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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">On 26 September 2020&#44; this journal published an important article that reported on the existence of a series of statistically significant associations &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;05&#41; between different genetic polymorphisms of the human leukocyte antigen &#40;HLA&#41; system and mortality due to COVID-19 in 72 patients&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> one of which included the HLA-A&#42;11 gene&#44; based on measurement of the odds ratio &#40;OR&#8239;&#61;&#8239;7&#46;693&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The replication of clinical investigations based on significance tests is advised&#46; This can be done through Bayesian inference&#44; since it allows us to reanalyze the significant finding reported by Lorente et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> where the Bayes factor &#40;BF&#41; method is referred to as the probability of the data under one hypothesis in relation to the other hypothesis &#40;null hypothesis versus alternative hypothesis&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> In other words&#44; the BF estimates quantification of the strength of proof on which the data support both hypotheses in contrasting them&#44; beyond the dichotomic interpretation or rejection or acceptance of the null hypothesis&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> The statistical replication of significant findings with the BF allows us to strengthen the practical credibility of articles in the field of Intensive Care Medicine &#40;experimental research&#44; clinical trials&#44; interventions and treatments&#41;&#46; This is required when Bayesian inference reports conclusive or greater level evidence &#40;BF<span class="elsevierStyleInf">10</span>&#8239;&#62;&#8239;10&#41;&#44; based on Jeffrey&#8217;s classification scale<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> for BF&#58; weak&#44; moderate&#44; strong&#44; very strong and extreme &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The aim of the present letter is to report an example of Bayesian reanalysis to define the level of evidence of statistical hypotheses&#46; Accordingly&#44; consideration was made of the sample size and conversion of OR to correlation effect size &#40;r&#41; through an online calculator&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> where the conversion value was r&#8239;&#61;&#8239;0&#46;49&#46; This method considers two interpretations&#58; BF<span class="elsevierStyleInf">10</span> &#40;in favor of the alternative hypothesis&#41; and BF<span class="elsevierStyleInf">01</span> &#40;in favor of the null hypothesis&#41;&#44; with a credibility interval of 95&#37;&#46; The results obtained for BF are&#58; BF<span class="elsevierStyleInf">10</span>&#8239;&#61;&#8239;1&#46;690 and BF<span class="elsevierStyleInf">01</span>&#8239;&#61;&#8239;0&#46;0006&#44; with 95&#37;CI&#58; 0&#46;284&#8722;0&#46;64&#44; which warrants the significant finding reported by Lorente et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> with extreme evidence in favor of the alternative hypothesis &#40;correlation&#41;&#46; This allows us to infer that the rest of statistical associations of greater magnitude between the HLA genes and mortality also exhibit extreme evidence &#8211; thus contributing greater credibility to the clinical conclusions drawn in the mentioned study&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In conclusion&#44; the inclusive use of effect size conversion and the BF is a great methodological contribution that has practical implications for medical decision making&#44; based on the confirmation of results that are effectively conclusive and of greater relevance in the context of COVID-19&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0025" class="elsevierStylePara elsevierViewall">This study has received no specific funding from the public&#44; commercial or non-profit sectors&#46;</p></span></span>"
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Letter to the Editor
Inclusive use of effect size conversion and Bayes factor in intensive care medicine research
Uso inclusivo de la conversión del tamaño de efecto y del factor Bayes en la investigación de medicina intensiva
C. Ramos-Vera
Área de investigación, Facultad de Ciencias de la Salud, Universidad Cesar Vallejo, Lima, Peru
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">On 26 September 2020&#44; this journal published an important article that reported on the existence of a series of statistically significant associations &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;05&#41; between different genetic polymorphisms of the human leukocyte antigen &#40;HLA&#41; system and mortality due to COVID-19 in 72 patients&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> one of which included the HLA-A&#42;11 gene&#44; based on measurement of the odds ratio &#40;OR&#8239;&#61;&#8239;7&#46;693&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The replication of clinical investigations based on significance tests is advised&#46; This can be done through Bayesian inference&#44; since it allows us to reanalyze the significant finding reported by Lorente et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> where the Bayes factor &#40;BF&#41; method is referred to as the probability of the data under one hypothesis in relation to the other hypothesis &#40;null hypothesis versus alternative hypothesis&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> In other words&#44; the BF estimates quantification of the strength of proof on which the data support both hypotheses in contrasting them&#44; beyond the dichotomic interpretation or rejection or acceptance of the null hypothesis&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> The statistical replication of significant findings with the BF allows us to strengthen the practical credibility of articles in the field of Intensive Care Medicine &#40;experimental research&#44; clinical trials&#44; interventions and treatments&#41;&#46; This is required when Bayesian inference reports conclusive or greater level evidence &#40;BF<span class="elsevierStyleInf">10</span>&#8239;&#62;&#8239;10&#41;&#44; based on Jeffrey&#8217;s classification scale<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> for BF&#58; weak&#44; moderate&#44; strong&#44; very strong and extreme &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The aim of the present letter is to report an example of Bayesian reanalysis to define the level of evidence of statistical hypotheses&#46; Accordingly&#44; consideration was made of the sample size and conversion of OR to correlation effect size &#40;r&#41; through an online calculator&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> where the conversion value was r&#8239;&#61;&#8239;0&#46;49&#46; This method considers two interpretations&#58; BF<span class="elsevierStyleInf">10</span> &#40;in favor of the alternative hypothesis&#41; and BF<span class="elsevierStyleInf">01</span> &#40;in favor of the null hypothesis&#41;&#44; with a credibility interval of 95&#37;&#46; The results obtained for BF are&#58; BF<span class="elsevierStyleInf">10</span>&#8239;&#61;&#8239;1&#46;690 and BF<span class="elsevierStyleInf">01</span>&#8239;&#61;&#8239;0&#46;0006&#44; with 95&#37;CI&#58; 0&#46;284&#8722;0&#46;64&#44; which warrants the significant finding reported by Lorente et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> with extreme evidence in favor of the alternative hypothesis &#40;correlation&#41;&#46; This allows us to infer that the rest of statistical associations of greater magnitude between the HLA genes and mortality also exhibit extreme evidence &#8211; thus contributing greater credibility to the clinical conclusions drawn in the mentioned study&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In conclusion&#44; the inclusive use of effect size conversion and the BF is a great methodological contribution that has practical implications for medical decision making&#44; based on the confirmation of results that are effectively conclusive and of greater relevance in the context of COVID-19&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0025" class="elsevierStylePara elsevierViewall">This study has received no specific funding from the public&#44; commercial or non-profit sectors&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Ramos-Vera C&#46; Uso inclusivo de la conversi&#243;n del tama&#241;o de efecto y del factor Bayes en la investigaci&#243;n de medicina intensiva&#46; Med Intensiva&#46; 2022&#59;46&#58;171&#8211;172&#46;</p>"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Note&#58; Proprietary table based on Jeffrey&#8217;s classification scale&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p>"
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                  \t\t\t\t">&#62;100&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Strong&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Alternative hypothesis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Alternative hypothesis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;09&#8722;0&#46;03&nbsp;\t\t\t\t\t\t\n
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                            4 => "J&#46;J&#46; C&#225;ceres"
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ISSN: 21735727
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Medicina Intensiva (English Edition)
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