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and few cases have been reported in patients subjected to cardiovascular surgery&#46; We present the case of a woman operated upon due to an atrial myxoma&#44; who in the postoperative period developed cardiogenic shock secondary to Takotsubo syndrome&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 68-year-old woman with arterial hypertension and non-insulin dependent diabetes reported to the emergency service due to clinically manifest heart failure for the last two weeks&#46; Upon admission she presented resting dyspnea and palpitations&#46; Rapid atrial fibrillation was detected&#44; requiring pharmacological cardioversion&#46; The echocardiographic study &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; revealed a large left atrial mass &#40;1&#46;8<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>7<span class="elsevierStyleHsp" style=""></span>cm in size&#41; protruding toward the left ventricle and causing secondary mitral valve stenosis and atrial dilatation&#44; 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Eight hours after surgery she suffered a sudden hypertensive crisis &#40;systolic blood pressure &#62;220<span class="elsevierStyleHsp" style=""></span>mmHg&#41; followed by hypotension and cardiac arrest with pulseless electrical activity &#40;electromechanical dissociation&#41;&#46; Resuscitation maneuvering restored the pulse within a few minutes&#46; The patient was in cardiogenic shock refractory to high-dose vasoactive medication &#40;adrenalin&#44; dobutamine&#44; noradrenalin&#41;&#59; as a result&#44; venous-arterial extracorporeal membrane oxygenation &#40;V-A ECMO&#41; was therefore finally decided&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Transthoracic echocardiography revealed severe left ventricular dysfunction &#40;LVEF<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>20&#37;&#41;&#44; hyperdynamic basal segments and akinesia of the middle and apical segments&#8211;these findings being typical of Takotsubo syndrome&#46; There were no significant cardiac enzyme elevations over the following days &#40;taking surgery into account&#41;&#44; with a maximum ultra-sensitive troponin I concentration of 4000<span class="elsevierStyleHsp" style=""></span>pg&#47;ml &#40;normal 2&#8211;15&#46;6<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#41;&#46; In contrast&#44; the electrocardiographic tracing showed significant changes with respect to the previous recordings&#44; with a long QTc &#40;680<span class="elsevierStyleHsp" style=""></span>ms&#41; and the appearance of inverted T-waves on precordial leads during several days &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The electrolyte profile and rest of the laboratory test parameters were normal&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Venous-arterial ECMO was maintained for four days&#44; allowing the withdrawal of vasoactive drug support&#44; and followed by a favorable clinical course&#46; The echocardiographic studies revealed gradual improvement of ventricular function&#46; The patient was extubated a few days later and moved to the hospital ward&#44; where she remained until discharge in good functional condition&#46; The last echocardiographic exploration showed slight anterior septal and inferior hypokinesia&#44; with globally preserved systolic function&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In this case the diagnosis of Takotsubo syndrome was established from the echocardiographic findings&#44; the absence of previous coronary lesions&#44; scant alteration of the cardiac enzyme levels despite the ventricular dysfunction and surgery&#44; and the precordial electrocardiographic tracings &#40;inverted T-waves and long QT syndrome&#44; with normal electrolyte levels&#41;&#46; There has been an increase in the number of diagnoses of this syndrome in recent years&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> also in cardiovascular surgery patients&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3&#8211;5</span></a> though Takotsubo syndrome has not been previously described in the postoperative period of atrial myxoma resection&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The etiology and physiopathology of Takotsubo syndrome have not been fully established&#44; though a number of mechanisms have been proposed&#44; such as coronary vasospasm&#44; coronary microvascular functional anomalies&#44; and particularly catecholamine-mediated cardiotoxicity&#46; Probably because of this&#44; the main risk factor is considered to be stress &#40;both physical and mental&#41;&#44; which is present in different diagnostic tests and surgical procedures&#8211;especially those of an emergent or urgent nature&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> Cardiac surgery and extracorporeal circulation generate important stress&#44; and may intrinsically account for the appearance of Takotsubo syndrome&#44; particularly if the epidemiological profile of the patient and the echocardiographic and electrocardiographic features are consistent with the diagnostic criteria&#44; as in our case&#46; The differential diagnosis includes coronary embolism or poor myocardial protection&#46; The typical echocardiographic findings&#44; with scant enzyme alterations&#44; brief surgery without incidents&#44; and previous hemodynamic stability with a normal first electrocardiographic tracing allow us to reasonably discard both of the aforementioned disorders&#46; In recent years&#44; evidence has been gained suggesting that magnetic resonance imaging may be useful in establishing a differential diagnosis with other disorders such as myocarditis or coronary embolism&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> though this technique could not be used in our case&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Of note is the appearance of a long QT interval on the electrocardiographic tracing&#46; The association between Takotsubo myocardiopathy and transient prolongation of the QT interval has been documented&#44;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">8&#44;9</span></a> being more frequent in patients with some form of heart disease&#44; previous long QT syndrome&#44; or genetic alterations&#46; In Takotsubo syndrome&#44; electrocardiographic normalization occurs approximately two months after the episode&#46; Although malignant ventricular arrhythmias&#44; sudden death or cardiac block are infrequent&#44; there have been reports of such situations&#46; Increased QT prolongation &#40;QTc<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>500<span class="elsevierStyleHsp" style=""></span>ms&#41; has been identified as a risk factor for complications of this kind&#59; close monitoring of the cardiac rhythm is thus required&#44; with the prevention or treatment of arrhythmias and the implantation of a pacemaker if necessary&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; Takotsubo syndrome is an infrequent cause of cardiogenic shock in the postoperative period of heart surgery&#44; though it must be considered in patients with apparently uncomplicated surgery&#44; normal coronary vessels and compatible echocardiographic findings&#44; since the prognosis is generally good when adequate supportive treatment is provided&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0050" class="elsevierStylePara elsevierViewall">This study has received no financial support&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Garc&#237;a-Delgado M&#44; Garc&#237;a-Huertas D&#44; Navarrete-S&#225;nchez I&#44; Olivencia-Pe&#241;a L&#44; Garrido JM&#46; Soporte con oxigenaci&#243;n de membrana extracorp&#243;rea en un s&#237;ndrome de Takotsubo y QT largo tras cirug&#237;a cardiaca&#46; Med Intensiva&#46; 2017&#59;41&#58;441&#8211;443&#46;</p>"
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Scientific Letter
Extracorporeal membrane oxygenation support for Takotsubo syndrome and long QT after cardiac surgery
Soporte con oxigenación de membrana extracorpórea en un síndrome de Takotsubo y QT largo tras cirugía cardiaca
M. García-Delgadoa,
Corresponding author
mjgardel@hotmail.com

Corresponding author.
, D. García-Huertasa, I. Navarrete-Sáncheza, L. Olivencia-Peñaa, J.M. Garridob
a Unidad de Cuidados Intensivos, Complejo Hospitalario Universitario de Granada, Granada, Spain
b Servicio de Cirugía Cardiaca, Complejo Hospitalario Universitario de Granada, Granada, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Takotsubo syndrome is a type of myocardiopathy characterized by transient left ventricular dysfunction associated to electrocardiographic changes similar to those of acute myocardial infarction&#44; though without evidence of coronary disease&#44; and with scantly altered myocardial enzyme levels&#46; The syndrome is also known as transient apical dysfunction&#44; &#8220;apical ballooning&#8221; or stress-induced myocardiopathy&#44; since it generally affects postmenopausal women following some stressing event&#46; The diagnostic criteria of Takotsubo syndrome are&#58; acute electrocardiographic anomalies such as ST-segment elevation or T-wave inversion&#59; the absence of obstructive coronary disease&#59; akinesia or transient dyskinesia of the left ventricle&#59; and the absence of traumatic brain injury&#44; intracranial hemorrhage&#44; pheochromocytoma&#44; myocarditis or hypertrophic myocardiopathy&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> The incidence and prevalence of the syndrome are not known&#44; and few cases have been reported in patients subjected to cardiovascular surgery&#46; We present the case of a woman operated upon due to an atrial myxoma&#44; who in the postoperative period developed cardiogenic shock secondary to Takotsubo syndrome&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 68-year-old woman with arterial hypertension and non-insulin dependent diabetes reported to the emergency service due to clinically manifest heart failure for the last two weeks&#46; Upon admission she presented resting dyspnea and palpitations&#46; Rapid atrial fibrillation was detected&#44; requiring pharmacological cardioversion&#46; The echocardiographic study &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; revealed a large left atrial mass &#40;1&#46;8<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>7<span class="elsevierStyleHsp" style=""></span>cm in size&#41; protruding toward the left ventricle and causing secondary mitral valve stenosis and atrial dilatation&#44; with a preserved left ventricular ejection fraction &#40;LVEF&#41;&#46; Preoperative coronary angiography showed no lesions&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Surgery was performed four days later&#44; with trans-septal removal of the myxoma&#46; There were no relevant incidents other than a tendency toward hypoxemia&#46; The clamping and extracorporeal circulation times were 52 and 83<span class="elsevierStyleHsp" style=""></span>min&#44; respectively&#46; Intraoperative echocardiography confirmed the absence of any remnant myxoma tissue&#44; with a normal LVEF&#46; The patient remained stable and subjected to mechanical ventilation during her first hours of stay in the Intensive Care Unit &#40;ICU&#41; due to the aforementioned hypoxemia&#44; with FiO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;6 and PEEP<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#8211;12<span class="elsevierStyleHsp" style=""></span>cmH<span class="elsevierStyleInf">2</span>O&#46; Eight hours after surgery she suffered a sudden hypertensive crisis &#40;systolic blood pressure &#62;220<span class="elsevierStyleHsp" style=""></span>mmHg&#41; followed by hypotension and cardiac arrest with pulseless electrical activity &#40;electromechanical dissociation&#41;&#46; Resuscitation maneuvering restored the pulse within a few minutes&#46; The patient was in cardiogenic shock refractory to high-dose vasoactive medication &#40;adrenalin&#44; dobutamine&#44; noradrenalin&#41;&#59; as a result&#44; venous-arterial extracorporeal membrane oxygenation &#40;V-A ECMO&#41; was therefore finally decided&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Transthoracic echocardiography revealed severe left ventricular dysfunction &#40;LVEF<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>20&#37;&#41;&#44; hyperdynamic basal segments and akinesia of the middle and apical segments&#8211;these findings being typical of Takotsubo syndrome&#46; There were no significant cardiac enzyme elevations over the following days &#40;taking surgery into account&#41;&#44; with a maximum ultra-sensitive troponin I concentration of 4000<span class="elsevierStyleHsp" style=""></span>pg&#47;ml &#40;normal 2&#8211;15&#46;6<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#41;&#46; In contrast&#44; the electrocardiographic tracing showed significant changes with respect to the previous recordings&#44; with a long QTc &#40;680<span class="elsevierStyleHsp" style=""></span>ms&#41; and the appearance of inverted T-waves on precordial leads during several days &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The electrolyte profile and rest of the laboratory test parameters were normal&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Venous-arterial ECMO was maintained for four days&#44; allowing the withdrawal of vasoactive drug support&#44; and followed by a favorable clinical course&#46; The echocardiographic studies revealed gradual improvement of ventricular function&#46; The patient was extubated a few days later and moved to the hospital ward&#44; where she remained until discharge in good functional condition&#46; The last echocardiographic exploration showed slight anterior septal and inferior hypokinesia&#44; with globally preserved systolic function&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In this case the diagnosis of Takotsubo syndrome was established from the echocardiographic findings&#44; the absence of previous coronary lesions&#44; scant alteration of the cardiac enzyme levels despite the ventricular dysfunction and surgery&#44; and the precordial electrocardiographic tracings &#40;inverted T-waves and long QT syndrome&#44; with normal electrolyte levels&#41;&#46; There has been an increase in the number of diagnoses of this syndrome in recent years&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> also in cardiovascular surgery patients&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3&#8211;5</span></a> though Takotsubo syndrome has not been previously described in the postoperative period of atrial myxoma resection&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The etiology and physiopathology of Takotsubo syndrome have not been fully established&#44; though a number of mechanisms have been proposed&#44; such as coronary vasospasm&#44; coronary microvascular functional anomalies&#44; and particularly catecholamine-mediated cardiotoxicity&#46; Probably because of this&#44; the main risk factor is considered to be stress &#40;both physical and mental&#41;&#44; which is present in different diagnostic tests and surgical procedures&#8211;especially those of an emergent or urgent nature&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> Cardiac surgery and extracorporeal circulation generate important stress&#44; and may intrinsically account for the appearance of Takotsubo syndrome&#44; particularly if the epidemiological profile of the patient and the echocardiographic and electrocardiographic features are consistent with the diagnostic criteria&#44; as in our case&#46; The differential diagnosis includes coronary embolism or poor myocardial protection&#46; The typical echocardiographic findings&#44; with scant enzyme alterations&#44; brief surgery without incidents&#44; and previous hemodynamic stability with a normal first electrocardiographic tracing allow us to reasonably discard both of the aforementioned disorders&#46; In recent years&#44; evidence has been gained suggesting that magnetic resonance imaging may be useful in establishing a differential diagnosis with other disorders such as myocarditis or coronary embolism&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> though this technique could not be used in our case&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Of note is the appearance of a long QT interval on the electrocardiographic tracing&#46; The association between Takotsubo myocardiopathy and transient prolongation of the QT interval has been documented&#44;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">8&#44;9</span></a> being more frequent in patients with some form of heart disease&#44; previous long QT syndrome&#44; or genetic alterations&#46; In Takotsubo syndrome&#44; electrocardiographic normalization occurs approximately two months after the episode&#46; Although malignant ventricular arrhythmias&#44; sudden death or cardiac block are infrequent&#44; there have been reports of such situations&#46; Increased QT prolongation &#40;QTc<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>500<span class="elsevierStyleHsp" style=""></span>ms&#41; has been identified as a risk factor for complications of this kind&#59; close monitoring of the cardiac rhythm is thus required&#44; with the prevention or treatment of arrhythmias and the implantation of a pacemaker if necessary&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; Takotsubo syndrome is an infrequent cause of cardiogenic shock in the postoperative period of heart surgery&#44; though it must be considered in patients with apparently uncomplicated surgery&#44; normal coronary vessels and compatible echocardiographic findings&#44; since the prognosis is generally good when adequate supportive treatment is provided&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0050" class="elsevierStylePara elsevierViewall">This study has received no financial support&#46;</p></span></span>"
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