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respiratory sounds suggestive of bronchoaspiration&#44; and finally tonic-clonic seizures&#46; Admission to our Intensive Care Unit &#40;ICU&#41; was thus decided&#46; The patient was admitted under postcritical condition&#44; with fever &#40;38&#46;6<span class="elsevierStyleHsp" style=""></span>&#176;C&#41; and SatO<span class="elsevierStyleInf">2</span> 75&#37; with oxygen therapy &#40;reservoir&#41;&#59; intubation was decided&#44; and mechanical ventilation was started&#46; There were few crepitants in the right lung base&#44; and the rest of the exploration yielded no findings of relevance&#46; The routine laboratory test parameters were normal&#44; with the exception of CPK 1800<span class="elsevierStyleHsp" style=""></span>U&#47;l&#44; and the chest X-rays showed a weak right basal infiltrate&#46; Repeat CAT showed no alterations&#44; and lumbar puncture yielded clear cerebrospinal fluid &#40;CSF&#41;&#44; emerging without pressure&#44; containing 13 cells &#40;with 92&#37; monocytes&#41;&#44; 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with negative PCR test results for the mentioned virus as well as for more common varicella-zoster virus and enterovirus&#44; and we requested CSF and serum testing for onconeural antibodies&#44; anti-Ma &#40;Ma1&#44; Ma2&#47;Ta&#41;&#44; anti-NMDA&#44; anti-LGI1&#44; anti-voltage gated potassium channel antibodies and anti-GAG&#46; All proved negative&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A guided interview revealed that the patient &#40;a musician&#41; had suffered marked hearing loss in the left ear as well as vision problems&#44; since his partner noticed that he failed to see the signals she usually showed him on stage&#46; The triad of encephalitis&#44; hearing impairment and loss of visual acuity secondary to retinal arterial obstruction&#44; together with the MRI findings&#44; were indicative of Susac&#39;s syndrome &#40;SS&#41;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> &#8211; a form of autoimmune encephalitis&#46; Evaluation of the ocular fundus confirmed the diagnosis&#44; with the right eye presenting sectorial macular edema and a pale retina in the area of the inferior cilioretinal artery suggestive of arterial obstruction&#46; The left eye in turn presented a small ischemic area in the region of the inferior temporal arch with sectorial vasculitis but no involvement of the foveal region&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Corticosteroid pulses were quickly prescribed &#40;1<span class="elsevierStyleHsp" style=""></span>g&#47;day for 3 days&#41;&#44; followed by 100<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; and immunoglobulin &#40;2<span class="elsevierStyleHsp" style=""></span>g&#47;kg in 5 days&#41;&#46; The patient started to awaken after 72<span class="elsevierStyleHsp" style=""></span>h&#44; being able to follow simple instructions&#44; and extubation was decided on day 6 of admission&#46; He was finally discharged to the ward awake&#44; though with slowed mental processing&#44; disorientation in time and space&#44; flaccid tetraparesis and a bilateral positive Babinski reflex&#46; Audiometry diagnosed hearing deficiency referred to acute tones in the left ear&#46; Clinical progression in the ward was interrupted by another psychotic outbreak coinciding with a lowering of the corticosteroid dose&#46; Ten months after the episode&#44; the patient has fully recovered&#44; except for mild frontal symptoms&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In recent years there has been an increase in reported encephalitis of non-infectious origin&#44; including cases published in our setting&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Most of these cases have been of autoimmune origin&#44; associated to the presence of antineuronal antibodies&#44; with a clinical picture that may simulate an infectious origin or manifest as neurological and&#47;or psychiatric disorders&#44; sometimes without fever or CSF pleocytosis&#46; This group of disorders comprises limbic encephalitis&#44; anti-NMDA receptor encephalitis&#44; Bickerstaff encephalitis and disseminated acute encephalitis &#8211; including SS&#46; The latter is a rare disease &#40;with about 350 cases described to date&#41;&#44; involving vasculitic alterations of the brain&#44; retina and cochlea&#46; The condition characteristically starts with psychiatric symptoms&#44; and admission to the psychiatric ward &#40;as in our patient&#41; is common&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;6&#44;7</span></a> The diagnostic criteria of SS have been established recently&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> The syndrome is three-fold more common in women than in men&#44; and the clinical triad is observed in only 13&#37; of the cases &#40;more often in males&#41;&#46; We consider that our case illustrates the importance of the differential diagnosis with viral encephalitis &#40;our case moreover involving two unusual viruses&#41; and the fundamental role played by early MRI study&#44; which in addition to discarding a herpetic origin of the disorder allows the differentiation of disease patterns characterizing each type of autoimmune encephalitis&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Involvement of the corpus callosum&#44; for example&#44; is considered to be pathognomonic of SS&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> An early diagnosis allows the prompt start of treatment&#44; which is associated to an improve patient response<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> with fewer sequelae in the form of persistent cognitive impairment&#46;</p></span>"
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Scientific letter
Susac's syndrome. A case of autoimmune encephalitis
Síndrome de Susac. A propósito de las encefalitis autoinmunes
D. Mora Lópeza,
Corresponding author
dmora2@gmail.com

Corresponding author.
, A. Tristancho Garzona, M. Guzmam Llorenteb, C. Jiménez Condea, A. Montero Urbinaa, P. Oliva Fernandeza
a Servicio de Medicina Intensiva, Hospital Juan Ramón Jiménez, Huelva, Spain
b Servicio de Psiquiatría, Hospital Juan Ramón Jiménez, Huelva, Spain
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The brain CAT study revealed no alterations&#46; In view of the variability of the clinical manifestations and the personal conflicts of the patient&#44; the condition was taken to represent a dissociative disorder&#44; and neuroleptic and antidepressive treatment was started&#46; However&#44; the patient continued to suffer disconnection from the environment and disorientation&#44; heteroaggressive behavior&#44; and oppositionist and behavioral disorders&#46; The patient was admitted to the psychiatric ward with akinetic mutism&#46; The neurological exploration revealed no alterations &#40;though the patient was totally uncooperative&#41;&#44; and the laboratory test results &#40;including serological testing for syphilis and HIV infection&#41; proved normal&#46; On the third day his condition worsened&#44; with no response to stimuli&#44; the appearance of flaccid tetraparesis and a left positive Babinski reflex&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">On day four the patient developed high fever&#44; respiratory sounds suggestive of bronchoaspiration&#44; and finally tonic-clonic seizures&#46; Admission to our Intensive Care Unit &#40;ICU&#41; was thus decided&#46; The patient was admitted under postcritical condition&#44; with fever &#40;38&#46;6<span class="elsevierStyleHsp" style=""></span>&#176;C&#41; and SatO<span class="elsevierStyleInf">2</span> 75&#37; with oxygen therapy &#40;reservoir&#41;&#59; intubation was decided&#44; and mechanical ventilation was started&#46; There were few crepitants in the right lung base&#44; and the rest of the exploration yielded no findings of relevance&#46; The routine laboratory test parameters were normal&#44; with the exception of CPK 1800<span class="elsevierStyleHsp" style=""></span>U&#47;l&#44; and the chest X-rays showed a weak right basal infiltrate&#46; Repeat CAT showed no alterations&#44; and lumbar puncture yielded clear cerebrospinal fluid &#40;CSF&#41;&#44; emerging without pressure&#44; containing 13 cells &#40;with 92&#37; monocytes&#41;&#44; no glucose depletion&#44; and a protein concentration of 189&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; Aciclovir and broad spectrum antibiotic treatment were prescribed&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The hemodynamic and respiratory alterations quickly reverted&#59; the blood and CSF cultures proved negative&#59; and the usual flora was identified in the tracheal aspirate&#46; Magnetic resonance imaging &#40;MRI&#41; revealed numerous foci with enhanced signal intensity in T2-FLAIR images&#46; The lesions were of small size&#44; tended to merge&#44; and presented a cotton-like appearance&#59; they were mostly restricted in size in diffusion sequencing and did not increase in intensity with contrast administration&#46; The lesions were located bilaterally in the basal ganglia&#44; corpus callosum &#40;body and splenium&#41;&#44; the medial regions of both thalami&#44; the deep periventricular white mater&#44; the frontal subcortical zone&#44; the cortico-subcortical region at right parasylvian level and the left anteromedial temporal region &#8211; with involvement of the cerebellar peduncles and right hemi-mesencephalon &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The epidemiological context required us to discard encephalitis caused by west Nile virus &#40;the patient worked in an area with a strong presence of mosquitoes and where this virus had already been isolated<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a>&#41;&#44; with a similar MRI pattern&#44; and encephalitis due to zika virus &#40;recently described&#41;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> &#40;his partner had returned from Cuba where an epidemic outbreak had been declared at the time&#41;&#46; Lumbar puncture was repeated&#44; with negative PCR test results for the mentioned virus as well as for more common varicella-zoster virus and enterovirus&#44; and we requested CSF and serum testing for onconeural antibodies&#44; anti-Ma &#40;Ma1&#44; Ma2&#47;Ta&#41;&#44; anti-NMDA&#44; anti-LGI1&#44; anti-voltage gated potassium channel antibodies and anti-GAG&#46; All proved negative&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A guided interview revealed that the patient &#40;a musician&#41; had suffered marked hearing loss in the left ear as well as vision problems&#44; since his partner noticed that he failed to see the signals she usually showed him on stage&#46; The triad of encephalitis&#44; hearing impairment and loss of visual acuity secondary to retinal arterial obstruction&#44; together with the MRI findings&#44; were indicative of Susac&#39;s syndrome &#40;SS&#41;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> &#8211; a form of autoimmune encephalitis&#46; Evaluation of the ocular fundus confirmed the diagnosis&#44; with the right eye presenting sectorial macular edema and a pale retina in the area of the inferior cilioretinal artery suggestive of arterial obstruction&#46; The left eye in turn presented a small ischemic area in the region of the inferior temporal arch with sectorial vasculitis but no involvement of the foveal region&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Corticosteroid pulses were quickly prescribed &#40;1<span class="elsevierStyleHsp" style=""></span>g&#47;day for 3 days&#41;&#44; followed by 100<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; and immunoglobulin &#40;2<span class="elsevierStyleHsp" style=""></span>g&#47;kg in 5 days&#41;&#46; The patient started to awaken after 72<span class="elsevierStyleHsp" style=""></span>h&#44; being able to follow simple instructions&#44; and extubation was decided on day 6 of admission&#46; He was finally discharged to the ward awake&#44; though with slowed mental processing&#44; disorientation in time and space&#44; flaccid tetraparesis and a bilateral positive Babinski reflex&#46; Audiometry diagnosed hearing deficiency referred to acute tones in the left ear&#46; Clinical progression in the ward was interrupted by another psychotic outbreak coinciding with a lowering of the corticosteroid dose&#46; Ten months after the episode&#44; the patient has fully recovered&#44; except for mild frontal symptoms&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In recent years there has been an increase in reported encephalitis of non-infectious origin&#44; including cases published in our setting&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Most of these cases have been of autoimmune origin&#44; associated to the presence of antineuronal antibodies&#44; with a clinical picture that may simulate an infectious origin or manifest as neurological and&#47;or psychiatric disorders&#44; sometimes without fever or CSF pleocytosis&#46; This group of disorders comprises limbic encephalitis&#44; anti-NMDA receptor encephalitis&#44; Bickerstaff encephalitis and disseminated acute encephalitis &#8211; including SS&#46; The latter is a rare disease &#40;with about 350 cases described to date&#41;&#44; involving vasculitic alterations of the brain&#44; retina and cochlea&#46; The condition characteristically starts with psychiatric symptoms&#44; and admission to the psychiatric ward &#40;as in our patient&#41; is common&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;6&#44;7</span></a> The diagnostic criteria of SS have been established recently&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> The syndrome is three-fold more common in women than in men&#44; and the clinical triad is observed in only 13&#37; of the cases &#40;more often in males&#41;&#46; We consider that our case illustrates the importance of the differential diagnosis with viral encephalitis &#40;our case moreover involving two unusual viruses&#41; and the fundamental role played by early MRI study&#44; which in addition to discarding a herpetic origin of the disorder allows the differentiation of disease patterns characterizing each type of autoimmune encephalitis&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Involvement of the corpus callosum&#44; for example&#44; is considered to be pathognomonic of SS&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> An early diagnosis allows the prompt start of treatment&#44; which is associated to an improve patient response<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> with fewer sequelae in the form of persistent cognitive impairment&#46;</p></span>"
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