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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Arterial catheterization is a frequent proceeding in critically ill to obtain repetitively blood sampling and continuous monitoring of systemic arterial pressure arterial&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> The incidence of accidental catheter removal &#40;ACR&#41; in arterial catheters has been scarcely studied&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;8</span></a> and we did not find studies comparing the ACR incidence between femoral&#44; cubital&#44; dorsalis pedis and brachial arterial sites&#46; The importance of ACR lies in that could cause severe complications&#44; such as severe external haemorrhage and vascular damage&#44; and some could be potentially life-threatening&#46; Thus&#44; due to the scarce published data and the possibility of severe complications in relation to ARC of arterial catheters we proposed this study&#46; The objective of this study was to compare the incidence of ACR in femoral&#44; cubital&#44; dorsalis pedis and brachial arterial sites&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We performed a retrospective study over seven years of all patients who were undergoing to femoral&#44; cubital&#44; dorsalis pedis or brachial arterial catheterization during their stay in the polyvalent Intensive Care Unit of the Hospital Universitario de Canarias&#44; Tenerife&#44; Spain&#46; The study was approved by the institutional review board&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The following data were collected&#58; age&#44; sex&#44; diabetes mellitus&#44; APACHE-II&#44; diagnosis group&#44; catheter access&#44; catheter insertion and removal dates&#44; and cause of catheter removal &#40;planned or accidental&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We considered accidental catheter removal as the presence of an unplanned removal produced by the patient or the staff&#46; The ACR can be performed by the patient&#44; either by taking hold of it with their hands or by making voluntary movements that led directly the removal&#46; The ACR can be performed by the staff as consequence of inadequate handling&#46; The catheters removed due to obstruction of the catheter were not considered as ACR&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Statistical analyses were performed with SPSS 12&#46;0&#46;1 &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#41;&#44; LogXact 4&#46;1 &#40;Cytel Co&#46;&#44; Cambridge&#44; MA&#41; and StatXact 5&#46;0&#46;3 &#40;Cytel Co&#46;&#44; Cambridge&#44; MA&#41;&#46; Continuous variables are reported as medians and percentiles 25th&#8211;75th&#44; and were compared using Mann&#8211;Whitney test&#46; Categorical variables are reported as frequencies and percentages&#44; and were compared using Chi-square test&#46; The incidence of ACR between groups was compared using Cox regression&#46; The magnitude of the effects is expressed as Hazard Ratio &#40;HR&#41; and 95&#37; confidence interval &#40;CI&#41;&#46; A <span class="elsevierStyleItalic">p</span>-value less than 0&#46;05 was considered statistically significant&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Were included a total of 2199 arterial catheters and remain in situ during 13&#44;237 days&#46; We detected 116 ACR&#44; thus the 5&#46;3&#37; arterial catheters were accidentally removed and we had 0&#46;88 ACR per 100 days of arterial catheterization&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We found 49 events of ACR in 1250 &#40;3&#46;9&#37;&#41; arterial femoral catheters during 7524 days of catheterization &#40;0&#46;65 events of ACR per 100 days of catheterization&#41;&#44; 39 events of ACR in 583 &#40;6&#46;7&#37;&#41; arterial cubital catheters during 3513 days of catheterization &#40;1&#46;11 events of ACR per 100 days of catheterization&#41;&#44; 15 events of ACR in 198 &#40;7&#46;6&#37;&#41; arterial dorsalis pedis catheters during 1187 days of catheterization &#40;1&#46;26 events of ACR per 100 days of catheterization&#41; and 13 events of ACR in 168 &#40;7&#46;7&#37;&#41; arterial brachial catheters during 1013 days of catheterization &#40;1&#46;28 events of ACR per 100 days of catheterization&#41;&#44; As shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; there were no significant differences between femoral&#44; cubital&#44; dorsalis pedis and brachial arterial catheters in age&#44; sex&#44; diabetes mellitus&#44; APACHE-II&#44; diagnosis group and duration of the catheter&#46; However&#44; there were found statistically significant differences in the percentage of catheters with ACR &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; and in the ACR incidence per 100 days of catheterization &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41; between the different arterial sites&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Cox regression analysis showed a lower ACR incidence in femoral than in cubital &#40;Hazard Ratio<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;608&#59; 95&#37; CI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;399&#8211;0&#46;926&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41;&#44; dorsalis pedis &#40;Hazard Ratio<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;534&#59; 95&#37; CI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;299&#8211;0&#46;952&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#41; and brachial &#40;Hazard Ratio<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;500&#59; 95&#37; CI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;271&#8211;0&#46;922&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#41; arterial catheters &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">To our knowledge&#44; this is the first study comparing ACR incidence between femoral&#44; cubital&#44; dorsalis pedis and brachial arterial sites&#46; The most relevant finding of our study is that femoral arterial catheter showed a lower ACR incidence that cubital&#44; dorsalis pedis and brachial arterial catheters&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In our study&#44; we found that the 5&#46;3&#37; of arterial catheters were accidentally removed and an ACR rate of 0&#46;88 events per 100 days of arterial catheterization&#46; Our ACR rate is in the limit low according the previously reported rates&#44; which is range between 3&#46;8 and 18&#46;4&#37; catheters and of 1&#46;17&#8211;1&#46;8 events of ACR per 100 days of catheterization&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;8</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In addition&#44; we found for the first time that femoral arterial catheter showed a lower ACR incidence that cubital&#44; dorsalis pedis and brachial arterial catheters&#46; This is a novel aspect in relation to ACR of arterial catheters due to that previously was not reported a comparison of ACR between these arterial sites&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In a previous study of our team&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> we did not find significant differences in the ACR rate between 1057 radial&#44; 125 femoral&#44; 30 dorsalis pedis and 19 brachial arterial sites&#46; Afterwards&#44; increasing the sample size to 2419 radial and 1085 femoral arterial catheters was found a lower ACR in femoral than in radial arterial catheter&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> In the same way&#44; the increase of sample size to 1250 femoral&#44; 583 cubital&#44; 198 dorsalis pedis and 168 brachial arterial sites could contributed in the appearance of significant differences in our current study&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Whereas the strength of our study was the relatively large sample size compared with previous studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;8</span></a> some limitations should be recognized&#46; First&#44; there was not a randomization in the different arterial catheter site and the site was chose by criteria physician&#46; Second&#44; cubital&#44; dorsalis pedis and brachial arterial catheters were fixed by steri-strip&#44; and femoral arterial catheters were fixed by silk suture&#46; Despite these limitations&#44; we think that the results of our study could contribute to know more about ACR in critically ill patient&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; ACR is a frequent complication between the critically ill patients and is another important aspect of patient safety&#46; In our study&#44; the arterial femoral site showed a lower risk of ACR than cubital&#44; dorsalis pedis and brachial arterial sites&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Competing interests</span><p id="par0075" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundings</span><p id="par0080" class="elsevierStylePara elsevierViewall">This study was supported&#44; in part&#44; by a grant from Instituto de Salud Carlos III &#40;I3SNS-INT-11-063 and I3SNS-INT-12-087&#41; &#40;Madrid&#44; Spain&#41;&#46;</p></span></span>"
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">15 &#40;7&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">13 &#40;7&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;01&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">ACR per 100 days of catheterization</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;26&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;28&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;02&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Characteristics of different arterial catheters&#46;</p>"
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          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">ACR&#58; accidental catheter removal&#59; ID&#58; incidence density &#40;defined as number of ACR per 100 catheter-days&#41;&#59; HR&#58; hazard ratio&#59; CI&#58; confidence interval&#46;</p>"
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">HR &#8211; 95&#37; CI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Femoral vs cubital&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;65 vs 1&#46;11&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Femoral vs dorsalis pedis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;65 vs 1&#46;26&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;534 &#40;0&#46;299&#8211;0&#46;952&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;65 vs 1&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#46;500 &#40;0&#46;271&#8211;0&#46;922&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;11 vs 1&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;873 &#40;0&#46;481&#8211;1&#46;583&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Cubital vs brachial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;11 vs 1&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;823 &#40;0&#46;439&#8211;1&#46;542&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;26 vs 1&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;943 &#40;0&#46;448&#8211;1&#46;985&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;88&nbsp;\t\t\t\t\t\t\n
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      "titulo" => "References"
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          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
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              "referencia" => array:1 [
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                  "contribucion" => array:1 [
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                          "etal" => false
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                            0 => "J&#46;L&#46; Vincent"
                            1 => "D&#46;J&#46; Bihari"
                            2 => "P&#46;M&#46; Suter"
                            3 => "H&#46;A&#46; Bruining"
                            4 => "J&#46; White"
                            5 => "M&#46;H&#46; Nicolas"
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                      ]
                    ]
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                  "host" => array:1 [
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                      "Revista" => array:5 [
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                      "titulo" => "Prospective study of peripheral arterial catheter infection and comparison with concurrently sited central venous catheters"
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;B&#46; Koh"
                            1 => "J&#46;R&#46; Gowardman"
                            2 => "C&#46;M&#46; Rickard"
                            3 => "I&#46;K&#46; Robertson"
                            4 => "A&#46; Brown"
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                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:6 [
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                      "titulo" => "Infectious risk associated with arterial catheters compared with central venous catheters"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;C&#46; Lucet"
                            1 => "L&#46; Bouadma"
                            2 => "J&#46;R&#46; Zahar"
                            3 => "C&#46; Schwebel"
                            4 => "A&#46; Geffroy"
                            5 => "S&#46; Pease"
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                      "doi" => "10.1097/CCM.0b013e3181d4502e"
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                        "link" => array:1 [
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                      "Revista" => array:6 [
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                            4 => "M&#46;C&#46; Asiain"
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Scientific letter
Lesser accidental arterial catheter removal with the femoral access than with the cubital, dorsalis pedis and brachial arterial accesses
Menor retirada accidental de catéter arterial en el acceso femoral que en los accesos cubital, dorsal del pie y braquial
L. Lorentea,
Corresponding author
lorentemartin@msn.com

Corresponding author.
, L. Lorenzoa, R. Santacreua, A. Jiménezb, J. Cabreraa, C. Llanosa, M.L. Moraa
a Department of Intensive Care, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
b Research Unit, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Arterial catheterization is a frequent proceeding in critically ill to obtain repetitively blood sampling and continuous monitoring of systemic arterial pressure arterial&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> The incidence of accidental catheter removal &#40;ACR&#41; in arterial catheters has been scarcely studied&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;8</span></a> and we did not find studies comparing the ACR incidence between femoral&#44; cubital&#44; dorsalis pedis and brachial arterial sites&#46; The importance of ACR lies in that could cause severe complications&#44; such as severe external haemorrhage and vascular damage&#44; and some could be potentially life-threatening&#46; Thus&#44; due to the scarce published data and the possibility of severe complications in relation to ARC of arterial catheters we proposed this study&#46; The objective of this study was to compare the incidence of ACR in femoral&#44; cubital&#44; dorsalis pedis and brachial arterial sites&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We performed a retrospective study over seven years of all patients who were undergoing to femoral&#44; cubital&#44; dorsalis pedis or brachial arterial catheterization during their stay in the polyvalent Intensive Care Unit of the Hospital Universitario de Canarias&#44; Tenerife&#44; Spain&#46; The study was approved by the institutional review board&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The following data were collected&#58; age&#44; sex&#44; diabetes mellitus&#44; APACHE-II&#44; diagnosis group&#44; catheter access&#44; catheter insertion and removal dates&#44; and cause of catheter removal &#40;planned or accidental&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We considered accidental catheter removal as the presence of an unplanned removal produced by the patient or the staff&#46; The ACR can be performed by the patient&#44; either by taking hold of it with their hands or by making voluntary movements that led directly the removal&#46; The ACR can be performed by the staff as consequence of inadequate handling&#46; The catheters removed due to obstruction of the catheter were not considered as ACR&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Statistical analyses were performed with SPSS 12&#46;0&#46;1 &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#41;&#44; LogXact 4&#46;1 &#40;Cytel Co&#46;&#44; Cambridge&#44; MA&#41; and StatXact 5&#46;0&#46;3 &#40;Cytel Co&#46;&#44; Cambridge&#44; MA&#41;&#46; Continuous variables are reported as medians and percentiles 25th&#8211;75th&#44; and were compared using Mann&#8211;Whitney test&#46; Categorical variables are reported as frequencies and percentages&#44; and were compared using Chi-square test&#46; The incidence of ACR between groups was compared using Cox regression&#46; The magnitude of the effects is expressed as Hazard Ratio &#40;HR&#41; and 95&#37; confidence interval &#40;CI&#41;&#46; A <span class="elsevierStyleItalic">p</span>-value less than 0&#46;05 was considered statistically significant&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Were included a total of 2199 arterial catheters and remain in situ during 13&#44;237 days&#46; We detected 116 ACR&#44; thus the 5&#46;3&#37; arterial catheters were accidentally removed and we had 0&#46;88 ACR per 100 days of arterial catheterization&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We found 49 events of ACR in 1250 &#40;3&#46;9&#37;&#41; arterial femoral catheters during 7524 days of catheterization &#40;0&#46;65 events of ACR per 100 days of catheterization&#41;&#44; 39 events of ACR in 583 &#40;6&#46;7&#37;&#41; arterial cubital catheters during 3513 days of catheterization &#40;1&#46;11 events of ACR per 100 days of catheterization&#41;&#44; 15 events of ACR in 198 &#40;7&#46;6&#37;&#41; arterial dorsalis pedis catheters during 1187 days of catheterization &#40;1&#46;26 events of ACR per 100 days of catheterization&#41; and 13 events of ACR in 168 &#40;7&#46;7&#37;&#41; arterial brachial catheters during 1013 days of catheterization &#40;1&#46;28 events of ACR per 100 days of catheterization&#41;&#44; As shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; there were no significant differences between femoral&#44; cubital&#44; dorsalis pedis and brachial arterial catheters in age&#44; sex&#44; diabetes mellitus&#44; APACHE-II&#44; diagnosis group and duration of the catheter&#46; However&#44; there were found statistically significant differences in the percentage of catheters with ACR &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; and in the ACR incidence per 100 days of catheterization &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41; between the different arterial sites&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Cox regression analysis showed a lower ACR incidence in femoral than in cubital &#40;Hazard Ratio<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;608&#59; 95&#37; CI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;399&#8211;0&#46;926&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41;&#44; dorsalis pedis &#40;Hazard Ratio<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;534&#59; 95&#37; CI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;299&#8211;0&#46;952&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#41; and brachial &#40;Hazard Ratio<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;500&#59; 95&#37; CI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;271&#8211;0&#46;922&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#41; arterial catheters &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">To our knowledge&#44; this is the first study comparing ACR incidence between femoral&#44; cubital&#44; dorsalis pedis and brachial arterial sites&#46; The most relevant finding of our study is that femoral arterial catheter showed a lower ACR incidence that cubital&#44; dorsalis pedis and brachial arterial catheters&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In our study&#44; we found that the 5&#46;3&#37; of arterial catheters were accidentally removed and an ACR rate of 0&#46;88 events per 100 days of arterial catheterization&#46; Our ACR rate is in the limit low according the previously reported rates&#44; which is range between 3&#46;8 and 18&#46;4&#37; catheters and of 1&#46;17&#8211;1&#46;8 events of ACR per 100 days of catheterization&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;8</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In addition&#44; we found for the first time that femoral arterial catheter showed a lower ACR incidence that cubital&#44; dorsalis pedis and brachial arterial catheters&#46; This is a novel aspect in relation to ACR of arterial catheters due to that previously was not reported a comparison of ACR between these arterial sites&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In a previous study of our team&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> we did not find significant differences in the ACR rate between 1057 radial&#44; 125 femoral&#44; 30 dorsalis pedis and 19 brachial arterial sites&#46; Afterwards&#44; increasing the sample size to 2419 radial and 1085 femoral arterial catheters was found a lower ACR in femoral than in radial arterial catheter&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> In the same way&#44; the increase of sample size to 1250 femoral&#44; 583 cubital&#44; 198 dorsalis pedis and 168 brachial arterial sites could contributed in the appearance of significant differences in our current study&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Whereas the strength of our study was the relatively large sample size compared with previous studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;8</span></a> some limitations should be recognized&#46; First&#44; there was not a randomization in the different arterial catheter site and the site was chose by criteria physician&#46; Second&#44; cubital&#44; dorsalis pedis and brachial arterial catheters were fixed by steri-strip&#44; and femoral arterial catheters were fixed by silk suture&#46; Despite these limitations&#44; we think that the results of our study could contribute to know more about ACR in critically ill patient&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; ACR is a frequent complication between the critically ill patients and is another important aspect of patient safety&#46; In our study&#44; the arterial femoral site showed a lower risk of ACR than cubital&#44; dorsalis pedis and brachial arterial sites&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Competing interests</span><p id="par0075" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundings</span><p id="par0080" class="elsevierStylePara elsevierViewall">This study was supported&#44; in part&#44; by a grant from Instituto de Salud Carlos III &#40;I3SNS-INT-11-063 and I3SNS-INT-12-087&#41; &#40;Madrid&#44; Spain&#41;&#46;</p></span></span>"
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                  \t\t\t\t" style="border-bottom: 2px solid black">Femoral &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1250&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;93&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cardiologic&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">288 &#40;23&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">123 &#40;21&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">45 &#40;22&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">40 &#40;23&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Respiratory&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">203 &#40;16&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">34 &#40;17&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Digestive&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">45 &#40;7&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10 &#40;5&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8 &#40;4&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neurological&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">292 &#40;23&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">52 &#40;26&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">39 &#40;23&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Traumatology&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">151 &#40;25&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">50 &#40;25&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;25&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Intoxication&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">59 &#40;4&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;5&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="6" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Catheter duration &#8211; days median &#40;25th&#8211;75th p&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">6 &#40;4&#8211;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;5&#8211;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;99&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">ACR &#8211; number &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">49 &#40;3&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">39 &#40;6&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;7&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">13 &#40;7&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">ACR per 100 days of catheterization</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;28&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;02&nbsp;\t\t\t\t\t\t\n
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                  """
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Characteristics of different arterial catheters&#46;</p>"
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          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">ACR&#58; accidental catheter removal&#59; ID&#58; incidence density &#40;defined as number of ACR per 100 catheter-days&#41;&#59; HR&#58; hazard ratio&#59; CI&#58; confidence interval&#46;</p>"
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                  \t\t\t\t">Femoral vs cubital&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;65 vs 1&#46;11&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Femoral vs dorsalis pedis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;65 vs 1&#46;26&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;65 vs 1&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;500 &#40;0&#46;271&#8211;0&#46;922&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cubital vs dorsalis pedis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;11 vs 1&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;873 &#40;0&#46;481&#8211;1&#46;583&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;65&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Cubital vs brachial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;11 vs 1&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;823 &#40;0&#46;439&#8211;1&#46;542&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dorsalis pedis vs brachial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;26 vs 1&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;943 &#40;0&#46;448&#8211;1&#46;985&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Comparisons of ACR incidence between different arterial sites&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prevalence of nosocomial infection in intensive care units in Europe"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "EPIC International Advisory Committee"
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Vincent"
                            1 => "D&#46;J&#46; Bihari"
                            2 => "P&#46;M&#46; Suter"
                            3 => "H&#46;A&#46; Bruining"
                            4 => "J&#46; White"
                            5 => "M&#46;H&#46; Nicolas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Med Assoc"
                        "fecha" => "1995"
                        "volumen" => "274"
                        "paginaInicial" => "639"
                        "paginaFinal" => "644"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prospective study of peripheral arterial catheter infection and comparison with concurrently sited central venous catheters"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;B&#46; Koh"
                            1 => "J&#46;R&#46; Gowardman"
                            2 => "C&#46;M&#46; Rickard"
                            3 => "I&#46;K&#46; Robertson"
                            4 => "A&#46; Brown"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CCM.0b013e318161f74b"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2008"
                        "volumen" => "36"
                        "paginaInicial" => "397"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18216598"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infectious risk associated with arterial catheters compared with central venous catheters"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;C&#46; Lucet"
                            1 => "L&#46; Bouadma"
                            2 => "J&#46;R&#46; Zahar"
                            3 => "C&#46; Schwebel"
                            4 => "A&#46; Geffroy"
                            5 => "S&#46; Pease"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CCM.0b013e3181d4502e"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2010"
                        "volumen" => "38"
                        "paginaInicial" => "1030"
                        "paginaFinal" => "1035"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20154601"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
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