A flagrant case of scientific fraud

Fernández Mondéjar, E.; Ceraso, Hugo

doi:10.1016/j.medine.2011.05.003

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Ocete Hita" "autores" => array:1 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Ocete Hita" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572711000233?idApp=WMIE" "url" => "/21735727/0000003500000006/v1_201212101034/S2173572711000233/v1_201212101034/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "Editorial" "titulo" => "A flagrant case of scientific fraud" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "323" "paginaFinal" => "327" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "E. Fernández Mondéjar, Hugo Ceraso" "autores" => array:2 [ 0 => array:4 [ "nombre" => "E." "apellidos" => "Fernández Mondéjar" "email" => array:1 [ 0 => "enrique.fernandez.mondejar.sspa@juntadeandalucia.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "¿" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Hugo" "apellidos" => "Ceraso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Director de Medicina Intensiva, Servicio de Cuidados Críticos y Urgencias, Hospital Virgen de las Nieves, Granada, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Redactor Jefe de Medicina Intensiva, Unidad de Terapia Intensiva, Hospital Juan A. Fernández, Buenos Aires, Argentina" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Un estrepitoso caso de fraude científico" ] ] "textoCompleto" => "Scientific fraud is a reality, and although its frequency is not known, it is suspected to be far more common than actually detected.Recently, a case has been identified that has had a great impact, and which has required the withdrawal of 88 articles published by Dr. Joachim Blodt in international journals (<a class="elsevierStyleCrossRef" href="#sec0005">Annex 1</a>). The triggering event was a series of denouncing letters, following the publication of an article (Joachim Boldt, Stephan Suttner, Christian Brosch, Andreas Lehmann, Kerstin Röhm, Andinet Mengistu. Anesthesia & Analgesia 2009;109:1752–62), reporting the suspected fraudulent generation of data. This led to an investigation and to the request for proof from Dr. Boldt, who failed to reply, and was thus unable to refute the accusations. The investigation was in turn extended to other publications in which he appeared as first signing author or as co-author, and resulted in the withdrawal of 88 articles—all in the setting of Intensive Care Medicine and Anesthesia.The fundamental reason for the denouncement made by Steven L. Shafer, Editor-in-Chief of Anesthesia & Analgesia, was the lack of approval by the Ethics Committee—in this case the Landesärztekammer Rheinland-Pfalz—and the absence of randomization and of the signing of informed consent on the part of the patients. These publications were considered non-ethical, since their reference to the Ethics Committee had been falsified. At present a committee is conducting an investigation of the data in order to determine whether the findings of the articles are confirmed by the actual results obtained, apart from the issue of the falsification of approval from the Landesärztekammer Rheinland-Pfalz. Although there is information pointing to both the absence of patient randomization and the falsification of certain data, the results of the ongoing investigation to clarify the magnitude of the fraud are still pending. The situation may even have penal implications, as had already occurred in the case in Massachusetts involving the pain specialist Scott Reuben, who spent six months in prison.This unfortunate situation involves aspects that generate morbid curiosity to which we do not wish to contribute; however, we consider that its importance justifies reporting the case to the readership of Medicina Intensiva.We would like to use the opportunity to make some observations, which while already known, are no less pertinent—particularly at this time. We are referring to the reasons or motives, unjustifiable in all cases, which can lead to cases such as this one. The need to uphold personal prestige and ego among investigators may serve as an incentive for such fraudulent practices, though there are also more down to earth reasons such as curricular necessities or the obligation to obtain results that can serve to maintain or obtain institutional support to ensure continuity in the work of many investigators. Undoubtedly, another element to be taken into consideration is the implication of companies with enormous economical interests that can contaminate the relationship between scientists and business entities. In the case we are commenting, Dr. Bolt, whose study focused on hydroxyethyl starch, has conflicts of interest with several companies that produce the drug product. This relationship, while essential and strongly encouraged by the public health administrations, is fundamented upon a fragile balance in which the obligate goal must be the search for truth. However, this objective is sometimes ambiguous, since there are many nuances, probably justified by a lack of biological uniformity, which explains why something that works in certain circumstances may not work in others– the tendency in such cases being to generalize things.It is important to underscore that scientific fraud not only damages the credibility of the journal accepting the manuscript, but also its readers, who may base changes in their clinical practice on the conclusions drawn from the fraudulent study—with the potential risk this poses for patients.To summarize, the present case must serve to reinforce our demands for transparency and for precise formal observation of the ethical norms, which are always the best guarantee of quality research." 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Can J Anesth. 2002;49:1021–8.</li><li class="elsevierStyleListItem" id="lsti0275">-Piper SN, Fent MT, Röhm KD, Maleck WH, Suttner SW, Boldt J. Urapidil does not prevent postanesthetic shivering: a dose-ranging study. Can J Anesth. 2001;48:742–7.</li><li class="elsevierStyleListItem" id="lsti0280">-Piper SN, Boldt J, Schmidt CC, Maleck WH, Brosch C, Kumle B. Hemodynamics, intramucosal pH and regulators of circulation during perioperative epidural analgesia. Can J Anesth. 2000;47:631–7.</li></ul>" "etiqueta" => "A.8" "titulo" => "Canadian Journal of Anesthesia/Journal Canadien d’anesthésie" "identificador" => "sec0045" ] 8 => array:4 [ "apendice" => "<ul class="elsevierStyleList" id="lis0045"><li class="elsevierStyleListItem" id="lsti0285">-Boldt J, Brosch C, Ducke M, Papsdorf M, Lehmann A. Influence of volume therapy with a modern hydroxyethylstarch preparation on kidney function in cardiac surgery patients with compromised renal function: a comparison with human albumin. Crit Care Med. 2007;35:2740–6.</li><li class="elsevierStyleListItem" id="lsti0290">-Boldt J, Brosch C, Piper SN, Suttner S, Lehmann A, Werling C. Influence of prophylactic use of pentoxifylline on postoperative organ function in elderly cardiac surgery patients. Crit Care Med. 2001;29:952–8.</li></ul>" "etiqueta" => "A.9" "titulo" => "Critical Care Medicine" "identificador" => "sec0050" ] 9 => array:4 [ "apendice" => "<ul class="elsevierStyleList" id="lis0050"><li class="elsevierStyleListItem" id="lsti0295">-Triem JG, Röhm KD, Boldt J, Piper SN. Propofol administration systems. Handling, hemodynamics and propofol consumption. Anaesthesist. 2009;58:231–4, 236–9.</li><li class="elsevierStyleListItem" id="lsti0300">-Piper SN, Triem JG, Röhm KD, Kranke P, Maleck WH, Boldt J. Prevention of post-operative nausea and vomiting. Randomised comparison of dolasetron versus dolasetron plus dexamethasone. Anaesthesist. 2003;52:120–6.</li></ul>" "etiqueta" => "A.10" "titulo" => "Der Anästhesist" "identificador" => "sec0055" ] 10 => array:4 [ "apendice" => "<ul class="elsevierStyleList" id="lis0055"><li class="elsevierStyleListItem" id="lsti0305">-Boldt J, Mengistu A. Balanced hydroxyethylstarch preparations: are they all the same? In-vitro thrombelastometry and whole blood aggregometry. Eur J Anaesthesiol. 2009;26:1020–25.</li><li class="elsevierStyleListItem" id="lsti0310">-Mayer J, Boldt J, Triem JG, Schellhaass A, Mengistu AM, Suttner S. Individual titration of propofol plasma target improves anaesthetic stability in patients undergoing major abdominal surgery: a comparison with manually controlled infusion. Eur J Anaesthesiol. 2008;25:741–7.</li><li class="elsevierStyleListItem" id="lsti0315">-Piper SN, Röhm KD, Boldt J, Odermatt B, Maleck WH, Suttner SW. Hepatocellular integrity in patients requiring parenteral nutrition: comparison of structured MCT/LCT vs. a standard MCT/LCT emulsion and a LCT emulsion. Eur J Anaesthesiol. 2008;25:557–65.</li><li class="elsevierStyleListItem" id="lsti0320">-Mengistu AM, Wolf MW, Boldt J, Röhm KD, Suttner SW, Piper SN. Influence of controlled hypotension using esmolol and sodium nitroprusside on natriuretic peptides in patients undergoing endonasal sinus surgery. Eur J Anaesthesiol. 2007;24:529–34.</li><li class="elsevierStyleListItem" id="lsti0325">-Boldt J, Schöllhorn T, Münchbach J, Pabsdorf M. A total balanced volume replacement strategy using a new balanced hydoxyethyl starch preparation (6% HES 130/0.42) in patients undergoing major abdominal surgery. Eur J Anaesthesiol. 2007;24:267–75.</li><li class="elsevierStyleListItem" id="lsti0330">-Röhm KD, Suttner SW, Boldt J, Schöllhorn TA, Piper SN. Insignificant effect of desflurane-fentanylthiopental on hepatocellular integrity – a comparison with total intravenous anaesthesia using propofolremifentanil. Eur J Anaesthesiol. 2005;22:209–14.</li><li class="elsevierStyleListItem" id="lsti0335">-Röhm KD, Schöllhorn TA, Gwosdek MJ, Piper SN, Maleck WH, Boldt J. Do we necessarily need local anaesthetics for venous cannulation? A comparison of different cannula sizes. Eur J Anaesthesiol. 2004;21:214–6.</li><li class="elsevierStyleListItem" id="lsti0340">-Piper SN, Suttner SW, Maleck WH, Kumle B, Haisch G, Boldt J. Effects of sodium nitroprusside-induced controlled hypotension on pancreatic function assessed by pancreatitis-associated protein in patients undergoing radical prostatectomy. Eur J Anaesthesiol. 2002;19:609–13.</li><li class="elsevierStyleListItem" id="lsti0345">-Piper SN, Triem JG, Maleck WH, Fent MT, Hüttner I, Boldt J. Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy. Eur J Anaesthesiol. 2001;18:251–6.</li></ul>" "etiqueta" => "A.11" "titulo" => "European Journal of Anaesthesiology" "identificador" => "sec0060" ] 11 => array:4 [ "apendice" => "<ul class="elsevierStyleList" id="lis0060"><li class="elsevierStyleListItem" id="lsti0350">-Boldt J, Suttner S, Brosch C, Lehmann A, Röhm K, Mengistu A. The influence of a balanced volume replacement concept on inflammation, endothelial activation, and kidney integrity in elderly cardiac surgery patients. Intensive Care Med. 2009;35:462–70.</li><li class="elsevierStyleListItem" id="lsti0355">-Suttner S, Schöllhorn T, Boldt J, Mayer J, Röhm KD, Lang K, Piper SN. Noninvasive assessment of cardiac output using thoracic electrical bioimpedance in hemodynamically stable and unstable patients after cardiac surgery: a comparison with pulmonary artery thermodilution. Intensive Care Med. 2006;32:2053–8.</li><li class="elsevierStyleListItem" id="lsti0360">-Boldt J, Ducke M, Kumle B, Papsdorf M, Zurmeyer EL. Influence of different volume replacement strategieson inflammation and endothelial activation in the elderly undergoing major abdominal surgery. Intensive Care Med. 2004;30:416–22.</li><li class="elsevierStyleListItem" id="lsti0365">-Boldt J, Brenner T, Lehmann A, Lang J, Kumle B, Werling C. Influence of two different volume replacement regimens on renal function in elderly patients undergoing cardiac surgery: comparison of a new starch preparation with gelatin. Intensive Care Med. 2003;29:763–9.</li><li class="elsevierStyleListItem" id="lsti0370">-Boldt J, Brosch C, Suttner S, Piper SN, Lehmann A, Werling C. Prophylactic use of the phospodiesterase III inhibitor enoximone in elderly cardiac surgery patients: effect on hemodynamics, inflammation, and markers of organ function. Intensive Care Med. 2002;28:1462–9.</li></ul>" "etiqueta" => "A.12" "titulo" => "Intensive Care Medicine" "identificador" => "sec0065" ] 12 => array:4 [ "apendice" => "<ul class="elsevierStyleList" id="lis0065"><li class="elsevierStyleListItem" id="lsti0375">-Mengistu AM, Mayer J, Boldt J, Röhm KD, Suttner SW. Usefulness of monitoring platelet function by multiple electrode aggregometry in primary coronary artery bypass surgery. J Cardiothorac Vasc Anesth. 2011;25:42–7.</li><li class="elsevierStyleListItem" id="lsti0380">-Boldt J, Mayer J, Brosch C, Lehmann A, Mengistu A. Volume replacement with a balanced hydroxyethyl starch (HES) preparation in cardiac surgery patients. J Cardiothorac Vasc Anesth. 2010;24:399–407.</li><li class="elsevierStyleListItem" id="lsti0385">-Boldt J, Mengistu A. A new plasma-adapted hydroxyethyl starch preparation: in vitro coagulation studies. J Cardiothorac Vasc Anesth. 2010;24:394–8.</li><li class="elsevierStyleListItem" id="lsti0390">-Mengistu AM, Wolf MW, Boldt J, Röhm KD, Lang J, Piper SN. Evaluation of a new platelet function analyzer in cardiac surgery: a comparison of modified thromboelastography and whole-blood aggregometry. J Cardiothorac Vasc Anesth. 2008;22:40–6.</li><li class="elsevierStyleListItem" id="lsti0395">-Lehmann A, Boldt J, Römpert R, Thaler E, Kumle B, Weisse U. Target-controlled infusion or manually controlled infusion of propofol in high-risk patients with severely reduced left ventricular function. J Cardiothorac Vasc Anesth. 2001;15:445–50.</li><li class="elsevierStyleListItem" id="lsti0400">-Haisch G, Boldt J, Krebs C, Suttner S, Lehmann A, Isgro F. Influence of a new hydroxyethylstarch preparation (HES 130/0.4) on coagulation in cardiac surgical patients. J Cardiothorac Vasc Anesth. 2001;15:316–21.</li><li class="elsevierStyleListItem" id="lsti0405">-Heck M, Kumle B, Boldt J, Lang J, Lehmann A, Saggau W. Electroencephalogram bispectral index predicts hemodynamic and arousal reactions during induction of anesthesia in patients undergoing cardiac surgery. J Cardiothorac Vasc Anesth. 2000;14:693–7.</li><li class="elsevierStyleListItem" id="lsti0410">-Lehmann A, Zeitler C, Thaler E, Isgro F, Boldt J. Comparison of two different anesthesia regimens in patients undergoing aortocoronary bypass grafting surgery: sufentanil-midazolam versus remifentanil-propofol. J Cardiothorac Vasc Anesth. 2000;14:416–20.</li><li class="elsevierStyleListItem" id="lsti0415">-Piper SN, Boldt J, Schmidt CC, Brosch C, Maleck WH, Berchtold C. Influence of dopexamine on hemodynamics, intramucosal pH, and regulators of the macrocirculation and microcirculation in patients undergoing abdominal aortic surgery. J Cardiothorac Vasc Anesth. 2000;14:281–7.</li></ul>" "etiqueta" => "A.13" "titulo" => "Journal of Cardiothoracic and Vascular Anesthesia" "identificador" => "sec0070" ] 13 => array:4 [ "apendice" => "<ul class="elsevierStyleList" id="lis0070"><li class="elsevierStyleListItem" id="lsti0420">-Piper SN, Röhm K, Boldt J, Kranke P, Maleck W, Seifert R, Suttner S. Postoperative nausea and vomiting after surgery for prognathism: not only a question of patients’ comfort. A placebo-controlled comparison of dolasetron and droperidol. J Craniomaxillofac Surg. 2008;36:173–9.</li></ul>" "etiqueta" => "A.14" "titulo" => "Journal of Cranio-Maxillo-Facial Surgery" "identificador" => "sec0075" ] 14 => array:4 [ "apendice" => "<ul class="elsevierStyleList" id="lis0075"><li class="elsevierStyleListItem" id="lsti0425">-Piper SN, Beschmann RB, Mengistu A, Maleck WH, Boldt J, Röhm KD. Postoperative analgosedation with S(+)-ketamine decreases the incidences of postanesthetic shivering and nausea and vomiting after cardiac surgery. Med Sci Monit. 2008;14:PI59–PI65.</li><li class="elsevierStyleListItem" id="lsti0430">-Röhm KD, Riechmann J, Boldt J, Suttner SW, Piper SN. Total intravenous anesthesia with propofol and remifentanil is associated with a nearly twofold higher incidence in postanesthetic shivering than desfluranefentanyl anesthesia. Med Sci Monit. 2006;12:CR452–6.</li></ul>" "etiqueta" => "A.15" "titulo" => "Medical Science Monitor" "identificador" => "sec0080" ] 15 => array:4 [ "apendice" => "<ul class="elsevierStyleList" id="lis0080"><li class="elsevierStyleListItem" id="lsti0435">-Piper SN, Beschmann R, Mengistu A, Kalenka A, Maleck WH, Boldt J, Röhm KD. Assessment of recovery, dreaming, hemodynamics, and satisfaction in postcardiac surgery patients receiving supplementary propofol sedation with S(+)-ketamine. Minerva Anestesiol. 2009;75:363–73.</li></ul>" "etiqueta" => "A.16" "titulo" => "Minerva Anestesiologica" "identificador" => "sec0085" ] 16 => array:4 [ "apendice" => "<ul class="elsevierStyleList" id="lis0085"><li class="elsevierStyleListItem" id="lsti0440">-Piper SN, Kiessling AH, Suttner SW, Ducke M, Boldt J, Röhm KD. Prevention of atrial fibrillation after coronary artery bypass graft surgery using a potassium-magnesium-aspartate solution (Inzolen). Thorac Cardiovasc Surg. 2007;55:418–23.</li></ul>" "etiqueta" => "A.17" "titulo" => "The Thoracic and Cardiovascular Surgeon" "identificador" => "sec0090" ] 17 => array:4 [ "apendice" => "<ul class="elsevierStyleList" id="lis0090"><li class="elsevierStyleListItem" id="lsti0445">-Boldt J, Mengistu A, Seyfert UT, Vogt A, Hellstern P. The impact of a medium molecular weight, low molar substitution hydroxyethyl starch dissolved in a physiologically balanced electrolyte solution on blood coagulation and platelet function in vitro. 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Scientific fraud is a reality, and although its frequency is not known, it is suspected to be far more common than actually detected.

Recently, a case has been identified that has had a great impact, and which has required the withdrawal of 88 articles published by Dr. Joachim Blodt in international journals (Annex 1). The triggering event was a series of denouncing letters, following the publication of an article (Joachim Boldt, Stephan Suttner, Christian Brosch, Andreas Lehmann, Kerstin Röhm, Andinet Mengistu. Anesthesia & Analgesia 2009;109:1752–62), reporting the suspected fraudulent generation of data. This led to an investigation and to the request for proof from Dr. Boldt, who failed to reply, and was thus unable to refute the accusations. The investigation was in turn extended to other publications in which he appeared as first signing author or as co-author, and resulted in the withdrawal of 88 articles—all in the setting of Intensive Care Medicine and Anesthesia.

The fundamental reason for the denouncement made by Steven L. Shafer, Editor-in-Chief of Anesthesia & Analgesia, was the lack of approval by the Ethics Committee—in this case the Landesärztekammer Rheinland-Pfalz—and the absence of randomization and of the signing of informed consent on the part of the patients. These publications were considered non-ethical, since their reference to the Ethics Committee had been falsified. At present a committee is conducting an investigation of the data in order to determine whether the findings of the articles are confirmed by the actual results obtained, apart from the issue of the falsification of approval from the Landesärztekammer Rheinland-Pfalz. Although there is information pointing to both the absence of patient randomization and the falsification of certain data, the results of the ongoing investigation to clarify the magnitude of the fraud are still pending. The situation may even have penal implications, as had already occurred in the case in Massachusetts involving the pain specialist Scott Reuben, who spent six months in prison.

This unfortunate situation involves aspects that generate morbid curiosity to which we do not wish to contribute; however, we consider that its importance justifies reporting the case to the readership of Medicina Intensiva.

We would like to use the opportunity to make some observations, which while already known, are no less pertinent—particularly at this time. We are referring to the reasons or motives, unjustifiable in all cases, which can lead to cases such as this one. The need to uphold personal prestige and ego among investigators may serve as an incentive for such fraudulent practices, though there are also more down to earth reasons such as curricular necessities or the obligation to obtain results that can serve to maintain or obtain institutional support to ensure continuity in the work of many investigators. Undoubtedly, another element to be taken into consideration is the implication of companies with enormous economical interests that can contaminate the relationship between scientists and business entities. In the case we are commenting, Dr. Bolt, whose study focused on hydroxyethyl starch, has conflicts of interest with several companies that produce the drug product. This relationship, while essential and strongly encouraged by the public health administrations, is fundamented upon a fragile balance in which the obligate goal must be the search for truth. However, this objective is sometimes ambiguous, since there are many nuances, probably justified by a lack of biological uniformity, which explains why something that works in certain circumstances may not work in others– the tendency in such cases being to generalize things.

It is important to underscore that scientific fraud not only damages the credibility of the journal accepting the manuscript, but also its readers, who may base changes in their clinical practice on the conclusions drawn from the fraudulent study—with the potential risk this poses for patients.

To summarize, the present case must serve to reinforce our demands for transparency and for precise formal observation of the ethical norms, which are always the best guarantee of quality research.

Annex I

List of articles withdrawn:

A.1

Acta Anaesthesiologica Scandinavica

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Mengistu AM, Mayer J, Boldt J, Röhm KD. Whole-blood aggregometry: are there any limits with regard to platelet counts? Acta Anaesthesiol Scand. 2009;53:72–6.
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Röhm KD, Piper SN, Suttner S, Schuler S, Boldt J. Early recovery, cognitive function and costs of a desflurane inhalational vs. a total intravenous anaesthesia regimen in long-term surgery. Acta Anaesthesiol Scand. 2006;50:14–8.
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Boldt J, Kumle B, Suttner S, Haisch G. Point-of-care (POC) testing of lactate in the intensive care patient. Accuracy, reliability, and costs of different measurement systems. Acta Anaesthesiol Scand. 2001;45:194–9.

A.2

Anaesthesia

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Röhm KD, Riechmann J, Boldt J, Schuler S, Suttner SW, Piper SN. Physostigmine for the prevention of postanaesthetic shivering following general anaesthesia – a placebo-controlled comparison with nefopam. Anaesthesia. 2005;60:433–8.
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Piper SN, Röhm KD, Suttner SW, Maleck WH, Kranke P, Boldt J. A comparison of nefopam and clonidine for the prevention of postanaesthetic shivering: a comparative, double-blind and placebo-controlled dose ranging study. Anaesthesia. 2004;59:559–64.
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Roehm KD, Piper SN, Maleck WH, Boldt J. Prevention of propofol-induced injection pain by remifentanil: a placebo-controlled comparison with lidocaine. Anaesthesia. 2003;58:165–70.
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Piper SN, Kumle B, Maleck WH, Suttner SW, Fent MT, Boldt J. Effects of postoperative sedation with propofol and midazolam on pancreatic function assessed by pancreatitis-associated protein. Anaesthesia. 2001;56:836–40.
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Piper SN, Suttner SW, Schmidt CC, Kumle B, Maleck WH, Boldt J. Acute phase response to nitroprussideinduced controlled hypotension in patients undergoing radical prostatectomy. Anaesthesia. 2000;55:131–6.
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Piper SN, Suttner SW, Schmidt CC, Maleck WH, Kumle B, Boldt J. Nefopam and clonidine in the prevention of postanaesthetic shivering. Aanesthesia. 1999;54:695–9.

A.3

Anästhesiolgie Intensivmedizin Notfallmedizin Schmerztherapie

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Triem JG, Röhm KD, Boldt J, Piper SN. Comparison of a propofol-based anesthesia regimen using optimated-target-controlled-infusion (OTCI) and manually-controlled infusion (MCI) technique. Anasthesiol Intensivmed Notfallmed Schmerzther. 2006;41:150–5.
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Piper SN, Triem JG, Röhm KD, Maleck WH, Schöllhorn TA, Boldt J. ProSeal-laryngeal mask versus endotracheal intubation in patients undergoing gynaecologic laparoscopy. Anasthesiol Intensivmed Notfallmed Schmerzther. 2004;39:132–7.
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Piper SN, Haisch G, Kumle B, Walz GA, Breining T, Mattinger P, Boldt J. Effects of esmolol- and sodium nitroprusside-induced controlled hypotension on hepatocellular integrity in patients undergoing endonasal sinus surgery. Anasthesiol Intensivmed Notfallmed Schmerzther. 2003;38:781–6.
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Röhm KD, Piper SN, Schöllhorn TA, Suttner SW, Maleck WH, Boldt J. Injection pain secondary to propofol-MCT/LCT and propofol-LCT-comparison of prophylaxis with lidocaine. Anasthesiol Intensivmed Notfallmed Schmerzther. 2003;38:643–7.
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Piper SN, Kumle B, Röhm KD, Suttner SW, Lang J, Blome M, Boldt J. Influence of cardiopulmonary bypass (CPB) on the natriuretic peptides ANP and BNP. A comparison between long and short duration of CPB and off pump surgery. Anasthesiol Intensivmed Notfallmed Schmerzther. 2003;38:463–9.
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Piper SN, Röhm KD, Papsdorf M, Maleck WH, Mattinger P, Boldt J. Dolasetron reduces pain on injection of propofol. Anasthesiol Intensivmed Notfallmed Schmerzther. 2002;37:528–31.

A.4

Anesthesia & Analgesia

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Riesmeier A, Schellhaass A, Boldt J, Suttner S. Crystalloid/colloid versus crystalloid intravascular volume administration before spinal anesthesia in elderly patients: the influence on cardiac output and stroke volume. Anesth Analg. 2009;108:650–4.
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Boldt J, Brosch Ch, Röhm K, Lehmann A, Mengistu A, Suttner S. Is albumin administration in hypoalbuminemic elderly cardiac surgery patients of benefit with regard to inflammation, endothelial activation, and long-term kidney function? Anesth Analg. 2008;107:1496–503.
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Mayer J, Boldt J, Wolf MW, Lang J, Suttner S. Cardiac output derived from arterial pressure waveform analysis in patients undergoing cardiac surgery: validity of a second generation device. Anesth Analg. 2008;106:867–72.
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Mengistu AM, Röhm KD, Boldt J, Mayer J, Suttner SW, Piper SN. The influence of aprotinin and tranexamic acid on platelet function and postoperative blood loss in cardiac surgery. Anesth Analg. 2008;107:391–7.
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Boldt J, Wolf M, Mengistu A. A new plasma-adapted hydroxyethylstarch preparation: in vitro coagulation studies using thrombelastography and whole blood aggregometry. Anesth Analg. 2007;104:425–30.
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Mayer J, Boldt J, Schellhaass A, Hiller B, Suttner SW. Bispectral index-guided general anesthesia in combination with thoracic epidural analgesia reduces recovery time in fast-track colon surgery. Anesth Analg. 2007;104:1145–9.
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Boldt J, Schölhorn T, Mayer J, Piper S, Suttner S. The value of an albumin-based intravascular volume replacement strategy in elderly patients undergoing major abdominal surgery. Anesth Analg. 2006;103:191–9.
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Mayer J, Boldt J, Röhm KD, Scheuermann K, Suttner SW. Desflurane anesthesia after sevoflurane inhaled induction reduces severity of emergence agitation in children undergoing minor ear-nose-throat surgery compared with sevoflurane induction and maintenance. Anesth Analg. 2006;102:400–4.
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Suttner S, Lang K, Piper SN, Schultz H, Röhm KD, Boldt J. Continuous intra- and postoperative thoracic epidural analgesia attenuates brain natriuretic peptide release after major abdominal surgery. Anesth Analg. 2005;101:896–903.
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Boldt J, Brosch C, Lehmann A, Suttner S, Isgro F. The prophylactic use of the beta-blocker esmolol in combination with phosphodiesterase III inhibitor enoximone in elderly cardiac surgery patients. Anesth Analg. 2004;99:1009–17.
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Suttner S, Piper SN, Kumle B, Lang K, Röhm KD, Isgro F, Boldt J. The influence of allogeneic red blood cell transfusion compared with 100% oxygen ventilation on systemic oxygen transport and skeletal muscle oxygen tension after cardiac surgery. Anesth Analg. 2004;99:2–11.
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Boldt J, Brenner T, Lang J, Kumle B, Isgro F. Kidney-specific proteins in elderly patients undergoing cardiac surgery with cardiopulmonary bypass. Anesth Analg. 2003;97:1582–9.
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Lehmann A, Karzau J, Boldt J, Thaler E, Lang J, Isgro F. Bispectral index-guided anesthesia in patients undergoing aortocoronary bypass grafting. Anesth Analg. 2003;96:336–43.
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Boldt J, Haisch G, Suttner S, Kumle B, Schellhase F. Are lactated Ringer's solution and normal saline solution equal with regard to coagulation? Anesth Analg. 2002;94:378–84.
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Lehmann A, Boldt J, Thaler E, Piper S, Weisse U. Bispectral index in patients with target-controlled or manually-controlled infusion of propofol. Anesth Analg. 2002;95:639–44.
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Piper SN, Röhm KD, Maleck WH, Fent MT, Suttner SW, Boldt J. Dolasetron for preventing postanesthetic shivering. Anesth Analg. 2002;94:106–11.
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Lang K, Boldt J, Suttner S, Haisch G. Colloids versus crystalloids and tissue oxygen tension in patients undergoing major abdominal surgery. Anesth Analg. 2001;93:405–9.
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Haisch G, Boldt J, Krebs C, Kumle B, Suttner S, Schulz A. The influence of intravascular volume therapy with a new hydroxyethyl starch preparation (6% HES 130/0.4) on coagulation in patients undergoing major abdominal surgery. Anesth Analg. 2001;92:565–71.
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Piper SN, Maleck WH, Boldt J, Suttner SW, Schmidt CC, Reich DG. A comparison of urapidil, clonidine, meperidine and placebo in preventing postanesthetic shivering. Anesth Analg. 2000;90:954–7.
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Suttner SW, Schmidt CC, Boldt J, Hüttner I, Kumle B, Piper SN. Low-flow desflurane and sevoflurane anesthesia minimally affect hepatic integrity and function in elderly patients. Anesth Analg. 2000;91:206–12.
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Suttner S, Boldt J, Schmidt C, Piper S, Kumle B. Cost analysis of target-controlled infusion-based anesthesia compared with standard anesthesia regimens. Anesth Analg. 1999;88:77–82.
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Suttner SW, Boldt J, Schmidt CC, Piper SN, Schuster P, Kumle B. The effects of sodium nitroprussideinduced hypotension on splanchnic perfusion and hepatocellular integrity. Anesth Analg. 1999;89:1371–7.

A.5

Anesthesiology

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Suttner SW, Lang K, Boldt J, Kumle B, Maleck WH, Piper SN. The influence of hyperoxic ventilation during sodium nitroprusside-induced hypotension on skeletal muscle tissue oxygen tension. Anesthesiology. 2002;96:1103–8.

A.6

Annals of Thoracic Surgery

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Kumle B, Boldt J, Suttner SW, Piper SN, Lehmann A, Blome M. Influence of prolonged cardiopulmonary bypass times on splanchnic perfusion and markers of splanchnic organ function. Ann Thorac Surg. 2003;75:1558–64.
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Boldt J, Brosch C, Lehmann A, Haisch G, Lang J, Isgro F. Prophylactic use of pentoxifylline on inflammation in elderly cardiac surgery patients. Ann Thorac Surg. 2001;71:1524–9.

A.7

British Journal of Aanesthesia

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Mayer J, Boldt J, Beschmann R, Stephan A, Suttner S. Uncalibrated arterial pressure waveform analysis for less-invasive cardiac output determination in obese patients undergoing cardiac surgery. Br J Anaesth. 2009;103:185–90.
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Suttner S, Boldt J, Mengistu A, Lang K, Mayer J. Influence of continuous perioperative beta-blockade in combination with phosphodiesterase inhibition on haemodynamics and myocardial ischaemia in high-risk vascular surgery patients. Br J Anaesth. 2009;102:597–607.
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Boldt J, Suttner S, Brosch C, Lehmann A, Mengistu A. Influence on coagulation of a potato-derived hydroxethylstarch (HES 130/0.42) and a maize-derived hydroxethylstarch (HES 130/0.4) in patients undergoing cardiac surgery. Br J Anaesth. 2009;102:191–7.
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Boldt J, Brosch Ch, Röhm K, Papsdorf M, Mengistu A. Comparison of the effects of gelatin and a modern hydroxyethyl starch solution on renal function and inflammatory response in elderly cardiac surgery patients. Br J Anaesth. 2008;100:457–64.
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Mayer J, Boldt J, Schöllhorn T, Röhm KD, Mengistu AM, Suttner S. Semi-invasive monitoring of cardiac output by a new device using arterial pressure waveform analysis: a comparison with intermittent pulmonary artery thermodilution in patients undergoing cardiac surgery. Br J Anaesth. 2007;98:176–82.
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Piper SN, Röhm KD, Boldt J, Faust KL, Maleck WH, Kranke P, Suttner SW. Inspired oxygen fraction of 0.8 compared with 0.4 does not further reduce postoperative nausea and vomiting in dolasetron-treated patients undergoing laparoscopic cholecystectomy. Br J Anaesth. 2006;97:647–53.
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Boldt J, Haisch G, Suttner S, Kumle B, Schellhaass A. Effects of a new modified, balanced hydroxyethyl starch preparation (Hextend) on measures of coagulation. Br J Anaesth. 2002;89:722–8.
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Boldt J, Hüttner I, Suttner S, Kumle B, Piper SN, Berchthold G. Changes of haemostasis in patients undergoing major abdominal surgery--is there a difference between elderly and younger patients? Br J Anaesth. 2001;87:435–40.
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Suttner SW, Piper SN, Lang K, Hüttner I, Kumle B, Boldt J. Cerebral effects and blood sparing efficiency of sodium nitroprusside-induced hypotension alone and in combination with acute normovolaemic haemodilution. Br J Anaesth. 2001;87:699–705.
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Hüttner I, Boldt J, Haisch G, Suttner S, Kumle B, Schulz H. Influence of different colloids on molecular markers of haemostasis and platelet function in patients undergoing major abdominal surgery. Br J Anaesth. 2000;85:417–23.
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Boldt J, Weber A, Mailer K, Papsdorf M, Schuster P. Acute normovolaemic haemodilution vs. controlled hypotension for reducing the use of allogeneic blood in patients undergoing radical prostatectomy. Br J Anaesth. 1999;82:170–4.

A.8

Canadian Journal of Anesthesia/Journal Canadien d’anesthésie

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Piper SN, Kumle B, Maleck WH, Kiessling AH, Lehmann A, Röhm KD, Suttner SW, Boldt J. Diltiazem may preserve renal tubular integrity after cardiac surgery. Can J Anesth. 2003;50:285–92.
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Lang K, Suttner S, Boldt J, Kumle B, Nagel D. Volume replacement with HES 130/0.4 may reduce the inflammatory response in patients undergoing major abdominal surgery. Can J Anesth. 2003;50:1009–16.
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Piper SN, Suttner SW, Röhm KD, Maleck WH, Larbig E, Boldt J. Dolasetron, but not metoclopramide prevents nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Can J Anesth. 2002;49:1021–8.
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Piper SN, Fent MT, Röhm KD, Maleck WH, Suttner SW, Boldt J. Urapidil does not prevent postanesthetic shivering: a dose-ranging study. Can J Anesth. 2001;48:742–7.
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Piper SN, Boldt J, Schmidt CC, Maleck WH, Brosch C, Kumle B. Hemodynamics, intramucosal pH and regulators of circulation during perioperative epidural analgesia. Can J Anesth. 2000;47:631–7.

A.9

Critical Care Medicine

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Boldt J, Brosch C, Ducke M, Papsdorf M, Lehmann A. Influence of volume therapy with a modern hydroxyethylstarch preparation on kidney function in cardiac surgery patients with compromised renal function: a comparison with human albumin. Crit Care Med. 2007;35:2740–6.
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Boldt J, Brosch C, Piper SN, Suttner S, Lehmann A, Werling C. Influence of prophylactic use of pentoxifylline on postoperative organ function in elderly cardiac surgery patients. Crit Care Med. 2001;29:952–8.

A.10

Der Anästhesist

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Triem JG, Röhm KD, Boldt J, Piper SN. Propofol administration systems. Handling, hemodynamics and propofol consumption. Anaesthesist. 2009;58:231–4, 236–9.
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Piper SN, Triem JG, Röhm KD, Kranke P, Maleck WH, Boldt J. Prevention of post-operative nausea and vomiting. Randomised comparison of dolasetron versus dolasetron plus dexamethasone. Anaesthesist. 2003;52:120–6.

A.11

European Journal of Anaesthesiology

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Boldt J, Mengistu A. Balanced hydroxyethylstarch preparations: are they all the same? In-vitro thrombelastometry and whole blood aggregometry. Eur J Anaesthesiol. 2009;26:1020–25.
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Mayer J, Boldt J, Triem JG, Schellhaass A, Mengistu AM, Suttner S. Individual titration of propofol plasma target improves anaesthetic stability in patients undergoing major abdominal surgery: a comparison with manually controlled infusion. Eur J Anaesthesiol. 2008;25:741–7.
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Piper SN, Röhm KD, Boldt J, Odermatt B, Maleck WH, Suttner SW. Hepatocellular integrity in patients requiring parenteral nutrition: comparison of structured MCT/LCT vs. a standard MCT/LCT emulsion and a LCT emulsion. Eur J Anaesthesiol. 2008;25:557–65.
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Mengistu AM, Wolf MW, Boldt J, Röhm KD, Suttner SW, Piper SN. Influence of controlled hypotension using esmolol and sodium nitroprusside on natriuretic peptides in patients undergoing endonasal sinus surgery. Eur J Anaesthesiol. 2007;24:529–34.
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Boldt J, Schöllhorn T, Münchbach J, Pabsdorf M. A total balanced volume replacement strategy using a new balanced hydoxyethyl starch preparation (6% HES 130/0.42) in patients undergoing major abdominal surgery. Eur J Anaesthesiol. 2007;24:267–75.
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Röhm KD, Suttner SW, Boldt J, Schöllhorn TA, Piper SN. Insignificant effect of desflurane-fentanylthiopental on hepatocellular integrity – a comparison with total intravenous anaesthesia using propofolremifentanil. Eur J Anaesthesiol. 2005;22:209–14.
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Röhm KD, Schöllhorn TA, Gwosdek MJ, Piper SN, Maleck WH, Boldt J. Do we necessarily need local anaesthetics for venous cannulation? A comparison of different cannula sizes. Eur J Anaesthesiol. 2004;21:214–6.
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Piper SN, Suttner SW, Maleck WH, Kumle B, Haisch G, Boldt J. Effects of sodium nitroprusside-induced controlled hypotension on pancreatic function assessed by pancreatitis-associated protein in patients undergoing radical prostatectomy. Eur J Anaesthesiol. 2002;19:609–13.
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Piper SN, Triem JG, Maleck WH, Fent MT, Hüttner I, Boldt J. Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy. Eur J Anaesthesiol. 2001;18:251–6.

A.12

Intensive Care Medicine

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Boldt J, Suttner S, Brosch C, Lehmann A, Röhm K, Mengistu A. The influence of a balanced volume replacement concept on inflammation, endothelial activation, and kidney integrity in elderly cardiac surgery patients. Intensive Care Med. 2009;35:462–70.
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Suttner S, Schöllhorn T, Boldt J, Mayer J, Röhm KD, Lang K, Piper SN. Noninvasive assessment of cardiac output using thoracic electrical bioimpedance in hemodynamically stable and unstable patients after cardiac surgery: a comparison with pulmonary artery thermodilution. Intensive Care Med. 2006;32:2053–8.
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Boldt J, Ducke M, Kumle B, Papsdorf M, Zurmeyer EL. Influence of different volume replacement strategieson inflammation and endothelial activation in the elderly undergoing major abdominal surgery. Intensive Care Med. 2004;30:416–22.
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Boldt J, Brenner T, Lehmann A, Lang J, Kumle B, Werling C. Influence of two different volume replacement regimens on renal function in elderly patients undergoing cardiac surgery: comparison of a new starch preparation with gelatin. Intensive Care Med. 2003;29:763–9.
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Boldt J, Brosch C, Suttner S, Piper SN, Lehmann A, Werling C. Prophylactic use of the phospodiesterase III inhibitor enoximone in elderly cardiac surgery patients: effect on hemodynamics, inflammation, and markers of organ function. Intensive Care Med. 2002;28:1462–9.

A.13

Journal of Cardiothoracic and Vascular Anesthesia

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Mengistu AM, Mayer J, Boldt J, Röhm KD, Suttner SW. Usefulness of monitoring platelet function by multiple electrode aggregometry in primary coronary artery bypass surgery. J Cardiothorac Vasc Anesth. 2011;25:42–7.
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Boldt J, Mayer J, Brosch C, Lehmann A, Mengistu A. Volume replacement with a balanced hydroxyethyl starch (HES) preparation in cardiac surgery patients. J Cardiothorac Vasc Anesth. 2010;24:399–407.
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Boldt J, Mengistu A. A new plasma-adapted hydroxyethyl starch preparation: in vitro coagulation studies. J Cardiothorac Vasc Anesth. 2010;24:394–8.
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Mengistu AM, Wolf MW, Boldt J, Röhm KD, Lang J, Piper SN. Evaluation of a new platelet function analyzer in cardiac surgery: a comparison of modified thromboelastography and whole-blood aggregometry. J Cardiothorac Vasc Anesth. 2008;22:40–6.
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Lehmann A, Boldt J, Römpert R, Thaler E, Kumle B, Weisse U. Target-controlled infusion or manually controlled infusion of propofol in high-risk patients with severely reduced left ventricular function. J Cardiothorac Vasc Anesth. 2001;15:445–50.
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Haisch G, Boldt J, Krebs C, Suttner S, Lehmann A, Isgro F. Influence of a new hydroxyethylstarch preparation (HES 130/0.4) on coagulation in cardiac surgical patients. J Cardiothorac Vasc Anesth. 2001;15:316–21.
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Heck M, Kumle B, Boldt J, Lang J, Lehmann A, Saggau W. Electroencephalogram bispectral index predicts hemodynamic and arousal reactions during induction of anesthesia in patients undergoing cardiac surgery. J Cardiothorac Vasc Anesth. 2000;14:693–7.
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Lehmann A, Zeitler C, Thaler E, Isgro F, Boldt J. Comparison of two different anesthesia regimens in patients undergoing aortocoronary bypass grafting surgery: sufentanil-midazolam versus remifentanil-propofol. J Cardiothorac Vasc Anesth. 2000;14:416–20.
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Piper SN, Boldt J, Schmidt CC, Brosch C, Maleck WH, Berchtold C. Influence of dopexamine on hemodynamics, intramucosal pH, and regulators of the macrocirculation and microcirculation in patients undergoing abdominal aortic surgery. J Cardiothorac Vasc Anesth. 2000;14:281–7.

A.14

Journal of Cranio-Maxillo-Facial Surgery

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Piper SN, Röhm K, Boldt J, Kranke P, Maleck W, Seifert R, Suttner S. Postoperative nausea and vomiting after surgery for prognathism: not only a question of patients’ comfort. A placebo-controlled comparison of dolasetron and droperidol. J Craniomaxillofac Surg. 2008;36:173–9.

A.15

Medical Science Monitor

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Piper SN, Beschmann RB, Mengistu A, Maleck WH, Boldt J, Röhm KD. Postoperative analgosedation with S(+)-ketamine decreases the incidences of postanesthetic shivering and nausea and vomiting after cardiac surgery. Med Sci Monit. 2008;14:PI59–PI65.
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Röhm KD, Riechmann J, Boldt J, Suttner SW, Piper SN. Total intravenous anesthesia with propofol and remifentanil is associated with a nearly twofold higher incidence in postanesthetic shivering than desfluranefentanyl anesthesia. Med Sci Monit. 2006;12:CR452–6.

A.16

Minerva Anestesiologica

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Piper SN, Beschmann R, Mengistu A, Kalenka A, Maleck WH, Boldt J, Röhm KD. Assessment of recovery, dreaming, hemodynamics, and satisfaction in postcardiac surgery patients receiving supplementary propofol sedation with S(+)-ketamine. Minerva Anestesiol. 2009;75:363–73.

A.17

The Thoracic and Cardiovascular Surgeon

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Piper SN, Kiessling AH, Suttner SW, Ducke M, Boldt J, Röhm KD. Prevention of atrial fibrillation after coronary artery bypass graft surgery using a potassium-magnesium-aspartate solution (Inzolen). Thorac Cardiovasc Surg. 2007;55:418–23.

A.18

Vox Sanguinis

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Boldt J, Mengistu A, Seyfert UT, Vogt A, Hellstern P. The impact of a medium molecular weight, low molar substitution hydroxyethyl starch dissolved in a physiologically balanced electrolyte solution on blood coagulation and platelet function in vitro. Vox Sang. 2007;93:139–44.

☆

Please cite this article as: Fernández Mondéjar E, Ceraso H. Un estrepitoso caso de fraude científico. Med Intensiva. 2011;35:323–7.

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