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          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Mean and standard deviation &#40;SD&#41; of the mean nutritional ratio per day of admission in the first phase of the study&#46; This figure shows the mean and SD of the mean nutritional ratio&#44; i&#46;e&#46;&#44; the proportion of calories administered by artificial nutrition in relation to the requirements per day of admission&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Artificial nutrition forms part of the management of critically ill patients that cannot receive an oral diet&#46; The benefits of artificial nutrition go beyond the provision of nutrients and can modify host response to aggression and patient outcome&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> Many studies have shown denutrition in critical patients to be associated to an increase in infectious complications and a longer stay in the Intensive Care Unit &#40;ICU&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">2&#44;3</span></a> Consequently&#44; one of the quality indicators in the management of critical patients is the early start of nutritional support&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Different recommendations and clinical practice guides on the metabolic and nutritional management of critical patients have been published both in Spain<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> and in other countries&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">4&#8211;6</span></a> Although the methodology followed by the different recommendations is similar&#44; the conclusions drawn sometimes differ depending on how the same available scientific evidence is interpreted&#46; In this regard&#44; one of the issues subject to debate refers to the early start of nutritional treatment or the use of pharmaconutrients&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">7</span></a> This requires the physician in charge of prescribing nutritional support in critical patients to decide which recommendation is best suited to each individual patient&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the context of routine clinical practice&#44; a number of studies have shown that it is difficult to reach the caloric targets in the first few days of admission to the ICU&#46; Indeed&#44; in most cases it is not possible to exceed 60&#37; of the prescribed daily energy intake&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">6&#44;8</span></a> The concomitant administration of parenteral nutrition &#40;PN&#41; is therefore recommended as a complement to enteral nutrition &#40;EN&#41; when the caloric target is not reached by day four of admission or during two consecutive days&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> Nevertheless&#44; the early introduction of PN is also subject to debate&#44; with contradictory recommendations being found in the different guides&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The present study analyzes the nutritional treatment practices in the Department of Intensive Care Medicine &#40;DICM&#41; of a high-complexity hospital center with the purpose of identifying weak points and adopting measures for improvement based on the existing recommendations&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Patients and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">A three-phase prospective observational study was carried out&#46; The first phase involved monitoring of compliance with nutrition practices according to the nutritional support protocol used in the DICM&#46; This protocol is based on the recommendations of the SEMICYUC-SENPE&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> and is periodically revised in order to adapt it to the existing scientific evidence and the type of patient involved&#46; The nutrition protocol was not modified during this phase of the study&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The second phase involved an analysis of the data obtained&#44; with the definition of proposals for improvement and their distribution within the ICUs&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The third phase in turn consisted of a new monitoring period&#44; with assessment of the nutritional practices&#44; in order to analyze compliance with the changes proposed in the previous study phase&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Two ICUs of the DICM participated in the study&#58; a Unit specialized in trauma and emergency care&#44; and a polyvalent Unit&#46; We included adult critical patients with indications of nutritional support &#40;artificial nutrition upon admission&#44; or expected impossibility of oral feeding during the first three days of admission&#41;&#46; Patients who did not receive nutritional treatment were excluded&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Data collection was carried out by an observer who did not participate in the clinical decisions &#40;NLM&#41;&#46; The following data were collected for all included patients&#58; age&#44; weight&#44; height&#44; reason for admission&#44; stay in the ICU&#44; condition at discharge&#44; mechanical ventilation &#40;duration&#41;&#44; PN &#40;start&#44; type&#44; duration&#44; metabolic complications&#41;&#44; EN &#40;type&#44; duration&#44; mean effective volume &#91;ratio of administered diet&#47;calculated diet&#93;&#44; complications&#44; cause of suspension&#41;&#44; oral diet&#44; nutritional requirements &#40;calculated using the Harris&#8211;Benedict equation corrected for stress&#41; and mean nutritional ratio &#40;proportion of calories administered in relation to the daily requirements&#41;&#46; Calculation of the kcal supplied per day was based on the sum of the energy provided by EN&#44; PN and other lipid infusions &#40;propofol&#41;&#46; Daily assessment was also made of whether the indications of nutritional support complied with the nutrition protocol &#40;nutrient administration route&#44; calorie supply&#44; definition and management of complications related to EN&#41;&#46; These data were collected from the time of inclusion in the study until patient discharge from the Unit&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The complications associated to EN were considered based on the critical patient nutritional intervention algorithms<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">9</span></a>&#58; increase in gastric residue&#44; abdominal distension&#44; diarrhea&#44; constipation&#44; nausea and vomiting-regurgitation&#46; An increase in gastric residue was defined as the presence of a volume of over 500<span class="elsevierStyleHsp" style=""></span>ml obtained at each evaluation of residue&#46; Abdominal distension was assessed on the basis of changes in the abdominal exploration&#44; with the presence of tympanism&#44; and with or without the presence of peristaltic sounds&#46; Diarrhea associated to EN in turn was defined as a number of depositions of 5 or more in a period of 24<span class="elsevierStyleHsp" style=""></span>h&#44; or as at least two depositions&#44; each with an estimated volume of 1000<span class="elsevierStyleHsp" style=""></span>ml&#44; over a period of 24<span class="elsevierStyleHsp" style=""></span>h&#46; Constipation was defined as the absence of depositions during four days from the start of EN&#44; or the absence of depositions during three consecutive days from the second week of EN&#46; Lastly&#44; regurgitation was defined as the presence of diet material in the oropharyngeal cavity&#44; detected at exploration of the oral cavity or in the course of patient oral hygiene care&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The first study phase covered a period of 2 months &#40;from 1 February 2010 to 31 March 2010&#41;&#46; The results obtained were analyzed internally by two of the investigators &#40;CGF&#44; JMG&#41;&#44; and a number of measures for improvement were proposed based on the recommendations of the scientific societies&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">1&#44;6</span></a> The proposed measures were presented by both investigators to the healthcare personnel &#40;physicians&#44; nurses and nursing assistants&#41; of each Unit in specific sessions&#44; in which the results of the observation period &#40;phase 1&#41; were commented&#46; Two sessions were held per Unit&#46; The measures were decided by consensus and consisted of the following&#58; increase in the percentage of patients receiving EN&#44; restriction of diets enriched with pharmaconutrients &#40;arginine&#44; omega-3 fatty acids&#44; docosahexaenoic acid &#91;DHA&#93;&#44; nucleotides&#44; glutamine&#41; after the first week of admission&#44; increase in protein supply with EN &#40;administration of hyperproteic diets&#41;&#44; the convenience of daily monitoring of the nutritional ratio&#44; and the use of complementary PN conditioned to the mentioned ratio &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">The third phase again comprised a 2-month data collection period in the same Units&#46; In order to determine whether the proposed measures had been adequately put into effect in routine clinical practice&#44; we decided to conduct the second observation period following a prolonged interval after the first phase&#44; in order to avoid immediacy effects in implementing the proposed measures &#40;i&#46;e&#46;&#44; changes made in the first few months after the sessions of the second phase of the study&#41;&#46; Accordingly&#44; data collection was performed from 1 February 2011 to 31 March 2011 in the trauma and emergency care Unit&#44; and from 15 September 2011 to 25 December 2011 in the polyvalent Unit&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The results were analyzed using the IBM SPSS<span class="elsevierStyleSup">&#174;</span> version 19 statistical package&#46; Quantitative variables exhibiting a normal distribution were reported as the mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;SD&#41;&#44; while qualitative variables were reported as absolute &#40;numbers&#41; or relative frequencies &#40;percentages&#41;&#46; Comparisons were made using the Student <span class="elsevierStyleItalic">t</span>-test in the case of quantitative variables exhibiting a normal distribution and homogeneous variance&#46; The Pearson chi-squared test in turn was used to compare qualitative variables&#46; Statistical significance was considered for <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Since this was an observational&#44; non-interventional and anonymized study&#44; informed consent for data collection was not considered necessary&#46; The study was approved by the Clinical Research Ethics Committee of the hospital&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><p id="par0075" class="elsevierStylePara elsevierViewall">In the first phase of the study&#44; a total of 162 patients were admitted to both Units&#46; Of these&#44; 110 were included in the study&#58; 34 patients in the trauma and emergency care Unit &#40;66 admissions&#41; and 76 patients in the polyvalent Unit &#40;96 admissions&#41;&#46; In the third phase of the study a total of 215 patients were admitted to both Units&#46; Of these&#44; 119 were included in the study&#58; 20 patients in the trauma and emergency care Unit &#40;75 admissions&#41; and 99 patients in the polyvalent Unit &#40;140 admissions&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the characteristics of the patients&#46; The distribution by diseases differed between the two data collection phases&#44; with a larger number of polytraumatized patients in the third phase&#46; The patients in the third phase presented a higher frequency &#40;and a longer duration&#41; of mechanical ventilation&#46; The duration of stay in the ICU and the mortality rate were also higher in this phase&#46; Nevertheless&#44; the severity level upon admission&#44; as assessed by the APACHE II score&#44; was similar in both phases&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Compliance with the established nutrition protocol was optimum in both study phases&#44; independently of the modifications introduced in the second phase&#46; There were no alterations in the parameters analyzed&#58; nutrient administration route&#44; recommended energy supply&#44; or definition and management of gastrointestinal complications of EN&#46; The incidence of gastrointestinal complications related to EN was similar in both periods &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; Two patients &#40;one in each group&#41; suffered metabolic complications probably related to EN &#40;one case of hypertriglyceridemia and one case of hyperbilirubinemia&#41;&#44; though no special treatment measures were required&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">In relation to monitoring of the measures for improvement&#44; we noted an increase in the use of EN during the third phase of the study&#44; in which 87&#46;2&#37; of the patients received EN versus 55&#46;5&#37; in the first phase &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Regarding the type of diet used&#44; no decrease in the administration of diets enriched with pharmaconutrients was achieved &#40;64&#46;6&#37; versus 64&#46;9&#37; of the days with EN&#41; &#8211; though the use of hyperproteic diets effectively increased &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The mean nutritional ratio &#40;volume of administered diet&#47;calculated diet&#41; during the data collection periods of the study was 0&#46;56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;28 in the first phase and 0&#46;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;27 in the third phase&#44; with no significant differences between the two phases &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;56&#41; &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; Nevertheless&#44; calculation of the nutritional ratio in clinical practice and its inclusion in the patient records &#40;nursing charts or medical evolution comments&#41; was merely anecdotal&#58; in most cases no such calculations were entered in the records&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">The use of PN&#8722;another of the proposed measures for improvement&#8211;was not seen to increase in the third study phase &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0105" class="elsevierStylePara elsevierViewall">Our DICM has used an artificial nutrition protocol since 1996&#46; The protocol is regularly updated to adapt it to the advances in knowledge&#44; the recommendations of the scientific societies&#44; and the work routines of the DICM&#46; It is important to mention that all the healthcare personnel involved in the process &#40;physicians&#44; nurses and nursing assistants&#41; intervene in the different versions of the protocol&#46; As a result&#44; the degree of implication in complying with the protocol is very high&#44; as reflected by its correct application in the scenarios analyzed in our study&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">With a well implemented artificial nutrition protocol&#44; the purpose of our study was to assess the points amenable to improvement&#44; with a view to updating the protocol&#46; The results indicate that divulgating actions alone for presenting the measures for improvement are not enough to ensure that such measures are adequately incorporated to clinical practice&#46; In effect&#44; only two of the 5 proposed recommendations were correctly implemented&#58; increased use of EN and increase administration of hyperproteic diets&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The preferential use of EN in patients who do not present contraindications to this form of nutrition is clearly accepted by the scientific community&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> Critical patients requiring mechanical ventilation also receive EN in most cases&#46; This circumstance may have conditioned the increased use of EN recorded in the third phase of our study&#44; since the patients in this phase presented a greater need for mechanical ventilation&#44; and ventilation moreover lasted longer&#46; These were also patients with a longer stay in the ICU and with greater mortality&#44; compared with the first phase&#46; Thus&#44; the differences in the population of patients admitted might explain the change in the use of EN between the two study phases&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Some authors<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">10</span></a> have analyzed the reasons why critical patients do not receive the amount of EN they need according to the calculated energy requirements&#46; The mean nutritional ratio recorded in different studies in critical patients is between 50&#37; and 90&#37;&#46; The reasons for this decrease in diet supply are diverse and include factors related to the patient disease condition&#44; the type of nutritional catheter used&#44; the timing of the start of EN&#44; and interruptions in diet supply &#40;due to the performance of tests&#44; nursing procedures&#44; surgery or complications of any kind&#41;&#46; In the present study we likewise recorded an inadequate nutritional ratio in the context of EN in critical patients&#44; though the study was not designed to analyze the reasons for this decrease in ratio&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Changes in nutritional practices designed to increase the effectiveness of nutritional treatment in critical patients have been evaluated by a number of authors&#46; In a study of the implementation of a nutritional protocol in the ICU&#44; Barr et al&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">11</span></a> compared different variables before and after introducing the protocol&#46; The authors found the use of EN to be more frequent after introducing the protocol&#44; with no changes in calorie supply by day four of nutritional support&#46; The main difference between their study and our own is that the mentioned Unit had no previously implemented protocol&#44; though the existing nutritional practices facilitated adoption of the protocol&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Other authors have published their experience with the introduction of changes in the nutritional management of critical patients&#46; Jones et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">12</span></a> conducted a randomized clinical study to assess the adoption of 17 measures recommended to improve nutritional treatment in different DICMs divided into two groups&#58; Departments with an educational program including the intervention of a nutritionist to facilitate access to and diffusion of the measures&#44; and Departments in which the measures were simply distributed to each Unit&#46; The results after a period of 12 months showed no differences in clinical evolution between the two groups&#44; with the exception of blood glucose control in the intervention group&#46; The factors complicating introduction of the changes in the nutritional process were related to the medical professional &#40;reluctance to accept change&#44; lack of knowledge and lack of experience&#41;&#44; the clinical characteristics of the patient&#44; the characteristics of the institution &#40;limited resources&#44; bureaucracy&#44; care overload&#41; and aspects related to the clinical practice guides &#40;obsolete or limited evidence&#44; and multiple or complicated recommendations&#41;&#46; In turn&#44; the factors facilitating introduction of the changes were their incorporation to routine practice&#44; training&#44; facility of access and application of the guides&#44; as well as the adoption of reminder strategies &#40;checklists&#44; protocols&#44; multidisciplinary sessions&#41;&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Cabana<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">13</span></a> classified the obstacles facing adequate compliance with the clinical practice guides into 7 categories&#58; lack of knowledge&#44; lack of familiarity&#44; lack of agreement&#44; self-efficacy&#44; expected benefit&#44; motivation and external barriers&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Doig et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">14</span></a> defined 18 interventions grouped into categories for the implementation of measures designed to improve nutritional support&#46; They identified a leader per Unit&#44; conducted visits and meetings&#44; included the role of the nutritionist&#44; and produced algorithms and posters&#46; The adoption of these measures resulted in statistically significant improvements in the provision of nutrition&#44; but no associated changes in hospital mortality were recorded&#46; In a study carried out in a Brazilian ICU&#44; the introduction of a nutritional protocol following an educational program improved the quality of nutrition practice&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">15</span></a> Cheater et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">16</span></a> in a systematic review of the interventions that can modify clinical practice&#44; concluded that the efficacy of the interventions is generally modest&#44; and that the particularities of each institution seem to be more important than the type of measures used to introduce change&#46; The best approach therefore would be to analyze the characteristics of each individual Unit referred to the presence of protocols and check their daily implementation&#46; This in turn should be followed by an analysis of the results obtained&#44; with definition of those circumstances that facilitate or complicate application of the protocols&#44; with a view to proposing corrective changes for incorporation to daily practice&#46; The way in which the protocols are diffused&#44; and the control of compliance&#44; should be adapted to each individual Unit and scenario in order to secure significant changes&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Our study has some limitations&#46; On one hand&#44; this was a single-center study&#46; However&#44; as has been mentioned above&#44; knowledge of the characteristics inherent to each individual Unit appears to be decisive in selecting the measures to be introduced and their success&#46; On the other hand&#44; our study included no control group to allow us to affirm that the changes observed were attributable to the program and not to other external factors&#46; The study was not designed for comparison with a control group&#44; and such comparison moreover would not have been possible&#44; since there were no other Units using the same nutrition protocol&#46; Another of the limitations of our study refers to the differences in the patient populations of the two data collection phases&#46; These differences are attributable to chance and probably to the short data collection time period involved &#40;2 months&#41;&#46; A longer period probably would have contributed to minimize the differences between the groups&#46; Nevertheless&#44; since this was a study designed to evaluate the impact of passive &#40;educational&#41; interventions upon changes in patient care&#44; such changes could have manifested in the same way&#46; Lastly&#44; our study was not designed to analyze the causes of success or failure of the implementation of measures to improve nutritional support&#59; rather&#44; it was limited to describing the impact of an intervention upon the process&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In sum&#44; our results indicate that the simple recommendation of changes in the nutritional support of critical patients induces minor modifications in clinical practice&#44; but is not accompanied by increased effectiveness of nutritional treatment&#46; The data obtained support the need to apply active measures of an educational nature&#44; with evaluation of the results&#44; in order to guarantee effective change of clinical relevance for the patients&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Financial support</span><p id="par0155" class="elsevierStylePara elsevierViewall">This project was financed in part by a research grant from <span class="elsevierStyleGrantSponsor" id="gs1">Abbott Nutrici&#243;n</span>&#44; Espa&#241;a&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conflict of interest</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyze the nutritional management practices in Intensive Care &#40;ICU&#41; to detect the need for improvement actions&#46; Re-evaluate the process after implementation of improvement actions&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective observational study in 3 phases&#58; &#40;1&#41; observation&#59; &#40;2&#41; analysis&#44; proposal development and dissemination&#59; &#40;3&#41; analysis of the implementation&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Setting</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">ICU of a hospital of high complexity&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Participants</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Adult ICU forecast more than 48<span class="elsevierStyleHsp" style=""></span>h of artificial nutrition&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Primary endpoints</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Parenteral nutrition &#40;PN&#41;&#44; enteral nutrition &#40;EN&#41; &#40;type&#44; average effective volume&#44; complications&#41; and average nutritional ratio&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A total of 229 patients &#40;phase 1&#58; 110&#44; phase 3&#58; 119&#41;&#44; after analyzing the initial results&#44; were proposed&#58; increased use and precocity of EN&#44; increased protein intake&#44; nutritional monitoring effectiveness and increased supplementary indication NP&#46; The measures were broadcast at specific meetings&#46; During phase 3 more patients received EN &#40;55&#46;5 vs&#46; 78&#46;2&#37;&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#44; with no significant difference in the start time &#40;1&#46;66 vs&#46; 2&#46;33 days&#41;&#44; duration &#40;6&#46;82 vs&#46; 10&#46;12 days&#41; or complications &#40;37&#46;7 vs&#46; 47&#46;3&#37;&#41;&#46; Use of hyperproteic diets was higher in phase 3 &#40;0 vs&#46; 13&#46;01&#37;&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; The use of NP was similar &#40;48&#46;2 vs&#46; 48&#46;7&#37;&#41; with a tendency to a later onset in phase 3 &#40;1&#46;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;25 vs&#46; 2&#46;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;22 days&#41;&#46; There were no significant differences in the average nutritional ratio &#40;0&#46;56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;28 vs&#46; 0&#46;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;27&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;56&#41;&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The use of EN and the protein intake increased&#44; without appreciating effects on other improvement measures&#46; Other methods appear to be necessary for the proper implementation of improvement measures&#46;</p></span>"
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        "resumen" => "<span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Objetivos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Analizar las pr&#225;cticas de tratamiento nutricional en un Servicio de Medicina Intensiva &#40;SMI&#41; para detectar la necesidad de acciones de mejora&#46; Reevaluar el proceso tras la implementaci&#243;n de las acciones de mejora&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Dise&#241;o</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional prospectivo en 3 fases&#58; 1&#41; observaci&#243;n&#59; 2&#41; an&#225;lisis&#44; elaboraci&#243;n de propuestas y su difusi&#243;n&#59; 3&#41; an&#225;lisis de la implantaci&#243;n&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">&#193;mbito</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">SMI de un hospital de alta complejidad&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Participantes</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Adultos en UCI con previsi&#243;n de nutrici&#243;n artificial de m&#225;s de 48&#160;h&#46;</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Variables de inter&#233;s principales</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Nutrici&#243;n parenteral &#40;NP&#41;&#44; nutrici&#243;n enteral &#40;NE&#41; &#40;tipo&#44; volumen eficaz medio&#44; complicaciones&#41; y ratio nutricional media&#46;</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Participaron 229 pacientes &#40;fase 1&#58; 110&#59; fase 3&#58; 119&#41;&#46; Tras el an&#225;lisis de los resultados&#44; se propusieron&#58; incremento en uso y precocidad de NE&#44; incremento en aporte proteico&#44; monitorizaci&#243;n de la eficacia nutricional y mayor indicaci&#243;n de NP complementaria&#46; Las medidas fueron difundidas en reuniones espec&#237;ficas&#46; Durante la fase 3 hubo m&#225;s pacientes con NE &#40;55&#44;5 vs&#46; 78&#44;2&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; sin diferencia significativa en el tiempo de inicio de NE &#40;1&#44;66 vs&#46; 2&#44;33 d&#237;as&#41;&#44; duraci&#243;n &#40;6&#44;82 vs&#46; 10&#44;12 d&#237;as&#41; o complicaciones &#40;37&#44;7 vs&#46; 47&#44;3&#37;&#41;&#46;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">La utilizaci&#243;n de dietas hiperproteicas fue mayor en la fase 3 &#40;0 vs&#46; 13&#44;01&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; El empleo de NP fue similar &#40;48&#44;2 vs&#46; 48&#44;7&#37;&#41; con tendencia al inicio m&#225;s tard&#237;o en la fase 3 &#40;1&#44;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;25 vs&#46; 2&#44;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;22 d&#237;as&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41;&#46; No hubo diferencias significativas en la ratio nutricional media &#40;0&#44;56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;28 vs&#46; 0&#44;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;27&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;56&#41;&#46;</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conclusiones</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Se increment&#243; la utilizaci&#243;n de la NE y el aporte proteico sin apreciarse efectos sobre el resto de las medidas propuestas&#46; Otros m&#233;todos parecen ser necesarios para la adecuada implantaci&#243;n de medidas de mejora&#46;</p></span>"
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          1 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Dise&#241;o"
          ]
          2 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "&#193;mbito"
          ]
          3 => array:2 [
            "identificador" => "abst0055"
            "titulo" => "Participantes"
          ]
          4 => array:2 [
            "identificador" => "abst0060"
            "titulo" => "Variables de inter&#233;s principales"
          ]
          5 => array:2 [
            "identificador" => "abst0065"
            "titulo" => "Resultados"
          ]
          6 => array:2 [
            "identificador" => "abst0070"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; L&#225;zaro-Mart&#237;n NI&#44; Catal&#225;n-Gonz&#225;lez M&#44; Garc&#237;a-Fuentes C&#44; Terceros-Almanza L&#44; Montejo-Gonz&#225;lez JC&#46; An&#225;lisis de los cambios en las pr&#225;cticas de nutrici&#243;n en UCI tras una intervenci&#243;n en el proceso&#46; Med Intensiva&#46; 2015&#59;39&#58;530&#8211;536&#46;</p>"
      ]
    ]
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      0 => array:7 [
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        "etiqueta" => "Figure 1"
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        "figura" => array:1 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Mean and standard deviation &#40;SD&#41; of the mean nutritional ratio per day of admission in the first phase of the study&#46; This figure shows the mean and SD of the mean nutritional ratio&#44; i&#46;e&#46;&#44; the proportion of calories administered by artificial nutrition in relation to the requirements per day of admission&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
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        "figura" => array:1 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Mean and standard deviation &#40;SD&#41; of the mean nutritional ratio per day of admission in the third phase of the study&#46; This figure shows the mean and SD of the mean nutritional ratio&#44; i&#46;e&#46;&#44; the proportion of calories administered by artificial nutrition in relation to the requirements per day of admission&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
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        "tabla" => array:1 [
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Modification of the nutrition practices in the DICM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Increase in use of EN&#46; Consider preferential indication of EN in patients without contraindications to EN</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Diets enriched with pharmaconutrients</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Use restricted to the first week of admission &#40;which usually coincides the phase of greatest metabolic stress&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Assess longer use in patients with persistently severe conditions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Select diet enriched with fish oil for patients with acute respiratory distress syndrome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#8220;Chronic phase&#8221; diets &#40;from the second week of admission&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Use preferably in stable patients after the first week of admission&#46; A hyperproteic diet with a mixture of dietetic fiber is proposed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Nutritional monitoring</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>The case history should reflect &#40;comments on evolution&#47;nursing chart&#41; the calories supplied each day and the administered calories&#47;calculated required calories &#40;nutritional ratio&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Use of complementary PN</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Suggestions&#58; prescribe if no more than 60&#37; of the calculated requirements are supplied by day 4 of enteral nutrition &#40;nutritional ratio<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Proposed measures for improvement&#46;</p>"
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        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">The results of quantitative variables are expressed as the mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;x<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;&#46; The results of qualitative variables are expressed as n and percentage&#46;</p><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Phase 2 corresponds to the educational period in which no data collection was carried out&#46;</p><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">The significant results appear in boldface&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Phase 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Phase 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Patients included</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">110&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">119&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age &#40;years&#41; &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52&#46;10<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;128&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55&#46;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;874&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">APACHE II &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#46;36<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Diagnoses upon admission &#40;n and &#37; with respect to total&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Medical disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">75 &#40;68&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">79 &#40;66&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Surgical disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;8&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;19&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Polytraumatisms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;23&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 &#40;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Days on mechanical ventilation &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;97<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;974&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;85<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;278&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Patients with mechanical ventilation n&#160;&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">81 &#40;73&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">110 &#40;92&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Stay &#40;days&#41; &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;89<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;4282&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;74<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;1723&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Survival n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">102 &#40;92&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">94 &#40;79&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Nutritional requirements &#40;kcal&#41; &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1891&#46;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>341&#46;631&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2127&#46;17<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>368&#46;943&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Patients with enteral nutrition n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61 &#40;55&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">93 &#40;78&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Patients with parenteral nutrition n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53 &#40;48&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">58 &#40;48&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Start of enteral nutrition &#40;days&#41; &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;66<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;998&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;33<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;050&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Start of parenteral nutrition &#40;days&#41; &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;254&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;224&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Duration of enteral nutrition &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;82<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;239&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;416&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Duration of parenteral nutrition &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;53<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;191&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;037&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Complications of PN n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;1&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;1&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab1374533.png"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Characteristics of the patients and of the nutritional treatment&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Phase 2 corresponds to the educational period in which no data collection was carried out&#46;</p>"
          "tablatextoimagen" => array:1 [
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Phase 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Phase 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Patients with EN</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Complications of EN</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleItalic">n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23 &#40;37&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44 &#40;47&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Increase in gastric residue<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;14&#46;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;16&#46;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Diarrhea<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;8&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;16&#46;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Abdominal distension<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;4&#46;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;4&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Constipation<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;21&#46;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;20&#46;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nausea<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Vomiting<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;8&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;15&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Number of days of EN</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">421&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">907&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Type of diet administered to the patients</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a><span class="elsevierStyleItalic">n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pharmaconutrition diet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">272 &#40;64&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">589 &#40;64&#46;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Normoproteic fiber diet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">139 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">173 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hyperglycemia diet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;1&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Oligomeric diet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;1&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hyperproteic diet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">118 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab1374532.png"
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            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Number of patients with complications and percentage with respect to the total patients administered EN&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Number of days with each type of diet and percentage with respect to the total of days of EN&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Characteristics of enteral nutrition &#40;EN&#41; in the study phases&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:16 [
            0 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recomendaciones para el soporte nutricional y metab&#243;lico especializado del paciente cr&#237;tico&#46; Actualizaci&#243;n&#46; Consenso SEMICYUC-SENPE&#58; Indicaciones&#44; momento de inicio y v&#237;as de aporte"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;F&#46; Fernandez-Ortega"
                            1 => "J&#46;I&#46; Herrero Meseguer"
                            2 => "P&#46; Martinez Garcia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Intensiv"
                        "fecha" => "2011"
                        "volumen" => "35"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "7"
                        "paginaFinal" => "11"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The link between nutritional status and clinical outcome&#58; can nutritional intervention modify it&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;T&#46; Dempsey"
                            1 => "J&#46;L&#46; Mullen"
                            2 => "G&#46;P&#46; Buzby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Clin Nutr"
                        "fecha" => "1988"
                        "volumen" => "47"
                        "numero" => "Suppl&#46; 2"
                        "paginaInicial" => "352"
                        "paginaFinal" => "356"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3124596"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Canadian critical care nutrition guidelines in 2013&#58; an update on current recommendations and implementation strategies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Dhaliwal"
                            1 => "N&#46; Cahill"
                            2 => "M&#46; Lemieux"
                            3 => "D&#46;K&#46; Heyland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0884533613510948"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nutr Clin Pract"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "paginaInicial" => "29"
                        "paginaFinal" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24297678"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ESPEN guidelines on enteral nutrition&#58; intensive care"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;G&#46; Kreymann"
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Analysis of the nutritional management practices in intensive care: Identification of needs for improvement
Análisis de los cambios en las prácticas de nutrición en UCI tras una intervención en el proceso
N.I. Lázaro-Martín
Corresponding author
lazaronoelia@hotmail.com

Corresponding author.
, M. Catalán-González, C. García-Fuentes, L. Terceros-Almanza, J.C. Montejo-González
Department of Intensive Care Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain
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          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Mean and standard deviation &#40;SD&#41; of the mean nutritional ratio per day of admission in the first phase of the study&#46; This figure shows the mean and SD of the mean nutritional ratio&#44; i&#46;e&#46;&#44; the proportion of calories administered by artificial nutrition in relation to the requirements per day of admission&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Artificial nutrition forms part of the management of critically ill patients that cannot receive an oral diet&#46; The benefits of artificial nutrition go beyond the provision of nutrients and can modify host response to aggression and patient outcome&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> Many studies have shown denutrition in critical patients to be associated to an increase in infectious complications and a longer stay in the Intensive Care Unit &#40;ICU&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">2&#44;3</span></a> Consequently&#44; one of the quality indicators in the management of critical patients is the early start of nutritional support&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Different recommendations and clinical practice guides on the metabolic and nutritional management of critical patients have been published both in Spain<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> and in other countries&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">4&#8211;6</span></a> Although the methodology followed by the different recommendations is similar&#44; the conclusions drawn sometimes differ depending on how the same available scientific evidence is interpreted&#46; In this regard&#44; one of the issues subject to debate refers to the early start of nutritional treatment or the use of pharmaconutrients&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">7</span></a> This requires the physician in charge of prescribing nutritional support in critical patients to decide which recommendation is best suited to each individual patient&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the context of routine clinical practice&#44; a number of studies have shown that it is difficult to reach the caloric targets in the first few days of admission to the ICU&#46; Indeed&#44; in most cases it is not possible to exceed 60&#37; of the prescribed daily energy intake&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">6&#44;8</span></a> The concomitant administration of parenteral nutrition &#40;PN&#41; is therefore recommended as a complement to enteral nutrition &#40;EN&#41; when the caloric target is not reached by day four of admission or during two consecutive days&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> Nevertheless&#44; the early introduction of PN is also subject to debate&#44; with contradictory recommendations being found in the different guides&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The present study analyzes the nutritional treatment practices in the Department of Intensive Care Medicine &#40;DICM&#41; of a high-complexity hospital center with the purpose of identifying weak points and adopting measures for improvement based on the existing recommendations&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Patients and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">A three-phase prospective observational study was carried out&#46; The first phase involved monitoring of compliance with nutrition practices according to the nutritional support protocol used in the DICM&#46; This protocol is based on the recommendations of the SEMICYUC-SENPE&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> and is periodically revised in order to adapt it to the existing scientific evidence and the type of patient involved&#46; The nutrition protocol was not modified during this phase of the study&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The second phase involved an analysis of the data obtained&#44; with the definition of proposals for improvement and their distribution within the ICUs&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The third phase in turn consisted of a new monitoring period&#44; with assessment of the nutritional practices&#44; in order to analyze compliance with the changes proposed in the previous study phase&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Two ICUs of the DICM participated in the study&#58; a Unit specialized in trauma and emergency care&#44; and a polyvalent Unit&#46; We included adult critical patients with indications of nutritional support &#40;artificial nutrition upon admission&#44; or expected impossibility of oral feeding during the first three days of admission&#41;&#46; Patients who did not receive nutritional treatment were excluded&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Data collection was carried out by an observer who did not participate in the clinical decisions &#40;NLM&#41;&#46; The following data were collected for all included patients&#58; age&#44; weight&#44; height&#44; reason for admission&#44; stay in the ICU&#44; condition at discharge&#44; mechanical ventilation &#40;duration&#41;&#44; PN &#40;start&#44; type&#44; duration&#44; metabolic complications&#41;&#44; EN &#40;type&#44; duration&#44; mean effective volume &#91;ratio of administered diet&#47;calculated diet&#93;&#44; complications&#44; cause of suspension&#41;&#44; oral diet&#44; nutritional requirements &#40;calculated using the Harris&#8211;Benedict equation corrected for stress&#41; and mean nutritional ratio &#40;proportion of calories administered in relation to the daily requirements&#41;&#46; Calculation of the kcal supplied per day was based on the sum of the energy provided by EN&#44; PN and other lipid infusions &#40;propofol&#41;&#46; Daily assessment was also made of whether the indications of nutritional support complied with the nutrition protocol &#40;nutrient administration route&#44; calorie supply&#44; definition and management of complications related to EN&#41;&#46; These data were collected from the time of inclusion in the study until patient discharge from the Unit&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The complications associated to EN were considered based on the critical patient nutritional intervention algorithms<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">9</span></a>&#58; increase in gastric residue&#44; abdominal distension&#44; diarrhea&#44; constipation&#44; nausea and vomiting-regurgitation&#46; An increase in gastric residue was defined as the presence of a volume of over 500<span class="elsevierStyleHsp" style=""></span>ml obtained at each evaluation of residue&#46; Abdominal distension was assessed on the basis of changes in the abdominal exploration&#44; with the presence of tympanism&#44; and with or without the presence of peristaltic sounds&#46; Diarrhea associated to EN in turn was defined as a number of depositions of 5 or more in a period of 24<span class="elsevierStyleHsp" style=""></span>h&#44; or as at least two depositions&#44; each with an estimated volume of 1000<span class="elsevierStyleHsp" style=""></span>ml&#44; over a period of 24<span class="elsevierStyleHsp" style=""></span>h&#46; Constipation was defined as the absence of depositions during four days from the start of EN&#44; or the absence of depositions during three consecutive days from the second week of EN&#46; Lastly&#44; regurgitation was defined as the presence of diet material in the oropharyngeal cavity&#44; detected at exploration of the oral cavity or in the course of patient oral hygiene care&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The first study phase covered a period of 2 months &#40;from 1 February 2010 to 31 March 2010&#41;&#46; The results obtained were analyzed internally by two of the investigators &#40;CGF&#44; JMG&#41;&#44; and a number of measures for improvement were proposed based on the recommendations of the scientific societies&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">1&#44;6</span></a> The proposed measures were presented by both investigators to the healthcare personnel &#40;physicians&#44; nurses and nursing assistants&#41; of each Unit in specific sessions&#44; in which the results of the observation period &#40;phase 1&#41; were commented&#46; Two sessions were held per Unit&#46; The measures were decided by consensus and consisted of the following&#58; increase in the percentage of patients receiving EN&#44; restriction of diets enriched with pharmaconutrients &#40;arginine&#44; omega-3 fatty acids&#44; docosahexaenoic acid &#91;DHA&#93;&#44; nucleotides&#44; glutamine&#41; after the first week of admission&#44; increase in protein supply with EN &#40;administration of hyperproteic diets&#41;&#44; the convenience of daily monitoring of the nutritional ratio&#44; and the use of complementary PN conditioned to the mentioned ratio &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">The third phase again comprised a 2-month data collection period in the same Units&#46; In order to determine whether the proposed measures had been adequately put into effect in routine clinical practice&#44; we decided to conduct the second observation period following a prolonged interval after the first phase&#44; in order to avoid immediacy effects in implementing the proposed measures &#40;i&#46;e&#46;&#44; changes made in the first few months after the sessions of the second phase of the study&#41;&#46; Accordingly&#44; data collection was performed from 1 February 2011 to 31 March 2011 in the trauma and emergency care Unit&#44; and from 15 September 2011 to 25 December 2011 in the polyvalent Unit&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The results were analyzed using the IBM SPSS<span class="elsevierStyleSup">&#174;</span> version 19 statistical package&#46; Quantitative variables exhibiting a normal distribution were reported as the mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;SD&#41;&#44; while qualitative variables were reported as absolute &#40;numbers&#41; or relative frequencies &#40;percentages&#41;&#46; Comparisons were made using the Student <span class="elsevierStyleItalic">t</span>-test in the case of quantitative variables exhibiting a normal distribution and homogeneous variance&#46; The Pearson chi-squared test in turn was used to compare qualitative variables&#46; Statistical significance was considered for <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Since this was an observational&#44; non-interventional and anonymized study&#44; informed consent for data collection was not considered necessary&#46; The study was approved by the Clinical Research Ethics Committee of the hospital&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><p id="par0075" class="elsevierStylePara elsevierViewall">In the first phase of the study&#44; a total of 162 patients were admitted to both Units&#46; Of these&#44; 110 were included in the study&#58; 34 patients in the trauma and emergency care Unit &#40;66 admissions&#41; and 76 patients in the polyvalent Unit &#40;96 admissions&#41;&#46; In the third phase of the study a total of 215 patients were admitted to both Units&#46; Of these&#44; 119 were included in the study&#58; 20 patients in the trauma and emergency care Unit &#40;75 admissions&#41; and 99 patients in the polyvalent Unit &#40;140 admissions&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the characteristics of the patients&#46; The distribution by diseases differed between the two data collection phases&#44; with a larger number of polytraumatized patients in the third phase&#46; The patients in the third phase presented a higher frequency &#40;and a longer duration&#41; of mechanical ventilation&#46; The duration of stay in the ICU and the mortality rate were also higher in this phase&#46; Nevertheless&#44; the severity level upon admission&#44; as assessed by the APACHE II score&#44; was similar in both phases&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Compliance with the established nutrition protocol was optimum in both study phases&#44; independently of the modifications introduced in the second phase&#46; There were no alterations in the parameters analyzed&#58; nutrient administration route&#44; recommended energy supply&#44; or definition and management of gastrointestinal complications of EN&#46; The incidence of gastrointestinal complications related to EN was similar in both periods &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; Two patients &#40;one in each group&#41; suffered metabolic complications probably related to EN &#40;one case of hypertriglyceridemia and one case of hyperbilirubinemia&#41;&#44; though no special treatment measures were required&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">In relation to monitoring of the measures for improvement&#44; we noted an increase in the use of EN during the third phase of the study&#44; in which 87&#46;2&#37; of the patients received EN versus 55&#46;5&#37; in the first phase &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Regarding the type of diet used&#44; no decrease in the administration of diets enriched with pharmaconutrients was achieved &#40;64&#46;6&#37; versus 64&#46;9&#37; of the days with EN&#41; &#8211; though the use of hyperproteic diets effectively increased &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The mean nutritional ratio &#40;volume of administered diet&#47;calculated diet&#41; during the data collection periods of the study was 0&#46;56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;28 in the first phase and 0&#46;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;27 in the third phase&#44; with no significant differences between the two phases &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;56&#41; &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; Nevertheless&#44; calculation of the nutritional ratio in clinical practice and its inclusion in the patient records &#40;nursing charts or medical evolution comments&#41; was merely anecdotal&#58; in most cases no such calculations were entered in the records&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">The use of PN&#8722;another of the proposed measures for improvement&#8211;was not seen to increase in the third study phase &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0105" class="elsevierStylePara elsevierViewall">Our DICM has used an artificial nutrition protocol since 1996&#46; The protocol is regularly updated to adapt it to the advances in knowledge&#44; the recommendations of the scientific societies&#44; and the work routines of the DICM&#46; It is important to mention that all the healthcare personnel involved in the process &#40;physicians&#44; nurses and nursing assistants&#41; intervene in the different versions of the protocol&#46; As a result&#44; the degree of implication in complying with the protocol is very high&#44; as reflected by its correct application in the scenarios analyzed in our study&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">With a well implemented artificial nutrition protocol&#44; the purpose of our study was to assess the points amenable to improvement&#44; with a view to updating the protocol&#46; The results indicate that divulgating actions alone for presenting the measures for improvement are not enough to ensure that such measures are adequately incorporated to clinical practice&#46; In effect&#44; only two of the 5 proposed recommendations were correctly implemented&#58; increased use of EN and increase administration of hyperproteic diets&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The preferential use of EN in patients who do not present contraindications to this form of nutrition is clearly accepted by the scientific community&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> Critical patients requiring mechanical ventilation also receive EN in most cases&#46; This circumstance may have conditioned the increased use of EN recorded in the third phase of our study&#44; since the patients in this phase presented a greater need for mechanical ventilation&#44; and ventilation moreover lasted longer&#46; These were also patients with a longer stay in the ICU and with greater mortality&#44; compared with the first phase&#46; Thus&#44; the differences in the population of patients admitted might explain the change in the use of EN between the two study phases&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Some authors<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">10</span></a> have analyzed the reasons why critical patients do not receive the amount of EN they need according to the calculated energy requirements&#46; The mean nutritional ratio recorded in different studies in critical patients is between 50&#37; and 90&#37;&#46; The reasons for this decrease in diet supply are diverse and include factors related to the patient disease condition&#44; the type of nutritional catheter used&#44; the timing of the start of EN&#44; and interruptions in diet supply &#40;due to the performance of tests&#44; nursing procedures&#44; surgery or complications of any kind&#41;&#46; In the present study we likewise recorded an inadequate nutritional ratio in the context of EN in critical patients&#44; though the study was not designed to analyze the reasons for this decrease in ratio&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Changes in nutritional practices designed to increase the effectiveness of nutritional treatment in critical patients have been evaluated by a number of authors&#46; In a study of the implementation of a nutritional protocol in the ICU&#44; Barr et al&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">11</span></a> compared different variables before and after introducing the protocol&#46; The authors found the use of EN to be more frequent after introducing the protocol&#44; with no changes in calorie supply by day four of nutritional support&#46; The main difference between their study and our own is that the mentioned Unit had no previously implemented protocol&#44; though the existing nutritional practices facilitated adoption of the protocol&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Other authors have published their experience with the introduction of changes in the nutritional management of critical patients&#46; Jones et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">12</span></a> conducted a randomized clinical study to assess the adoption of 17 measures recommended to improve nutritional treatment in different DICMs divided into two groups&#58; Departments with an educational program including the intervention of a nutritionist to facilitate access to and diffusion of the measures&#44; and Departments in which the measures were simply distributed to each Unit&#46; The results after a period of 12 months showed no differences in clinical evolution between the two groups&#44; with the exception of blood glucose control in the intervention group&#46; The factors complicating introduction of the changes in the nutritional process were related to the medical professional &#40;reluctance to accept change&#44; lack of knowledge and lack of experience&#41;&#44; the clinical characteristics of the patient&#44; the characteristics of the institution &#40;limited resources&#44; bureaucracy&#44; care overload&#41; and aspects related to the clinical practice guides &#40;obsolete or limited evidence&#44; and multiple or complicated recommendations&#41;&#46; In turn&#44; the factors facilitating introduction of the changes were their incorporation to routine practice&#44; training&#44; facility of access and application of the guides&#44; as well as the adoption of reminder strategies &#40;checklists&#44; protocols&#44; multidisciplinary sessions&#41;&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Cabana<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">13</span></a> classified the obstacles facing adequate compliance with the clinical practice guides into 7 categories&#58; lack of knowledge&#44; lack of familiarity&#44; lack of agreement&#44; self-efficacy&#44; expected benefit&#44; motivation and external barriers&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Doig et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">14</span></a> defined 18 interventions grouped into categories for the implementation of measures designed to improve nutritional support&#46; They identified a leader per Unit&#44; conducted visits and meetings&#44; included the role of the nutritionist&#44; and produced algorithms and posters&#46; The adoption of these measures resulted in statistically significant improvements in the provision of nutrition&#44; but no associated changes in hospital mortality were recorded&#46; In a study carried out in a Brazilian ICU&#44; the introduction of a nutritional protocol following an educational program improved the quality of nutrition practice&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">15</span></a> Cheater et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">16</span></a> in a systematic review of the interventions that can modify clinical practice&#44; concluded that the efficacy of the interventions is generally modest&#44; and that the particularities of each institution seem to be more important than the type of measures used to introduce change&#46; The best approach therefore would be to analyze the characteristics of each individual Unit referred to the presence of protocols and check their daily implementation&#46; This in turn should be followed by an analysis of the results obtained&#44; with definition of those circumstances that facilitate or complicate application of the protocols&#44; with a view to proposing corrective changes for incorporation to daily practice&#46; The way in which the protocols are diffused&#44; and the control of compliance&#44; should be adapted to each individual Unit and scenario in order to secure significant changes&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Our study has some limitations&#46; On one hand&#44; this was a single-center study&#46; However&#44; as has been mentioned above&#44; knowledge of the characteristics inherent to each individual Unit appears to be decisive in selecting the measures to be introduced and their success&#46; On the other hand&#44; our study included no control group to allow us to affirm that the changes observed were attributable to the program and not to other external factors&#46; The study was not designed for comparison with a control group&#44; and such comparison moreover would not have been possible&#44; since there were no other Units using the same nutrition protocol&#46; Another of the limitations of our study refers to the differences in the patient populations of the two data collection phases&#46; These differences are attributable to chance and probably to the short data collection time period involved &#40;2 months&#41;&#46; A longer period probably would have contributed to minimize the differences between the groups&#46; Nevertheless&#44; since this was a study designed to evaluate the impact of passive &#40;educational&#41; interventions upon changes in patient care&#44; such changes could have manifested in the same way&#46; Lastly&#44; our study was not designed to analyze the causes of success or failure of the implementation of measures to improve nutritional support&#59; rather&#44; it was limited to describing the impact of an intervention upon the process&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In sum&#44; our results indicate that the simple recommendation of changes in the nutritional support of critical patients induces minor modifications in clinical practice&#44; but is not accompanied by increased effectiveness of nutritional treatment&#46; The data obtained support the need to apply active measures of an educational nature&#44; with evaluation of the results&#44; in order to guarantee effective change of clinical relevance for the patients&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Financial support</span><p id="par0155" class="elsevierStylePara elsevierViewall">This project was financed in part by a research grant from <span class="elsevierStyleGrantSponsor" id="gs1">Abbott Nutrici&#243;n</span>&#44; Espa&#241;a&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conflict of interest</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyze the nutritional management practices in Intensive Care &#40;ICU&#41; to detect the need for improvement actions&#46; Re-evaluate the process after implementation of improvement actions&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective observational study in 3 phases&#58; &#40;1&#41; observation&#59; &#40;2&#41; analysis&#44; proposal development and dissemination&#59; &#40;3&#41; analysis of the implementation&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Setting</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">ICU of a hospital of high complexity&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Participants</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Adult ICU forecast more than 48<span class="elsevierStyleHsp" style=""></span>h of artificial nutrition&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Primary endpoints</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Parenteral nutrition &#40;PN&#41;&#44; enteral nutrition &#40;EN&#41; &#40;type&#44; average effective volume&#44; complications&#41; and average nutritional ratio&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A total of 229 patients &#40;phase 1&#58; 110&#44; phase 3&#58; 119&#41;&#44; after analyzing the initial results&#44; were proposed&#58; increased use and precocity of EN&#44; increased protein intake&#44; nutritional monitoring effectiveness and increased supplementary indication NP&#46; The measures were broadcast at specific meetings&#46; During phase 3 more patients received EN &#40;55&#46;5 vs&#46; 78&#46;2&#37;&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#44; with no significant difference in the start time &#40;1&#46;66 vs&#46; 2&#46;33 days&#41;&#44; duration &#40;6&#46;82 vs&#46; 10&#46;12 days&#41; or complications &#40;37&#46;7 vs&#46; 47&#46;3&#37;&#41;&#46; Use of hyperproteic diets was higher in phase 3 &#40;0 vs&#46; 13&#46;01&#37;&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; The use of NP was similar &#40;48&#46;2 vs&#46; 48&#46;7&#37;&#41; with a tendency to a later onset in phase 3 &#40;1&#46;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;25 vs&#46; 2&#46;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;22 days&#41;&#46; There were no significant differences in the average nutritional ratio &#40;0&#46;56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;28 vs&#46; 0&#46;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;27&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;56&#41;&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The use of EN and the protein intake increased&#44; without appreciating effects on other improvement measures&#46; Other methods appear to be necessary for the proper implementation of improvement measures&#46;</p></span>"
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        "resumen" => "<span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Objetivos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Analizar las pr&#225;cticas de tratamiento nutricional en un Servicio de Medicina Intensiva &#40;SMI&#41; para detectar la necesidad de acciones de mejora&#46; Reevaluar el proceso tras la implementaci&#243;n de las acciones de mejora&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Dise&#241;o</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional prospectivo en 3 fases&#58; 1&#41; observaci&#243;n&#59; 2&#41; an&#225;lisis&#44; elaboraci&#243;n de propuestas y su difusi&#243;n&#59; 3&#41; an&#225;lisis de la implantaci&#243;n&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">&#193;mbito</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">SMI de un hospital de alta complejidad&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Participantes</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Adultos en UCI con previsi&#243;n de nutrici&#243;n artificial de m&#225;s de 48&#160;h&#46;</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Variables de inter&#233;s principales</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Nutrici&#243;n parenteral &#40;NP&#41;&#44; nutrici&#243;n enteral &#40;NE&#41; &#40;tipo&#44; volumen eficaz medio&#44; complicaciones&#41; y ratio nutricional media&#46;</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Participaron 229 pacientes &#40;fase 1&#58; 110&#59; fase 3&#58; 119&#41;&#46; Tras el an&#225;lisis de los resultados&#44; se propusieron&#58; incremento en uso y precocidad de NE&#44; incremento en aporte proteico&#44; monitorizaci&#243;n de la eficacia nutricional y mayor indicaci&#243;n de NP complementaria&#46; Las medidas fueron difundidas en reuniones espec&#237;ficas&#46; Durante la fase 3 hubo m&#225;s pacientes con NE &#40;55&#44;5 vs&#46; 78&#44;2&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; sin diferencia significativa en el tiempo de inicio de NE &#40;1&#44;66 vs&#46; 2&#44;33 d&#237;as&#41;&#44; duraci&#243;n &#40;6&#44;82 vs&#46; 10&#44;12 d&#237;as&#41; o complicaciones &#40;37&#44;7 vs&#46; 47&#44;3&#37;&#41;&#46;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">La utilizaci&#243;n de dietas hiperproteicas fue mayor en la fase 3 &#40;0 vs&#46; 13&#44;01&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; El empleo de NP fue similar &#40;48&#44;2 vs&#46; 48&#44;7&#37;&#41; con tendencia al inicio m&#225;s tard&#237;o en la fase 3 &#40;1&#44;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;25 vs&#46; 2&#44;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;22 d&#237;as&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41;&#46; No hubo diferencias significativas en la ratio nutricional media &#40;0&#44;56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;28 vs&#46; 0&#44;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;27&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;56&#41;&#46;</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conclusiones</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Se increment&#243; la utilizaci&#243;n de la NE y el aporte proteico sin apreciarse efectos sobre el resto de las medidas propuestas&#46; Otros m&#233;todos parecen ser necesarios para la adecuada implantaci&#243;n de medidas de mejora&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; L&#225;zaro-Mart&#237;n NI&#44; Catal&#225;n-Gonz&#225;lez M&#44; Garc&#237;a-Fuentes C&#44; Terceros-Almanza L&#44; Montejo-Gonz&#225;lez JC&#46; An&#225;lisis de los cambios en las pr&#225;cticas de nutrici&#243;n en UCI tras una intervenci&#243;n en el proceso&#46; Med Intensiva&#46; 2015&#59;39&#58;530&#8211;536&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Modification of the nutrition practices in the DICM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Increase in use of EN&#46; Consider preferential indication of EN in patients without contraindications to EN</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Diets enriched with pharmaconutrients</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Use restricted to the first week of admission &#40;which usually coincides the phase of greatest metabolic stress&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Assess longer use in patients with persistently severe conditions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Select diet enriched with fish oil for patients with acute respiratory distress syndrome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#8220;Chronic phase&#8221; diets &#40;from the second week of admission&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Use preferably in stable patients after the first week of admission&#46; A hyperproteic diet with a mixture of dietetic fiber is proposed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Nutritional monitoring</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>The case history should reflect &#40;comments on evolution&#47;nursing chart&#41; the calories supplied each day and the administered calories&#47;calculated required calories &#40;nutritional ratio&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Use of complementary PN</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Suggestions&#58; prescribe if no more than 60&#37; of the calculated requirements are supplied by day 4 of enteral nutrition &#40;nutritional ratio<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Proposed measures for improvement&#46;</p>"
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      ]
      3 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">The results of quantitative variables are expressed as the mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;x<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;&#46; The results of qualitative variables are expressed as n and percentage&#46;</p><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Phase 2 corresponds to the educational period in which no data collection was carried out&#46;</p><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">The significant results appear in boldface&#46;</p>"
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Phase 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Phase 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Patients included</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">110&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">119&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age &#40;years&#41; &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52&#46;10<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;128&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55&#46;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;874&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">APACHE II &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#46;36<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Diagnoses upon admission &#40;n and &#37; with respect to total&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Medical disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">75 &#40;68&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">79 &#40;66&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Surgical disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;8&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;19&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Polytraumatisms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;23&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 &#40;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Days on mechanical ventilation &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;97<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;974&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;85<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;278&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Patients with mechanical ventilation n&#160;&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">81 &#40;73&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">110 &#40;92&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Stay &#40;days&#41; &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;89<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;4282&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;74<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;1723&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Survival n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">102 &#40;92&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">94 &#40;79&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Nutritional requirements &#40;kcal&#41; &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1891&#46;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>341&#46;631&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2127&#46;17<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>368&#46;943&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Patients with enteral nutrition n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61 &#40;55&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">93 &#40;78&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Patients with parenteral nutrition n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53 &#40;48&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">58 &#40;48&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Start of enteral nutrition &#40;days&#41; &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;66<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;998&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;33<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;050&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Start of parenteral nutrition &#40;days&#41; &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;254&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;224&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Duration of enteral nutrition &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;82<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;239&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;416&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Duration of parenteral nutrition &#40;x</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;53<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;191&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;037&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Complications of PN n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;1&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;1&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Characteristics of the patients and of the nutritional treatment&#46;</p>"
        ]
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      4 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
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        "tabla" => array:3 [
          "leyenda" => "<p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Phase 2 corresponds to the educational period in which no data collection was carried out&#46;</p>"
          "tablatextoimagen" => array:1 [
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              "tabla" => array:1 [
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">272 &#40;64&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">139 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">173 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hyperglycemia diet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;1&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Oligomeric diet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;1&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
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                      "titulo" => "Recomendaciones para el soporte nutricional y metab&#243;lico especializado del paciente cr&#237;tico&#46; Actualizaci&#243;n&#46; Consenso SEMICYUC-SENPE&#58; Indicaciones&#44; momento de inicio y v&#237;as de aporte"
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ISSN: 21735727
Original language: English
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