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Letter to the Editor
Primary angioplasty versus fibrinolysis in ST-segment elevation acute myocardial infarction: Reassessing the best strategy
Angioplastia primaria frente a fibrinólisis en infarto agudo de miocardio con elevación del segmento ST: reevaluación de la mejor estrategia
R. Blancas
Corresponding author
rafael.blancas@salud.madrid.org

Corresponding author.
, B. López-Matamala, Ó. Martínez-González, D. Ballesteros-Ortega
Servicio de Medicina Intensiva, Hospital Universitario del Tajo, Aranjuez, Madrid, Spain
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    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Primary angioplasty versus fibrinolysis in ST-segment elevation acute myocardial infarction&#58; Reassessing the best strategy"
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        "titulo" => "Angioplastia primaria frente a fibrin&#243;lisis en infarto agudo de miocardio con elevaci&#243;n del segmento ST&#58; reevaluaci&#243;n de la mejor estrategia"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In the year 2006&#44; the results published in Circulation&#44; with data from the National Registry of Myocardial Infarction&#44; showed the need for reassuring the best strategy of revascularization following an episode of acute ST-segment elevation myocardial infarction &#40;STEMI&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Primary angioplasty improved outcomes compared with fibrinolysis in the cases of shorter needle-to-balloon time&#44; decreasing its benefit if this elapsed time increased&#44; especially in younger early presenters with an anterior STEMI&#46; For the rest of settings&#44; results with both reperfusion treatments were similar&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">One concern with percutaneous coronary intervention &#40;PCI&#41; after successful fibrinolysis is to find the better time to carry out an interventional approach&#46; The conclusions of the TRANSFER-AMI trial laid the groundwork to establish the most appropriate moment to perform PCI after successful fibrinolysis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> This study concluded that fibrinolysis followed by PCI within 6<span class="elsevierStyleHsp" style=""></span>h showed fewer ischemic complications than fibrinolysis alone&#46; It is remarkable that clopidogrel was more frequently administered in the group of routine early PCI&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The interval elapsed between fibrinolysis and PCI seems to be of main importance&#46; The FINESSE study&#44; where the median of this time was 2&#46;2<span class="elsevierStyleHsp" style=""></span>h&#44; did not show any benefit of facilitated PCI with abciximab or abciximab plus reteplase compared with primary PCI&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The GRACIA-2 study&#44; where PCI was performed 3&#8211;12<span class="elsevierStyleHsp" style=""></span>h after fibrinolysis&#44; concluded that this option seems to be equivalent to primary PCI in limiting infarct size and preserving left ventricular function&#44; although it results in better myocardial perfusion&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The recent publication of the results of the STREAM study in The New England Journal of Medicine could change the medical practice in STEMI&#46; In this work&#44; fibrinolysis followed by PCI within 6&#8211;24<span class="elsevierStyleHsp" style=""></span>h was compared with primary PCI&#46; Fibrinolysis and primary PCI were performed at a median of 100 and 178<span class="elsevierStyleHsp" style=""></span>min after symptoms onset&#44; respectively&#46; An amendment made for the safety monitoring board&#44; reducing the fibrinolytic dose to 50&#37; in patients older than 75 years&#44; was implemented because of an excess of intracranial hemorrhages in this age group&#46; No differences were seen for the primary end point &#40;a composite of death&#44; shock&#44; congestive heart failure&#44; or reinfarction up to 30 days&#41; between both groups of treatment&#44; although patients with inferior STEMI had a lower risk for the primary end point&#46; No differences were found for intracranial hemorrhages after protocol amendment&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> However&#44; other factors deserve a mention regarding this article&#46; The dose of enoxaparin and loading dose of clopidogrel was reduced for patients older than 75 years&#44; unfractionated heparin was never used and TNK was employed instead of rtPA &#40;the usual fibrinolytic agent in earlier studies&#41;&#46; The effects of upstream intensive antiplatelet treatment and the adjusted dose of fibrinolytics and enoxaparin for high hemorrhagic risk patients had not been previously assessed&#46; Perhaps&#44; the current and diverse antithrombotic combinations for STEMI treatment need to be more individualized&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Blancas R&#44; et al&#46; Primary angioplasty versus fibrinolysis in ST- segment elevation acute myocardial infarction&#58; Reassessing the best strategy&#46; Med Intensiva&#46; 2013&#46; <span class="elsevierStyleInterRef" id="intr0005" href="doi:10.1016/j.medin.2013.05.003">http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;medin&#46;2013&#46;05&#46;003</span></p>"
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Article information
ISSN: 21735727
Original language: English
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