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and due to the increase in its indications and configurations&#44; ultrasound &#8211; particularly transthoracic echocardiography &#40;TTE&#41; or transesophageal echocardiography &#40;TEE&#41; in the case of a poor exploration window &#8211; has become a key instrument&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a> Adequately trained professionals are needed&#44; since ultrasound allows precise anatomical and functional cardiopulmonary evaluation&#44; guides the insertion and placement of cannulas&#44; helps to optimize flow&#44; allows monitoring to detect and resolve clinical changes&#44; facilitates weaning from ECMO&#44; and contributes to the post-implantation assessment of possible complications&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#8211;15</span></a><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> summarizes the echocardiographic parameters that should be evaluated and recorded in patients with ECMO&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Despite its great usefulness&#44; the use of ultrasound in patients with ECMO has important limitations&#46; In the case of two-dimensional &#40;2D&#41; explorations&#44; imaging acquisition may be adversely affected by both the patient&#8217;s position &#40;dorsal or even prone decubitus&#41; and the presence of invasive mechanical ventilation or devices such as vascular catheters&#44; tubes or drains&#46; Furthermore&#44; the functional evaluation and interpretation of the recordings that will guide ECMO adjustment cannot be made by any operator&#44; since advanced technical as well as clinical knowledge is needed&#46; The level of knowledge influences decisions and adjustments that clearly may have an impact on the course of the patient&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Although there are different configurations&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> the present review focuses on the usefulness of ultrasound in patients with veno-venous &#40;VV&#41; and veno-arterial &#40;VA&#41; ECMO&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Veno-venous &#40;VV&#41; ECMO</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Pre-VV ECMO evaluation</span><p id="par0025" class="elsevierStylePara elsevierViewall">Pre-implant echographic evaluation of VV ECMO should be made on a routine basis&#44; since different conditions need to be considered in order to select the type of assist and the optimum configuration&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The presence of severe left ventricular &#40;LV&#41; dysfunction refractory to inotropic drug treatment may require a change in configuration from VV to VA&#44; or to veno-arterial-venous &#40;VAV&#41; mode&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> In addition to echocardiographic evaluation &#40;left ventricular ejection fraction &#40;LVEF&#41;&#8239;&#60;&#8239;30&#37; and&#47;or left ventricular outflow tract &#40;LVOT&#41; velocity-time integral &#40;VTI&#41;&#8239;&#60;&#8239;10&#8239;cm&#41;&#44; the presence of persistently elevated lactate concentrations &#40;&#62;5&#8239;mmol&#47;l&#41;&#44; central venous saturation &#60;55&#37;&#44; cardiac index &#60;2&#46;1&#44; the presence of arrhythmia with hemodynamic alterations&#44; cardiac arrest and a vasoactive inotropic score &#62;50 points during one hour or &#62;45 points during 8&#8239;h&#44; are factors that may prove useful for predicting claudication with VV ECMO&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In evaluating VV ECMO implantation&#44; another essential factor is right ventricular &#40;RV&#41; function&#46; Many patients with severe acute respiratory distress syndrome &#40;ARDS&#41; present pulmonary hypertension and RV dysfunction in relation to hypoxia&#44; hypercapnia&#44; increased airway pressure and mechanical ventilation&#46; Veno-venous ECMO&#44; by correcting hypoxia and hypercapnia&#44; reduces afterload and can improve RV function&#44; thus correcting the hemodynamic instability&#46; In the event of significant right ventricular dysfunction&#44; echocardiographic monitoring is important&#44; and if shock persists and the echocardiographic parameters fail to improve despite VV ECMO&#44; we should consider changing the strategy to VA or VAV&#46; The evaluation of RV dysfunction must consider the following&#58; tricuspid annular plane systolic excursion &#40;TAPSE&#41;&#8239;&#60;&#8239;16&#8239;mm&#44; S&#8217; wave&#8239;&#60;&#8239;10&#8239;cm&#47;s&#44; shortening fraction &#40;SF&#41;&#8239;&#60;&#8239;35&#37;&#44; RV&#47;LV end-diastolic area ratio&#8239;&#62;&#8239;0&#46;6 &#40;significant&#41; and &#62;1 &#40;severe&#41; or flattening&#47;bulging &#40;&#8220;D&#8221; form&#41; of the interventricular septum in both systole and diastole &#40;Supplementary material 1&#41;&#46; This inter-dependence can be quantified using the ventricular eccentricity index&#44; which is the ratio between the septum-inferior surface and anterior surface-inferior surface diameter in systole and diastole&#44; with a normal value of 1&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">On the other hand&#44; we should evaluate the existence of underlying disease conditions or anatomical alterations that may contraindicate implantation&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> In this regard&#44; severe tricuspid valve disease &#40;insufficiency and&#47;or stenosis&#41; may impair ECMO oxygenated blood flow from the right atrium &#40;RA&#41; to the LV&#46; The presence of a persistent foramen ovale or interatrial communication&#44; during weaning from ECMO&#44; could increase the right-side pressures and generate a right-left shunt affecting oxygenation and even making removal of the device necessary&#46; A prominent Chiari network may complicate the placement of the cannula and guide it toward the interatrial septum&#46; The presence of a coronary sinus dilated by a left superior vena cava &#40;SVC&#41;&#44; if accidentally cannulated for the return&#44; may drain the blood towards the left arm instead of to the RA&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Lastly&#44; we must choose the best cannulation strategy according to the characteristics of the vascular accesses&#44; emphasizing the presence of thrombi and&#47;or anatomical variants&#47;anomalies &#40;Supplementary material 2&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Cannulation and start of VV support</span><p id="par0050" class="elsevierStylePara elsevierViewall">The systematic use of ultrasound is recommended during the different cannulation phases<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&#58;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Vascular ultrasound allows us to measure vessel diameter to select the optimum cannula size &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The following formula is used for this purpose&#58; cannula caliber &#40;French &#40;Fr&#41;&#41;&#8239;&#61;&#8239;3&#8239;&#215;&#8239;vessel diameter &#40;mm&#41;&#46; The largest cannula size should be used for both drainage and return&#44; in order to ensure the greatest flow possible&#46; Ultrasound-guided vascular puncture increases the safety and success rate at the first attempt&#44; reducing the risk of local complications &#40;arterial cannulation&#44; cannulation of the saphenofemoral junction or transfixation of the inguinal ligament&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20&#44;11</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">During cannulation&#44; using ultrasound&#44; we can check the intravascular insertion of the guides and subsequently of the cannulas&#46; In the case of using a double-lumen cannula&#44; transesophageal echocardiography &#40;TEE&#41; is essential&#44; since serious complications may occur during implantation &#40;perforation of the RA or cava superior&#44; migration towards the RV&#41;&#44; and we must check the correct orientation of the return flow towards the tricuspid valve&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">21</span></a> In cannulation with a simple double cannula&#44; we can use transthoracic echocardiography &#40;TTE&#41; or TEE in the absence of a good acoustic window&#46; When using the femoral-jugular configuration&#44; the draining cannula must be located in the inferior cava below the left suprahepatic vein&#44; and the tip of the return cannula must be positioned at RA level &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; &#40;Supplementary material 3&#41;&#46; In the femoral-femoral configuration&#44; the draining cannula should be positioned in the inferior cava and the return cannula in the RA&#46; The distance between the two cannulas should be at least 10&#8239;cm to avoid recirculation&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Management of the patient with VV ECMO</span><p id="par0065" class="elsevierStylePara elsevierViewall">During support&#44; ultrasound helps us to assess the pulmonary response to the treatment&#44; with dynamic monitoring of the hemodynamic changes and the detection of possible complications&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> For this purpose&#44; we assess the following&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Cannulas</span>&#58; daily monitoring is required of the correct positioning of the cannulas using echocardiography&#44; assisted by the plain thorax-abdominal radiographic study&#46; Mobilization of the cannulas can have an impact on oxygenation through an increase in recirculation&#44; and moreover increases the risk of accidental decannulation&#46; Changes in intra-circuit pressures can indicate possible migration of the cannulas&#44; and ultrasound assessment can quickly confirm this complication&#46; On the other hand&#44; we should assess the appearance of thrombi around or within the cannulas &#40;Supplementary material 4&#41;&#46; This complication requires the optimization of anticoagulation&#44; and a change in cannula and&#47;or location may be needed&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0075" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Right ventricle function</span> may be impaired in the context of ARDS or secondary to concomitant complications such as pulmonary thromboembolism &#40;PTE&#41;&#46; The existence of echocardiographic evidence of severe ventricular dysfunction together with refractory hemodynamic instability may suggest the need for a change in configuration to VA or VVA&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Left ventricle function</span> should be evaluated using TTE&#47;TEE&#46; The presence of LVEF&#8239;&#60;&#8239;30&#37;&#44; VTI of the LVOT&#8239;&#60;&#8239;10&#8239;cm&#44; E&#47;A&#8239;&#62;&#8239;2 and&#47;or a mitral flow E wave deceleration time &#40;EDT&#41;&#8239;&#60;&#8239;150&#8239;ms is suggestive of LV dysfunction&#44; increased left-side pressures&#44; and the possible need for a configuration change&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0085" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Intracavitary or heart valve thrombi</span>&#58; The presence of such thrombi&#44; in the same way as the presence of peri-cannula thrombi&#44; requires the optimization of anticoagulation and should alert us to the risk of hemodynamic complications&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0090" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Pulmonary ultrasound</span> allows easy&#44; dynamic and safe monitoring of pulmonary response to the treatment and the evolution of the primary disease condition based on the Lung Ultrasound Score &#40;LUS&#41;&#46; This score divides the lung areas into 12 regions &#40;6 for each hemithorax&#41; and assigns a score of 0&#8211;3 to each of them&#46; The poorest score observed in each zone is recorded&#46; We in turn speak of pattern A &#40;0 points&#41; in the presence of lung sliding with A-lines and &#8804;2 isolated B lines per intercostal space&#59; pattern B1 &#40;1 point&#41; in the presence of &#8805;3 isolated non-coalescent B lines&#59; pattern B2 &#40;2 points&#41; in the presence of coalescent B lines or &#8220;white lung&#8221; with or without small subpleural consolidations&#59; and pattern C &#40;3 points&#41; in the presence of extensive lung consolidation &#40;small subpleural consolidations are excluded&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">22&#44;23</span></a></p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Resolution of VV ECMO problems</span><p id="par0095" class="elsevierStylePara elsevierViewall">Ultrasound contributes to the diagnosis of complications during VV ECMO&#44; and in some cases is of help in treating them&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In the case of refractory hypoxia&#44; ultrasound helps us to evaluate the position of the cannulas as a cause of recirculation and also to assess cardiac output &#40;CO&#41; in order to examine the relationship between ECMO flow and CO of the patient&#44; or Q<span class="elsevierStyleInf">ECMO</span>&#47;Q<span class="elsevierStyleInf">CO</span> ratio&#46; A low ratio &#40;&#8804;60&#37;&#41; reflects insufficient ECMO flow for the existing CO&#59; the first option&#44; in this case&#44; is therefore to increase the ECMO flow&#46; If this is not possible&#44; then in addition to controlling the underlying cause&#44; we can adopt other measures such as the control of temperature or the use of beta blockers to reduce CO&#46; In contrast&#44; when the ECMO flow is adequate for the existing CO &#40;&#62;60&#37;&#41;&#44; in the presence of hypoxemia we should assume that there is a greater flow of deoxygenated blood that does not pass through the circuit&#44; and should consider measures to optimize blood oxygenation&#44; such as patient prone decubitus in ECMO&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;24</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Ultrasound also allows the early and safe detection of pulmonary complications&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0110" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Pneumothorax&#58;</span> the diagnosis of pneumothorax is established by the presence of two signs&#58;<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0115" class="elsevierStylePara elsevierViewall">Abolished lung sliding with&#47;without the presence of E lines&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">&#8226;</span><p id="par0120" class="elsevierStylePara elsevierViewall">Lung point&#44; corresponding to the place of contact between the collapsed lung and the collection of air from the pneumothorax&#46; This is a dynamic sign with a specificity of 100&#37; that shows alternation between normal sliding &#40;seashore sign&#41; in inspiration and abolished sliding &#40;stratosphere or barcode sign&#41; during expiration in 2D and M mode &#40;Supplementary material 5&#41;&#46;</p></li></ul></p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">-</span><p id="par0125" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Pleural effusion&#58;</span> this is seen as a generally echo-free anechoic space above the diaphragm&#46; The presence of a heterogeneous image or with enhanced echogenicity can suggest blood&#44; and the appearance of septae in the effusion is indicative of organized pleural effusion&#46;</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">-</span><p id="par0130" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Bronchogram&#58;</span> this is observed as a hypoechogenic subpleural zone containing hyperechogenic images &#40;air bronchogram&#41; or a hypoechogenic content with hyperechogenic walls &#40;fluid bronchogram&#41;&#46; The presentation may be static &#40;atelectasis&#41; or dynamic &#40;pneumonia&#41; &#40;Supplementary material 6&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">-</span><p id="par0135" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Hepatization&#47;condensation&#58;</span> this is observed when the echographic density of the lung is similar to that of the liver&#46;</p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Weaning and post-decannulation usefulness of VV ECMO</span><p id="par0140" class="elsevierStylePara elsevierViewall">In patients showing respiratory improvement and in which weaning of VV ECMO is considered&#44; echocardiography can help us to evaluate the response of the RV and the signs of PHT on reducing assist&#46; On the other hand&#44; before removing the cannulas&#44; echocardiography can be used to evaluate the existence of intraatrial thrombi that may delay weaning&#44; increasing anticoagulation in order to try to reduce the size of the thrombi and prevent them from migrating during decannulation&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">After withdrawing ECMO&#44; it is necessary to assess the persistence of thrombi in the RA&#44; cava and&#47;or lower extremities &#40;Supplementary materials 7 and 8&#41;&#46; This is very useful in clinical follow-up for guiding the required duration of post-assist anticoagulation&#44; diagnosing the appearance of deep vein thrombi in the vessels that have been cannulated&#44; or identifying the appearance of PTE that may require other coadjuvant treatments &#40;thrombectomy&#44; cava filters&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">25</span></a></p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Veno-arterial &#40;VA&#41; ECMO</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Pre-VA ECMO evaluation</span><p id="par0150" class="elsevierStylePara elsevierViewall">There are different indications &#40;cardiogenic shock in acute myocardial infarction&#44; myocarditis or intoxications&#44; postcardiotomy shock&#44; PTE&#44; cardiac arrest&#44; etc&#46;&#41; for ECMO as circulatory assist&#44; and the technique may involve different configurations &#40;peripheral&#44; central&#44; hybrid&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">26</span></a> Therefore&#44; and unless there is a contraindication or the situation does not allow the use of ultrasound&#44; the latter is essential as an exploratory tool before implantation&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Basal TTE&#47;TEE is required to evaluate both ventricular and atrial interdependence&#44; function and size&#46; We should seek possible anatomical defects &#40;communications&#44; thrombi&#44; prominent valves&#44; etc&#46;&#41; or aortic disorders &#40;dissection&#44; aneurysms&#41; that may complicate or even impede the implantation of the device&#46; In addition&#44; we must detect the existence of valve anomalies &#40;mitral or aortic valve insufficiency&#41; that might worsen after starting the treatment &#40;Supplementary material 9&#41;&#44; or which may even require prior surgery&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Along with the cardiac evaluation&#44; we should assess the possible presence of effusion &#40;especially pericardial effusion&#41; or vascular disease &#40;arteriosclerosis&#44; thrombosis&#41; that may worsen or appear in relation to the implant&#46; The presence of such disorders may require a configuration change &#40;central or peripheral&#41; or access &#40;right&#47;left or femoral&#47;subclavian&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">In addition to the echographic signs&#44; it is important to take into account and register the hemodynamic conditions&#44; measures of support &#40;mechanical ventilation&#44; counterpulsation balloon&#44; etc&#46;&#41; and drug treatments &#40;type and dose of vasoactive medication&#44; inotropic agents or vasodilators&#41; that may influence interpretation&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Cannulation and start of VA support</span><p id="par0170" class="elsevierStylePara elsevierViewall">Evaluation&#44; vascular puncture and positioning of the guides are carried out in the same way as in VV ECMO&#44; and the same protocol is followed&#46; With regard to the placement of the venous cannula&#44; a multiperforated cannula is indicated in VA support and should be positioned at the RA&#44; with the tip at the SVC level&#44; in order to secure the greatest drainage possible &#40;Supplementary material 10&#41;&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">In percutaneous femoral arterial cannulation&#44; vascular ultrasound is very useful for the correct evaluation of the point of insertion&#44; avoiding atheroma plaques or vascular alterations&#46; When inserting the return cannula&#44; we must puncture and insert the guides in the cranial direction&#44; above the femoral bifurcation&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">27</span></a> Since the cannula can completely occlude the arterial lumen and therefore affect flow in the cannulated extremity&#44; ultrasound-guided cannulation should be performed of the superficial femoral artery in the caudad direction to ensure perfusion of the extremity&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Once the guide has been placed at the arterial level&#44; TTE&#47;TEE can identify its position at the descending aorta&#44; confirming the correct arterial access of the guide&#46; This is useful in cases of very low flow or pulsatility&#44; as in cardiac arrest&#44; where peripheral evaluation may prove difficult and urgent cannulation is required&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">28</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">On starting assist&#44; TTE&#47;TEE allows us to evaluate the situation&#44; size and degree of decompression of the heart cavities&#59; assess septal position as the expression of ventricular interdependence&#59; and analyze volemia&#47;preload that may affect ECMO flow and the development of early complications such as pericardial effusion&#44; aortic valve closure or increased valve insufficiencies secondary to the increase in LV afterload conditioned by ECMO&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">29</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Management of the patient with VA ECMO</span><p id="par0185" class="elsevierStylePara elsevierViewall">It must be taken into account that most of the monitoring systems &#40;transpulmonary thermodilution&#44; pulse profile analysis&#41; present artifacts due to the hemodynamic effect of ECMO&#59; TTE&#47;TEE therefore must be included in the daily evaluation of these patients&#46; Based on this exploration we can assess and compare the following versus the basal exploration<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#58;<ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">-</span><p id="par0190" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Biventricular contractility and size</span>&#44; which reflects the evolution of the cardiac condition for which ECMO was prescribed&#46;</p></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">-</span><p id="par0195" class="elsevierStylePara elsevierViewall">The presence of echocardiographic signs &#40;E&#47;A ratio&#44; E wave deceleration gradient&#44; E&#47;e&#8217; ratio&#41; of <span class="elsevierStyleBold">high left end-diastolic pressures</span> indicating inadequate ventricular function&#46;</p></li><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">-</span><p id="par0200" class="elsevierStylePara elsevierViewall">The appearance or progression of <span class="elsevierStyleBold">mitral valve insufficiency</span> due to ventricular dilatation and&#47;or increased pressures &#40;Supplementary material 11&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">-</span><p id="par0205" class="elsevierStylePara elsevierViewall">The presence of <span class="elsevierStyleBold">auto contrast</span> suggesting blood stasis or even <span class="elsevierStyleBold">intracavitary thrombi</span> that can give rise to distal embolism &#40;Supplementary material 12&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">-</span><p id="par0210" class="elsevierStylePara elsevierViewall">The increase in afterload conditioned by ECMO&#44; together with low left ventricular contractility&#44; can adversely affect <span class="elsevierStyleBold">aortic valve opening</span>&#44; with early closure of the valve &#40;Supplementary material 13&#41;&#44; or the valve may even remain closed &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a> and Supplementary material 14&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0085"><span class="elsevierStyleLabel">-</span><p id="par0215" class="elsevierStylePara elsevierViewall">Appearance or progression of <span class="elsevierStyleBold">aortic insufficiency</span>&#44; impeding LV emptying and perpetuating the high-end-diastolic pressures &#40;Supplementary material 15&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0090"><span class="elsevierStyleLabel">-</span><p id="par0220" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Stroke volume and native CO</span> using VTI of the LVOT to assess the evolution of ventricular function&#46; It must be taken into account that the volume circulating in the lung territory&#44; and which reaches the left cavities can vary according to the presence of aortopulmonary collaterals&#44; bronchial circulation and especially ECMO flow&#46;</p></li><li class="elsevierStyleListItem" id="lsti0095"><span class="elsevierStyleLabel">-</span><p id="par0225" class="elsevierStylePara elsevierViewall">The presence and characteristics of <span class="elsevierStyleBold">pericardial effusion</span>&#46; In these cases&#44; it must be taken into account that the data referred to right cavity collapse can be increased by the negative pressure generated by ECMO&#44; though not so in the left cavities&#59; consequently&#44; signs of tamponade must be correlated with the clinical situation and the behavior of ECMO&#46;</p></li><li class="elsevierStyleListItem" id="lsti0100"><span class="elsevierStyleLabel">-</span><p id="par0230" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleBold">position and flow of the cannulas</span>&#46; Patient mobilization can cause the cannulas to shift position&#46; They consequently must be evaluated on a daily basis&#44; with an assessment of the appearance of adhered thrombi that may embolize or even affect ECMO flow&#46;</p></li></ul></p><p id="par0235" class="elsevierStylePara elsevierViewall">In addition to echocardiography&#44; daily monitoring can involve pleuropulmonary ultrasound for evaluating both the lung parenchyma and the diaphragm or pleura&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">29&#44;30</span></a> Transcranial Doppler poses limitations because it experiences artifacts due to the continuous flow of ECMO and other devices &#40;Intra aortic balloon counterpulsation &#40;IAoBC&#41;&#44; Impella&#174;&#41; &#40;Supplementary material 16&#41;&#59; nevertheless&#44; it also may be useful in the evaluation of cerebral hemodynamics and even in diagnosing brain death&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">31&#44;32</span></a></p><p id="par0240" class="elsevierStylePara elsevierViewall">Lastly&#44; many patients with VA ECMO may also carry some other left ventricular assist device &#40;IAoBC&#44; Impella&#174;&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">33</span></a> and its position and function must be monitored as well&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> In the case of IAoBC&#44; we can use TTE&#47;TEE to observe insufflation of the balloon at the level of the descending aorta&#44; with its distal extremity at the left subclavian root level &#40;Supplementary material 17&#41;&#46; Impella&#174; can be explored with both TTE &#40;long-axis parasternal or three-chamber apical&#41; and TEE &#40;mid-esophageal 120&#186;&#41;&#44; and we should see the device entering from the ascending aorta and the inlet or suction zone at 3&#8211;4&#8239;cm from the aortic valve<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">34&#44;35</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a> and Supplementary material 18&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resolution of VA ECMO problems</span><p id="par0245" class="elsevierStylePara elsevierViewall">One of the most frequent complications in patients with VA ECMO is a decrease in flow&#46; Using TTE&#47;TEE&#44; we can check the positioning of the cannulas with suction events &#40;Supplementary material 19&#41;&#44; the presence of thrombi or the presence of pericardial effusion accounting for the impossibility of filling of the device as the cause of diminished flow &#40;Supplementary material 20&#41;&#46; It must be taken into account that if there is no impairment of flow&#44; the presence of pericardial effusion does not need to imply intervention&#46; Nevertheless&#44; we must monitor its characteristics and evolution&#44; for in some cases the signs of cardiac tamponade only manifest at the time of withdrawal&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">Aortic closure is a complication that must be resolved&#44; since persistent closure gives rise to intraventricular blood stasis and increased left-side pressures that in turn lead to left cavity dilatation and ultimately persistent lung edema&#46; If this happens&#44; TTE can evidence &#8220;smoke&#8221; or even intraventricular thrombi and signs of high left-side pressures &#40;E&#47;A ratio &#62;2 and&#47;or a mitral flow deceleration time &#40;EDT&#41; of &#60;150&#8239;ms&#41;&#46; In addition to its diagnostic&#47;evolutive usefulness&#44; TTE can be of help in guiding the treatment of this complication through assessment of the response to the use or increase in inotropic treatment &#40;Supplementary material 21&#41;&#44; or in guiding the implantation of devices &#40;IAoBC&#47;Impella&#174;&#41; or interventionism &#40;atrial septostomy&#44; apical drainage&#44; left atrial VA ECMO &#40;LAVA ECMO&#41;&#41; for alleviating left-side pressures&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0255" class="elsevierStylePara elsevierViewall">In patients with femoral-femoral VA ECMO&#44; when ventricle function recovers and lung function has not yet improved&#44; we can observe differential hypoxemia&#44; north-south syndrome &#40;or harlequin syndrome&#41;&#44; due to upper trunk perfusion with poorly oxygenated blood from the pulmonary circulation and lower trunk perfusion with oxygenated blood from ECMO&#46; This complication is usually detected by the determination of oxygenation &#40;arterial blood gases&#44; pulse oximetry&#41; at the right upper extremity or cerebral level &#40;near-infrared spectroscopy &#40;NIRS&#41;&#41;&#44; requiring us to optimize native lung ventilation&#46; In this respect&#44; pulmonary ultrasound is useful for evaluating both the lung pattern and the possible response to the adopted measures&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">29</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Weaning and post-decannulation usefulness of VA ECMO</span><p id="par0260" class="elsevierStylePara elsevierViewall">For weaning from VA ECMO&#44; the patient must be clinically &#40;lactic acid &#60;2&#8239;mmol&#47;l&#44; Pa&#47;FiO<span class="elsevierStyleInf">2</span>&#8239;&#62;&#8239;200&#44; improvement of organ dysfunction&#41; and hemodynamically stable &#40;mean blood pressure&#8239;&#62;&#8239;65&#8239;mmHg&#44; pulse pressure&#8239;&#62;&#8239;20&#8239;mmHg&#44; SvO<span class="elsevierStyleInf">2</span>&#8239;&#62;&#8239;65&#37;&#41;&#44; indicating that the underlying cause is controlled&#46; Although there are no validated echocardiographic protocols or scientific recommendations as to when and how to perform weaning from ECMO&#44; it is accepted that the patient must present echocardiographic signs of recovery of biventricular function &#40;LVEF&#8239;&#62;&#8239;25&#37;&#8211;30&#37;&#44; VTI of the LVOT&#8239;&#62;&#8239;10&#8239;cm&#44; mitral ring S&#8217;&#8239;&#62;&#8239;6&#8239;cm&#47;s&#44; TAPSE&#8239;&#62;&#8239;16&#8239;cm&#41;&#44; with no evidence of high end-diastolic pressures that may worsen on suspending the assist measures&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">36</span></a> In the same way&#44; as in VV ECMO&#44; we must evaluate the presence of thrombi surrounding the cannula that could delay removal of the latter&#44; or we at least should continue early with anticoagulation therapy once the cannula has been removed&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">Weaning involves a progressive decrease &#40;500&#8239;ml every 15&#8211;20&#8239;min&#41; in VA ECMO support&#44; gradually restoring cardiac preload&#46; This requires adequate patient anticoagulation&#46; We evaluate the hemodynamic &#40;central venous pressure&#44; mean and differential blood pressure&#44; SvO<span class="elsevierStyleInf">2</span>&#44; SatO<span class="elsevierStyleInf">2</span>&#41; and echocardiographic repercussions of the procedure &#40;LVEF&#44; VTI&#44; E wave&#44; E&#8217; wave or S&#8217; of the lateral mitral ring&#41; to a level &#40;normally 1&#8211;1&#46;5&#8239;l per min&#41; indicating that the patient can tolerate suspension of the assist measures&#46; During the latter&#44; we check that LVEF is maintained or even exceeds 25&#37;&#8211;30&#37;&#44; with VTI above 10&#8239;cm and an S&#8217; wave of &#62;6&#8239;cm&#47;s &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a> and Supplementary material 22&#41;&#46; In addition&#44; we should also evaluate the behavior of the right-side cavities &#40;TAPSE&#8239;&#62;&#8239;16&#8239;cm&#47;S&#8217; wave&#8239;&#62;&#8239;10&#8239;cm&#47;s and RV size&#41; and the possible appearance of signs of PHT &#40;increase in peak velocity of tricuspid insufficiency &#40;TI&#41;&#41; predicting RV failure&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">37&#8211;39</span></a></p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0270" class="elsevierStylePara elsevierViewall">After weaning&#44; we perform the same controls as in the case of VV ECMO&#44; taking special care in screening for intracavitary or intravascular thrombi that require the maintenance of anticoagulation therapy&#44; or which may migrate&#46;</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusions</span><p id="par0275" class="elsevierStylePara elsevierViewall">Ultrasound in patients with ECMO is a key tool in all the assist phases&#46; In preimplantation it is used to evaluate the vessels to be cannulated and biventricular function&#59; during implantation&#44; it is of help in ensuring safe and correct insertion of the cannulas&#59; and in the assist phase&#44; it is used to detect and treat complications and to study the pulmonary and&#47;or cardiac evolution to ensure safe weaning &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>&#41;&#46;</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0280" class="elsevierStylePara elsevierViewall">Taking into account its usefulness&#44; ultrasound should be seen as a crucial instrument in the management of these patients&#44; and the intensivists that perform the technique must have advanced knowledge of the anatomical&#44; technical and functional aspects of the procedure&#46; Further research is needed in this field&#44; together with the development of scientific recommendations allowing correct training and improvement of patient outcomes&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Authors&#8217; contributions</span><p id="par0285" class="elsevierStylePara elsevierViewall">LMV&#44; MPFG&#44; RMB and HPC designed the study&#44; conducted the literature review and wrote the manuscript&#46; LMV&#44; RMB and MPFG participated in the preparation of the tables and figures&#46; LMV&#44; MPFG&#44; RMB and HPC reviewed the final version of the manuscript&#46; All authors read and approved the final manuscript&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflict of interests</span><p id="par0290" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interests&#46;</p></span></span>"
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          "titulo" => "Introduction"
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          "titulo" => "Veno-venous &#40;VV&#41; ECMO"
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              "titulo" => "Pre-VV ECMO evaluation"
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              "titulo" => "Cannulation and start of VV support"
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              "titulo" => "Management of the patient with VV ECMO"
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              "titulo" => "Cannulation and start of VA support"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Ultrasound is an essential diagnostic tool in critically ill patients with extracorporeal membrane oxygenation &#40;ECMO&#41;&#46; With it&#44; we can make an anatomical and functional &#40;cardiac&#44; pulmonary and vascular&#41; evaluation which allows us to execute an adequate configuration&#44; guides implantation&#44; helps clinical monitorization and detects complications&#44; facilitates withdrawal and complete post-implant evaluation&#46; In patients with ECMO as respiratory support &#40;veno-venous&#41;&#44; thoracic ultrasound allows monitoring pulmonary illness evolution and echocardiography the evaluation of biventricular function&#44; especially right ventricle function&#44; and cardiac output to optimize oxygen transport&#46; In ECMO as circulatory support &#40;veno-arterial&#41;&#44; echocardiography is the guide of hemodynamic monitoring&#44; allows detecting the most frequent complications and helps the weaning&#46; In ECMO teams&#44; for a proper management of these patients&#44; there must be trained intensivists with advanced knowledge on this technique&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La ecograf&#237;a es un instrumento diagn&#243;stico fundamental en el paciente cr&#237;tico con membrana de oxigenaci&#243;n extracorp&#243;rea &#40;ECMO&#41;&#46; Con ella podemos hacer una evaluaci&#243;n anat&#243;mica y funcional &#40;cardiaca&#44; pulmonar y vascular&#41; para plantear una adecuada configuraci&#243;n&#59; adem&#225;s&#44; gu&#237;a su implante&#44; ayuda en la monitorizaci&#243;n cl&#237;nica y la detecci&#243;n de complicaciones&#44; facilita su retirada y completa la evaluaci&#243;n postimplante&#46; En los pacientes con ECMO como soporte respiratorio &#40;veno-venosa&#41;&#44; la ecograf&#237;a tor&#225;cica permite monitorizar la evoluci&#243;n de la enfermedad pulmonar y la ecocardiograf&#237;a la evaluaci&#243;n de la funci&#243;n biventricular&#44; especialmente la derecha&#44; y el gasto cardiaco para optimizar el transporte de ox&#237;geno&#46; En la ECMO como soporte circulatorio &#40;veno-arterial&#41;&#44; la ecocardiograf&#237;a supone la gu&#237;a de la monitorizaci&#243;n hemodin&#225;mica&#44; permite detectar las principales complicaciones y ayuda al destete del dispositivo&#46; En los equipos ECMO&#44; para un adecuado manejo de estos pacientes&#44; debe haber intensivistas entrenados y con conocimientos avanzados sobre esta t&#233;cnica&#46;</p></span>"
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            "apendice" => "<p id="par0300" class="elsevierStylePara elsevierViewall">The following are Supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia><elsevierMultimedia ident="upi0010"></elsevierMultimedia><elsevierMultimedia ident="upi0015"></elsevierMultimedia><elsevierMultimedia ident="upi0020"></elsevierMultimedia><elsevierMultimedia ident="upi0025"></elsevierMultimedia><elsevierMultimedia ident="upi0030"></elsevierMultimedia><elsevierMultimedia ident="upi0035"></elsevierMultimedia><elsevierMultimedia ident="upi0040"></elsevierMultimedia><elsevierMultimedia ident="upi0045"></elsevierMultimedia><elsevierMultimedia ident="upi0050"></elsevierMultimedia><elsevierMultimedia ident="upi0055"></elsevierMultimedia><elsevierMultimedia ident="upi0060"></elsevierMultimedia><elsevierMultimedia ident="upi0065"></elsevierMultimedia><elsevierMultimedia ident="upi0070"></elsevierMultimedia><elsevierMultimedia ident="upi0075"></elsevierMultimedia><elsevierMultimedia ident="upi0080"></elsevierMultimedia><elsevierMultimedia ident="upi0085"></elsevierMultimedia><elsevierMultimedia ident="upi0090"></elsevierMultimedia><elsevierMultimedia ident="upi0095"></elsevierMultimedia><elsevierMultimedia ident="upi0100"></elsevierMultimedia><elsevierMultimedia ident="upi0105"></elsevierMultimedia><elsevierMultimedia ident="upi0110"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Echocardiographic evaluation of weaning in a patient with VA ECMO&#46; Transthoracic echocardiography &#40;TTE&#41; and velocity-time integral &#40;VTI&#41; of the left ventricle outlet tract &#40;LVOT&#41; on reducing flow &#40;A&#58; 3&#8239;l&#47;min&#44; B&#58; 2&#46;5&#8239;l&#47;min&#44; C&#58; 2&#8239;l&#47;min&#41; of VA ECMO&#46; Note the increase in magnitude of VTI and consequently of stroke volume &#40;SV&#41; and cardiac output &#40;CO&#41;&#46;</p>"
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          "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">TDI&#58; tissue Doppler&#59; VTI&#58; velocity-time integral&#59; LVOT&#58; left ventricular outflow tract&#59; EDT&#58; E wave deceleration time&#59; RV&#58; right ventricle&#59; LV&#58; left ventricle&#59; TAPSE&#58; tricuspid annular plane systolic excursion&#59; PAPs&#58; systolic pulmonary artery pressure&#59; Tac&#58; acceleration time&#59; RA-LA&#58; right atrium&#8211;left atrium&#46;</p>"
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Parameter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Reference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Left ventricle</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8226; Morphology</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Myocardial size and thickness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Septal position&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presence of autocontrast&#47;thrombi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8226; Systolic function</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ejection fraction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Segmental motility&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mitral S wave &#40;TDI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62; 6&#8239;cm&#47;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Velocity and size of VTI of LVOT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62; 1&#8239;m&#47;s and &#62;10&#8239;cm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8226; Diastolic function</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E&#47;A ratio of transmitral flow&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EDT of mitral flow&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62;150&#8239;ms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E&#47;e&#8217; ratio of the mitral ring&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Mitral and aortic valves</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diagnosis and grading of possible insufficiency and&#47;or stenosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Left atrium</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Size and volume&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;35&#8239;ml&#47;m<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulmonary vein flow&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S wave&#8239;&#62;&#8239;D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Right ventricle</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8226; Morphology</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RV&#47;LV end-diastolic area ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Septal position and motion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ventricular geometry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Triangular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Eccentricity index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Myocardial thickness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;8&#8239;mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8226; Systolic function</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TAPSE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62;16&#8239;mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tricuspid S&#8217; wave &#40;TDI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62;10&#8239;cm&#47;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Shortening fraction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62;35&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">McConnell sign&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8226; Diastolic function&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tricuspid flow E&#47;A ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Tricuspid and pulmonary valves</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tricuspid insufficiency for estimation of PAPs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;3&#8239;m&#47;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulmonary flow &#40;Tac&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62;120&#8239;ms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Right atrium</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;20&#8239;cm<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Structures &#40;valves&#44; Chiari&#44; coronary sinus&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Septal integrity &#40;foramen ovale&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RA-LA shunt &#40;color Doppler&#8239;&#177;&#8239;shaken saline test&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="3" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Inferior&#47;superior vena cava</span></td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Size and respiratory variation&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;20&#8239;cm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Position of cannulas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Thrombi&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Aorta</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Pericardium&#47;pleura</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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Update in intensive care medicine: ultrasound in the critically ill patient. Clinical applications
Role of ultrasound in the critical ill patient with ECMO
Papel de la ecografía en el paciente crítico con ECMO
Luis Martin-Villena,
Corresponding author
lmartinvillen@gmail.com

Corresponding author.
, Rafael Martin-Bermudeza, Helena Perez-Chomonb, Mari Paz Fuset Cabanesc
a Unidad de Gestión Clínica de Medicina Intensiva, Hospital Universitario Virgen del Rocío, Sevilla, Spain
b Unidad de Gestión Clínica de Medicina Intensiva, Hospital Universitario Virgen Macarena, Sevilla, Spain
c Servicio de Medicina Intensiva, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
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        "titulo" => "Papel de la ecograf&#237;a en el paciente cr&#237;tico con ECMO"
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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Role of ultrasound in the critical patient with ECMO&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Extracorporeal membrane oxygenation &#40;ECMO&#41; is a mechanical support system used to secure total or partial cardiopulmonary stabilization in patients with circulatory and&#47;or respiratory failure&#46; Although the history of ECMO goes back over 50 years since it was first used for therapeutic purposes&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> it has only become widely used throughout the world in recent decades&#46; The introduction of new devices and materials&#44; the results obtained during the influenza A pandemic&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> and patient centralization in reference centers with multidisciplinary teams are a number of the factors that have caused ECMO to form part of the therapeutic measures for dealing with refractory cardiorespiratory failure&#46; Due to the characteristics of these patients and the complexity of the processes&#44; the available scientific evidence is limited&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> though many studies have evidenced the usefulness of the technique&#44; and for this reason different scientific societies have established recommendations on its use&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The use of ultrasound in critical patients is an established practice and is crucial for both the general and specific evaluation of cardiovascular and respiratory disease&#46; Despite the complexity of the exploration and the technical requirements&#44; it can afford information with a high diagnostic capacity at the patient&#8217;s bedside and on an immediate basis&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> In the case of patients with ECMO&#44; and due to the increase in its indications and configurations&#44; ultrasound &#8211; particularly transthoracic echocardiography &#40;TTE&#41; or transesophageal echocardiography &#40;TEE&#41; in the case of a poor exploration window &#8211; has become a key instrument&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a> Adequately trained professionals are needed&#44; since ultrasound allows precise anatomical and functional cardiopulmonary evaluation&#44; guides the insertion and placement of cannulas&#44; helps to optimize flow&#44; allows monitoring to detect and resolve clinical changes&#44; facilitates weaning from ECMO&#44; and contributes to the post-implantation assessment of possible complications&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#8211;15</span></a><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> summarizes the echocardiographic parameters that should be evaluated and recorded in patients with ECMO&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Despite its great usefulness&#44; the use of ultrasound in patients with ECMO has important limitations&#46; In the case of two-dimensional &#40;2D&#41; explorations&#44; imaging acquisition may be adversely affected by both the patient&#8217;s position &#40;dorsal or even prone decubitus&#41; and the presence of invasive mechanical ventilation or devices such as vascular catheters&#44; tubes or drains&#46; Furthermore&#44; the functional evaluation and interpretation of the recordings that will guide ECMO adjustment cannot be made by any operator&#44; since advanced technical as well as clinical knowledge is needed&#46; The level of knowledge influences decisions and adjustments that clearly may have an impact on the course of the patient&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Although there are different configurations&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> the present review focuses on the usefulness of ultrasound in patients with veno-venous &#40;VV&#41; and veno-arterial &#40;VA&#41; ECMO&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Veno-venous &#40;VV&#41; ECMO</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Pre-VV ECMO evaluation</span><p id="par0025" class="elsevierStylePara elsevierViewall">Pre-implant echographic evaluation of VV ECMO should be made on a routine basis&#44; since different conditions need to be considered in order to select the type of assist and the optimum configuration&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The presence of severe left ventricular &#40;LV&#41; dysfunction refractory to inotropic drug treatment may require a change in configuration from VV to VA&#44; or to veno-arterial-venous &#40;VAV&#41; mode&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> In addition to echocardiographic evaluation &#40;left ventricular ejection fraction &#40;LVEF&#41;&#8239;&#60;&#8239;30&#37; and&#47;or left ventricular outflow tract &#40;LVOT&#41; velocity-time integral &#40;VTI&#41;&#8239;&#60;&#8239;10&#8239;cm&#41;&#44; the presence of persistently elevated lactate concentrations &#40;&#62;5&#8239;mmol&#47;l&#41;&#44; central venous saturation &#60;55&#37;&#44; cardiac index &#60;2&#46;1&#44; the presence of arrhythmia with hemodynamic alterations&#44; cardiac arrest and a vasoactive inotropic score &#62;50 points during one hour or &#62;45 points during 8&#8239;h&#44; are factors that may prove useful for predicting claudication with VV ECMO&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In evaluating VV ECMO implantation&#44; another essential factor is right ventricular &#40;RV&#41; function&#46; Many patients with severe acute respiratory distress syndrome &#40;ARDS&#41; present pulmonary hypertension and RV dysfunction in relation to hypoxia&#44; hypercapnia&#44; increased airway pressure and mechanical ventilation&#46; Veno-venous ECMO&#44; by correcting hypoxia and hypercapnia&#44; reduces afterload and can improve RV function&#44; thus correcting the hemodynamic instability&#46; In the event of significant right ventricular dysfunction&#44; echocardiographic monitoring is important&#44; and if shock persists and the echocardiographic parameters fail to improve despite VV ECMO&#44; we should consider changing the strategy to VA or VAV&#46; The evaluation of RV dysfunction must consider the following&#58; tricuspid annular plane systolic excursion &#40;TAPSE&#41;&#8239;&#60;&#8239;16&#8239;mm&#44; S&#8217; wave&#8239;&#60;&#8239;10&#8239;cm&#47;s&#44; shortening fraction &#40;SF&#41;&#8239;&#60;&#8239;35&#37;&#44; RV&#47;LV end-diastolic area ratio&#8239;&#62;&#8239;0&#46;6 &#40;significant&#41; and &#62;1 &#40;severe&#41; or flattening&#47;bulging &#40;&#8220;D&#8221; form&#41; of the interventricular septum in both systole and diastole &#40;Supplementary material 1&#41;&#46; This inter-dependence can be quantified using the ventricular eccentricity index&#44; which is the ratio between the septum-inferior surface and anterior surface-inferior surface diameter in systole and diastole&#44; with a normal value of 1&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">On the other hand&#44; we should evaluate the existence of underlying disease conditions or anatomical alterations that may contraindicate implantation&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> In this regard&#44; severe tricuspid valve disease &#40;insufficiency and&#47;or stenosis&#41; may impair ECMO oxygenated blood flow from the right atrium &#40;RA&#41; to the LV&#46; The presence of a persistent foramen ovale or interatrial communication&#44; during weaning from ECMO&#44; could increase the right-side pressures and generate a right-left shunt affecting oxygenation and even making removal of the device necessary&#46; A prominent Chiari network may complicate the placement of the cannula and guide it toward the interatrial septum&#46; The presence of a coronary sinus dilated by a left superior vena cava &#40;SVC&#41;&#44; if accidentally cannulated for the return&#44; may drain the blood towards the left arm instead of to the RA&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Lastly&#44; we must choose the best cannulation strategy according to the characteristics of the vascular accesses&#44; emphasizing the presence of thrombi and&#47;or anatomical variants&#47;anomalies &#40;Supplementary material 2&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Cannulation and start of VV support</span><p id="par0050" class="elsevierStylePara elsevierViewall">The systematic use of ultrasound is recommended during the different cannulation phases<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&#58;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Vascular ultrasound allows us to measure vessel diameter to select the optimum cannula size &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The following formula is used for this purpose&#58; cannula caliber &#40;French &#40;Fr&#41;&#41;&#8239;&#61;&#8239;3&#8239;&#215;&#8239;vessel diameter &#40;mm&#41;&#46; The largest cannula size should be used for both drainage and return&#44; in order to ensure the greatest flow possible&#46; Ultrasound-guided vascular puncture increases the safety and success rate at the first attempt&#44; reducing the risk of local complications &#40;arterial cannulation&#44; cannulation of the saphenofemoral junction or transfixation of the inguinal ligament&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20&#44;11</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">During cannulation&#44; using ultrasound&#44; we can check the intravascular insertion of the guides and subsequently of the cannulas&#46; In the case of using a double-lumen cannula&#44; transesophageal echocardiography &#40;TEE&#41; is essential&#44; since serious complications may occur during implantation &#40;perforation of the RA or cava superior&#44; migration towards the RV&#41;&#44; and we must check the correct orientation of the return flow towards the tricuspid valve&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">21</span></a> In cannulation with a simple double cannula&#44; we can use transthoracic echocardiography &#40;TTE&#41; or TEE in the absence of a good acoustic window&#46; When using the femoral-jugular configuration&#44; the draining cannula must be located in the inferior cava below the left suprahepatic vein&#44; and the tip of the return cannula must be positioned at RA level &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; &#40;Supplementary material 3&#41;&#46; In the femoral-femoral configuration&#44; the draining cannula should be positioned in the inferior cava and the return cannula in the RA&#46; The distance between the two cannulas should be at least 10&#8239;cm to avoid recirculation&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Management of the patient with VV ECMO</span><p id="par0065" class="elsevierStylePara elsevierViewall">During support&#44; ultrasound helps us to assess the pulmonary response to the treatment&#44; with dynamic monitoring of the hemodynamic changes and the detection of possible complications&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> For this purpose&#44; we assess the following&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Cannulas</span>&#58; daily monitoring is required of the correct positioning of the cannulas using echocardiography&#44; assisted by the plain thorax-abdominal radiographic study&#46; Mobilization of the cannulas can have an impact on oxygenation through an increase in recirculation&#44; and moreover increases the risk of accidental decannulation&#46; Changes in intra-circuit pressures can indicate possible migration of the cannulas&#44; and ultrasound assessment can quickly confirm this complication&#46; On the other hand&#44; we should assess the appearance of thrombi around or within the cannulas &#40;Supplementary material 4&#41;&#46; This complication requires the optimization of anticoagulation&#44; and a change in cannula and&#47;or location may be needed&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0075" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Right ventricle function</span> may be impaired in the context of ARDS or secondary to concomitant complications such as pulmonary thromboembolism &#40;PTE&#41;&#46; The existence of echocardiographic evidence of severe ventricular dysfunction together with refractory hemodynamic instability may suggest the need for a change in configuration to VA or VVA&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Left ventricle function</span> should be evaluated using TTE&#47;TEE&#46; The presence of LVEF&#8239;&#60;&#8239;30&#37;&#44; VTI of the LVOT&#8239;&#60;&#8239;10&#8239;cm&#44; E&#47;A&#8239;&#62;&#8239;2 and&#47;or a mitral flow E wave deceleration time &#40;EDT&#41;&#8239;&#60;&#8239;150&#8239;ms is suggestive of LV dysfunction&#44; increased left-side pressures&#44; and the possible need for a configuration change&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0085" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Intracavitary or heart valve thrombi</span>&#58; The presence of such thrombi&#44; in the same way as the presence of peri-cannula thrombi&#44; requires the optimization of anticoagulation and should alert us to the risk of hemodynamic complications&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0090" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Pulmonary ultrasound</span> allows easy&#44; dynamic and safe monitoring of pulmonary response to the treatment and the evolution of the primary disease condition based on the Lung Ultrasound Score &#40;LUS&#41;&#46; This score divides the lung areas into 12 regions &#40;6 for each hemithorax&#41; and assigns a score of 0&#8211;3 to each of them&#46; The poorest score observed in each zone is recorded&#46; We in turn speak of pattern A &#40;0 points&#41; in the presence of lung sliding with A-lines and &#8804;2 isolated B lines per intercostal space&#59; pattern B1 &#40;1 point&#41; in the presence of &#8805;3 isolated non-coalescent B lines&#59; pattern B2 &#40;2 points&#41; in the presence of coalescent B lines or &#8220;white lung&#8221; with or without small subpleural consolidations&#59; and pattern C &#40;3 points&#41; in the presence of extensive lung consolidation &#40;small subpleural consolidations are excluded&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">22&#44;23</span></a></p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Resolution of VV ECMO problems</span><p id="par0095" class="elsevierStylePara elsevierViewall">Ultrasound contributes to the diagnosis of complications during VV ECMO&#44; and in some cases is of help in treating them&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In the case of refractory hypoxia&#44; ultrasound helps us to evaluate the position of the cannulas as a cause of recirculation and also to assess cardiac output &#40;CO&#41; in order to examine the relationship between ECMO flow and CO of the patient&#44; or Q<span class="elsevierStyleInf">ECMO</span>&#47;Q<span class="elsevierStyleInf">CO</span> ratio&#46; A low ratio &#40;&#8804;60&#37;&#41; reflects insufficient ECMO flow for the existing CO&#59; the first option&#44; in this case&#44; is therefore to increase the ECMO flow&#46; If this is not possible&#44; then in addition to controlling the underlying cause&#44; we can adopt other measures such as the control of temperature or the use of beta blockers to reduce CO&#46; In contrast&#44; when the ECMO flow is adequate for the existing CO &#40;&#62;60&#37;&#41;&#44; in the presence of hypoxemia we should assume that there is a greater flow of deoxygenated blood that does not pass through the circuit&#44; and should consider measures to optimize blood oxygenation&#44; such as patient prone decubitus in ECMO&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;24</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Ultrasound also allows the early and safe detection of pulmonary complications&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0110" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Pneumothorax&#58;</span> the diagnosis of pneumothorax is established by the presence of two signs&#58;<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0115" class="elsevierStylePara elsevierViewall">Abolished lung sliding with&#47;without the presence of E lines&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">&#8226;</span><p id="par0120" class="elsevierStylePara elsevierViewall">Lung point&#44; corresponding to the place of contact between the collapsed lung and the collection of air from the pneumothorax&#46; This is a dynamic sign with a specificity of 100&#37; that shows alternation between normal sliding &#40;seashore sign&#41; in inspiration and abolished sliding &#40;stratosphere or barcode sign&#41; during expiration in 2D and M mode &#40;Supplementary material 5&#41;&#46;</p></li></ul></p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">-</span><p id="par0125" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Pleural effusion&#58;</span> this is seen as a generally echo-free anechoic space above the diaphragm&#46; The presence of a heterogeneous image or with enhanced echogenicity can suggest blood&#44; and the appearance of septae in the effusion is indicative of organized pleural effusion&#46;</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">-</span><p id="par0130" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Bronchogram&#58;</span> this is observed as a hypoechogenic subpleural zone containing hyperechogenic images &#40;air bronchogram&#41; or a hypoechogenic content with hyperechogenic walls &#40;fluid bronchogram&#41;&#46; The presentation may be static &#40;atelectasis&#41; or dynamic &#40;pneumonia&#41; &#40;Supplementary material 6&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">-</span><p id="par0135" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Hepatization&#47;condensation&#58;</span> this is observed when the echographic density of the lung is similar to that of the liver&#46;</p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Weaning and post-decannulation usefulness of VV ECMO</span><p id="par0140" class="elsevierStylePara elsevierViewall">In patients showing respiratory improvement and in which weaning of VV ECMO is considered&#44; echocardiography can help us to evaluate the response of the RV and the signs of PHT on reducing assist&#46; On the other hand&#44; before removing the cannulas&#44; echocardiography can be used to evaluate the existence of intraatrial thrombi that may delay weaning&#44; increasing anticoagulation in order to try to reduce the size of the thrombi and prevent them from migrating during decannulation&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">After withdrawing ECMO&#44; it is necessary to assess the persistence of thrombi in the RA&#44; cava and&#47;or lower extremities &#40;Supplementary materials 7 and 8&#41;&#46; This is very useful in clinical follow-up for guiding the required duration of post-assist anticoagulation&#44; diagnosing the appearance of deep vein thrombi in the vessels that have been cannulated&#44; or identifying the appearance of PTE that may require other coadjuvant treatments &#40;thrombectomy&#44; cava filters&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">25</span></a></p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Veno-arterial &#40;VA&#41; ECMO</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Pre-VA ECMO evaluation</span><p id="par0150" class="elsevierStylePara elsevierViewall">There are different indications &#40;cardiogenic shock in acute myocardial infarction&#44; myocarditis or intoxications&#44; postcardiotomy shock&#44; PTE&#44; cardiac arrest&#44; etc&#46;&#41; for ECMO as circulatory assist&#44; and the technique may involve different configurations &#40;peripheral&#44; central&#44; hybrid&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">26</span></a> Therefore&#44; and unless there is a contraindication or the situation does not allow the use of ultrasound&#44; the latter is essential as an exploratory tool before implantation&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Basal TTE&#47;TEE is required to evaluate both ventricular and atrial interdependence&#44; function and size&#46; We should seek possible anatomical defects &#40;communications&#44; thrombi&#44; prominent valves&#44; etc&#46;&#41; or aortic disorders &#40;dissection&#44; aneurysms&#41; that may complicate or even impede the implantation of the device&#46; In addition&#44; we must detect the existence of valve anomalies &#40;mitral or aortic valve insufficiency&#41; that might worsen after starting the treatment &#40;Supplementary material 9&#41;&#44; or which may even require prior surgery&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Along with the cardiac evaluation&#44; we should assess the possible presence of effusion &#40;especially pericardial effusion&#41; or vascular disease &#40;arteriosclerosis&#44; thrombosis&#41; that may worsen or appear in relation to the implant&#46; The presence of such disorders may require a configuration change &#40;central or peripheral&#41; or access &#40;right&#47;left or femoral&#47;subclavian&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">In addition to the echographic signs&#44; it is important to take into account and register the hemodynamic conditions&#44; measures of support &#40;mechanical ventilation&#44; counterpulsation balloon&#44; etc&#46;&#41; and drug treatments &#40;type and dose of vasoactive medication&#44; inotropic agents or vasodilators&#41; that may influence interpretation&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Cannulation and start of VA support</span><p id="par0170" class="elsevierStylePara elsevierViewall">Evaluation&#44; vascular puncture and positioning of the guides are carried out in the same way as in VV ECMO&#44; and the same protocol is followed&#46; With regard to the placement of the venous cannula&#44; a multiperforated cannula is indicated in VA support and should be positioned at the RA&#44; with the tip at the SVC level&#44; in order to secure the greatest drainage possible &#40;Supplementary material 10&#41;&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">In percutaneous femoral arterial cannulation&#44; vascular ultrasound is very useful for the correct evaluation of the point of insertion&#44; avoiding atheroma plaques or vascular alterations&#46; When inserting the return cannula&#44; we must puncture and insert the guides in the cranial direction&#44; above the femoral bifurcation&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">27</span></a> Since the cannula can completely occlude the arterial lumen and therefore affect flow in the cannulated extremity&#44; ultrasound-guided cannulation should be performed of the superficial femoral artery in the caudad direction to ensure perfusion of the extremity&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Once the guide has been placed at the arterial level&#44; TTE&#47;TEE can identify its position at the descending aorta&#44; confirming the correct arterial access of the guide&#46; This is useful in cases of very low flow or pulsatility&#44; as in cardiac arrest&#44; where peripheral evaluation may prove difficult and urgent cannulation is required&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">28</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">On starting assist&#44; TTE&#47;TEE allows us to evaluate the situation&#44; size and degree of decompression of the heart cavities&#59; assess septal position as the expression of ventricular interdependence&#59; and analyze volemia&#47;preload that may affect ECMO flow and the development of early complications such as pericardial effusion&#44; aortic valve closure or increased valve insufficiencies secondary to the increase in LV afterload conditioned by ECMO&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">29</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Management of the patient with VA ECMO</span><p id="par0185" class="elsevierStylePara elsevierViewall">It must be taken into account that most of the monitoring systems &#40;transpulmonary thermodilution&#44; pulse profile analysis&#41; present artifacts due to the hemodynamic effect of ECMO&#59; TTE&#47;TEE therefore must be included in the daily evaluation of these patients&#46; Based on this exploration we can assess and compare the following versus the basal exploration<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#58;<ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">-</span><p id="par0190" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Biventricular contractility and size</span>&#44; which reflects the evolution of the cardiac condition for which ECMO was prescribed&#46;</p></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">-</span><p id="par0195" class="elsevierStylePara elsevierViewall">The presence of echocardiographic signs &#40;E&#47;A ratio&#44; E wave deceleration gradient&#44; E&#47;e&#8217; ratio&#41; of <span class="elsevierStyleBold">high left end-diastolic pressures</span> indicating inadequate ventricular function&#46;</p></li><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">-</span><p id="par0200" class="elsevierStylePara elsevierViewall">The appearance or progression of <span class="elsevierStyleBold">mitral valve insufficiency</span> due to ventricular dilatation and&#47;or increased pressures &#40;Supplementary material 11&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">-</span><p id="par0205" class="elsevierStylePara elsevierViewall">The presence of <span class="elsevierStyleBold">auto contrast</span> suggesting blood stasis or even <span class="elsevierStyleBold">intracavitary thrombi</span> that can give rise to distal embolism &#40;Supplementary material 12&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">-</span><p id="par0210" class="elsevierStylePara elsevierViewall">The increase in afterload conditioned by ECMO&#44; together with low left ventricular contractility&#44; can adversely affect <span class="elsevierStyleBold">aortic valve opening</span>&#44; with early closure of the valve &#40;Supplementary material 13&#41;&#44; or the valve may even remain closed &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a> and Supplementary material 14&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0085"><span class="elsevierStyleLabel">-</span><p id="par0215" class="elsevierStylePara elsevierViewall">Appearance or progression of <span class="elsevierStyleBold">aortic insufficiency</span>&#44; impeding LV emptying and perpetuating the high-end-diastolic pressures &#40;Supplementary material 15&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0090"><span class="elsevierStyleLabel">-</span><p id="par0220" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Stroke volume and native CO</span> using VTI of the LVOT to assess the evolution of ventricular function&#46; It must be taken into account that the volume circulating in the lung territory&#44; and which reaches the left cavities can vary according to the presence of aortopulmonary collaterals&#44; bronchial circulation and especially ECMO flow&#46;</p></li><li class="elsevierStyleListItem" id="lsti0095"><span class="elsevierStyleLabel">-</span><p id="par0225" class="elsevierStylePara elsevierViewall">The presence and characteristics of <span class="elsevierStyleBold">pericardial effusion</span>&#46; In these cases&#44; it must be taken into account that the data referred to right cavity collapse can be increased by the negative pressure generated by ECMO&#44; though not so in the left cavities&#59; consequently&#44; signs of tamponade must be correlated with the clinical situation and the behavior of ECMO&#46;</p></li><li class="elsevierStyleListItem" id="lsti0100"><span class="elsevierStyleLabel">-</span><p id="par0230" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleBold">position and flow of the cannulas</span>&#46; Patient mobilization can cause the cannulas to shift position&#46; They consequently must be evaluated on a daily basis&#44; with an assessment of the appearance of adhered thrombi that may embolize or even affect ECMO flow&#46;</p></li></ul></p><p id="par0235" class="elsevierStylePara elsevierViewall">In addition to echocardiography&#44; daily monitoring can involve pleuropulmonary ultrasound for evaluating both the lung parenchyma and the diaphragm or pleura&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">29&#44;30</span></a> Transcranial Doppler poses limitations because it experiences artifacts due to the continuous flow of ECMO and other devices &#40;Intra aortic balloon counterpulsation &#40;IAoBC&#41;&#44; Impella&#174;&#41; &#40;Supplementary material 16&#41;&#59; nevertheless&#44; it also may be useful in the evaluation of cerebral hemodynamics and even in diagnosing brain death&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">31&#44;32</span></a></p><p id="par0240" class="elsevierStylePara elsevierViewall">Lastly&#44; many patients with VA ECMO may also carry some other left ventricular assist device &#40;IAoBC&#44; Impella&#174;&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">33</span></a> and its position and function must be monitored as well&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> In the case of IAoBC&#44; we can use TTE&#47;TEE to observe insufflation of the balloon at the level of the descending aorta&#44; with its distal extremity at the left subclavian root level &#40;Supplementary material 17&#41;&#46; Impella&#174; can be explored with both TTE &#40;long-axis parasternal or three-chamber apical&#41; and TEE &#40;mid-esophageal 120&#186;&#41;&#44; and we should see the device entering from the ascending aorta and the inlet or suction zone at 3&#8211;4&#8239;cm from the aortic valve<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">34&#44;35</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a> and Supplementary material 18&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resolution of VA ECMO problems</span><p id="par0245" class="elsevierStylePara elsevierViewall">One of the most frequent complications in patients with VA ECMO is a decrease in flow&#46; Using TTE&#47;TEE&#44; we can check the positioning of the cannulas with suction events &#40;Supplementary material 19&#41;&#44; the presence of thrombi or the presence of pericardial effusion accounting for the impossibility of filling of the device as the cause of diminished flow &#40;Supplementary material 20&#41;&#46; It must be taken into account that if there is no impairment of flow&#44; the presence of pericardial effusion does not need to imply intervention&#46; Nevertheless&#44; we must monitor its characteristics and evolution&#44; for in some cases the signs of cardiac tamponade only manifest at the time of withdrawal&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">Aortic closure is a complication that must be resolved&#44; since persistent closure gives rise to intraventricular blood stasis and increased left-side pressures that in turn lead to left cavity dilatation and ultimately persistent lung edema&#46; If this happens&#44; TTE can evidence &#8220;smoke&#8221; or even intraventricular thrombi and signs of high left-side pressures &#40;E&#47;A ratio &#62;2 and&#47;or a mitral flow deceleration time &#40;EDT&#41; of &#60;150&#8239;ms&#41;&#46; In addition to its diagnostic&#47;evolutive usefulness&#44; TTE can be of help in guiding the treatment of this complication through assessment of the response to the use or increase in inotropic treatment &#40;Supplementary material 21&#41;&#44; or in guiding the implantation of devices &#40;IAoBC&#47;Impella&#174;&#41; or interventionism &#40;atrial septostomy&#44; apical drainage&#44; left atrial VA ECMO &#40;LAVA ECMO&#41;&#41; for alleviating left-side pressures&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0255" class="elsevierStylePara elsevierViewall">In patients with femoral-femoral VA ECMO&#44; when ventricle function recovers and lung function has not yet improved&#44; we can observe differential hypoxemia&#44; north-south syndrome &#40;or harlequin syndrome&#41;&#44; due to upper trunk perfusion with poorly oxygenated blood from the pulmonary circulation and lower trunk perfusion with oxygenated blood from ECMO&#46; This complication is usually detected by the determination of oxygenation &#40;arterial blood gases&#44; pulse oximetry&#41; at the right upper extremity or cerebral level &#40;near-infrared spectroscopy &#40;NIRS&#41;&#41;&#44; requiring us to optimize native lung ventilation&#46; In this respect&#44; pulmonary ultrasound is useful for evaluating both the lung pattern and the possible response to the adopted measures&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">29</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Weaning and post-decannulation usefulness of VA ECMO</span><p id="par0260" class="elsevierStylePara elsevierViewall">For weaning from VA ECMO&#44; the patient must be clinically &#40;lactic acid &#60;2&#8239;mmol&#47;l&#44; Pa&#47;FiO<span class="elsevierStyleInf">2</span>&#8239;&#62;&#8239;200&#44; improvement of organ dysfunction&#41; and hemodynamically stable &#40;mean blood pressure&#8239;&#62;&#8239;65&#8239;mmHg&#44; pulse pressure&#8239;&#62;&#8239;20&#8239;mmHg&#44; SvO<span class="elsevierStyleInf">2</span>&#8239;&#62;&#8239;65&#37;&#41;&#44; indicating that the underlying cause is controlled&#46; Although there are no validated echocardiographic protocols or scientific recommendations as to when and how to perform weaning from ECMO&#44; it is accepted that the patient must present echocardiographic signs of recovery of biventricular function &#40;LVEF&#8239;&#62;&#8239;25&#37;&#8211;30&#37;&#44; VTI of the LVOT&#8239;&#62;&#8239;10&#8239;cm&#44; mitral ring S&#8217;&#8239;&#62;&#8239;6&#8239;cm&#47;s&#44; TAPSE&#8239;&#62;&#8239;16&#8239;cm&#41;&#44; with no evidence of high end-diastolic pressures that may worsen on suspending the assist measures&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">36</span></a> In the same way&#44; as in VV ECMO&#44; we must evaluate the presence of thrombi surrounding the cannula that could delay removal of the latter&#44; or we at least should continue early with anticoagulation therapy once the cannula has been removed&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">Weaning involves a progressive decrease &#40;500&#8239;ml every 15&#8211;20&#8239;min&#41; in VA ECMO support&#44; gradually restoring cardiac preload&#46; This requires adequate patient anticoagulation&#46; We evaluate the hemodynamic &#40;central venous pressure&#44; mean and differential blood pressure&#44; SvO<span class="elsevierStyleInf">2</span>&#44; SatO<span class="elsevierStyleInf">2</span>&#41; and echocardiographic repercussions of the procedure &#40;LVEF&#44; VTI&#44; E wave&#44; E&#8217; wave or S&#8217; of the lateral mitral ring&#41; to a level &#40;normally 1&#8211;1&#46;5&#8239;l per min&#41; indicating that the patient can tolerate suspension of the assist measures&#46; During the latter&#44; we check that LVEF is maintained or even exceeds 25&#37;&#8211;30&#37;&#44; with VTI above 10&#8239;cm and an S&#8217; wave of &#62;6&#8239;cm&#47;s &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a> and Supplementary material 22&#41;&#46; In addition&#44; we should also evaluate the behavior of the right-side cavities &#40;TAPSE&#8239;&#62;&#8239;16&#8239;cm&#47;S&#8217; wave&#8239;&#62;&#8239;10&#8239;cm&#47;s and RV size&#41; and the possible appearance of signs of PHT &#40;increase in peak velocity of tricuspid insufficiency &#40;TI&#41;&#41; predicting RV failure&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">37&#8211;39</span></a></p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0270" class="elsevierStylePara elsevierViewall">After weaning&#44; we perform the same controls as in the case of VV ECMO&#44; taking special care in screening for intracavitary or intravascular thrombi that require the maintenance of anticoagulation therapy&#44; or which may migrate&#46;</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusions</span><p id="par0275" class="elsevierStylePara elsevierViewall">Ultrasound in patients with ECMO is a key tool in all the assist phases&#46; In preimplantation it is used to evaluate the vessels to be cannulated and biventricular function&#59; during implantation&#44; it is of help in ensuring safe and correct insertion of the cannulas&#59; and in the assist phase&#44; it is used to detect and treat complications and to study the pulmonary and&#47;or cardiac evolution to ensure safe weaning &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>&#41;&#46;</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0280" class="elsevierStylePara elsevierViewall">Taking into account its usefulness&#44; ultrasound should be seen as a crucial instrument in the management of these patients&#44; and the intensivists that perform the technique must have advanced knowledge of the anatomical&#44; technical and functional aspects of the procedure&#46; Further research is needed in this field&#44; together with the development of scientific recommendations allowing correct training and improvement of patient outcomes&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Authors&#8217; contributions</span><p id="par0285" class="elsevierStylePara elsevierViewall">LMV&#44; MPFG&#44; RMB and HPC designed the study&#44; conducted the literature review and wrote the manuscript&#46; LMV&#44; RMB and MPFG participated in the preparation of the tables and figures&#46; LMV&#44; MPFG&#44; RMB and HPC reviewed the final version of the manuscript&#46; All authors read and approved the final manuscript&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflict of interests</span><p id="par0290" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interests&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Ultrasound is an essential diagnostic tool in critically ill patients with extracorporeal membrane oxygenation &#40;ECMO&#41;&#46; With it&#44; we can make an anatomical and functional &#40;cardiac&#44; pulmonary and vascular&#41; evaluation which allows us to execute an adequate configuration&#44; guides implantation&#44; helps clinical monitorization and detects complications&#44; facilitates withdrawal and complete post-implant evaluation&#46; In patients with ECMO as respiratory support &#40;veno-venous&#41;&#44; thoracic ultrasound allows monitoring pulmonary illness evolution and echocardiography the evaluation of biventricular function&#44; especially right ventricle function&#44; and cardiac output to optimize oxygen transport&#46; In ECMO as circulatory support &#40;veno-arterial&#41;&#44; echocardiography is the guide of hemodynamic monitoring&#44; allows detecting the most frequent complications and helps the weaning&#46; In ECMO teams&#44; for a proper management of these patients&#44; there must be trained intensivists with advanced knowledge on this technique&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La ecograf&#237;a es un instrumento diagn&#243;stico fundamental en el paciente cr&#237;tico con membrana de oxigenaci&#243;n extracorp&#243;rea &#40;ECMO&#41;&#46; Con ella podemos hacer una evaluaci&#243;n anat&#243;mica y funcional &#40;cardiaca&#44; pulmonar y vascular&#41; para plantear una adecuada configuraci&#243;n&#59; adem&#225;s&#44; gu&#237;a su implante&#44; ayuda en la monitorizaci&#243;n cl&#237;nica y la detecci&#243;n de complicaciones&#44; facilita su retirada y completa la evaluaci&#243;n postimplante&#46; En los pacientes con ECMO como soporte respiratorio &#40;veno-venosa&#41;&#44; la ecograf&#237;a tor&#225;cica permite monitorizar la evoluci&#243;n de la enfermedad pulmonar y la ecocardiograf&#237;a la evaluaci&#243;n de la funci&#243;n biventricular&#44; especialmente la derecha&#44; y el gasto cardiaco para optimizar el transporte de ox&#237;geno&#46; En la ECMO como soporte circulatorio &#40;veno-arterial&#41;&#44; la ecocardiograf&#237;a supone la gu&#237;a de la monitorizaci&#243;n hemodin&#225;mica&#44; permite detectar las principales complicaciones y ayuda al destete del dispositivo&#46; En los equipos ECMO&#44; para un adecuado manejo de estos pacientes&#44; debe haber intensivistas entrenados y con conocimientos avanzados sobre esta t&#233;cnica&#46;</p></span>"
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            "apendice" => "<p id="par0300" class="elsevierStylePara elsevierViewall">The following are Supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia><elsevierMultimedia ident="upi0010"></elsevierMultimedia><elsevierMultimedia ident="upi0015"></elsevierMultimedia><elsevierMultimedia ident="upi0020"></elsevierMultimedia><elsevierMultimedia ident="upi0025"></elsevierMultimedia><elsevierMultimedia ident="upi0030"></elsevierMultimedia><elsevierMultimedia ident="upi0035"></elsevierMultimedia><elsevierMultimedia ident="upi0040"></elsevierMultimedia><elsevierMultimedia ident="upi0045"></elsevierMultimedia><elsevierMultimedia ident="upi0050"></elsevierMultimedia><elsevierMultimedia ident="upi0055"></elsevierMultimedia><elsevierMultimedia ident="upi0060"></elsevierMultimedia><elsevierMultimedia ident="upi0065"></elsevierMultimedia><elsevierMultimedia ident="upi0070"></elsevierMultimedia><elsevierMultimedia ident="upi0075"></elsevierMultimedia><elsevierMultimedia ident="upi0080"></elsevierMultimedia><elsevierMultimedia ident="upi0085"></elsevierMultimedia><elsevierMultimedia ident="upi0090"></elsevierMultimedia><elsevierMultimedia ident="upi0095"></elsevierMultimedia><elsevierMultimedia ident="upi0100"></elsevierMultimedia><elsevierMultimedia ident="upi0105"></elsevierMultimedia><elsevierMultimedia ident="upi0110"></elsevierMultimedia></p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Transesophageal echocardiography &#40;TEE&#41; of thrombotic aortic valve in a patient with VA ECMO&#46; Closed aortic valve &#40;AV&#41; with thrombus &#40;arrow&#41; at sinus of Valsalva level in a patient with VA ECMO and ventricular draining cannula&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Transthoracic echocardiography &#40;TTE&#41; of Impella&#174; in a patient with VA ECMO&#46; Long-axis parasternal TTE &#40;A&#41; and three-chamber apical TTE &#40;B&#41; of Impella&#174; &#40;arrow&#41; at left ventricle &#40;LV&#41; level&#46;</p>"
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Echocardiographic evaluation of weaning in a patient with VA ECMO&#46; Transthoracic echocardiography &#40;TTE&#41; and velocity-time integral &#40;VTI&#41; of the left ventricle outlet tract &#40;LVOT&#41; on reducing flow &#40;A&#58; 3&#8239;l&#47;min&#44; B&#58; 2&#46;5&#8239;l&#47;min&#44; C&#58; 2&#8239;l&#47;min&#41; of VA ECMO&#46; Note the increase in magnitude of VTI and consequently of stroke volume &#40;SV&#41; and cardiac output &#40;CO&#41;&#46;</p>"
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          "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">TDI&#58; tissue Doppler&#59; VTI&#58; velocity-time integral&#59; LVOT&#58; left ventricular outflow tract&#59; EDT&#58; E wave deceleration time&#59; RV&#58; right ventricle&#59; LV&#58; left ventricle&#59; TAPSE&#58; tricuspid annular plane systolic excursion&#59; PAPs&#58; systolic pulmonary artery pressure&#59; Tac&#58; acceleration time&#59; RA-LA&#58; right atrium&#8211;left atrium&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Structure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Parameter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Reference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Left ventricle</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8226; Morphology</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Myocardial size and thickness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Septal position&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presence of autocontrast&#47;thrombi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8226; Systolic function</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ejection fraction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Segmental motility&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mitral S wave &#40;TDI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62; 6&#8239;cm&#47;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Velocity and size of VTI of LVOT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62; 1&#8239;m&#47;s and &#62;10&#8239;cm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8226; Diastolic function</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E&#47;A ratio of transmitral flow&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EDT of mitral flow&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62;150&#8239;ms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E&#47;e&#8217; ratio of the mitral ring&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Mitral and aortic valves</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diagnosis and grading of possible insufficiency and&#47;or stenosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Left atrium</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Size and volume&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;35&#8239;ml&#47;m<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulmonary vein flow&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S wave&#8239;&#62;&#8239;D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Right ventricle</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8226; Morphology</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RV&#47;LV end-diastolic area ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Septal position and motion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ventricular geometry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Triangular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Eccentricity index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Myocardial thickness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;8&#8239;mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8226; Systolic function</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TAPSE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62;16&#8239;mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tricuspid S&#8217; wave &#40;TDI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62;10&#8239;cm&#47;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Shortening fraction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62;35&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">McConnell sign&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8226; Diastolic function&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tricuspid flow E&#47;A ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Tricuspid and pulmonary valves</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tricuspid insufficiency for estimation of PAPs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;3&#8239;m&#47;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulmonary flow &#40;Tac&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62;120&#8239;ms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Right atrium</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;20&#8239;cm<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Structures &#40;valves&#44; Chiari&#44; coronary sinus&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Septal integrity &#40;foramen ovale&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RA-LA shunt &#40;color Doppler&#8239;&#177;&#8239;shaken saline test&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Inferior&#47;superior vena cava</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Size and respiratory variation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;20&#8239;cm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Position of cannulas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Thrombi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Aorta</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Thrombosis&#47;atheromatosis&#47;dissection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Pericardium&#47;pleura</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Effusion &#40;characteristics and grading&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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ISSN: 21735727
Original language: English
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