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Se observan prótesis traqueal, hidroneumotórax izquierdo, neumomediastino y extenso enfisema subcutáneo.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Ramírez-Romero, B. Hernández-Alonso, C. García-Polo, A.J. Abraldes-Bechiarelli, A. Garrino-Fernández, A. Gordillo-Brenes" "autores" => array:6 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Ramírez-Romero" ] 1 => array:2 [ "nombre" => "B." "apellidos" => "Hernández-Alonso" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "García-Polo" ] 3 => array:2 [ "nombre" => "A.J." "apellidos" => "Abraldes-Bechiarelli" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Garrino-Fernández" ] 5 => array:2 [ "nombre" => "A." 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Gorordo" "apellidos" => "Delsol" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0210569117301481" "doi" => "10.1016/j.medin.2017.04.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569117301481?idApp=WMIE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572718301012?idApp=WMIE" "url" => "/21735727/0000004200000005/v1_201805310404/S2173572718301012/v1_201805310404/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173572718300882" "issn" => "21735727" "doi" => "10.1016/j.medine.2018.04.004" "estado" => "S300" "fechaPublicacion" => "2018-06-01" "aid" => "1099" "copyright" => "Elsevier España, S.L.U. and SEMICYUC" "documento" => "article" "crossmark" => 1 "subdocumento" => "ssu" "cita" => "Med Intensiva. 2018;42:306-16" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4302 "formatos" => array:3 [ "EPUB" => 199 "HTML" => 2440 "PDF" => 1663 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Update on metabolism and nutrition therapy in critically ill burned patients" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "306" "paginaFinal" => "316" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Metabolismo y terapia nutricional en el paciente quemado crítico: una revisión actualizada" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2434 "Ancho" => 2467 "Tamanyo" => 361731 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Physiopathological and metabolic alterations in the critically ill burned patient.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. 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"apellidos" => "Manzanares" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0210569117302231" "doi" => "10.1016/j.medin.2017.07.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569117302231?idApp=WMIE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572718300882?idApp=WMIE" "url" => "/21735727/0000004200000005/v1_201805310404/S2173572718300882/v1_201805310404/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Central airway obstruction due to inflammatory bowel disease and rescue with extracorporeal membrane oxygenation" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "317" "paginaFinal" => "319" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Ramírez-Romero, B. Hernández-Alonso, C. García-Polo, A.J. Abraldes-Bechiarelli, A. Garrino-Fernández, A. Gordillo-Brenes" "autores" => array:6 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Ramírez-Romero" "email" => array:1 [ 0 => "miguel.ramirez.romero.1979@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "B." "apellidos" => "Hernández-Alonso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "García-Polo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "A.J." "apellidos" => "Abraldes-Bechiarelli" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "A." "apellidos" => "Garrino-Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "A." "apellidos" => "Gordillo-Brenes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Intensiva, Hospital Universitario Puerta del Mar, Cádiz, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario Puerta del Mar, Cádiz, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Aparato Digestivo, Hospital Universitario Puerta del Mar, Cádiz, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Obstrucción de la vía aérea central por enfermedad inflamatoria intestinal y rescate terapéutico con membrana de oxigenación extracorpórea" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1244 "Ancho" => 1138 "Tamanyo" => 95821 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chest X-ray at admission showing pneumomediastinum and subcutaneous emphysema on the neck.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We hereby present here the case of a previously healthy 15-year-old female hospitalized with fever, nonproductive cough, and respiratory failure. Six weeks prior to being hospitalized she had started with mild and intermittent clinical manifestations of watery diarrhea, with fever and dry cough over a two-week period. In an outpatient consultation conducted ten days prior to being hospitalized, the blood test results were confirmed leukocytosis (15,660/mm<span class="elsevierStyleSup">3</span>), anemia (Hb 11<span class="elsevierStyleHsp" style=""></span>g/dL), mild elevation of transaminase levels (AST/ALT 62/75<span class="elsevierStyleHsp" style=""></span>IU/L), and significant elevation of CRP levels (243<span class="elsevierStyleHsp" style=""></span>mg/dL). Treatment with azithromycin and ambroxol was administered with no improvement whatsoever. She was admitted to the ER on several occasions due to clinical manifestations of persistent fever, cough, and mild dyspnea. The medical examination confirmed the presence of sinus tachycardia, wheezing, and relative hypoxemia, and the chest X-ray conducted confirmed signs of hyperinflation too. In her last visit to the ER, the patient had more severe hypoxemia (SaO<span class="elsevierStyleInf">2</span> 87%), the chest X-ray showed pneumomediastinum and subcutaneous emphysema (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), and the blood test results confirmed leukocytosis (23.590/mm<span class="elsevierStyleSup">3</span>) with neutrophilia (78%), anemia (Hb 10<span class="elsevierStyleHsp" style=""></span>g/dL), thrombocytosis (643,000/mm<span class="elsevierStyleSup">3</span>), elevation of the CRP levels (180<span class="elsevierStyleHsp" style=""></span>mg/dL, and procalcitonin (21<span class="elsevierStyleHsp" style=""></span>ng/mL). She was hospitalized with oxygen therapy, inhaled ipratropium bromide and budesonide, methylprednisolone (20<span class="elsevierStyleHsp" style=""></span>mg/12<span class="elsevierStyleHsp" style=""></span>h) and levofloxacin. Within a few hours she suffered from severe respiratory failure that became agonic, with severe jugular ingurgitation, hypoxemia, and extreme respiratory acidosis (SaO<span class="elsevierStyleInf">2</span> 37% via a face mask of high FiO<span class="elsevierStyleInf">2</span> and PaCO<span class="elsevierStyleInf">2</span> 144<span class="elsevierStyleHsp" style=""></span>mmHg with pH 6.9). She was easily intubated, but mechanical ventilation turned out to be complicated due to the extraordinary resistance of the airway with hyperinflation, auto-PEEP, and hemodynamic instability, all of which made it virtually impossible to achieve the minimum goals of oxygenation and ventilation, yet despite the use of very low oxygen volumes, prolonged expiratory times, and vasopressor therapy with very high doses of noradrenaline. The auscultation confirmed the presence of a very acute inspiratory wheezing at the sternal region. In this context, the patient suffered from two consecutive episodes of cardiac arrest of 10 and 5<span class="elsevierStyleHsp" style=""></span>min duration, respectively with electromechanical dissociation from which she recovered precariously through cardiac massage and adrenaline, followed by very severe hypoxemia, hypercapnia and acidosis (SatO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>50%, PaCO<span class="elsevierStyleInf">2</span> above the upper range of the gasometer and pH 6.7), and extreme hemodynamic instability that required vasopressor support at fairly high doses. On suspicion of central airway obstruction (CAO), the medical team decided to conduct one fibrobronchoscopy under circulatory and respiratory assistance using extracorporeal membrane oxygenation (ECMO). This procedure was conducted in the operating room under general anesthesia through open femoro-femoral cannulation and veno-arterial assistance. The fibrobronchoscopy conducted confirmed the almost complete obstruction of the tracheal lumen due to the presence of a white material of mamelonated appearance that was later biopsized obtaining a fibrin-leukocytarian material and mucoid without atypia (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The argon-plasma coagulation electrocautery procedure allowed enough tracheal lumen to facilitate ventilation and improve gas exchange and hemodynamics, leading the team to disconnect the ECMO at the very operating room. On suspicion of an inflammatory process, pulse methylprednisolone therapy (0.5<span class="elsevierStyleHsp" style=""></span>g IV) was started followed by antibiotic therapy. Some 12<span class="elsevierStyleHsp" style=""></span>h later, while the patient was in a more stable hemodynamic and respiratory condition, one thoracoabdominal CT scan was conducted that confirmed the presence of concentric thickening of the tracheal wall and main bronchi, pneumomediastinum, left hydropneumothorax, thoracoabdominal subcutaneous emphysema, and pneumoretroperitoneum (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The left hydropneumothorax was drained and one rigid bronchoscopy was conducted that confirmed less inflammatory material and tracheobronchial occupation. Even so, contemplating the possibility of recurrence, a Y-shaped tracheobronchial tube was implanted. The patient's prognosis was favorable and she experienced a total neurological and cardiorespiratory recovery that allowed the early withdrawal (∼<span class="elsevierStyleHsp" style=""></span>24<span class="elsevierStyleHsp" style=""></span>h) of mechanical ventilation and, eventually, hospital discharge without any sequelae.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">All the microbiological studies including bacteria, mycobacteria, fungi, viruses and the biopsized material culture tested negative. On suspicion of inflammatory bowel disease (IBD), the serological markers tested positive for ANCA-c and anti-<span class="elsevierStyleItalic">Saccharomyces cerevisiae</span> antibodies. The endoscopic studies showed pancolitis and aphtous ileitis consistent with Crohn's disease, and the biopsies confirmed the presence of “focal active ileitis and diffuse active colitis, with architectural distortion, surface irregularity, and inflammatory infiltrate in the lamina propria of moderate intensity by lymphocytes, plasma cells, and neutrophils, with neutrophil exocytosis, cryptic abscesses and basal plasmacytosis without granulomas”—all of it consistent with IBD. Today the patient is still on steroids and azathioprine with an acceptable control of the disease.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The CAO is extremely rare, and its diagnosis requires high clinical suspicion, which is difficult in the absence of pathological history.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> It usually kicks in with cough, respiratory failure, and wheezing. At times, it can even simulate a process of asthmatic crisis or acute bronchitis. A simple X-ray can show data of hyperinflation and, in extreme cases, signs of barotrauma due to entrapment. Also, the CT scan can show circumferential or nodular narrowing of the trachea and main bronchi. For diagnostic purposes, the morphology of the flow-volume loop that shows the intrathoracic obstruction in both phases of the respiratory cycle can be useful.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Bronchoscopy is definitely the diagnostic and therapeutic procedure of choice. In the most serious cases, the use of ECMO can help with the therapeutic rescue and recent medical literature reports isolated cases with high survival rates.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> The type of cannulation and assistance that should be used, whether veno-arterial or veno-venous, depends on the clinical situation we are dealing with. The veno-arterial option allows respiratory and hemodynamic support, and it is the option of choice in patients in shock or who have suffered a cardiac arrest. The veno-venous option should do in situations of hemodynamic stability when gas exchange is an issue.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Extraintestinal manifestations of the IBD could involve almost every organ system, being pulmonary damage the less common of all, with a prevalence >0.5%.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4,5</span></a> The pathogenic mechanism is still unknown, but it is common to the inflammatory process affecting the intestine.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> It usually occurs years after the diagnosis of IBD, when the disease goes into remission or after one colectomy, being pulmonary damage, exceptional<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> and tracheobronchial damage, incidental. Thus, until now only 11 cases of CAO<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> have been reported, none of them serious. The data available on these cases show how effective systemic or inhaled steroid treatment really is<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a>; occasionally it will be necessary to resort to bronchoscopic techniques to maintain airway patency.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">9,10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The case we presented here is unheard of due to its dramatic clinical presentation, to its exceptionality given the CAO occurred at the beginning of the IBD; and because it gave the medical team the opportunity to use ECMO allowing therapeutic rescue in a case whose outcome would have been dramatic in other circumstances. It is the first case ever reported of rescue with ECMO,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> without a prior diagnosis, with impossibility of ventilation, and obstructive shock with cardiac arrest.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Ramírez-Romero M, Hernández-Alonso B, García-Polo C, Abraldes-Bechiarelli AJ, Garrino-Fernández A, Gordillo-Brenes A. Obstrucción de la vía aérea central por enfermedad inflamatoria intestinal y rescate terapéutico con membrana de oxigenación extracorpórea. Med Intensiva. 2018;42:317–319.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1244 "Ancho" => 1138 "Tamanyo" => 95821 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chest X-ray at admission showing pneumomediastinum and subcutaneous emphysema on the neck.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1272 "Ancho" => 1138 "Tamanyo" => 127064 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">View of tracheal lumen through fibrobronchoscopy.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 705 "Ancho" => 1137 "Tamanyo" => 93963 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Thoracic CT scan image. 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Year/Month | Html | Total | |
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2024 November | 9 | 14 | 23 |
2024 October | 47 | 44 | 91 |
2024 September | 57 | 27 | 84 |
2024 August | 54 | 37 | 91 |
2024 July | 42 | 27 | 69 |
2024 June | 41 | 40 | 81 |
2024 May | 42 | 30 | 72 |
2024 April | 69 | 30 | 99 |
2024 March | 73 | 28 | 101 |
2024 February | 62 | 31 | 93 |
2024 January | 74 | 37 | 111 |
2023 December | 40 | 36 | 76 |
2023 November | 44 | 27 | 71 |
2023 October | 54 | 40 | 94 |
2023 September | 37 | 34 | 71 |
2023 August | 43 | 21 | 64 |
2023 July | 38 | 30 | 68 |
2023 June | 33 | 16 | 49 |
2023 May | 47 | 28 | 75 |
2023 April | 46 | 24 | 70 |
2023 March | 73 | 34 | 107 |
2023 February | 64 | 38 | 102 |
2023 January | 35 | 23 | 58 |
2022 December | 65 | 32 | 97 |
2022 November | 60 | 41 | 101 |
2022 October | 65 | 38 | 103 |
2022 September | 38 | 41 | 79 |
2022 August | 47 | 41 | 88 |
2022 July | 39 | 37 | 76 |
2022 June | 41 | 32 | 73 |
2022 May | 39 | 41 | 80 |
2022 April | 35 | 52 | 87 |
2022 March | 59 | 56 | 115 |
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2021 November | 29 | 38 | 67 |
2021 October | 42 | 70 | 112 |
2021 September | 39 | 24 | 63 |
2021 August | 22 | 37 | 59 |
2021 July | 25 | 39 | 64 |
2021 June | 30 | 26 | 56 |
2021 May | 38 | 51 | 89 |
2021 April | 134 | 85 | 219 |
2021 March | 49 | 40 | 89 |
2021 February | 48 | 19 | 67 |
2021 January | 61 | 23 | 84 |
2020 December | 31 | 25 | 56 |
2020 November | 27 | 20 | 47 |
2020 October | 32 | 32 | 64 |
2020 September | 35 | 22 | 57 |
2020 August | 37 | 24 | 61 |
2020 July | 24 | 25 | 49 |
2020 June | 28 | 15 | 43 |
2020 May | 26 | 18 | 44 |
2020 April | 24 | 20 | 44 |
2020 March | 19 | 22 | 41 |
2020 February | 43 | 72 | 115 |
2020 January | 29 | 29 | 58 |
2019 December | 35 | 25 | 60 |
2019 November | 32 | 24 | 56 |
2019 October | 41 | 16 | 57 |
2019 September | 41 | 27 | 68 |
2019 August | 31 | 22 | 53 |
2019 July | 25 | 31 | 56 |
2019 June | 20 | 20 | 40 |
2019 May | 36 | 36 | 72 |
2019 April | 13 | 42 | 55 |
2019 March | 19 | 25 | 44 |
2019 February | 18 | 35 | 53 |
2019 January | 27 | 37 | 64 |
2018 December | 22 | 31 | 53 |
2018 November | 47 | 89 | 136 |
2018 October | 13 | 13 | 26 |
2018 July | 0 | 2 | 2 |
2018 June | 0 | 1 | 1 |