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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Up to one-quarter of trauma admissions to the intensive care unit &#40;ICU&#41; correspond to patients over 65 years&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">1</span></a> It is expected that the progressive aging of the population will double the number of geriatric trauma admissions in the next decades&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">2</span></a> Ground-level falls constitute the leading mechanism of injury because of decreased vision and hearing&#44; slower reflexes&#44; poorer balance&#44; impaired motor and cognitive function&#44; decreased muscle mass&#44; strength&#44; bone density and joint flexibility&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">2&#44;3</span></a> Despite these conditions&#44; geriatric patients are currently undergoing more recreational activities&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Specifically&#44; traumatic brain injury &#40;TBI&#41; represents the major challenge&#46; The central nervous system may be impaired because of cortical atrophy and plaque buildup in the cerebrovascular vessels&#44; making the brain a more susceptible area to traumatic injury&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">2</span></a> Subdural hematomas are common&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">4</span></a> Geriatric TBI patients have greater morbidity and mortality compared with younger counterparts&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">2&#44;5</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Specific problems</span><p id="par0015" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0020" class="elsevierStylePara elsevierViewall">Under-triage&#58; This is one of the major concerns in the attention of geriatric trauma patients<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">6</span></a> and constitutes a modifiable factor&#46; Mortality of these patients decreases when they are transferred to trauma centers with a high volume of geriatric trauma patients&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">7</span></a> Underlying reasons of under-triage include low-energy mechanisms of injury&#44; unconscious age bias&#44; unreliability of vital signs&#44; the use of medications that blunt the physiologic response to injury and the lack of specific triaging scores&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a></p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0025" class="elsevierStylePara elsevierViewall">Unreliability of clinical scales&#58; Due to the increment in the subarachnoid space&#44; the performance of clinical scales such as the Glasgow Coma Scale &#40;GCS&#41; is poor&#46; In this context&#44; prompt evaluation&#44; a high index of suspicion and a low threshold to perform repeated cranial tomography &#40;CT&#41; scans even with subtle clinical changes is mandatory&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">2&#44;5</span></a></p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0030" class="elsevierStylePara elsevierViewall">Use of antiplatelets and anticoagulants&#58; According to the results of <span class="elsevierStyleItalic">RETRAUCI</span>&#44; the use of antiplatelets or anticoagulants in trauma patients admitted to the ICUs of our environment reaches half of the patients over 75 years-old&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">5</span></a> The use of clopidogrel and anticoagulants is associated with progression of intracranial hemorrhages and poorer outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a> The use of direct anticoagulants does not seem to be associated with worst prognosis when compared to warfarin&#46;</p></li></ul></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">How can we improve outcomes of geriatric TBI&#63;</span><p id="par0035" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0040" class="elsevierStylePara elsevierViewall">Appropriate evaluation of comorbidity and frailty&#58; Age itself is not an accurate indicator of the ability of the geriatric patient to respond to injury&#46; Traditional vital signs and conventional severity scores do not work well in this population&#46; Frailty refers to a decreased physiologic reserve in multiple organ systems which leads to an impaired ability to withstand physiological stress&#46; Frailty can be evaluated using the 15-variable Trauma-specific Frailty Index<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">10</span></a> and may help to determine the optimal hospital and treatment for geriatric trauma patients&#44; since frail patients are at higher risk of poor outcomes following trauma&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0045" class="elsevierStylePara elsevierViewall">Prompt evaluation and reversal of anticoagulation&#58; Ivascu et al&#46; published an aggressive protocol for TBI patients on prior anticoagulant treatment&#46; By performing a rapid CT scan of the head and correction of INR to less than 1&#46;6 within 4<span class="elsevierStyleHsp" style=""></span>h of admission&#44; they obtained a 75&#37; decrease in mortality for posttraumatic intracranial hemorrhage in geriatric patients&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">11</span></a> Another controversial topic is when to resume anticoagulation therapy in patients who presented TBI&#46; In a large-retrospective study&#44; Albrecht et al&#46; reported that restarting warfarin following discharge was associated with a 51&#37; increased risk of hemorrhagic events and a 23&#37; reduction in thrombotic events over the following year&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> No recommendations on the exact moment after TBI to restart anticoagulation can be made in the light of the current evidence and must be considered on an individual basis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0050" class="elsevierStylePara elsevierViewall">Biomarkers constitute a promising tool in the initial management of TBI patients&#44; since they could help to identify patients more likely to present complications or die&#46; Whilst the number of biomarkers available is increasing&#44; to date&#44; no specific one has been developed for geriatric TBI patients&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">13</span></a> The aging process and comorbid conditions can affect biomarker production&#44; distribution&#44; metabolism and clearance&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">13&#44;14</span></a> We believe that this is a potential area of improvement in the care of geriatric TBI patients&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">-</span><p id="par0055" class="elsevierStylePara elsevierViewall">Design of prospective multicenter studies in geriatric patients&#58; Geriatric patients are usually excluded from multicenter studies evaluating neuroprotective agents in TBI&#46; In addition&#44; classic prognostic models do not take into consideration comorbidities&#46; Future studies will determine whether incorporating comorbidities&#44; baseline function or measures of frailty into these models will improve their prognostic value&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">14</span></a></p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">-</span><p id="par0060" class="elsevierStylePara elsevierViewall">Rehabilitation&#58; Evidence suggests that intensive inpatient rehabilitation greatly benefits geriatric TBI patients&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">14</span></a> Unfortunately&#44; geriatric patients are less likely to receive rehabilitation compared with younger patients&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">-</span><p id="par0065" class="elsevierStylePara elsevierViewall">Preventive measures&#58; Interventions to reduce frailty in the community&#44; including exercise&#44; nutrition&#44; cognitive training&#44; geriatric assessment and management and prehabilitation are potentially effective to improve the ability to prevent and recover from injuries&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a> A more restrictive use of antiplatelets and anticoagulants in the community in patients with high risk of falls must be also considered&#46;</p></li></ul></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">How must the intensivist face geriatric TBI&#63;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Classical studies showed an ominous prognosis in geriatric severe TBI patients&#46; No patient with admission GCS less than 9 had good 6-month outcomes&#46; Mortality achieved 80&#37; in this group&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">16</span></a> Therefore&#44; logical concerns about futility surrounded the ICU care of these patients&#46; Routine use of neuromonitoring is controversial&#46; Czosnyka et al&#46; showed that older patients had lower intracranial pressure and therefore higher cerebral perfusion pressure&#44; combined with worse vascular pressure reactivity and autoregulation&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">17</span></a> Neurosurgical interventions and modern neurointensive care have improved outcomes geriatric TBI&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">4</span></a> In our opinion&#44; aggressive initial treatment is mandatory&#46; After a reasonable time-frame and taking into account the comorbidities and frailty&#44; limitation of life-sustaining therapies and palliative care must be considered in non-responding patients&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">In summary&#44; the management of geriatric TBI patients constitutes a challenge for intensivists&#46; New prognostic models including baseline conditions&#44; appropriate triaging and prompt reversal of anticoagulation may improve outcome&#46; Aggressive neurosurgical and neurointensive care can achieve better outcomes than expected&#46; Limitation of life-sustaining therapies and palliative care must be considered&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Authors&#8217; contribution</span><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Juan Antonio Llompart-Pou&#58;</span> Reviewed literature&#46; Wrote the first and final drafts of the manuscript&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Jon P&#233;rez-B&#225;rcena&#58;</span> Reviewed literature&#46; Critical review of the first draft&#46; Gave final approval of the submitted version&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflict of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest related to this manuscript&#46;</p></span></span>"
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Geriatric traumatic brain injury: An old challenge
Traumatismo craneoencefálico en el anciano: un viejo reto
J.A. Llompart-Pou
Corresponding author
juanantonio.llompart@ssib.es

Corresponding author.
, J. Pérez-Bárcena
Servei de Medicina Intensiva, Hospital Universitari Son Espases, Institut de Investigació Sanitària Illes Balears (IdISBa), Palma, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Up to one-quarter of trauma admissions to the intensive care unit &#40;ICU&#41; correspond to patients over 65 years&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">1</span></a> It is expected that the progressive aging of the population will double the number of geriatric trauma admissions in the next decades&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">2</span></a> Ground-level falls constitute the leading mechanism of injury because of decreased vision and hearing&#44; slower reflexes&#44; poorer balance&#44; impaired motor and cognitive function&#44; decreased muscle mass&#44; strength&#44; bone density and joint flexibility&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">2&#44;3</span></a> Despite these conditions&#44; geriatric patients are currently undergoing more recreational activities&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Specifically&#44; traumatic brain injury &#40;TBI&#41; represents the major challenge&#46; The central nervous system may be impaired because of cortical atrophy and plaque buildup in the cerebrovascular vessels&#44; making the brain a more susceptible area to traumatic injury&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">2</span></a> Subdural hematomas are common&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">4</span></a> Geriatric TBI patients have greater morbidity and mortality compared with younger counterparts&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">2&#44;5</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Specific problems</span><p id="par0015" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0020" class="elsevierStylePara elsevierViewall">Under-triage&#58; This is one of the major concerns in the attention of geriatric trauma patients<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">6</span></a> and constitutes a modifiable factor&#46; Mortality of these patients decreases when they are transferred to trauma centers with a high volume of geriatric trauma patients&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">7</span></a> Underlying reasons of under-triage include low-energy mechanisms of injury&#44; unconscious age bias&#44; unreliability of vital signs&#44; the use of medications that blunt the physiologic response to injury and the lack of specific triaging scores&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a></p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0025" class="elsevierStylePara elsevierViewall">Unreliability of clinical scales&#58; Due to the increment in the subarachnoid space&#44; the performance of clinical scales such as the Glasgow Coma Scale &#40;GCS&#41; is poor&#46; In this context&#44; prompt evaluation&#44; a high index of suspicion and a low threshold to perform repeated cranial tomography &#40;CT&#41; scans even with subtle clinical changes is mandatory&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">2&#44;5</span></a></p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0030" class="elsevierStylePara elsevierViewall">Use of antiplatelets and anticoagulants&#58; According to the results of <span class="elsevierStyleItalic">RETRAUCI</span>&#44; the use of antiplatelets or anticoagulants in trauma patients admitted to the ICUs of our environment reaches half of the patients over 75 years-old&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">5</span></a> The use of clopidogrel and anticoagulants is associated with progression of intracranial hemorrhages and poorer outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a> The use of direct anticoagulants does not seem to be associated with worst prognosis when compared to warfarin&#46;</p></li></ul></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">How can we improve outcomes of geriatric TBI&#63;</span><p id="par0035" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0040" class="elsevierStylePara elsevierViewall">Appropriate evaluation of comorbidity and frailty&#58; Age itself is not an accurate indicator of the ability of the geriatric patient to respond to injury&#46; Traditional vital signs and conventional severity scores do not work well in this population&#46; Frailty refers to a decreased physiologic reserve in multiple organ systems which leads to an impaired ability to withstand physiological stress&#46; Frailty can be evaluated using the 15-variable Trauma-specific Frailty Index<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">10</span></a> and may help to determine the optimal hospital and treatment for geriatric trauma patients&#44; since frail patients are at higher risk of poor outcomes following trauma&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0045" class="elsevierStylePara elsevierViewall">Prompt evaluation and reversal of anticoagulation&#58; Ivascu et al&#46; published an aggressive protocol for TBI patients on prior anticoagulant treatment&#46; By performing a rapid CT scan of the head and correction of INR to less than 1&#46;6 within 4<span class="elsevierStyleHsp" style=""></span>h of admission&#44; they obtained a 75&#37; decrease in mortality for posttraumatic intracranial hemorrhage in geriatric patients&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">11</span></a> Another controversial topic is when to resume anticoagulation therapy in patients who presented TBI&#46; In a large-retrospective study&#44; Albrecht et al&#46; reported that restarting warfarin following discharge was associated with a 51&#37; increased risk of hemorrhagic events and a 23&#37; reduction in thrombotic events over the following year&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">12</span></a> No recommendations on the exact moment after TBI to restart anticoagulation can be made in the light of the current evidence and must be considered on an individual basis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0050" class="elsevierStylePara elsevierViewall">Biomarkers constitute a promising tool in the initial management of TBI patients&#44; since they could help to identify patients more likely to present complications or die&#46; Whilst the number of biomarkers available is increasing&#44; to date&#44; no specific one has been developed for geriatric TBI patients&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">13</span></a> The aging process and comorbid conditions can affect biomarker production&#44; distribution&#44; metabolism and clearance&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">13&#44;14</span></a> We believe that this is a potential area of improvement in the care of geriatric TBI patients&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">-</span><p id="par0055" class="elsevierStylePara elsevierViewall">Design of prospective multicenter studies in geriatric patients&#58; Geriatric patients are usually excluded from multicenter studies evaluating neuroprotective agents in TBI&#46; In addition&#44; classic prognostic models do not take into consideration comorbidities&#46; Future studies will determine whether incorporating comorbidities&#44; baseline function or measures of frailty into these models will improve their prognostic value&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">14</span></a></p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">-</span><p id="par0060" class="elsevierStylePara elsevierViewall">Rehabilitation&#58; Evidence suggests that intensive inpatient rehabilitation greatly benefits geriatric TBI patients&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">14</span></a> Unfortunately&#44; geriatric patients are less likely to receive rehabilitation compared with younger patients&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">-</span><p id="par0065" class="elsevierStylePara elsevierViewall">Preventive measures&#58; Interventions to reduce frailty in the community&#44; including exercise&#44; nutrition&#44; cognitive training&#44; geriatric assessment and management and prehabilitation are potentially effective to improve the ability to prevent and recover from injuries&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a> A more restrictive use of antiplatelets and anticoagulants in the community in patients with high risk of falls must be also considered&#46;</p></li></ul></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">How must the intensivist face geriatric TBI&#63;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Classical studies showed an ominous prognosis in geriatric severe TBI patients&#46; No patient with admission GCS less than 9 had good 6-month outcomes&#46; Mortality achieved 80&#37; in this group&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">16</span></a> Therefore&#44; logical concerns about futility surrounded the ICU care of these patients&#46; Routine use of neuromonitoring is controversial&#46; Czosnyka et al&#46; showed that older patients had lower intracranial pressure and therefore higher cerebral perfusion pressure&#44; combined with worse vascular pressure reactivity and autoregulation&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">17</span></a> Neurosurgical interventions and modern neurointensive care have improved outcomes geriatric TBI&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">4</span></a> In our opinion&#44; aggressive initial treatment is mandatory&#46; After a reasonable time-frame and taking into account the comorbidities and frailty&#44; limitation of life-sustaining therapies and palliative care must be considered in non-responding patients&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">In summary&#44; the management of geriatric TBI patients constitutes a challenge for intensivists&#46; New prognostic models including baseline conditions&#44; appropriate triaging and prompt reversal of anticoagulation may improve outcome&#46; Aggressive neurosurgical and neurointensive care can achieve better outcomes than expected&#46; Limitation of life-sustaining therapies and palliative care must be considered&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Authors&#8217; contribution</span><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Juan Antonio Llompart-Pou&#58;</span> Reviewed literature&#46; Wrote the first and final drafts of the manuscript&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Jon P&#233;rez-B&#225;rcena&#58;</span> Reviewed literature&#46; Critical review of the first draft&#46; Gave final approval of the submitted version&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflict of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest related to this manuscript&#46;</p></span></span>"
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Idiomas
Medicina Intensiva (English Edition)
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?