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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In this issue of <span class="elsevierStyleItalic">Medicina Intensiva</span>&#44; Mora-Arteaga et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> present a systematic review and metaanalysis involving the final inclusion of 7 randomized clinical trials &#40;2119 patients&#41; in which an analysis was made of the effect of changing the position to prone &#40;ventral&#41; decubitus in patients with acute respiratory distress syndrome &#40;ARDS&#41;&#46; Specifically&#44; the study aimed to determine whether the change in position in this patient population has an impact upon an outcome as important as mortality&#8211;independently of other outcomes such as the time on mechanical ventilation&#44; the duration of stay&#44; or possible improvement of the oxygenation parameters&#46; Although the overall studies did not suggest a decrease in mortality&#44; the analysis by subgroups did reveal a significant decrease in this outcome&#46; In effect&#44; a significant decrease was noted in mortality risk associated to prone decubitus in patients subjected to low tidal volume ventilation &#40;OR 0&#46;58&#59; 95&#37; CI&#58; 0&#46;38&#8211;0&#46;87&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;009&#44; I2 33&#37;&#41;&#44; prolonged pronation &#40;OR 0&#46;6&#59; 95&#37; CI 0&#46;43&#8211;0&#46;83&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#44; I2 27&#37;&#41;&#44; implementation in under 48<span class="elsevierStyleHsp" style=""></span>h after onset of the disease condition &#40;OR 0&#46;49&#59; 95&#37; CI 0&#46;35&#8211;0&#46;68&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#44; I2 0&#37;&#41; and severe hypoxemia &#40;OR 0&#46;51&#59; 95&#37; CI 0&#46;36&#8211;1&#46;25&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#44; I2 0&#37;&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">These results can be well explained from a purely physiological perspective&#46; The physiopathology of ARDS fundamentally involves alveolar-capillary membrane damage with lung edema&#44; surfactant loss and the formation of high-density areas &#40;occupied and atelectatic alveoli&#41;&#44; which as a result of the action of gravity are mainly located in the posterior lung regions&#46; The release of inflammatory mediators moreover cause bronchoconstriction&#44; the formation of emboli&#44; pulmonary artery vasoconstriction and&#44; ultimately&#44; lung fibrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> Apart from these more traditional phenomena&#44; the changes inherent to the lung parenchyma repair process also exert an effect&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#44;4</span></a> In any case&#44; all these phenomena essentially give rise to worsened gas exchange secondary to a loss of aeration of the dependent lung zones&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Based on physiological and physiopathological principles&#44; &#8220;lung protecting&#8221; ventilatory strategies were developed which when applied on either a preventive or therapeutic basis in severe ARDS result in a decrease in lung collapse and overdistension&#46; These strategies fundamentally involve the application of low tidal volumes &#40;or at least volumes lower than those used in routine clinical practice&#41; and the adoption of measures destined to increase residual functional capacity &#40;RFC&#41; and lung volume &#8211; though in actual clinical practice mortality remains high among patients with ARDS&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">All these strategies are fundamentally based on &#8220;ideal&#8221; lung size&#46; However&#44; Amato et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> recently have indicated that such strategies must be applied individually and should be optimized according to lung compliance and the ratio between the applied tidal volume and lung compliance&#8211;i&#46;e&#46;&#44; the strategies should be based not so much on reduction of the tidal volume according to &#8220;ideal&#8221; lung size but on &#8220;functional&#8221; lung size&#46; In clinical practice it is not easy to estimate transpulmonary pressure &#40;which is the pressure that truly drives ventilation&#41;&#44; though we do have variables that are able to estimate this parameter&#44; such as distension pressure &#40;the difference between pause pressure and total PEEP&#41;&#46; In this regard&#44; the study published by Amato et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> showed a decrease in distension pressure to be associated to improved prognosis among patients with ARDS&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">It has been known since the 1960s that the prone position improves oxygenation in patients with ARDS&#46; Furthermore&#44; some of the physiological mechanisms in prone decubitus in patients with ARDS facilitate the application of protective ventilation strategies&#8211;thereby securing a dual objective&#46; The main mechanisms are the following<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">8&#44;9</span></a>&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8211;</span><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Increased RFC</span>&#58; Patients who respond in the prone position experience a regional increase in RFC in the dorsal areas due to alveolar recruitment&#44; while at the same time RFC is minimized in the ventral or anterior regions&#46; The end result is a similar global RFC in the prone and supine position&#44; though aeration of dependent lung zones is achieved&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8211;</span><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Increased respiratory system elasticity</span>&#58; This refers to the changes in global respiratory system distensibility &#40;pulmonary and thoracoabdominal cavity&#41;&#44; on which lung ventilation is dependent&#46; Increased global elasticity has been observed in the prone position&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8211;</span><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Increased diaphragmatic mobility</span>&#58; Mechanical ventilation is characterized by cephalad displacement of the diaphragm&#44; resulting in lesser excursion with inspiration in the dorsal regions&#46; Such diaphragmatic motion is improved in the prone position&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8211;</span><p id="par0045" class="elsevierStylePara elsevierViewall">Reduction of the weight of the heart upon the lungs&#44; thereby favoring pulmonary expansion&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8211;</span><p id="par0050" class="elsevierStylePara elsevierViewall">The effects of recruitment maneuvering and PEEP application are improved&#46; Seeking optimum PEEP is often futile&#44; though it seems clear that in cases of ARDS higher PEEP levels should be used &#40;15&#8211;20<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#41;&#44; paying special attention to lung compliance and the hemodynamic situation&#46; We must know the degree of lung recruitment in patients with ARDS &#40;in order to avoid atelectrauma effects&#41; and balance it with an adequate tidal volume &#40;in order to avoid overdistension phenomena&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8211;</span><p id="par0055" class="elsevierStylePara elsevierViewall">The hemodynamic profile is also improved&#44; reducing right ventricle overload&#44; since the transpulmonary pressure and PEEP level are also reduced while maintaining recruitment capacity&#8211;thereby protecting right ventricle function&#46;</p></li></ul></p><p id="par0060" class="elsevierStylePara elsevierViewall">In sum&#44; both the physiology and the scientific evidence obtained from clinical trials and metaanalyses such as that published by Mora-Arteaga et al&#46; suggest that the current gold standard for the ventilation of patients with severe ARDS should include measures for reducing the tidal volume &#40;adapted to its effects upon lung mechanics&#44; and taking lung functional volume and compliance into account&#41;&#44; the maintenance of an adequate RFC&#44; and close monitoring of lung mechanics and its relation to right ventricle function&#46; This strategy must include patient positioning in prone decubitus&#46; In future&#44; other strategies should be compared with this ventilation gold standard in order to establish their possible efficacy and efficiency&#44; and it might prove necessary to use adequate regional lung ventilation monitoring techniques&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> This is all the more important when considering that we even must question the efficacy of the formulas used to estimate ideal weight &#40;this being the basis for estimating the adequate tidal volume for each patient&#41;&#44; where the differences that can vary by as much as 25&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0065" class="elsevierStylePara elsevierViewall">This study has received no financial support&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest in relation to the present document&#46;</p></span></span>"
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Editorial
Physiology and evidence join in favor of prone decubitus
Fisiología y evidencia se unen en favor de la posición de decúbito prono
F. Gordoa,b,
Corresponding author
fgordo5@gmail.com

Corresponding author.
, C. Hermosaa,b
a Servicio de Medicina Intensiva, Hospital Universitario del Henares, Coslada, Madrid, Spain
b Universidad Francisco de Vitoria, Madrid, Spain
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        "titulo" => "Fisiolog&#237;a y evidencia se unen en favor de la posici&#243;n de dec&#250;bito prono"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In this issue of <span class="elsevierStyleItalic">Medicina Intensiva</span>&#44; Mora-Arteaga et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> present a systematic review and metaanalysis involving the final inclusion of 7 randomized clinical trials &#40;2119 patients&#41; in which an analysis was made of the effect of changing the position to prone &#40;ventral&#41; decubitus in patients with acute respiratory distress syndrome &#40;ARDS&#41;&#46; Specifically&#44; the study aimed to determine whether the change in position in this patient population has an impact upon an outcome as important as mortality&#8211;independently of other outcomes such as the time on mechanical ventilation&#44; the duration of stay&#44; or possible improvement of the oxygenation parameters&#46; Although the overall studies did not suggest a decrease in mortality&#44; the analysis by subgroups did reveal a significant decrease in this outcome&#46; In effect&#44; a significant decrease was noted in mortality risk associated to prone decubitus in patients subjected to low tidal volume ventilation &#40;OR 0&#46;58&#59; 95&#37; CI&#58; 0&#46;38&#8211;0&#46;87&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;009&#44; I2 33&#37;&#41;&#44; prolonged pronation &#40;OR 0&#46;6&#59; 95&#37; CI 0&#46;43&#8211;0&#46;83&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#44; I2 27&#37;&#41;&#44; implementation in under 48<span class="elsevierStyleHsp" style=""></span>h after onset of the disease condition &#40;OR 0&#46;49&#59; 95&#37; CI 0&#46;35&#8211;0&#46;68&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#44; I2 0&#37;&#41; and severe hypoxemia &#40;OR 0&#46;51&#59; 95&#37; CI 0&#46;36&#8211;1&#46;25&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#44; I2 0&#37;&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">These results can be well explained from a purely physiological perspective&#46; The physiopathology of ARDS fundamentally involves alveolar-capillary membrane damage with lung edema&#44; surfactant loss and the formation of high-density areas &#40;occupied and atelectatic alveoli&#41;&#44; which as a result of the action of gravity are mainly located in the posterior lung regions&#46; The release of inflammatory mediators moreover cause bronchoconstriction&#44; the formation of emboli&#44; pulmonary artery vasoconstriction and&#44; ultimately&#44; lung fibrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> Apart from these more traditional phenomena&#44; the changes inherent to the lung parenchyma repair process also exert an effect&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#44;4</span></a> In any case&#44; all these phenomena essentially give rise to worsened gas exchange secondary to a loss of aeration of the dependent lung zones&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Based on physiological and physiopathological principles&#44; &#8220;lung protecting&#8221; ventilatory strategies were developed which when applied on either a preventive or therapeutic basis in severe ARDS result in a decrease in lung collapse and overdistension&#46; These strategies fundamentally involve the application of low tidal volumes &#40;or at least volumes lower than those used in routine clinical practice&#41; and the adoption of measures destined to increase residual functional capacity &#40;RFC&#41; and lung volume &#8211; though in actual clinical practice mortality remains high among patients with ARDS&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">All these strategies are fundamentally based on &#8220;ideal&#8221; lung size&#46; However&#44; Amato et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> recently have indicated that such strategies must be applied individually and should be optimized according to lung compliance and the ratio between the applied tidal volume and lung compliance&#8211;i&#46;e&#46;&#44; the strategies should be based not so much on reduction of the tidal volume according to &#8220;ideal&#8221; lung size but on &#8220;functional&#8221; lung size&#46; In clinical practice it is not easy to estimate transpulmonary pressure &#40;which is the pressure that truly drives ventilation&#41;&#44; though we do have variables that are able to estimate this parameter&#44; such as distension pressure &#40;the difference between pause pressure and total PEEP&#41;&#46; In this regard&#44; the study published by Amato et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> showed a decrease in distension pressure to be associated to improved prognosis among patients with ARDS&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">It has been known since the 1960s that the prone position improves oxygenation in patients with ARDS&#46; Furthermore&#44; some of the physiological mechanisms in prone decubitus in patients with ARDS facilitate the application of protective ventilation strategies&#8211;thereby securing a dual objective&#46; The main mechanisms are the following<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">8&#44;9</span></a>&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8211;</span><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Increased RFC</span>&#58; Patients who respond in the prone position experience a regional increase in RFC in the dorsal areas due to alveolar recruitment&#44; while at the same time RFC is minimized in the ventral or anterior regions&#46; The end result is a similar global RFC in the prone and supine position&#44; though aeration of dependent lung zones is achieved&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8211;</span><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Increased respiratory system elasticity</span>&#58; This refers to the changes in global respiratory system distensibility &#40;pulmonary and thoracoabdominal cavity&#41;&#44; on which lung ventilation is dependent&#46; Increased global elasticity has been observed in the prone position&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8211;</span><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Increased diaphragmatic mobility</span>&#58; Mechanical ventilation is characterized by cephalad displacement of the diaphragm&#44; resulting in lesser excursion with inspiration in the dorsal regions&#46; Such diaphragmatic motion is improved in the prone position&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8211;</span><p id="par0045" class="elsevierStylePara elsevierViewall">Reduction of the weight of the heart upon the lungs&#44; thereby favoring pulmonary expansion&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8211;</span><p id="par0050" class="elsevierStylePara elsevierViewall">The effects of recruitment maneuvering and PEEP application are improved&#46; Seeking optimum PEEP is often futile&#44; though it seems clear that in cases of ARDS higher PEEP levels should be used &#40;15&#8211;20<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#41;&#44; paying special attention to lung compliance and the hemodynamic situation&#46; We must know the degree of lung recruitment in patients with ARDS &#40;in order to avoid atelectrauma effects&#41; and balance it with an adequate tidal volume &#40;in order to avoid overdistension phenomena&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8211;</span><p id="par0055" class="elsevierStylePara elsevierViewall">The hemodynamic profile is also improved&#44; reducing right ventricle overload&#44; since the transpulmonary pressure and PEEP level are also reduced while maintaining recruitment capacity&#8211;thereby protecting right ventricle function&#46;</p></li></ul></p><p id="par0060" class="elsevierStylePara elsevierViewall">In sum&#44; both the physiology and the scientific evidence obtained from clinical trials and metaanalyses such as that published by Mora-Arteaga et al&#46; suggest that the current gold standard for the ventilation of patients with severe ARDS should include measures for reducing the tidal volume &#40;adapted to its effects upon lung mechanics&#44; and taking lung functional volume and compliance into account&#41;&#44; the maintenance of an adequate RFC&#44; and close monitoring of lung mechanics and its relation to right ventricle function&#46; This strategy must include patient positioning in prone decubitus&#46; In future&#44; other strategies should be compared with this ventilation gold standard in order to establish their possible efficacy and efficiency&#44; and it might prove necessary to use adequate regional lung ventilation monitoring techniques&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> This is all the more important when considering that we even must question the efficacy of the formulas used to estimate ideal weight &#40;this being the basis for estimating the adequate tidal volume for each patient&#41;&#44; where the differences that can vary by as much as 25&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0065" class="elsevierStylePara elsevierViewall">This study has received no financial support&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest in relation to the present document&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Gordo F&#44; Hermosa C&#46; Fisiolog&#237;a y evidencia se unen en favor de la posici&#243;n de dec&#250;bito prono&#46; Med Intensiva&#46; 2015&#59;39&#58;327&#8211;328&#46;</p>"
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Article information
ISSN: 21735727
Original language: English
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Idiomas
Medicina Intensiva (English Edition)
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?