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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hospital antimicrobial stewardship programmes have achieved savings and a more rational use of antimicrobial treatments in general wards&#46; The purpose of this report is to evaluate the experience of an antimicrobial stewardship programme in an intensive care unit &#40;ICU&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective interventional&#44; before-and-after study&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Scope</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">24-bed medical ICU in a tertiary hospital&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Intervention</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Prospective audit and feedback antimicrobial stewardship programme&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Endpoints</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Antimicrobial consumption&#44; antimicrobial related costs&#44; multi-drug resistant microorganisms &#40;MDRM&#41; prevalence&#44; nosocomial infections incidence&#44; ICU length of stay&#44; and ICU mortality rates were compared before and after one-year intervention&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A total of 218 antimicrobial episodes of 182 patients were evaluated in 61 team meetings&#46; Antimicrobial stewardship suggestions were accepted in 91&#46;5&#37; of the cases&#46; Total antimicrobial DDD&#47;100 patient-days consumption was reduced from 380&#46;6 to 295&#46;2 &#40;-22&#46;4&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;037&#41;&#46; Antimicrobial stewardship programme was associated with a significant decrease in the prescription of penicillins plus b-lactamase inhibitors&#44; linezolid&#44; cephalosporins&#44; and aminoglycosides&#46; Overall antimicrobial spending was reduced by &#8364;119&#44;636&#46; MDRM isolation and nosocomial infections per 100 patient-days did not change after the intervention period&#46; No changes in length of stay or mortality rate were observed&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">An ICU antimicrobial stewardship programme significantly reduced antimicrobial use without affecting inpatient mortality and length of stay&#46; Our results further support the implementation of an antimicrobial stewardship programme in critical care units&#46;</p></span>"
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        "resumen" => "<span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Objetivo</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los programas de optimizaci&#243;n de antimicrobianos &#40;PROA&#41; han demostrado ser herramientas eficaces para reducir el uso de antimicrobianos&#46; El prop&#243;sito de este estudio es evaluar el efecto de la implantaci&#243;n de un PROA en una unidad de cuidados intensivos &#40;UCI&#41;&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Dise&#241;o</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo de intervenci&#243;n&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">&#193;mbito</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">UCI de 24 camas en un hospital terciario&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Intervenci&#243;n</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Implantaci&#243;n de un PROA basado en auditor&#237;as prospectivas&#46;</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Variables de inter&#233;s principales</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">El consumo de antimicrobianos y sus los costes&#44; la prevalencia de colonizaci&#243;n por bacterias multi-resistentes &#40;BMR&#41;&#44; la incidencia de infecci&#243;n nosocomial&#44; la estancia en UCI y las tasas de mortalidad fueron comparadas antes y tras un a&#241;o de implantaci&#243;n del programa&#46;</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Se evaluaron un total de 218 episodios antimicrobianos de 182 pacientes en 61 reuniones&#46; &#201;l 91&#44;5&#37; de las sugerencias dadas por el equipo PROA fueron aceptadas por el prescriptor&#46; El consumo total de antimicrobianos en DDD&#47;100 estancias se redujo de 380&#44;6 a 295&#44;2 &#40;-22&#44;4&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;037&#41;&#46; La implantaci&#243;n del PROA se asoci&#243; con una disminuci&#243;n significativa en la prescripci&#243;n de penicilinas&#47;inhibidores de b-lactamasa&#44; linezolid&#44; cefalosporinas y aminogluc&#243;sidos&#46; El gasto total en antimicrobianos se redujo en 119&#46;636 &#8364;&#46; La incidencia de colonizaci&#243;n por BMR y de infecciones nosocomiales no cambiaron tras del per&#237;odo de intervenci&#243;n&#46; No se observaron cambios en la duraci&#243;n de la estancia ni en la tasa de mortalidad&#46;</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conclusiones</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">La implantaci&#243;n de un PROA en una UCI reduce significativamente el uso de antimicrobianos sin afectar a la evoluci&#243;n de los pacientes ingresados&#46; Nuestros resultados apoyan la implementaci&#243;n de este tipo de programas en las unidades de pacientes cr&#237;ticos&#46;</p></span>"
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Antimicrobial stewardship programme in critical care medicine: A prospective interventional study
Implantación de un programa de optimización de antimicrobianos en el paciente crítico: Estudio de intervención
J. Ruiza, P. Ramireza,
Corresponding author
ramirez_pau@gva.es

Corresponding author.
, M. Gordona, E. Villarreala, J. Frasquetb, J.L. Poveda-Andresc, M. Salavert-Lletíd, A. Catellanosa
a Intensive Care Unit, Hospital Universitario y Politecnico La Fe, Valencia, Spain
b Microbiology Department, Hospital Universitario y Politecnico La Fe, Valencia, Spain
c Pharmacy Department, Hospital Universitario y Politecnico La Fe, Valencia, Spain
d Infectious Disease Department, Hospital Universitario y Politecnico La Fe, Valencia, Spain
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hospital antimicrobial stewardship programmes have achieved savings and a more rational use of antimicrobial treatments in general wards&#46; The purpose of this report is to evaluate the experience of an antimicrobial stewardship programme in an intensive care unit &#40;ICU&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective interventional&#44; before-and-after study&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Scope</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">24-bed medical ICU in a tertiary hospital&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Intervention</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Prospective audit and feedback antimicrobial stewardship programme&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Endpoints</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Antimicrobial consumption&#44; antimicrobial related costs&#44; multi-drug resistant microorganisms &#40;MDRM&#41; prevalence&#44; nosocomial infections incidence&#44; ICU length of stay&#44; and ICU mortality rates were compared before and after one-year intervention&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A total of 218 antimicrobial episodes of 182 patients were evaluated in 61 team meetings&#46; Antimicrobial stewardship suggestions were accepted in 91&#46;5&#37; of the cases&#46; Total antimicrobial DDD&#47;100 patient-days consumption was reduced from 380&#46;6 to 295&#46;2 &#40;-22&#46;4&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;037&#41;&#46; Antimicrobial stewardship programme was associated with a significant decrease in the prescription of penicillins plus b-lactamase inhibitors&#44; linezolid&#44; cephalosporins&#44; and aminoglycosides&#46; Overall antimicrobial spending was reduced by &#8364;119&#44;636&#46; MDRM isolation and nosocomial infections per 100 patient-days did not change after the intervention period&#46; No changes in length of stay or mortality rate were observed&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">An ICU antimicrobial stewardship programme significantly reduced antimicrobial use without affecting inpatient mortality and length of stay&#46; Our results further support the implementation of an antimicrobial stewardship programme in critical care units&#46;</p></span>"
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Article information
ISSN: 21735727
Original language: English
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Idiomas
Medicina Intensiva (English Edition)
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