Original
Capnometry levels as an indicator of renal graft evolution in uncontrolled non-heart beating donors
Niveles de capnometría como indicador de evolución de injerto renal de donantes en asistolia no controlada
A. Mateos Rodrígueza,b,e,
, D. Varillas Delgadob,e, A. Villar Ariasc,e, C. Rubio Chacónc, A. Andrés Belmonted
Corresponding author
a Oficina Regional de Coordinación de Trasplantes, Consejería de Sanidad, Comunidad de Madrid, Spain
b Facultad de Ciencias de la Salud, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain
c Servicio de Urgencias Médicas de Madrid SUMMA112, Comunidad de Madrid, Spain
d Coordinación de Trasplantes, Hospital Universitario 12 de Octubre, Madrid, Spain
e Grupo de Investigación en Donación y Trasplantes, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain
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Andrés" "apellidos" => "Belmonte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Oficina Regional de Coordinación de Trasplantes, Consejería de Sanidad, Comunidad de Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Facultad de Ciencias de la Salud, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Urgencias Médicas de Madrid SUMMA112, Comunidad de Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Coordinación de Trasplantes, Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Grupo de Investigación en Donación y Trasplantes, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Niveles de capnometría como indicador de evolución de injerto renal de donantes en asistolia no controlada" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 716 "Ancho" => 1583 "Tamanyo" => 68861 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Time course of the serum creatinine concentrations and proteinuria in the graft recipients.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Capnometry, or end-expiratory CO<span class="elsevierStyleInf">2</span> (EtCO<span class="elsevierStyleInf">2</span>), is a very useful tool in the emergency care setting for assessing the hemodynamic condition of the patient, particularly in situations of cardiopulmonary arrest (CPA), where it has been shown to be a prognostic indicator and an appropriate means of support in resuscitation maneuvering.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> Likewise, in less seriously ill patients, capnometry affords information about ventilation status and tissue perfusion.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3–5</span></a> The latest recommendations on the management of CPA are clear about the use of capnography<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> as a method for checking endotracheal tube positioning and for the prognosis of CPA in combination with other indicators. Accordingly, in recent years capnometry has become established as an essential clinical tool in the critically ill.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7–11</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The assessment of all potential organ donors comprises a series of tests and markers for evaluating suitability as a donor and safety for the recipient. Capnography is increasingly used among such markers, since it allows indirect but precise assessment of tissue perfusion of the organs of the possible donor.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12,13</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In the concrete case of uncontrolled non-heart beating donation (NHBD), these indicators are especially relevant, since decision making must be made in a shorter period of time. Most NHDB procedures in Spain have an efficacy rate of about 70%<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>; it is therefore of interest to establish scientifically tested indicators that are effective in selecting possible donors. Capnography could be one of these indicators, and although this field has not been extensively developed to date, a number of studies have suggested that capnography may be a method to be taken into account.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In view of the above, the present study was designed to assess capnography as a predictor of the viability of renal grafts in NHBD, exploring the relationship between application of the technique during the donor management process in the emergency care setting and the condition of the possible renal grafts obtained.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Patients and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">A retrospective study was made of the interventions carried out for kidney transplantation from non-heart beating donors in Doce de Octubre University Hospital (Madrid, Spain) between January 2013 and May 2017.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Type IIA NHBD according to the Maastricht classification (modified, Madrid 2011)<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> refers to donation from patients that have suffered cardiac arrest and who following resuscitation maneuvering by the out-hospital emergency services, without the recovery of pulse, are transferred to hospital under cardiac massage with mechanical chest compression, intubation and mechanical ventilation.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Once resuscitation maneuvering was found to be ineffective and the transplantation coordinator of the hospital had been alerted, the donors were transferred with mechanical chest compression (LUCAS2®) and mechanical ventilation using an Oxylog 3000 plus® transport respirator. In hospital, the possible donors were subjected to extracorporeal circulation and the kidneys were preserved under normothermal abdominal perfusion until harvesting.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The case selection criteria comprised all potential donors transferred to Doce de Octubre University Hospital in the context of NHBD. The inclusion criteria were therefore the same as those applied to NHBD: patients between 18–60 years of age, with a time to onset of resuscitation maneuvering of under 15 min from the time of CPA, arrival in hospital in less than 120 min from the time of CPA, with no bleeding abdominal injuries, and with no suspected neoplastic disease, infections or parenteral drug abuse. The potential donors were subjected to normothermal extracorporeal membrane oxygenation (ECMO) according to the routine procedure described in the literature.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> The recipients in turn were patients subjected to hemodialysis and on the transplant waiting list.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The study was approved by the Ethics Committee of Francisco de Vitoria University (Madrid, Spain).</p><p id="par0050" class="elsevierStylePara elsevierViewall">The following data were collected corresponding to the donors registered by the transplantation coordinator of Doce de Octubre University Hospital: gender, age, smoking, background diseases, time of CPA, time of start of advanced life support (ALS) measures, time of patient hospital transfer, time of arterial catheterization, time of start of extracorporeal circulation, time of clamping prior to organ harvesting, transplantation or not of the kidney, and the capnography values at the start of cardiopulmonary resuscitation (CPR), half-way through the emergency services care period, and at the time of in-hospital transfer. On a consensus basis among the authors, with their experience in interpreting capnographic data, and in accordance with the literature,<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> the capnography values were classified as normal or adequate if over 30 mmHg.</p><p id="par0055" class="elsevierStylePara elsevierViewall">We also recorded the cold ischemia time, defined as the time between organ harvesting from the donor and its implantation in the recipient.</p><p id="par0060" class="elsevierStylePara elsevierViewall">For the measurement of EtCO<span class="elsevierStyleInf">2</span>, and once the patient was intubated, use was made of a LifePack 15® monitor / defibrillator (Physio-Control, Redmond, WA, USA), with measurements based on side stream technology.</p><p id="par0065" class="elsevierStylePara elsevierViewall">The hospital case histories of the transplant patients were reviewed for compilation of the following variables: gender, age, cause of chronic renal failure, duration of dialysis before transplantation, HLA system incompatibilities, presence of primary renal failure, acute graft rejection, delayed renal function (over 7 days), measurement of serum creatinine (day 1, day 7, month 3, month 6, 1 year, 1.5 years, 2 years, 3 years and 4 years) and proteinuria (day 1, day 7, month 3, month 6, 1 year, 1.5 years, 2 years, 3 years and 4 years), graft survival and patient survival at 12 months.</p><p id="par0070" class="elsevierStylePara elsevierViewall">A descriptive statistical study was made, reporting quantitative variables as the mean ± standard deviation (SD) and qualitative variables as frequencies. Normal distribution of the quantitative variables was assessed using the Shapiro-Wilk test. With regard to the comparative study, and for a limited sample size, we performed univariate analysis with assessment of the association between qualitative variables using the chi-squared test and Fisher exact test if any of the expected values was less than 5. Associations between qualitative and quantitative variables in turn were evaluated with the nonparametric Mann-Whitney U-test.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Statistical significance was considered for p < 0.05. The SPSS version 21.0 statistical package (SPSS® Inc., Chicago, IL, USA) for MS Windows was used throughout.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Results</span><p id="par0080" class="elsevierStylePara elsevierViewall">A total of 37 donors were recorded during the period of the study, with a mean age of 44.81 ± 6.64 years. Of these, 34 were males (91.9%) and three females (8.1%). The mean time from CPA to the start of ALS was 12 ± 4.83 min. The mean time elapsed from the confirmation of donor death to organ harvesting was 3.61 ± 0.54 h. The EtCO<span class="elsevierStyleInf">2</span> values at the start of ALS, half-way through the emergency services care period, and at the time of in-hospital transfer are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Thirty donors yielded organs (n = 55 kidneys). <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> compares the donors that were used versus those not used, for each of the donor group variables: no significant differences were observed, apart from the capnometry values.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">A total of 83.6% recipients (n = 46) were males and 9 females, with a mean age of 49.59 ± 9.10 years. The mean duration of dialysis among the recipients was 1.45 ± 1.11 years.</p><p id="par0095" class="elsevierStylePara elsevierViewall">A total of 81.2% of the grafts (n = 45 patients) presented delayed renal function, with a mean of 17.76 ± 9.01 days. These patients required an average of 4.56 ± 2.27 hemodialysis sessions until the graft started to function normally. No primary renal failures were recorded.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Likewise, no statistically significant association was observed between the initial and final capnography values, age, cold and warm ischemia time, or time from CPA to basic life support, and the delay in renal function (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>).</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">The determinations referred to serum creatinine and proteinuria over follow-up of the recipients are reported in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>. The graft survival rate was 100% in all the studied patients, with no transplant-related deaths.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0110" class="elsevierStylePara elsevierViewall">Non-heart beating donation has become an important source of organs for transplantation, particularly kidneys, in the course of the last decade.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14,16</span></a> According to data from the Spanish National Transplantation Organization (<span class="elsevierStyleItalic">Organización Nacional de Trasplantes</span>), a total of 126 kidneys, 15 lungs and 9 livers were transplanted in the year 2016.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> However, the conditions characterizing CPA imply increased tissue vulnerability and aggression. Although it seems logical for renal grafts obtained from NHBD to suffer greater stress than organs obtained from other types of donors, the study carried out by Gagandeep et al.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> recorded no major differences between kidneys obtained from NHBD and those obtained from brain dead donors.</p><p id="par0115" class="elsevierStylePara elsevierViewall">Capnometry is commonly used in the monitorization of critical patients, and particularly in the context of CPA, where it has been shown to act as a prognostic indicator and marker of the adequacy of ALS maneuvering.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18,19</span></a> Different studies have warranted the relationship between capnography values and adequate organ perfusion.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In this regard, a number of studies have explored variables or factors capable of predicting the viability of organs for donation, taking into consideration donors of this kind, in the same way as has been done in predicting sepsis in the out-hospital setting<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20–22</span></a> or admission to the Intensive Care Unit (ICU).<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Our review of the literature yielded no studies on capnography as a predictor of graft evolution, with the exception of a letter to the Editor describing liver graft rejection due to ischemia in an uncontrolled non-heart beating donor, in which the capnography readings were seen to be low during resuscitation maneuvering.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Capnography values have been related to the validity of harvested kidneys. In this respect, kidneys rejected due to ischemia or poor perfusion were found to come from donors with lower EtCO<span class="elsevierStyleInf">2</span> readings than those in which organ transplantation was effectively carried out – with statistically significant findings at the time of transfer. This observation is consistent with the data found in the literature on the association between capnography and tissue perfusion,<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> though it must be underscored that other factors may also condition graft viability, such as the duration of cardiopulmonary resuscitation, among others. However, these factors have only been referred to in a clinical case published in 2011 by Cordero-Escobar et al.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Lower capnometry values have been recorded at the time of transfer in the case of kidneys that were not successful and had to be rejected to the effects of donation (p = 0.016). No such data have been recorded to date in the context of NHBD resulting in renal transplantation, though information is indeed available in relation to lung grafting, where higher capnometry readings have been shown to be correlated to increased organ viability in transplant patients.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26,27</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Lower capnometry values have been documented at the time of transfer in kidneys with delayed renal function, though the results were not statistically significant – possibly because of limitations in sample size. However, the data contrasting patients with delayed renal function (19 mmHg) versus those without delayed function (26.33 mmHg) suggest that a study with a larger sample size and involving a prospective and controlled design could produce more convincing conclusions in this key aspect referred to organ donors and increased patient quality of life. With regard to the delay in renal function, the patients of the series presented an average overall delay of 17.76 days, which is consistent with the available literature, which describes a delay in renal function in NHBD recipients of 15 days versus 7 days in patients receiving grafts from brain dead donors.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Another aspect that has been cited as possibly conditioning delays in renal function is the duration of cold ischemia. In this respect, although no statistically significant differences were observed between patients without delayed renal function (8.875 h) versus those with delayed function (15.023) (p = 0.144), the evidence suggests that there is a clear association between cold ischemia time and delayed renal graft function, as observed in the study published by Emiroğlu et al. in 2005.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">With regard to the possible complications after transplantation, an association has only been found between the EtCO<span class="elsevierStyleInf">2</span> values and the delay in renal graft function after transplantation – though statistical significance was not reached (p = 0.062). This finding may be conditioned by the limited sample size involved (one of the limitations of this retrospective study). Accordingly, it has been necessary to exclude those possible donors with last capnography readings that were not close in time to in-hospital transfer. The capnometry data are recorded according to the criterion of the healthcare staff, and in some cases the last capnography readings were obtained far in time from the time of transfer. As a result, with a view to securing a more reliable analysis, some of these cases were obviated.</p><p id="par0150" class="elsevierStylePara elsevierViewall">The limitations of the present study are clear and evident, and need to be resolved by the research team in future studies, since on the basis of the data generated by our analysis, we can only insist on the need for a prospective study involving a large sample size in order to confirm all the assumptions of this first evaluation of the capnometry results in NHBD patients, with a view to better understanding the crucial role of capnography and posterior intervention on the part of the emergency services.</p><p id="par0155" class="elsevierStylePara elsevierViewall">In conclusion, capnometry could be a factor to be considered in the selection of possible non-heart beating donors, as it is related to the rejection of organs for transplantation purposes. On the other hand, further research is required, involving larger sample sizes and more adequate designs for the appropriate collection of variables, with a view to confirming the hypothesis that the capnography values recorded during resuscitation are related to delayed renal graft function after transplantation.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Authorship</span><p id="par0160" class="elsevierStylePara elsevierViewall">Alonso Mateos and Alicia Villar carried out the clinical interpretation of the statistical analysis.</p><p id="par0165" class="elsevierStylePara elsevierViewall">David Varillas performed the statistical analysis and editing and drafting of the manuscript, together with Alonso Mateos and Alicia Villar.</p><p id="par0170" class="elsevierStylePara elsevierViewall">Carlos Rubio and Alicia Villar compiled the patient data from the case history records of Doce de Octubre University Hospital.</p><p id="par0175" class="elsevierStylePara elsevierViewall">Francisco José del Río and Amado Andrés facilitated access to the data and endorsed the study.</p><p id="par0180" class="elsevierStylePara elsevierViewall">Alonso Mateos, David Varillas and Alicia Villar are members of the Donation and Transplant Research Group of Francisco de Vitoria University.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflicts of interest</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1332816" "titulo" => "Abstract" "secciones" => array:8 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Design" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Scope" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Patients" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Interventions" ] 5 => array:2 [ "identificador" => "abst0030" "titulo" => "Variables" ] 6 => array:2 [ "identificador" => "abst0035" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1227928" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1332817" "titulo" => "Resumen" "secciones" => array:8 [ 0 => array:2 [ "identificador" => "abst0045" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0050" "titulo" => "Diseño" ] 2 => array:2 [ "identificador" => "abst0055" "titulo" => "Ámbito" ] 3 => array:2 [ "identificador" => "abst0060" "titulo" => "Pacientes" ] 4 => array:2 [ "identificador" => "abst0065" "titulo" => "Intervenciones" ] 5 => array:2 [ "identificador" => "abst0070" "titulo" => "Variables" ] 6 => array:2 [ "identificador" => "abst0075" "titulo" => "Resultados" ] 7 => array:2 [ "identificador" => "abst0080" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1227927" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Patients and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Authorship" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflicts of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-07-26" "fechaAceptado" => "2018-10-30" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1227928" "palabras" => array:5 [ 0 => "Capnometry" 1 => "Kidney transplantation" 2 => "Asystole" 3 => "Resuscitation" 4 => "Emergency medical services" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1227927" "palabras" => array:5 [ 0 => "Capnometría" 1 => "Trasplante renal" 2 => "Asistolia" 3 => "Resucitación" 4 => "Servicios de emergencias médicas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The capnometry values during resuscitation are an evolutive predictor of kidneys obtained from uncontrolled non-heart beating donors.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The study comprised a retrospective onset cohort of 37 non-heart beating donors and a validation cohort of 55 transplanted kidneys in the period 2013–2017.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Scope</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The population served by the emergency service and referred to Hospital Universitario Doce de Octubre (Madrid, Spain) as potential uncontrolled non-heart beating donors.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Patients</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A total of 55 renal transplant patients subjected to hemodialysis and with grafts from uncontrolled non-heart beating donors.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Interventions</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Capnometry and capnography measurements in potential uncontrolled non-heart beating donors.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Variables</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Capnometry values recorded initially and at transfer in hospital for comparison with the viability of the extracted kidneys; renal failure and delayed renal function.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Results</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">A total of 55 out of 74 extracted kidneys were transplanted (74.3%). The rest were ruled out due to poor perfusion or signs of ischemia. An association was observed (p = 0.016) between the capnometry values during resuscitation in the grafted kidneys (µ = 22.8 mmHg) and in the kidneys discarded for transplantation (µ = 17.35 mmHg).</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusions</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Capnometry during resuscitation serves as a marker to be taken into account in relation to the viability of the transplanted organs in uncontrolled non-heart beating donors.</p></span>" "secciones" => array:8 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Design" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Scope" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Patients" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Interventions" ] 5 => array:2 [ "identificador" => "abst0030" "titulo" => "Variables" ] 6 => array:2 [ "identificador" => "abst0035" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Objetivo</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Los valores de capnometría durante la resucitación son un factor predictor de la evolución de los riñones obtenidos a partir de donantes en asistolia no controlada.</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Diseño</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Cohorte de comienzo retrospectivo de 37 donantes en asistolia, y cohorte de validación de 55 trasplantados de riñón, entre 2013–2017.</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Ámbito</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">población atendida por el servicio de emergencias y derivada al Hospital Universitario 12 de Octubre, Madrid, como potenciales donantes en asistolia no controlada.</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pacientes</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">55 trasplantados renales con hemodiálisis, procedentes de donantes en asistolia no controlada.</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Intervenciones</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">determinaciones de capnometría y capnografía en pacientes candidatos a donación en asistolia no controlada.</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Variables</span><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Valores de capnometría inicial y en el momento de la transferencia en el hospital para su comparación con la viabilidad de los riñones extraídos; fallo renal y retraso en función renal.</p></span> <span id="abst0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">37 potenciales donantes de los que se consiguen 30 utilizados, de los cuales se trasplantan 55 riñones. El resto fueron descartados por mala perfusión o signos de isquemia. Se encontró una asociación (p = 0.016) entre valores de capnometría durante la resucitación en los donantes utilizados (µ = 22.8 mmHg) frente a los donantes no utlizados para el trasplante (µ = 17.35 mmHg).</p></span> <span id="abst0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusiones</span><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Se ha demostrado que los valores de capnometría durante las maniobras de resucitación ofrecen un marcador a tener en cuenta en relación con la viabilidad de los órganos a trasplantar en la donación en asistolia no controlada.</p></span>" "secciones" => array:8 [ 0 => array:2 [ "identificador" => "abst0045" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0050" "titulo" => "Diseño" ] 2 => array:2 [ "identificador" => "abst0055" "titulo" => "Ámbito" ] 3 => array:2 [ "identificador" => "abst0060" "titulo" => "Pacientes" ] 4 => array:2 [ "identificador" => "abst0065" "titulo" => "Intervenciones" ] 5 => array:2 [ "identificador" => "abst0070" "titulo" => "Variables" ] 6 => array:2 [ "identificador" => "abst0075" "titulo" => "Resultados" ] 7 => array:2 [ "identificador" => "abst0080" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Mateos Rodríguez A, Varillas Delgado D, Villar Arias A, Rubio Chacón C, Andrés Belmonte A. Niveles de capnometría como indicador de evolución de injerto renal de donantes en asistolia no controlada. Med Intensiva. 2020;44:233–238.</p>" ] ] "multimedia" => array:4 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 716 "Ancho" => 1583 "Tamanyo" => 68861 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Time course of the serum creatinine concentrations and proteinuria in the graft recipients.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean (mmHg) ± SD \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Maximum (mmHg) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Minimum (mmHg) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Initial capnometry \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22.8 ± 12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Transfer capnometry \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26.8 ± 18.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2284573.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Capnometry (EtCO<span class="elsevierStyleInf">2</span>) data during organ donor management.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Used (n = 30) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Non-used (n = 7) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-Value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.83 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.051 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male gender \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.306 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Initial capnometry (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21.57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.471 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Final capnometry (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.016 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Disease (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.624 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Smoker (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42.85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.890 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time CPA-ALS (min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.119 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2284572.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Comparison between used and non-used organ donors.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No (n = 10) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Yes (n = 45) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-Value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Initial capnometry (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.963 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Transfer capnometry (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.235 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45.53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.196 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cold ischemia time (h) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.875 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.023 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.144 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Warm ischemia time (h) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.478 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.555 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.729 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time PCS-ALS (min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.245 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2284574.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Comparison of delayed renal function with the capnometry data.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A review of carbon dioxide monitoring during adult cardiopulmonary resuscitation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 6 | 8 |
| 2024 October | 40 | 43 | 83 |
| 2024 September | 51 | 34 | 85 |
| 2024 August | 52 | 34 | 86 |
| 2024 July | 92 | 29 | 121 |
| 2024 June | 41 | 41 | 82 |
| 2024 May | 34 | 38 | 72 |
| 2024 April | 41 | 36 | 77 |
| 2024 March | 47 | 29 | 76 |
| 2024 February | 26 | 42 | 68 |
| 2024 January | 33 | 31 | 64 |
| 2023 December | 22 | 46 | 68 |
| 2023 November | 46 | 65 | 111 |
| 2023 October | 30 | 29 | 59 |
| 2023 September | 15 | 48 | 63 |
| 2023 August | 22 | 29 | 51 |
| 2023 July | 30 | 41 | 71 |
| 2023 June | 31 | 20 | 51 |
| 2023 May | 34 | 29 | 63 |
| 2023 April | 42 | 19 | 61 |
| 2023 March | 65 | 39 | 104 |
| 2023 February | 60 | 39 | 99 |
| 2023 January | 33 | 27 | 60 |
| 2022 December | 62 | 46 | 108 |
| 2022 November | 57 | 52 | 109 |
| 2022 October | 57 | 59 | 116 |
| 2022 September | 45 | 37 | 82 |
| 2022 August | 49 | 47 | 96 |
| 2022 July | 49 | 37 | 86 |
| 2022 June | 54 | 30 | 84 |
| 2022 May | 44 | 32 | 76 |
| 2022 April | 49 | 40 | 89 |
| 2022 March | 56 | 55 | 111 |
| 2022 February | 43 | 34 | 77 |
| 2022 January | 63 | 48 | 111 |
| 2021 December | 45 | 66 | 111 |
| 2021 November | 34 | 53 | 87 |
| 2021 October | 58 | 71 | 129 |
| 2021 September | 31 | 35 | 66 |
| 2021 August | 39 | 42 | 81 |
| 2021 July | 24 | 24 | 48 |
| 2021 June | 27 | 10 | 37 |
| 2021 May | 31 | 48 | 79 |
| 2021 April | 73 | 87 | 160 |
| 2021 March | 55 | 35 | 90 |
| 2021 February | 58 | 34 | 92 |
| 2021 January | 38 | 27 | 65 |
| 2020 December | 48 | 35 | 83 |
| 2020 November | 27 | 18 | 45 |
| 2020 October | 10 | 11 | 21 |
| 2020 July | 10 | 9 | 19 |
| 2020 June | 25 | 14 | 39 |
| 2020 May | 41 | 23 | 64 |
| 2020 April | 30 | 21 | 51 |
| 2020 March | 2 | 0 | 2 |
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