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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">SARS-CoV-2 challenged ICU doctors&#8217; ability to support patients with acute respiratory insufficiency&#46; This was due to both the unexpectedly high rate of admissions and the severity of these patients&#46; Through this case we would like to highlight the physiology guided management of a patient with profound hypoxemia&#46; In spite of an apparently life threatening condition this patient had a good course with conventional management guided by invasive hemodynamic monitoring&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 46 years old male was admitted to the ICU with presumptive diagnosis of SARS-CoV-2&#46; Respiratory symptoms had started 10 days before admission to the emergency room&#46; Due to hypoxemia and tachypnea as well as an X-ray with bilateral infiltrates&#44; the patient was early transferred to ICU&#46; Support with high flow oxygen was started but escalation to invasive mechanical ventilation &#40;MV&#41; was required due to persistent hypoxemia&#46; Due to a PaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>mmHg despite FiO<span class="elsevierStyleInf">2</span> 1 &#40;with protective mechanical ventilation settings PEEP 10 cmH<span class="elsevierStyleInf">2</span>O&#44; tidal volume 6<span class="elsevierStyleHsp" style=""></span>ml&#47;kg&#44; plateau pressure 20<span class="elsevierStyleHsp" style=""></span>cmH<span class="elsevierStyleInf">2</span>O&#41; the patient was subjected to prone positioning therapy&#46; The patient showed no change in respiratory mechanics during prone positioning but a slight improvement in oxygenation was observed&#46; He completed a 16<span class="elsevierStyleHsp" style=""></span>h prone therapy session&#46; Once in supine&#44; oxygenation was severely deteriorated again with a PaO<span class="elsevierStyleInf">2</span>&#47;FIO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>mmHg hence extracorporeal membrane oxygenation &#40;ECMO&#41; therapy was proposed&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> Additionally&#44; he underwent invasive monitoring with a Swan-Ganz catheter&#46; The patient showed moderate pulmonary hypertension &#40;PASP 45<span class="elsevierStyleHsp" style=""></span>mmHg&#44; PVRi 388<span class="elsevierStyleHsp" style=""></span>dyn<span class="elsevierStyleHsp" style=""></span>s<span class="elsevierStyleHsp" style=""></span>cm<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a>&#41;&#44; cardiac index 3&#46;5<span class="elsevierStyleHsp" style=""></span>l<span class="elsevierStyleHsp" style=""></span>min<span class="elsevierStyleSup">&#8722;1</span><span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> and a preserved mixed blood oxygen saturation around 75&#37;&#46; These data were complemented with a transthoracic echocardiogram that showed no right ventricular &#40;RV&#41; dysfunction &#40;which was concordant with a pulmonary artery pulsatility index<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;7&#41;&#44; preserved left ventricular function and no signs of hypovolemia&#46; Based on the preserved RV function and an adequate oxygen delivery with protective MV settings the decision of starting ECMO was postponed&#46; Prone positioning sessions were continued up to a number of 5 and during the following days both the patient&#39;s lung function &#40;which was more prominent in prone&#41; as well as pulmonary hemodynamics progressively improved&#46; The patient was extubated 2 weeks later&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">During times of health services overwhelming&#44; the selection of patients who will benefit from therapies related with a high consumption of resources should be carefully and efficiently performed&#46; In the ICU one of these therapies is ECMO&#46; There are doubts about the long term prognosis of patients with SARS-CoV-2 who develop severe hypoxemia despite the gentlest MV&#46; Besides this&#44; the physiology of the patient with SARS-CoV-2 has been proposed to be different from typical ARDS<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a>&#58; &#40;1&#41; A high proportion of them have good compliance &#40;Gatinnoni&#39;s phenotype L&#41; and in consequence management with low PEEP is recommended and &#40;2&#41; they show a blunted pulmonary vasoconstriction&#46; Also&#44; at least in our experience a low rate of systemic hemodynamic involvement is seen&#46; Such differences could affect the indications of ECMO in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Respiratory ECMO is indicated to ensure oxygen delivery in patients in whom this cannot be reached under protective MV settings&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> Other indications or goals are at least doubtful&#46; Following this reasoning&#44; comparing with typical ARDS&#44; for the same arterial oxygen content&#44; probably a lower proportion of SARS-CoV-2 patients would be subsidiaries of ECMO&#46; A high compliance in a patient managed with relatively low PEEP could make it easier to reach safe settings including low plateau pressure&#44; low driving pressure and tidal volume around 6<span class="elsevierStyleHsp" style=""></span>ml&#47;kg<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a>&#46; If we put this altogether with the decreased pulmonary vascular response to hypoxia&#44; a low prevalence of RV failure could be expected&#46; Finally&#44; in the absence of RV dysfunction&#44; patients with preserved left ventricle function can maintain a cardiac output enough to keep an adequate oxygen delivery&#46; Therefore&#44; deciding starting ECMO based only on PaO<span class="elsevierStyleInf">2</span> may not be adequate to cover the entire physiologic process in some patients with severe respiratory insufficiency in the context of COVID-19&#46; This resolution should be adjusted to the current recommendations regarding the availability of resources&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Another important finding of this case is the apparently low O<span class="elsevierStyleInf">2</span> extraction which could be compatible with low systemic involvement at least at the disease stage at which the patient was&#46; Also this could be due to the adequate sedation and the use neuromuscular blockade&#46; In this context we would like to highlight that oxygen delivery depends essentially on cardiac output&#44; hemoglobin concentration and SaO<span class="elsevierStyleInf">2</span>&#46; Therefore in patients without risk of low cardiac output&#44; taking into account SaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> instead of PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> could be a better index when taking the decision of escalating toward therapies such as ECMO&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Finally&#44; we would like to remark that despite the severity of the hypoxemia in this patient&#44; he did improve with conventional therapies&#46; Moreover&#44; in spite of the doubts regarding the usefulness of prone positioning in the presence of good compliance&#44; the patient&#39;s improvement was initially more evident with this approach&#46; This could be due to a more marked dependence of pulmonary perfusion on gravity when hypoxic vasoconstriction is blunted&#46; From this point of view prone positioning could be helpful in keeping the patient safe while waiting for the lung to heal&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; through this case we would like to remark the importance of oxygen delivery in the management of patients with SARS-CoV-2 as this pathology could behave differently from typical ARDS&#46; In this line of thought we recommend to be patient as long as we are able to reach the combination of protective MV settings and adequate peripheral oxygenation&#46; This therapeutic attitude could contribute to a decrease in the necessity of more resource consuming therapies&#44; which should be allocated following recommendations that take into account their scarcity during the pandemic&#44; as pointed out by specific guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">Authors have nothing to disclosure&#46;</p></span></span>"
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Scientific Letter
When success means focusing on the oxygen delivery. A case of conventional management of severe hypoxemia in SARS-CoV-2
Cuando el tratamiento adecuado consiste en evaluar el aporte de oxígeno. Manejo convencional de la hipoxemia severa en un paciente con SARS-CoV-2
J.L. Franquezaa, E. Rosasa, A.-M. Ioana, A. Durante-Lópezb, C. Pérez-Calvoa, A. Santosa,c,
Corresponding author
asantosviedo@yahoo.com

Corresponding author.
a Intensive Care Medicine Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
b Department of Cardiology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
c CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain
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was required due to persistent hypoxemia&#46; Due to a PaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>mmHg despite FiO<span class="elsevierStyleInf">2</span> 1 &#40;with protective mechanical ventilation settings PEEP 10 cmH<span class="elsevierStyleInf">2</span>O&#44; tidal volume 6<span class="elsevierStyleHsp" style=""></span>ml&#47;kg&#44; plateau pressure 20<span class="elsevierStyleHsp" style=""></span>cmH<span class="elsevierStyleInf">2</span>O&#41; the patient was subjected to prone positioning therapy&#46; The patient showed no change in respiratory mechanics during prone positioning but a slight improvement in oxygenation was observed&#46; He completed a 16<span class="elsevierStyleHsp" style=""></span>h prone therapy session&#46; Once in supine&#44; oxygenation was severely deteriorated again with a PaO<span class="elsevierStyleInf">2</span>&#47;FIO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>mmHg hence extracorporeal membrane oxygenation &#40;ECMO&#41; therapy was proposed&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> Additionally&#44; he underwent invasive monitoring with a Swan-Ganz catheter&#46; The patient showed moderate pulmonary hypertension &#40;PASP 45<span class="elsevierStyleHsp" style=""></span>mmHg&#44; PVRi 388<span class="elsevierStyleHsp" style=""></span>dyn<span class="elsevierStyleHsp" style=""></span>s<span class="elsevierStyleHsp" style=""></span>cm<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a>&#41;&#44; cardiac index 3&#46;5<span class="elsevierStyleHsp" style=""></span>l<span class="elsevierStyleHsp" style=""></span>min<span class="elsevierStyleSup">&#8722;1</span><span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> and a preserved mixed blood oxygen saturation around 75&#37;&#46; These data were complemented with a transthoracic echocardiogram that showed no right ventricular &#40;RV&#41; dysfunction &#40;which was concordant with a pulmonary artery pulsatility index<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;7&#41;&#44; preserved left ventricular function and no signs of hypovolemia&#46; Based on the preserved RV function and an adequate oxygen delivery with protective MV settings the decision of starting ECMO was postponed&#46; Prone positioning sessions were continued up to a number of 5 and during the following days both the patient&#39;s lung function &#40;which was more prominent in prone&#41; as well as pulmonary hemodynamics progressively improved&#46; The patient was extubated 2 weeks later&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">During times of health services overwhelming&#44; the selection of patients who will benefit from therapies related with a high consumption of resources should be carefully and efficiently performed&#46; In the ICU one of these therapies is ECMO&#46; There are doubts about the long term prognosis of patients with SARS-CoV-2 who develop severe hypoxemia despite the gentlest MV&#46; Besides this&#44; the physiology of the patient with SARS-CoV-2 has been proposed to be different from typical ARDS<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a>&#58; &#40;1&#41; A high proportion of them have good compliance &#40;Gatinnoni&#39;s phenotype L&#41; and in consequence management with low PEEP is recommended and &#40;2&#41; they show a blunted pulmonary vasoconstriction&#46; Also&#44; at least in our experience a low rate of systemic hemodynamic involvement is seen&#46; Such differences could affect the indications of ECMO in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Respiratory ECMO is indicated to ensure oxygen delivery in patients in whom this cannot be reached under protective MV settings&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> Other indications or goals are at least doubtful&#46; Following this reasoning&#44; comparing with typical ARDS&#44; for the same arterial oxygen content&#44; probably a lower proportion of SARS-CoV-2 patients would be subsidiaries of ECMO&#46; A high compliance in a patient managed with relatively low PEEP could make it easier to reach safe settings including low plateau pressure&#44; low driving pressure and tidal volume around 6<span class="elsevierStyleHsp" style=""></span>ml&#47;kg<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a>&#46; If we put this altogether with the decreased pulmonary vascular response to hypoxia&#44; a low prevalence of RV failure could be expected&#46; Finally&#44; in the absence of RV dysfunction&#44; patients with preserved left ventricle function can maintain a cardiac output enough to keep an adequate oxygen delivery&#46; Therefore&#44; deciding starting ECMO based only on PaO<span class="elsevierStyleInf">2</span> may not be adequate to cover the entire physiologic process in some patients with severe respiratory insufficiency in the context of COVID-19&#46; This resolution should be adjusted to the current recommendations regarding the availability of resources&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Another important finding of this case is the apparently low O<span class="elsevierStyleInf">2</span> extraction which could be compatible with low systemic involvement at least at the disease stage at which the patient was&#46; Also this could be due to the adequate sedation and the use neuromuscular blockade&#46; In this context we would like to highlight that oxygen delivery depends essentially on cardiac output&#44; hemoglobin concentration and SaO<span class="elsevierStyleInf">2</span>&#46; Therefore in patients without risk of low cardiac output&#44; taking into account SaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> instead of PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> could be a better index when taking the decision of escalating toward therapies such as ECMO&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Finally&#44; we would like to remark that despite the severity of the hypoxemia in this patient&#44; he did improve with conventional therapies&#46; Moreover&#44; in spite of the doubts regarding the usefulness of prone positioning in the presence of good compliance&#44; the patient&#39;s improvement was initially more evident with this approach&#46; This could be due to a more marked dependence of pulmonary perfusion on gravity when hypoxic vasoconstriction is blunted&#46; From this point of view prone positioning could be helpful in keeping the patient safe while waiting for the lung to heal&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; through this case we would like to remark the importance of oxygen delivery in the management of patients with SARS-CoV-2 as this pathology could behave differently from typical ARDS&#46; In this line of thought we recommend to be patient as long as we are able to reach the combination of protective MV settings and adequate peripheral oxygenation&#46; This therapeutic attitude could contribute to a decrease in the necessity of more resource consuming therapies&#44; which should be allocated following recommendations that take into account their scarcity during the pandemic&#44; as pointed out by specific guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">Authors have nothing to disclosure&#46;</p></span></span>"
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ISSN: 21735727
Original language: English
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