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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pulmonary toxicity by oxygen has been known for over a century&#46; Exposure to a fraction of inspired oxygen &#40;FiO<span class="elsevierStyleInf">2</span>&#41; of 0&#46;7 causes progressive pulmonary lesion and the intensity of the lesions is associated with the concentration and duration of hyperoxia&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Lesion manifests just a few hours after the administration of oxygen in high concentrations causing an increased alveolar-capillary patency and a complex cellular response including epithelial&#44; endothelial&#44; proinflammatory cells&#44; and platelets that induce the destruction of alveolocapillary membranes with increased air spaces&#44; vascular obstruction due to microthrombi&#44; and cellular infiltration that eventually leads to the loss of alveolar architecture and&#44; in the long run&#44; to pulmonary fibrosis&#46; All oxygen-induced lesions are similar to those due to acute respiratory distress syndrome &#40;ARDS&#41;&#46; Also&#44; in patients with established ARDS&#44; hyperoxia can worsen clinical results&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Finally&#44; many of the pathological characteristics reported in hyperoxia occur also in ARDS due to COVID-19 since it has been reported that in these patients&#8217; lungs increased air spaces following the destruction of alveolar septa&#44; alveolar swelling&#44; capillary thrombosis&#44; perivascular infiltrates&#44; and fibrosis have been found&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The appearance of COVID19 has challenged respiratory support&#44; and the need for applying elevated fractions of inspired oxygen has been a constant in many patients whether through high-flow nasal oxygen &#40;HFNO&#41; therapy or concomitantly to ventilation systems&#46; However&#44; the high mortality rates reported in cases of ARDS&#8212;an average of 39&#37;&#8212;is indicative that&#44; at least in some cases&#44; the application of elevated concentrations of oxygen is worsening or triggering COVID-19<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>-related ARDS-like lesions&#46; It could even cause a vicious circle that would create the need to increase the concentration of oxygen gradually in the air breathed in thus causing greater pulmonary impairment&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">This possibility&#8212;together with data obtained by other authors<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> that most patients with moderate-to-severe acute respiratory failure due to COVID-19&#44; and even cases with radiological findings and compatible gas exchange with ARDS recovered with CPAP and FiO<span class="elsevierStyleInf">2</span> between 0&#46;4 and 0&#46;6&#44; should&#44; in own opinion&#44; make us reconsider or detail the current strategy of respiratory support&#46; Therefore&#44; following the plan established by current recommendations&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> although the next step towards conventional oxygen therapy can still be HFNO when FiO<span class="elsevierStyleInf">2</span> &#62; 0&#46;6 would be needed respiratory support like CPAP should be attempted to recruit more alveolar units before increasing FiO<span class="elsevierStyleInf">2</span> to levels that can be toxic to an already damaged lung&#46; Even under certain safety and monitoring conditions&#44; the saturation target currently established at around 95&#37; in the aforementioned current recommendations could be reduced down to 92&#37; to stop FiO<span class="elsevierStyleInf">2</span> from going &#62; 0&#46;6&#46;</p></span>"
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Letter to the Editor
Pulmonary toxicity by oxygen and COVID-19
Toxicidad pulmonar por oxígeno y COVID-19
A. León-Jiménez, E. Vázquez-Gandullo
Corresponding author
evavgandullo@gmail.com

Corresponding author.
, F. Montoro-Ballesteros
Unidad de Gestión Clínica de Neumología, Alergología y Cirugía Torácica, Servicio de Neumología, Hospital Universitario Puerta del Mar, Cádiz, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pulmonary toxicity by oxygen has been known for over a century&#46; Exposure to a fraction of inspired oxygen &#40;FiO<span class="elsevierStyleInf">2</span>&#41; of 0&#46;7 causes progressive pulmonary lesion and the intensity of the lesions is associated with the concentration and duration of hyperoxia&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Lesion manifests just a few hours after the administration of oxygen in high concentrations causing an increased alveolar-capillary patency and a complex cellular response including epithelial&#44; endothelial&#44; proinflammatory cells&#44; and platelets that induce the destruction of alveolocapillary membranes with increased air spaces&#44; vascular obstruction due to microthrombi&#44; and cellular infiltration that eventually leads to the loss of alveolar architecture and&#44; in the long run&#44; to pulmonary fibrosis&#46; All oxygen-induced lesions are similar to those due to acute respiratory distress syndrome &#40;ARDS&#41;&#46; Also&#44; in patients with established ARDS&#44; hyperoxia can worsen clinical results&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Finally&#44; many of the pathological characteristics reported in hyperoxia occur also in ARDS due to COVID-19 since it has been reported that in these patients&#8217; lungs increased air spaces following the destruction of alveolar septa&#44; alveolar swelling&#44; capillary thrombosis&#44; perivascular infiltrates&#44; and fibrosis have been found&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The appearance of COVID19 has challenged respiratory support&#44; and the need for applying elevated fractions of inspired oxygen has been a constant in many patients whether through high-flow nasal oxygen &#40;HFNO&#41; therapy or concomitantly to ventilation systems&#46; However&#44; the high mortality rates reported in cases of ARDS&#8212;an average of 39&#37;&#8212;is indicative that&#44; at least in some cases&#44; the application of elevated concentrations of oxygen is worsening or triggering COVID-19<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>-related ARDS-like lesions&#46; It could even cause a vicious circle that would create the need to increase the concentration of oxygen gradually in the air breathed in thus causing greater pulmonary impairment&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">This possibility&#8212;together with data obtained by other authors<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> that most patients with moderate-to-severe acute respiratory failure due to COVID-19&#44; and even cases with radiological findings and compatible gas exchange with ARDS recovered with CPAP and FiO<span class="elsevierStyleInf">2</span> between 0&#46;4 and 0&#46;6&#44; should&#44; in own opinion&#44; make us reconsider or detail the current strategy of respiratory support&#46; Therefore&#44; following the plan established by current recommendations&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> although the next step towards conventional oxygen therapy can still be HFNO when FiO<span class="elsevierStyleInf">2</span> &#62; 0&#46;6 would be needed respiratory support like CPAP should be attempted to recruit more alveolar units before increasing FiO<span class="elsevierStyleInf">2</span> to levels that can be toxic to an already damaged lung&#46; Even under certain safety and monitoring conditions&#44; the saturation target currently established at around 95&#37; in the aforementioned current recommendations could be reduced down to 92&#37; to stop FiO<span class="elsevierStyleInf">2</span> from going &#62; 0&#46;6&#46;</p></span>"
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Article information
ISSN: 21735727
Original language: English
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