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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Durante la pandemia de gripe A&#44; se publicaron diferentes comunicaciones&#46; No obstante&#44; el perfil cl&#237;nico de los pacientes cr&#237;ticos afectados por este virus durante este segundo brote epid&#233;mico es poco conocido&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo&#44; observacional y multic&#233;ntrico realizado en 148 UCI espa¿nolas entre las semanas epidemiol&#243;gicas 50 de 2010 y 4 de 2011&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a los primeros 300 pacientes ingresados en UCI con infecci&#243;n confirmada por An&#47;H1N1&#46; La media de edad fue de 49 &#91;38&#8211;58&#93; a¿nos y el 62&#37; eran varones&#46; La media de APACHE II fue 16&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;5&#44; con una media de SOFA de 6&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;5&#46; El 76&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>228&#41; de los pacientes presentaron alguna comorbilidad&#44; 111 &#40;37&#44;4&#37;&#41; eran obesos y 59 &#40;20&#37;&#41; presentaban EPOC&#46; La presentaci&#243;n cl&#237;nica m&#225;s habitual fue la neumon&#237;a viral con hipoxemia severa &#40;65&#44;7&#37;&#59; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>197&#41;&#44; mientras que se observ&#243; coinfecci&#243;n en 54 pacientes &#40;18&#37;&#41;&#46; Todos recibieron tratamiento antiviral&#44; de forma emp&#237;rica en 194 &#40;65&#44;3&#37;&#41;&#46; S&#243;lo 53 pacientes &#40;17&#44;6&#37;&#41; recibieron tratamiento antiviral precoz&#59; 22 pacientes &#40;7&#44;3&#37;&#41; estaban vacunados&#46; Cumplieron su evoluci&#243;n en UCI 200 pacientes&#44; y fallecieron 67 de ellos&#46; La enfermedad hematol&#243;gica&#44; la gravedad general&#44; los infiltrados en la radiograf&#237;a de t&#243;rax y la necesidad de ventilaci&#243;n mec&#225;nica fueron las variables asociadas de forma independiente con la mortalidad&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los pacientes cr&#237;ticos ingresados en UCI durante el brote estacional de gripe pospand&#233;mica evidenciaron escaso nivel de vacunaci&#243;n&#44; mayor frecuencia de comorbilidades&#44; un nivel gravedad m&#225;s elevado&#44; mayor incidencia de neumon&#237;a viral primaria y una mortalidad superior en comparaci&#243;n con lo observado durante la pandemia de 2009&#46;</p>"
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First influenza season after the 2009 pandemic influenza: report of the first 300 ICU admissions in Spain
Primera epidemia de gripe estacional después de la pandemia por gripe A en 2009: descripción de los primeros 300 ingresos en UCI espa¿nolas
A. Rodrígueza,
Corresponding author
ahr1161@yahoo.es

Corresponding author.
, I. Martin-Loechesa, J. Bonastreb, P. Olaecheac, F. Álvarez-Lermad, R. Zaragozae, J. Guerrerof, J. Blancog, F. Gordoh, F. Pozoi, J. Lorentej, J. Carratalák, M. Corderol, J. Rellom, A. Estebani, C. Leónn, SEMICYUC-CIBERES-REIPI working group *
a Hospital Joan XXIII, Critical Care Department, IISPV, URV, CIBER Enfermedades Respiratorias, Tarragona, Spain
b Hospital La Fe, Critical Care Department, CIBER Enfermedades Respiratorias, Valencia, Spain
c Hospital Galdakao-Usansolo, Critical Care Department, CIBER Enfermedades Respiratorias, Vizcaya, Spain
d Hospital del Mar, Critical Care Department, CIBER Enfermedades Respiratorias, Barcelona, Spain
e Hospital Dr. Peset, Critical Care Department, Valencia, Spain
f Hospital Gregorio Mara¿nón, Critical Care Department, CIBER Enfermedades Respiratorias, Madrid, Spain
g Hospital Rio Hortega, Critical Care Department, CIBER Enfermedades Respiratorias, Valladolid, Spain
h Hospital del Henares, Critical Care Department, Madrid, Spain
i Pulmonology Department, Hospital 12 de Octubre, Madrid, Spain
j Hospital de Getafe, Critical Care Department, CIBER Enfermedades Respiratorias, Madird, Spain
k Hospital de Bellvitge, Infectious Disease Department, REIPI, L’Hospitalet de Llobregat, Barcelona, Spain
l Hospital Virgen del Rocío, Infectious Disease Department, REIPI, Sevilla, Spain
m Hospital Vall d’Hebron, Critical Care Department, IRVH, CIBER Enfermedades Respiratorias, Barcelona, Spain
n Critical Care Department, Hospital Universitario de Valme, Sevilla, Spain
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      "es" => array:1 [
        "titulo" => "Primera epidemia de gripe estacional despu&#233;s de la pandemia por gripe A en 2009&#58; descripci&#243;n de los primeros 300 ingresos en UCI espa¿nolas"
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    "fechaRecibido" => "2011-03-08"
    "fechaAceptado" => "2011-03-10"
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          "clase" => "keyword"
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            0 => "An&#47;H1N1 influenza"
            1 => "Critically ill patients"
            2 => "Prognostic"
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          "titulo" => "Palabras clave"
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          "palabras" => array:3 [
            0 => "Nueva Gripe An&#47;H1N1"
            1 => "Pacientes cr&#237;ticos"
            2 => "Pron&#243;stico"
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">During the 2009 influenza pandemic&#44; several reports were published&#44; nevertheless&#44; data on the clinical profiles of critically ill patients with the new virus infection during this second outbreak are still lacking&#46;</p> <span class="elsevierStyleSectionTitle">Material methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective&#44; observational&#44; multi-center study conducted in 148 Spanish intensive care units &#40;ICU&#41; during epidemiological weeks 50&#8211;52 of 2010 and weeks 1&#8211;4 of 2011&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Three hundred patients admitted to an intensive care unit &#40;ICU&#41; with confirmed An&#47;H1N1 infection were analyzed&#46; The median age was 49 years &#91;IQR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>38&#8211;58&#93; and 62&#37; were male&#46; The mean APACHE II score was 16&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;5 and the mean SOFA score was 6&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;5 on admission&#46; Comorbidities were present in 76&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>228&#41; of cases and 111 &#40;37&#46;4&#37;&#41; patients were reportedly obese and 59 &#40;20&#37;&#41; were COPD&#46; The main presentation was viral pneumonia with severe hypoxemia in 65&#46;7&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>197&#41; of the patients whereas co-infection was identified in 54 &#40;18&#37;&#41; patients&#46; All patients received antiviral treatment and initiated empirically in 194 patients &#40;65&#46;3&#37;&#41;&#44; however only 53 patients &#40;17&#46;6&#37;&#41; received early antiviral treatment&#46; Vaccination was only administered in 22 &#40;7&#46;3&#37;&#41; patients&#46; Sixty-seven of 200 patients with ICU discharge died&#46; Haematological disease&#44; severity of illness&#44; infiltrates in chest X-ray and need for mechanical ventilation were variables independently associated with ICU mortality&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In patients admitted to the ICU in the post-pandemic seasonal influenza outbreak vaccination was poorly implemented and appear to have higher frequency of severe comorbidities&#44; severity of illness&#44; incidence of primary viral pneumonia and increased mortality when compared with those observed in the 2009 pandemic outbreak&#46;</p>"
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      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Durante la pandemia de gripe A&#44; se publicaron diferentes comunicaciones&#46; No obstante&#44; el perfil cl&#237;nico de los pacientes cr&#237;ticos afectados por este virus durante este segundo brote epid&#233;mico es poco conocido&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo&#44; observacional y multic&#233;ntrico realizado en 148 UCI espa¿nolas entre las semanas epidemiol&#243;gicas 50 de 2010 y 4 de 2011&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a los primeros 300 pacientes ingresados en UCI con infecci&#243;n confirmada por An&#47;H1N1&#46; La media de edad fue de 49 &#91;38&#8211;58&#93; a¿nos y el 62&#37; eran varones&#46; La media de APACHE II fue 16&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;5&#44; con una media de SOFA de 6&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;5&#46; El 76&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>228&#41; de los pacientes presentaron alguna comorbilidad&#44; 111 &#40;37&#44;4&#37;&#41; eran obesos y 59 &#40;20&#37;&#41; presentaban EPOC&#46; La presentaci&#243;n cl&#237;nica m&#225;s habitual fue la neumon&#237;a viral con hipoxemia severa &#40;65&#44;7&#37;&#59; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>197&#41;&#44; mientras que se observ&#243; coinfecci&#243;n en 54 pacientes &#40;18&#37;&#41;&#46; Todos recibieron tratamiento antiviral&#44; de forma emp&#237;rica en 194 &#40;65&#44;3&#37;&#41;&#46; S&#243;lo 53 pacientes &#40;17&#44;6&#37;&#41; recibieron tratamiento antiviral precoz&#59; 22 pacientes &#40;7&#44;3&#37;&#41; estaban vacunados&#46; Cumplieron su evoluci&#243;n en UCI 200 pacientes&#44; y fallecieron 67 de ellos&#46; La enfermedad hematol&#243;gica&#44; la gravedad general&#44; los infiltrados en la radiograf&#237;a de t&#243;rax y la necesidad de ventilaci&#243;n mec&#225;nica fueron las variables asociadas de forma independiente con la mortalidad&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los pacientes cr&#237;ticos ingresados en UCI durante el brote estacional de gripe pospand&#233;mica evidenciaron escaso nivel de vacunaci&#243;n&#44; mayor frecuencia de comorbilidades&#44; un nivel gravedad m&#225;s elevado&#44; mayor incidencia de neumon&#237;a viral primaria y una mortalidad superior en comparaci&#243;n con lo observado durante la pandemia de 2009&#46;</p>"
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