array:23 [
  "pii" => "S2173572711700297"
  "issn" => "21735727"
  "doi" => "10.1016/S2173-5727(11)70029-7"
  "estado" => "S300"
  "fechaPublicacion" => "2011-01-01"
  "aid" => "70029"
  "copyright" => "Elsevier y Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Med Intensiva. 2011;35:226-31"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2285
    "formatos" => array:3 [
      "EPUB" => 134
      "HTML" => 884
      "PDF" => 1267
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173572711700303"
    "issn" => "21735727"
    "doi" => "10.1016/S2173-5727(11)70030-3"
    "estado" => "S300"
    "fechaPublicacion" => "2011-01-01"
    "aid" => "70030"
    "copyright" => "Elsevier y Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Med Intensiva. 2011;35:232-5"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1520
      "formatos" => array:3 [
        "EPUB" => 128
        "HTML" => 649
        "PDF" => 743
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "The future of intensive medicine"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "232"
          "paginaFinal" => "235"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "El futuro de la Medicina Intensiva"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "E. Palencia Herrejón, G. González Díaz, J. Mancebo Cortés"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "E."
              "apellidos" => "Palencia Herrejón"
            ]
            1 => array:2 [
              "nombre" => "G."
              "apellidos" => "González Díaz"
            ]
            2 => array:2 [
              "nombre" => "J."
              "apellidos" => "Mancebo Cortés"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572711700303?idApp=WMIE"
    "url" => "/21735727/0000003500000004/v1_201212101039/S2173572711700303/v1_201212101039/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S2173572711700285"
    "issn" => "21735727"
    "doi" => "10.1016/S2173-5727(11)70028-5"
    "estado" => "S300"
    "fechaPublicacion" => "2011-01-01"
    "aid" => "70028"
    "copyright" => "Elsevier y Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Med Intensiva. 2011;35:217-25"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1571
      "formatos" => array:3 [
        "EPUB" => 136
        "HTML" => 600
        "PDF" => 835
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Impact of primary and intravascular catheter-related bacteremia due to coagulase-negative staphylococci in critically ill patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "217"
          "paginaFinal" => "225"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Impacto de la bacteriemia primaria y relacionada con cat&#233;ter intravascular causada por <span class="elsevierStyleItalic">Staphylococcus</span> coagulasa negativo en pacientes cr&#237;ticos"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46;M&#46; Olaechea, F&#46; &#193;lvarez-Lerma, M&#46; Palomar, J&#46; Insausti, M&#46;J&#46; L&#243;pez-Pueyo, A&#46; Mart&#237;nez-Pell&#250;s, M&#46;L&#46; Cant&#243;n"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "P&#46;M&#46;"
              "apellidos" => "Olaechea"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "&#193;lvarez-Lerma"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Palomar"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Insausti"
            ]
            4 => array:2 [
              "nombre" => "M&#46;J&#46;"
              "apellidos" => "L&#243;pez-Pueyo"
            ]
            5 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mart&#237;nez-Pell&#250;s"
            ]
            6 => array:2 [
              "nombre" => "M&#46;L&#46;"
              "apellidos" => "Cant&#243;n"
            ]
            7 => array:1 [
              "colaborador" => "the ENVIN-HELICS Group"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572711700285?idApp=WMIE"
    "url" => "/21735727/0000003500000004/v1_201212101039/S2173572711700285/v1_201212101039/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "Nebulized colistin treatment of multi-resistant <span class="elsevierStyleItalic">Acinetobacter baumannii</span> pulmonary infection in critical ill patients"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "226"
        "paginaFinal" => "231"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46;J&#46; P&#233;rez-Pedrero, M&#46; S&#225;nchez-Casado, S&#46; Rodr&#237;guez-Villar"
        "autores" => array:3 [
          0 => array:2 [
            "nombre" => "M&#46;J&#46;"
            "apellidos" => "P&#233;rez-Pedrero"
          ]
          1 => array:4 [
            "nombre" => "M&#46;"
            "apellidos" => "S&#225;nchez-Casado"
            "email" => array:1 [
              0 => "marcel55&#64;terra&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:2 [
            "nombre" => "S&#46;"
            "apellidos" => "Rodr&#237;guez-Villar"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Medicina Intensiva&#44; Complejo Hospitalario de Toledo&#44; Toledo&#44; Spain"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Utilizaci&#243;n de la colistina nebulizada en la colonizaci&#243;n e infecci&#243;n respiratoria por <span class="elsevierStyleItalic">Acinetobacter baumannii</span> en pacientes cr&#237;ticos"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2010-10-14"
    "fechaAceptado" => "2011-01-19"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec10632"
          "palabras" => array:4 [
            0 => "Colistin"
            1 => "Nebulized colistin"
            2 => "Multi-resistant germs"
            3 => "<span class="elsevierStyleItalic">Acinetobacter baumannii</span>"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec10633"
          "palabras" => array:4 [
            0 => "Colistina"
            1 => "Colistina nebulizada"
            2 => "Microorganismos multirresistentes"
            3 => "<span class="elsevierStyleItalic">Acinetobacter baumannii</span>"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyze the efficacy of nebulized colistin in the microbiological eradication and clinical improvement of patients with pulmonary infection by multi-resistant <span class="elsevierStyleItalic">Acinetobacter baumannii</span> &#40;MAB&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective study&#46;</p> <span class="elsevierStyleSectionTitle">Setting</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Intensive Care Unit of a Tertiary hospital&#46;</p> <span class="elsevierStyleSectionTitle">Patients</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Hospitalized patients on invasive mechanical ventilation with positive MAB cultures of the airway&#46;</p> <span class="elsevierStyleSectionTitle">Interventions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">All received treatment with colistin &#40;CL&#41;&#46; Nosocomial pneumonia &#40;NP&#41; or Tracheobronchitis &#40;TB&#41; was determined according to routine criteria and colonization &#40;CO&#41; was determined in the case of a positive culture in the absence of infection criteria&#46; Three groups of patients were defined&#58; those treated with nebulized CL&#44; those treated with IV CL and those treated with IV CL plus nebulized CL&#46;</p> <span class="elsevierStyleSectionTitle">Main measurements</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristics&#46; Microbiological eradication and clinical recovery were evaluated according to routine criteria&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">83 patients were studied&#44; 54 of whom were treated&#44; with the following diagnoses&#58; 15 &#40;27&#46;8&#37;&#41; with NP&#44; 16 &#40;29&#46;6&#37;&#41; with TB and 23 patients &#40;42&#46;6&#37;&#41; with CO&#46; Nebulized CL was used in 36 patients &#40;66&#46;7&#37;&#41;&#58; 66&#46;7&#37; of which for CO&#44; 33&#46;3&#37; in treatment for TB and in no case of NP&#46; In 61&#46;1&#37; of the patients&#44; IV CL was used&#58; 22&#46;2&#37; of which for CO&#44; 38&#46;9&#37; for TB and 38&#46;9&#37; in NP&#46; The combination of IV CL and nebulized CL was used in 15 patients &#40;27&#46;8&#37;&#41;&#58; 5 patients &#40;33&#46;3&#37;&#41; CO&#44; 2 patients &#40;13&#46;3&#37;&#41; TB and 8 patients &#40;53&#46;3&#37;&#41; NP&#46; Microbiological eradication was achieved in 32 patients &#40;59&#46;3&#37;&#41;&#44; with the following distribution&#58; 8 &#40;47&#46;1&#37;&#41; with IV CL&#44; 15 &#40;83&#46;3&#37;&#41; with nebulized CL and 9 patients &#40;69&#46;2&#37;&#41; with a combination of IV CL and nebulized CL&#46; Clinical recovery was achieved in 42 patients &#40;77&#46;8&#37;&#41;&#58; 12 &#40;80&#37;&#41; with IV CL&#44; 18 &#40;94&#46;7&#37;&#41; with nebulized CL and 12 &#40;85&#46;7&#37;&#41; with a combination of nebulized and IV CL&#46; These differences were not significant&#46; In the group of patients with infection due to TB and NP &#40;31 patients&#44; 57&#46;4&#37;&#41;&#44; microbiological eradication was achieved in 5 patients &#40;100&#37;&#41; treated with nebulized CL and in 6 of the 9 patients &#40;42&#46;9&#37;&#41; treated with IV CL&#44; the difference being significant &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; Clinical recovery in this group was 100&#37; &#40;6 patients&#41; treated with nebulized CL and 75&#37; &#40;9 of the 12 patients&#41; in the IV CL group&#46; This difference was not significant&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Our study suggests that treatment with colistin in patients with pulmonary infection with multi-resistant <span class="elsevierStyleItalic">Acinetobacter baumannii</span> could be more efficient if it were to be administrated solely nebulized or in combination with IV colistin rather than administered solely intravenously&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Evaluar la eficacia de la colistina nebulizada en la erradicaci&#243;n microbiol&#243;gica y la mejor&#237;a cl&#237;nica de pacientes con Acinetobacter baumannii en v&#237;as respiratorias&#46;</p> <span class="elsevierStyleSectionTitle">Dise&#241;o</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo&#46;</p> <span class="elsevierStyleSectionTitle">&#193;mbito</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Servicio de medicina intensiva en hospital terciario&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Pacientes ingresados en ventilaci&#243;n mec&#225;nica invasiva con cultivos positivos en v&#237;a a&#233;rea para <span class="elsevierStyleItalic">A&#46; baumannii</span> multirresistente&#46;</p> <span class="elsevierStyleSectionTitle">Intervenciones</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Todos recibieron tratamiento con colistina &#40;CL&#41;&#46; Se determin&#243; neumon&#237;a nosocomial &#40;NN&#41; o traqueobronquitis &#40;TB&#41; seg&#250;n criterios habituales y colonizaci&#243;n &#40;CO&#41; si hab&#237;a cultivo positivo en ausencia de criterios de infecci&#243;n&#46; Se definieron 3 grupos de pacientes&#58; tratados con CL nebulizada&#44; con CL i&#46;v&#46; y con CL i&#46;v&#46; m&#225;s nebulizada&#46;</p> <span class="elsevierStyleSectionTitle">Variables de inter&#233;s</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas basales&#46; Se consider&#243; erradicaci&#243;n microbiol&#243;gica y curaci&#243;n cl&#237;nica seg&#250;n criterios habituales&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Se estudi&#243; a 83 pacientes&#59; 54 fueron tratados&#44; con los diagn&#243;sticos&#58; 15 &#40;27&#44;8&#37;&#41; con NN&#44; 16 &#40;29&#44;6&#37;&#41; con TB y 23 pacientes &#40;42&#44;6&#37;&#41; con CO&#46; La CL nebulizada fue utilizada en 36 pacientes &#40;66&#44;7&#37;&#41;&#58; en el 66&#44;7&#37; en CO&#44; el 33&#44;3&#37; en tratamiento de TB y en ning&#250;n caso de NN&#46; En el 61&#44;1&#37; de los pacientes se utiliz&#243; CL i&#46;v&#46;&#58; en la CO en el 22&#44;2&#37;&#44; en la TB en el 38&#44;9&#37; y en las NN en el 38&#44;9&#37;&#46; La combinaci&#243;n de CL i&#46;v&#46; m&#225;s nebulizada fue utilizada en 15 pacientes &#40;27&#44;8&#37;&#41;&#44; que se emple&#243;&#58; 5 &#40;33&#44;3&#37;&#41; CO&#44; 2 &#40;13&#44;3&#37;&#41; TB y 8 &#40;53&#44;3&#37;&#41; NN&#46; La erradicaci&#243;n microbiol&#243;gica se consigui&#243; en 32 pacientes &#40;59&#44;3&#37;&#41;&#44; con la distribuci&#243;n&#58; 8 &#40;47&#44;1&#37;&#41; con CL i&#46;v&#46;&#44; 15 &#40;83&#44;3&#37;&#41; con CL nebulizadas y 9 pacientes &#40;69&#44;2&#37;&#41; con la combinaci&#243;n CL i&#46;v&#46; m&#225;s nebulizada&#46; La curaci&#243;n cl&#237;nica se consigue en 42 pacientes &#40;77&#44;8&#37;&#41;&#58; 12 &#40;80&#37;&#41; con CL i&#46;v&#46;&#44; 18 &#40;94&#44;7&#37;&#41; con CL nebulizada y 12 &#40;85&#44;7&#37;&#41; con la combinaci&#243;n de CL nebulizada e intravenosa&#46; Estas diferencias no fueron significativas&#46; En el grupo de pacientes con infecci&#243;n por TB y NN &#40;31 pacientes&#44; 57&#44;4&#37;&#41; la erradicaci&#243;n microbiol&#243;gica se consigui&#243; en 5 pacientes &#40;100&#37;&#41; tratados con CL nebulizada y en 6 de 14 &#40;42&#44;9&#37;&#41; tratados con CL i&#46;v&#46;&#59; esta diferencia fue significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; La curaci&#243;n cl&#237;nica en este grupo fue del 100&#37; &#40;6 pacientes&#41; tratados con CL nebulizada y del 75&#37; &#40;9 de 12&#41; en el grupo de CL i&#46;v&#46; Esta diferencia no fue significativa&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Nuestro estudio se&#241;ala que el tratamiento con colistina en pacientes con infecci&#243;n pulmonar por A&#46; baumannii multirresistente podr&#237;a ser m&#225;s eficaz si se administra nebulizada o en combinaci&#243;n con colistina i&#46;v&#46; que si se administra de forma intravenosa solamente&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:16 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiresistant Acinetobacter baumannii infections&#58; epidemiology and management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Garnacho-Montero"
                            1 => "R&#46; Amaya-Villar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/QCO.0b013e32833ae38b"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Infect Dis"
                        "fecha" => "2010"
                        "volumen" => "23"
                        "paginaInicial" => "332"
                        "paginaFinal" => "339"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20581674"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multidrug-resistant Gramnegative infections&#58; the use of colistin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;S&#46; Michalopoulos"
                            1 => "D&#46;C&#46; Karatza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1586/eri.10.88"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Anti Infect Ther"
                        "fecha" => "2010"
                        "volumen" => "8"
                        "paginaInicial" => "1009"
                        "paginaFinal" => "1017"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20818945"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacokinetics of inhaled colistin in patients with cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Ratjen"
                            1 => "E&#46; Rietschel"
                            2 => "D&#46; Kasel"
                            3 => "D&#46; Kasel"
                            4 => "R&#46; Schwiertz"
                            5 => "K&#46; Starke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/jac/dki461"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Antimicrob Chemother"
                        "fecha" => "2006"
                        "volumen" => "57"
                        "paginaInicial" => "306"
                        "paginaFinal" => "311"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16396919"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aerosolized colistin for the treatment of nosocomial pneumonia due to multidrug-resistant gramnegative bacteria in patients without cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Michalopoulos"
                            1 => "S&#46;K&#46; Kasiakou"
                            2 => "Z&#46; Mastora"
                            3 => "K&#46; Rellos"
                            4 => "A&#46;M&#46; Kapaskelis"
                            5 => "M&#46;E&#46; Falagas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/cc3020"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care"
                        "fecha" => "2005"
                        "volumen" => "9"
                        "paginaInicial" => "R53"
                        "paginaFinal" => "R59"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15693967"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guidelines for the management of adults with hospital-acquired&#44; ventilator-associated&#44; and healthcareassociated pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "American Thoracic Society&#47;Infectious Disease Society of America"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200405-644ST"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2005"
                        "volumen" => "171"
                        "paginaInicial" => "388"
                        "paginaFinal" => "416"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15699079"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of aerosolized antimicrobials in the treatment of ventilator-associated pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Dhand"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Care"
                        "fecha" => "2007"
                        "volumen" => "52"
                        "paginaInicial" => "866"
                        "paginaFinal" => "884"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17594731"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhaled anti-infective agents&#58; emphasis on colistin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Michalopoulos"
                            1 => "E&#46; Papadakis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s15010-009-9148-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Infection"
                        "fecha" => "2010"
                        "volumen" => "38"
                        "paginaInicial" => "81"
                        "paginaFinal" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20191398"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aerosolized antibiotics in critically ill ventilated patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46;B&#46; Palmer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MCC.0b013e328330abcf"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Crit Care"
                        "fecha" => "2009"
                        "volumen" => "15"
                        "paginaInicial" => "413"
                        "paginaFinal" => "418"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19657273"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Parenteral and inhaled colistin for treatment of ventilator-associated pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;K&#46; Linden"
                            1 => "D&#46;L&#46; Paterson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/504485"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2006"
                        "volumen" => "43"
                        "paginaInicial" => "S89"
                        "paginaFinal" => "S94"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16894521"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nebulized and intravenous colistin in expeimenal neumonia caused by Pseudomonas aeruginosa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Q&#46; Lu"
                            1 => "C&#46; Girardi"
                            2 => "M&#46; Zhang"
                            3 => "B&#46; Bouhemad"
                            4 => "K&#46; Louchahi"
                            5 => "O&#46; Petitijean"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-010-1879-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2010"
                        "volumen" => "36"
                        "paginaInicial" => "1147"
                        "paginaFinal" => "1155"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20397007"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nebulized colistin in the treatment of neumonia due to multidrug-resistant Acinetobacter baumannii and seudomonas aeruginosa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;L&#46; Kwa"
                            1 => "C&#46; Loh"
                            2 => "J&#46;G&#46; Low"
                            3 => "A&#46; Kurup"
                            4 => "V&#46;H&#46; Tam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/432583"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2005"
                        "volumen" => "41"
                        "paginaInicial" => "754"
                        "paginaFinal" => "757"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16080101"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Salvage treatment of pneumonia and initial treatment of tracheobronchitis caused by multidrug-resistant gram-negative bacilli with inhaled polymyxin B"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;H&#46; Pereira"
                            1 => "P&#46;R&#46; Muller"
                            2 => "A&#46;S&#46; Levin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.diagmicrobio.2007.01.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diagn Microbiol Infect Dis"
                        "fecha" => "2007"
                        "volumen" => "58"
                        "paginaInicial" => "235"
                        "paginaFinal" => "240"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17350201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aerosolized colistin as adjunctive treatment of ventilator-associated pneumonia due to multidrug-resistant Gram-negative bacteria&#58; A prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Michalopoulos"
                            1 => "D&#46; Fotakis"
                            2 => "S&#46; Virtzili"
                            3 => "C&#46; Vletsas"
                            4 => "S&#46; Raftopoulou"
                            5 => "Z&#46; Mastora"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Resp Med"
                        "fecha" => "2008"
                        "volumen" => "102"
                        "paginaInicial" => "407"
                        "paginaFinal" => "412"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhaled colistin as monotherapy for multidrugresistant gram &#40;&#8211;&#41; nosocomial pneumonia&#58; A case series"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;E&#46; Falagas"
                            1 => "I&#46;I&#46; Siempos"
                            2 => "P&#46;I&#46; Rafailidis"
                            3 => "I&#46;P&#46; Korbila"
                            4 => "E&#46; Ioannidou"
                            5 => "A&#46; Michalopoulos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1586/17476348.2016.1121103"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respiratory Medicine"
                        "fecha" => "2009"
                        "volumen" => "10"
                        "paginaInicial" => "1"
                        "paginaFinal" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26567613"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhaled colistin as adjunctive therapy to intravenous colistin for the treatment of microbiologically documented ventilator-associated pneumonia&#58; a comparative cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46;P&#46; Korbila"
                            1 => "A&#46; Michalopoulos"
                            2 => "P&#46;I&#46; Rafailidis"
                            3 => "D&#46; Nikita"
                            4 => "G&#46; Samonis"
                            5 => "M&#46;E&#46; Falagas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1469-0691.2009.03040.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Microbiol Infect"
                        "fecha" => "2010"
                        "volumen" => "16"
                        "paginaInicial" => "1230"
                        "paginaFinal" => "1236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19732088"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiolog&#237;a e impacto de las infecciones nosocomiales"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Olaechea"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medin.2009.11.013"
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2010"
                        "volumen" => "34"
                        "paginaInicial" => "256"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20096484"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735727/0000003500000004/v1_201212101039/S2173572711700297/v1_201212101039/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "420"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Original"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735727/0000003500000004/v1_201212101039/S2173572711700297/v1_201212101039/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572711700297?idApp=WMIE"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Nebulized colistin treatment of multi-resistant Acinetobacter baumannii pulmonary infection in critical ill patients
Utilización de la colistina nebulizada en la colonización e infección respiratoria por Acinetobacter baumannii en pacientes críticos
M.J. Pérez-Pedrero, M. Sánchez-Casado
Corresponding author
marcel55@terra.es

Corresponding author.
, S. Rodríguez-Villar
Servicio de Medicina Intensiva, Complejo Hospitalario de Toledo, Toledo, Spain
Read
1630
Times
was read the article
1020
Total PDF
610
Total HTML
Share statistics
 array:23 [
  "pii" => "S2173572711700297"
  "issn" => "21735727"
  "doi" => "10.1016/S2173-5727(11)70029-7"
  "estado" => "S300"
  "fechaPublicacion" => "2011-01-01"
  "aid" => "70029"
  "copyright" => "Elsevier y Sociedad Espa&#241;ola de Medicina Intensiva&#44; Critica y Unidades Coronarias"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Med Intensiva. 2011;35:226-31"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2285
    "formatos" => array:3 [
      "EPUB" => 134
      "HTML" => 884
      "PDF" => 1267
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173572711700303"
    "issn" => "21735727"
    "doi" => "10.1016/S2173-5727(11)70030-3"
    "estado" => "S300"
    "fechaPublicacion" => "2011-01-01"
    "aid" => "70030"
    "copyright" => "Elsevier y Sociedad Espa&#241;ola de Medicina Intensiva&#44; Critica y Unidades Coronarias"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Med Intensiva. 2011;35:232-5"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1520
      "formatos" => array:3 [
        "EPUB" => 128
        "HTML" => 649
        "PDF" => 743
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "The future of intensive medicine"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "232"
          "paginaFinal" => "235"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "El futuro de la Medicina Intensiva"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "E&#46; Palencia Herrej&#243;n, G&#46; Gonz&#225;lez D&#237;az, J&#46; Mancebo Cort&#233;s"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Palencia Herrej&#243;n"
            ]
            1 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Gonz&#225;lez D&#237;az"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Mancebo Cort&#233;s"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572711700303?idApp=WMIE"
    "url" => "/21735727/0000003500000004/v1_201212101039/S2173572711700303/v1_201212101039/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S2173572711700285"
    "issn" => "21735727"
    "doi" => "10.1016/S2173-5727(11)70028-5"
    "estado" => "S300"
    "fechaPublicacion" => "2011-01-01"
    "aid" => "70028"
    "copyright" => "Elsevier y Sociedad Espa&#241;ola de Medicina Intensiva&#44; Critica y Unidades Coronarias"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Med Intensiva. 2011;35:217-25"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1571
      "formatos" => array:3 [
        "EPUB" => 136
        "HTML" => 600
        "PDF" => 835
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Impact of primary and intravascular catheter-related bacteremia due to coagulase-negative staphylococci in critically ill patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "217"
          "paginaFinal" => "225"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Impacto de la bacteriemia primaria y relacionada con cat&#233;ter intravascular causada por <span class="elsevierStyleItalic">Staphylococcus</span> coagulasa negativo en pacientes cr&#237;ticos"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46;M&#46; Olaechea, F&#46; &#193;lvarez-Lerma, M&#46; Palomar, J&#46; Insausti, M&#46;J&#46; L&#243;pez-Pueyo, A&#46; Mart&#237;nez-Pell&#250;s, M&#46;L&#46; Cant&#243;n"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "P&#46;M&#46;"
              "apellidos" => "Olaechea"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "&#193;lvarez-Lerma"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Palomar"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Insausti"
            ]
            4 => array:2 [
              "nombre" => "M&#46;J&#46;"
              "apellidos" => "L&#243;pez-Pueyo"
            ]
            5 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mart&#237;nez-Pell&#250;s"
            ]
            6 => array:2 [
              "nombre" => "M&#46;L&#46;"
              "apellidos" => "Cant&#243;n"
            ]
            7 => array:1 [
              "colaborador" => "the ENVIN-HELICS Group"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572711700285?idApp=WMIE"
    "url" => "/21735727/0000003500000004/v1_201212101039/S2173572711700285/v1_201212101039/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "Nebulized colistin treatment of multi-resistant <span class="elsevierStyleItalic">Acinetobacter baumannii</span> pulmonary infection in critical ill patients"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "226"
        "paginaFinal" => "231"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46;J&#46; P&#233;rez-Pedrero, M&#46; S&#225;nchez-Casado, S&#46; Rodr&#237;guez-Villar"
        "autores" => array:3 [
          0 => array:2 [
            "nombre" => "M&#46;J&#46;"
            "apellidos" => "P&#233;rez-Pedrero"
          ]
          1 => array:4 [
            "nombre" => "M&#46;"
            "apellidos" => "S&#225;nchez-Casado"
            "email" => array:1 [
              0 => "marcel55&#64;terra&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:2 [
            "nombre" => "S&#46;"
            "apellidos" => "Rodr&#237;guez-Villar"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Medicina Intensiva&#44; Complejo Hospitalario de Toledo&#44; Toledo&#44; Spain"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Utilizaci&#243;n de la colistina nebulizada en la colonizaci&#243;n e infecci&#243;n respiratoria por <span class="elsevierStyleItalic">Acinetobacter baumannii</span> en pacientes cr&#237;ticos"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2010-10-14"
    "fechaAceptado" => "2011-01-19"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec10632"
          "palabras" => array:4 [
            0 => "Colistin"
            1 => "Nebulized colistin"
            2 => "Multi-resistant germs"
            3 => "<span class="elsevierStyleItalic">Acinetobacter baumannii</span>"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec10633"
          "palabras" => array:4 [
            0 => "Colistina"
            1 => "Colistina nebulizada"
            2 => "Microorganismos multirresistentes"
            3 => "<span class="elsevierStyleItalic">Acinetobacter baumannii</span>"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyze the efficacy of nebulized colistin in the microbiological eradication and clinical improvement of patients with pulmonary infection by multi-resistant <span class="elsevierStyleItalic">Acinetobacter baumannii</span> &#40;MAB&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective study&#46;</p> <span class="elsevierStyleSectionTitle">Setting</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Intensive Care Unit of a Tertiary hospital&#46;</p> <span class="elsevierStyleSectionTitle">Patients</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Hospitalized patients on invasive mechanical ventilation with positive MAB cultures of the airway&#46;</p> <span class="elsevierStyleSectionTitle">Interventions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">All received treatment with colistin &#40;CL&#41;&#46; Nosocomial pneumonia &#40;NP&#41; or Tracheobronchitis &#40;TB&#41; was determined according to routine criteria and colonization &#40;CO&#41; was determined in the case of a positive culture in the absence of infection criteria&#46; Three groups of patients were defined&#58; those treated with nebulized CL&#44; those treated with IV CL and those treated with IV CL plus nebulized CL&#46;</p> <span class="elsevierStyleSectionTitle">Main measurements</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristics&#46; Microbiological eradication and clinical recovery were evaluated according to routine criteria&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">83 patients were studied&#44; 54 of whom were treated&#44; with the following diagnoses&#58; 15 &#40;27&#46;8&#37;&#41; with NP&#44; 16 &#40;29&#46;6&#37;&#41; with TB and 23 patients &#40;42&#46;6&#37;&#41; with CO&#46; Nebulized CL was used in 36 patients &#40;66&#46;7&#37;&#41;&#58; 66&#46;7&#37; of which for CO&#44; 33&#46;3&#37; in treatment for TB and in no case of NP&#46; In 61&#46;1&#37; of the patients&#44; IV CL was used&#58; 22&#46;2&#37; of which for CO&#44; 38&#46;9&#37; for TB and 38&#46;9&#37; in NP&#46; The combination of IV CL and nebulized CL was used in 15 patients &#40;27&#46;8&#37;&#41;&#58; 5 patients &#40;33&#46;3&#37;&#41; CO&#44; 2 patients &#40;13&#46;3&#37;&#41; TB and 8 patients &#40;53&#46;3&#37;&#41; NP&#46; Microbiological eradication was achieved in 32 patients &#40;59&#46;3&#37;&#41;&#44; with the following distribution&#58; 8 &#40;47&#46;1&#37;&#41; with IV CL&#44; 15 &#40;83&#46;3&#37;&#41; with nebulized CL and 9 patients &#40;69&#46;2&#37;&#41; with a combination of IV CL and nebulized CL&#46; Clinical recovery was achieved in 42 patients &#40;77&#46;8&#37;&#41;&#58; 12 &#40;80&#37;&#41; with IV CL&#44; 18 &#40;94&#46;7&#37;&#41; with nebulized CL and 12 &#40;85&#46;7&#37;&#41; with a combination of nebulized and IV CL&#46; These differences were not significant&#46; In the group of patients with infection due to TB and NP &#40;31 patients&#44; 57&#46;4&#37;&#41;&#44; microbiological eradication was achieved in 5 patients &#40;100&#37;&#41; treated with nebulized CL and in 6 of the 9 patients &#40;42&#46;9&#37;&#41; treated with IV CL&#44; the difference being significant &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; Clinical recovery in this group was 100&#37; &#40;6 patients&#41; treated with nebulized CL and 75&#37; &#40;9 of the 12 patients&#41; in the IV CL group&#46; This difference was not significant&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Our study suggests that treatment with colistin in patients with pulmonary infection with multi-resistant <span class="elsevierStyleItalic">Acinetobacter baumannii</span> could be more efficient if it were to be administrated solely nebulized or in combination with IV colistin rather than administered solely intravenously&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Evaluar la eficacia de la colistina nebulizada en la erradicaci&#243;n microbiol&#243;gica y la mejor&#237;a cl&#237;nica de pacientes con Acinetobacter baumannii en v&#237;as respiratorias&#46;</p> <span class="elsevierStyleSectionTitle">Dise&#241;o</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo&#46;</p> <span class="elsevierStyleSectionTitle">&#193;mbito</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Servicio de medicina intensiva en hospital terciario&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Pacientes ingresados en ventilaci&#243;n mec&#225;nica invasiva con cultivos positivos en v&#237;a a&#233;rea para <span class="elsevierStyleItalic">A&#46; baumannii</span> multirresistente&#46;</p> <span class="elsevierStyleSectionTitle">Intervenciones</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Todos recibieron tratamiento con colistina &#40;CL&#41;&#46; Se determin&#243; neumon&#237;a nosocomial &#40;NN&#41; o traqueobronquitis &#40;TB&#41; seg&#250;n criterios habituales y colonizaci&#243;n &#40;CO&#41; si hab&#237;a cultivo positivo en ausencia de criterios de infecci&#243;n&#46; Se definieron 3 grupos de pacientes&#58; tratados con CL nebulizada&#44; con CL i&#46;v&#46; y con CL i&#46;v&#46; m&#225;s nebulizada&#46;</p> <span class="elsevierStyleSectionTitle">Variables de inter&#233;s</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas basales&#46; Se consider&#243; erradicaci&#243;n microbiol&#243;gica y curaci&#243;n cl&#237;nica seg&#250;n criterios habituales&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Se estudi&#243; a 83 pacientes&#59; 54 fueron tratados&#44; con los diagn&#243;sticos&#58; 15 &#40;27&#44;8&#37;&#41; con NN&#44; 16 &#40;29&#44;6&#37;&#41; con TB y 23 pacientes &#40;42&#44;6&#37;&#41; con CO&#46; La CL nebulizada fue utilizada en 36 pacientes &#40;66&#44;7&#37;&#41;&#58; en el 66&#44;7&#37; en CO&#44; el 33&#44;3&#37; en tratamiento de TB y en ning&#250;n caso de NN&#46; En el 61&#44;1&#37; de los pacientes se utiliz&#243; CL i&#46;v&#46;&#58; en la CO en el 22&#44;2&#37;&#44; en la TB en el 38&#44;9&#37; y en las NN en el 38&#44;9&#37;&#46; La combinaci&#243;n de CL i&#46;v&#46; m&#225;s nebulizada fue utilizada en 15 pacientes &#40;27&#44;8&#37;&#41;&#44; que se emple&#243;&#58; 5 &#40;33&#44;3&#37;&#41; CO&#44; 2 &#40;13&#44;3&#37;&#41; TB y 8 &#40;53&#44;3&#37;&#41; NN&#46; La erradicaci&#243;n microbiol&#243;gica se consigui&#243; en 32 pacientes &#40;59&#44;3&#37;&#41;&#44; con la distribuci&#243;n&#58; 8 &#40;47&#44;1&#37;&#41; con CL i&#46;v&#46;&#44; 15 &#40;83&#44;3&#37;&#41; con CL nebulizadas y 9 pacientes &#40;69&#44;2&#37;&#41; con la combinaci&#243;n CL i&#46;v&#46; m&#225;s nebulizada&#46; La curaci&#243;n cl&#237;nica se consigue en 42 pacientes &#40;77&#44;8&#37;&#41;&#58; 12 &#40;80&#37;&#41; con CL i&#46;v&#46;&#44; 18 &#40;94&#44;7&#37;&#41; con CL nebulizada y 12 &#40;85&#44;7&#37;&#41; con la combinaci&#243;n de CL nebulizada e intravenosa&#46; Estas diferencias no fueron significativas&#46; En el grupo de pacientes con infecci&#243;n por TB y NN &#40;31 pacientes&#44; 57&#44;4&#37;&#41; la erradicaci&#243;n microbiol&#243;gica se consigui&#243; en 5 pacientes &#40;100&#37;&#41; tratados con CL nebulizada y en 6 de 14 &#40;42&#44;9&#37;&#41; tratados con CL i&#46;v&#46;&#59; esta diferencia fue significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; La curaci&#243;n cl&#237;nica en este grupo fue del 100&#37; &#40;6 pacientes&#41; tratados con CL nebulizada y del 75&#37; &#40;9 de 12&#41; en el grupo de CL i&#46;v&#46; Esta diferencia no fue significativa&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Nuestro estudio se&#241;ala que el tratamiento con colistina en pacientes con infecci&#243;n pulmonar por A&#46; baumannii multirresistente podr&#237;a ser m&#225;s eficaz si se administra nebulizada o en combinaci&#243;n con colistina i&#46;v&#46; que si se administra de forma intravenosa solamente&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:16 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiresistant Acinetobacter baumannii infections&#58; epidemiology and management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Garnacho-Montero"
                            1 => "R&#46; Amaya-Villar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/QCO.0b013e32833ae38b"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Infect Dis"
                        "fecha" => "2010"
                        "volumen" => "23"
                        "paginaInicial" => "332"
                        "paginaFinal" => "339"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20581674"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multidrug-resistant Gramnegative infections&#58; the use of colistin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;S&#46; Michalopoulos"
                            1 => "D&#46;C&#46; Karatza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1586/eri.10.88"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Anti Infect Ther"
                        "fecha" => "2010"
                        "volumen" => "8"
                        "paginaInicial" => "1009"
                        "paginaFinal" => "1017"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20818945"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacokinetics of inhaled colistin in patients with cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Ratjen"
                            1 => "E&#46; Rietschel"
                            2 => "D&#46; Kasel"
                            3 => "D&#46; Kasel"
                            4 => "R&#46; Schwiertz"
                            5 => "K&#46; Starke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/jac/dki461"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Antimicrob Chemother"
                        "fecha" => "2006"
                        "volumen" => "57"
                        "paginaInicial" => "306"
                        "paginaFinal" => "311"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16396919"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aerosolized colistin for the treatment of nosocomial pneumonia due to multidrug-resistant gramnegative bacteria in patients without cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Michalopoulos"
                            1 => "S&#46;K&#46; Kasiakou"
                            2 => "Z&#46; Mastora"
                            3 => "K&#46; Rellos"
                            4 => "A&#46;M&#46; Kapaskelis"
                            5 => "M&#46;E&#46; Falagas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/cc3020"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care"
                        "fecha" => "2005"
                        "volumen" => "9"
                        "paginaInicial" => "R53"
                        "paginaFinal" => "R59"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15693967"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guidelines for the management of adults with hospital-acquired&#44; ventilator-associated&#44; and healthcareassociated pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "American Thoracic Society&#47;Infectious Disease Society of America"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200405-644ST"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2005"
                        "volumen" => "171"
                        "paginaInicial" => "388"
                        "paginaFinal" => "416"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15699079"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of aerosolized antimicrobials in the treatment of ventilator-associated pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Dhand"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Care"
                        "fecha" => "2007"
                        "volumen" => "52"
                        "paginaInicial" => "866"
                        "paginaFinal" => "884"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17594731"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhaled anti-infective agents&#58; emphasis on colistin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Michalopoulos"
                            1 => "E&#46; Papadakis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s15010-009-9148-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Infection"
                        "fecha" => "2010"
                        "volumen" => "38"
                        "paginaInicial" => "81"
                        "paginaFinal" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20191398"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aerosolized antibiotics in critically ill ventilated patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46;B&#46; Palmer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MCC.0b013e328330abcf"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Crit Care"
                        "fecha" => "2009"
                        "volumen" => "15"
                        "paginaInicial" => "413"
                        "paginaFinal" => "418"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19657273"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Parenteral and inhaled colistin for treatment of ventilator-associated pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;K&#46; Linden"
                            1 => "D&#46;L&#46; Paterson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/504485"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2006"
                        "volumen" => "43"
                        "paginaInicial" => "S89"
                        "paginaFinal" => "S94"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16894521"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nebulized and intravenous colistin in expeimenal neumonia caused by Pseudomonas aeruginosa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Q&#46; Lu"
                            1 => "C&#46; Girardi"
                            2 => "M&#46; Zhang"
                            3 => "B&#46; Bouhemad"
                            4 => "K&#46; Louchahi"
                            5 => "O&#46; Petitijean"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-010-1879-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2010"
                        "volumen" => "36"
                        "paginaInicial" => "1147"
                        "paginaFinal" => "1155"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20397007"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nebulized colistin in the treatment of neumonia due to multidrug-resistant Acinetobacter baumannii and seudomonas aeruginosa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;L&#46; Kwa"
                            1 => "C&#46; Loh"
                            2 => "J&#46;G&#46; Low"
                            3 => "A&#46; Kurup"
                            4 => "V&#46;H&#46; Tam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/432583"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2005"
                        "volumen" => "41"
                        "paginaInicial" => "754"
                        "paginaFinal" => "757"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16080101"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Salvage treatment of pneumonia and initial treatment of tracheobronchitis caused by multidrug-resistant gram-negative bacilli with inhaled polymyxin B"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;H&#46; Pereira"
                            1 => "P&#46;R&#46; Muller"
                            2 => "A&#46;S&#46; Levin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.diagmicrobio.2007.01.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diagn Microbiol Infect Dis"
                        "fecha" => "2007"
                        "volumen" => "58"
                        "paginaInicial" => "235"
                        "paginaFinal" => "240"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17350201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aerosolized colistin as adjunctive treatment of ventilator-associated pneumonia due to multidrug-resistant Gram-negative bacteria&#58; A prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Michalopoulos"
                            1 => "D&#46; Fotakis"
                            2 => "S&#46; Virtzili"
                            3 => "C&#46; Vletsas"
                            4 => "S&#46; Raftopoulou"
                            5 => "Z&#46; Mastora"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Resp Med"
                        "fecha" => "2008"
                        "volumen" => "102"
                        "paginaInicial" => "407"
                        "paginaFinal" => "412"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhaled colistin as monotherapy for multidrugresistant gram &#40;&#8211;&#41; nosocomial pneumonia&#58; A case series"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;E&#46; Falagas"
                            1 => "I&#46;I&#46; Siempos"
                            2 => "P&#46;I&#46; Rafailidis"
                            3 => "I&#46;P&#46; Korbila"
                            4 => "E&#46; Ioannidou"
                            5 => "A&#46; Michalopoulos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1586/17476348.2016.1121103"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respiratory Medicine"
                        "fecha" => "2009"
                        "volumen" => "10"
                        "paginaInicial" => "1"
                        "paginaFinal" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26567613"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhaled colistin as adjunctive therapy to intravenous colistin for the treatment of microbiologically documented ventilator-associated pneumonia&#58; a comparative cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46;P&#46; Korbila"
                            1 => "A&#46; Michalopoulos"
                            2 => "P&#46;I&#46; Rafailidis"
                            3 => "D&#46; Nikita"
                            4 => "G&#46; Samonis"
                            5 => "M&#46;E&#46; Falagas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1469-0691.2009.03040.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Microbiol Infect"
                        "fecha" => "2010"
                        "volumen" => "16"
                        "paginaInicial" => "1230"
                        "paginaFinal" => "1236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19732088"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiolog&#237;a e impacto de las infecciones nosocomiales"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Olaechea"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medin.2009.11.013"
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2010"
                        "volumen" => "34"
                        "paginaInicial" => "256"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20096484"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735727/0000003500000004/v1_201212101039/S2173572711700297/v1_201212101039/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "420"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Original"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735727/0000003500000004/v1_201212101039/S2173572711700297/v1_201212101039/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572711700297?idApp=WMIE"
]
Article information
ISSN: 21735727
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 8 14 22
2024 October 42 75 117
2024 September 51 52 103
2024 August 53 73 126
2024 July 39 67 106
2024 June 37 50 87
2024 May 45 46 91
2024 April 44 52 96
2024 March 36 47 83
2024 February 27 67 94
2024 January 28 87 115
2023 December 35 102 137
2023 November 22 85 107
2023 October 28 79 107
2023 September 31 46 77
2023 August 18 22 40
2023 July 30 31 61
2023 June 25 15 40
2023 May 11 10 21
Show all

Follow this link to access the full text of the article

Idiomas
Medicina Intensiva (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?