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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Thank you for your interest in our article&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> It addresses a very current subject that generates much controversy&#44; and with which we are greatly committed&#46; We are aware of the importance of patient safety when receiving a blood transfusion&#44; and we therefore seek to apply measures capable of reducing the adverse effects and improving transfusion yield&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In reply to your questions about the methodology&#44; with regard to the blood component&#44; we do keep a registry of the age of the packed red blood cells&#44; knowing that some authors have demonstrated the appearance of adverse effects associated to the transfusion of &#8220;old blood&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> In our study&#44; each blood product was supplied by the hospital blood bank&#44; specifying the characteristics of the product&#44; together with its extraction and expiry dates&#46; No specific analysis of each packed red blood cell unit was made&#44; though all the units met the following characteristics according to the blood bank&#58; storage in saline&#8211;adenine&#8211;glucose&#8211;mannitol&#44; a volume of 250<span class="elsevierStyleHsp" style=""></span>ml&#44; a minimum content of 45<span class="elsevierStyleHsp" style=""></span>g of hemoglobin per transfused unit&#44; minimum red cell viability of 80&#37;&#44; hematocrit 60&#8211;80&#37;&#44; and a shelf life of 42 days counting from the date of extraction&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">With regard to the compatibility of the packed red blood cells&#44; no specific analysis was made&#44; though compatibility was guaranteed by the protocol applied in the center&#44; involving cross-tests with the patient and blood products&#46; Likewise&#44; we did not specifically quantify the post-transfusion potassium levels&#44; though this aspect would be of interest in future studies&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We analyzed the transfusion yield and degree of hemolysis&#44; calculated with respect to the patient body surface&#44; using the formula of Dubois and Dubois&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Both parameters were also analyzed according to the age of the packed red blood cells&#46; In this respect&#44; we found the yield to be lower than expected&#44; and the degree of hemolysis higher&#44; in the case of older cells &#40;age over 14 days&#41;&#46; However&#44; these differences failed to reach statistical significance due to the small proportion of young blood cells in the study sample&#46; In fact&#44; and as a result of this study&#44; a change in transfusion policy was decided in agreement with the blood bank&#44; with the supply from that time onwards of a larger proportion of packed red blood cells corresponding to young blood &#40;under 14 days&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">With regard to the patients that required a second transfusion&#44; 19&#37; needed it in the course of admission to the Intensive Care Unit &#40;ICU&#41;&#44; though only two patients required a second transfusion in the 24<span class="elsevierStyleHsp" style=""></span>h following the first transfusion&#46; We therefore agree that the administration of a packed red blood cell unit may be a valid option&#46; Likewise&#44; and although no specific analysis was made in this respect&#44; we agree with the Blood Product Work Group<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> that a hemoglobin control every 24<span class="elsevierStyleHsp" style=""></span>h suffices in patients of this kind&#44; thereby avoiding &#8220;vampirism&#8221;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Lastly&#44; in relation to premedication and diuretic use&#44; the transfusion protocol in our center<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> does not contemplate their administration on a routine basis&#59; as a result&#44; such products were not used in any of the patients in our study&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We hope to have clarified the issues raised in relation to our study&#44; and again wish to express our thanks for the interest shown both in the article and in the subject&#46; We have a shared concern in this field&#44; and hope to carry out more studies with a view to improving the transfusion policies&#46;</p></span>"
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Letter to the Editor
Hemolysis and transfusion of old packed red blood cells in critical patients
Hemólisis y transfusión de concentrados de hematíes «viejos» en pacientes críticos
S. Chacón-Alves
Corresponding author
silvia.chacon@hotmail.com

Corresponding author.
, M. Chico-Fernández, C. García-Fuentes, L. Umezawa-Makikado, J.C. Montejo-González
UCI de Trauma y Emergencias, Servicio de Medicina Intensiva, Hospital Universitario Doce de Octubre, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Thank you for your interest in our article&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> It addresses a very current subject that generates much controversy&#44; and with which we are greatly committed&#46; We are aware of the importance of patient safety when receiving a blood transfusion&#44; and we therefore seek to apply measures capable of reducing the adverse effects and improving transfusion yield&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In reply to your questions about the methodology&#44; with regard to the blood component&#44; we do keep a registry of the age of the packed red blood cells&#44; knowing that some authors have demonstrated the appearance of adverse effects associated to the transfusion of &#8220;old blood&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> In our study&#44; each blood product was supplied by the hospital blood bank&#44; specifying the characteristics of the product&#44; together with its extraction and expiry dates&#46; No specific analysis of each packed red blood cell unit was made&#44; though all the units met the following characteristics according to the blood bank&#58; storage in saline&#8211;adenine&#8211;glucose&#8211;mannitol&#44; a volume of 250<span class="elsevierStyleHsp" style=""></span>ml&#44; a minimum content of 45<span class="elsevierStyleHsp" style=""></span>g of hemoglobin per transfused unit&#44; minimum red cell viability of 80&#37;&#44; hematocrit 60&#8211;80&#37;&#44; and a shelf life of 42 days counting from the date of extraction&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">With regard to the compatibility of the packed red blood cells&#44; no specific analysis was made&#44; though compatibility was guaranteed by the protocol applied in the center&#44; involving cross-tests with the patient and blood products&#46; Likewise&#44; we did not specifically quantify the post-transfusion potassium levels&#44; though this aspect would be of interest in future studies&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We analyzed the transfusion yield and degree of hemolysis&#44; calculated with respect to the patient body surface&#44; using the formula of Dubois and Dubois&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Both parameters were also analyzed according to the age of the packed red blood cells&#46; In this respect&#44; we found the yield to be lower than expected&#44; and the degree of hemolysis higher&#44; in the case of older cells &#40;age over 14 days&#41;&#46; However&#44; these differences failed to reach statistical significance due to the small proportion of young blood cells in the study sample&#46; In fact&#44; and as a result of this study&#44; a change in transfusion policy was decided in agreement with the blood bank&#44; with the supply from that time onwards of a larger proportion of packed red blood cells corresponding to young blood &#40;under 14 days&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">With regard to the patients that required a second transfusion&#44; 19&#37; needed it in the course of admission to the Intensive Care Unit &#40;ICU&#41;&#44; though only two patients required a second transfusion in the 24<span class="elsevierStyleHsp" style=""></span>h following the first transfusion&#46; We therefore agree that the administration of a packed red blood cell unit may be a valid option&#46; Likewise&#44; and although no specific analysis was made in this respect&#44; we agree with the Blood Product Work Group<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> that a hemoglobin control every 24<span class="elsevierStyleHsp" style=""></span>h suffices in patients of this kind&#44; thereby avoiding &#8220;vampirism&#8221;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Lastly&#44; in relation to premedication and diuretic use&#44; the transfusion protocol in our center<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> does not contemplate their administration on a routine basis&#59; as a result&#44; such products were not used in any of the patients in our study&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We hope to have clarified the issues raised in relation to our study&#44; and again wish to express our thanks for the interest shown both in the article and in the subject&#46; We have a shared concern in this field&#44; and hope to carry out more studies with a view to improving the transfusion policies&#46;</p></span>"
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