes&#58; the MIRACL study&#58; a randomized controlled trial"
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                    0 => array:2 [
                      "titulo" => "Effect of fluvastatin on ischaemia following acute myocardial infarction&#58; a randomized trial"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Fluvastatin on Risk Diminishment after Acute myocardial infarction study group"
                          "etal" => false
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                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
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                        "paginaFinal" => "1937"
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                0 => array:2 [
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                      "titulo" => "Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes phase Z of the A to Z trial"
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                        0 => array:3 [
                          "colaboracion" => "A to Z Investigators"
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "M&#46;A&#46; Blazing"
                            2 => "S&#46;D&#46; Wiviott"
                            3 => "E&#46;F&#46; Lewis"
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                          "etal" => true
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                          "autores" => array:5 [
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                          "colaboracion" => "National Registry of Myocardial Infarction 4 Investigators"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of statin therapy with outcomes of acute coronary syndromes&#58; the GRACE study"
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                        0 => array:3 [
                          "colaboracion" => "GRACE Investigators"
                          "etal" => true
                          "autores" => array:6 [
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                            5 => "C&#46;B&#46; Granger"
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                        "paginaInicial" => "857"
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                          0 => array:2 [
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