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Original article
Available online 18 November 2024
The association between body temperature and 28-day mortality in sepsis patients: A retrospective observational study
La asociación entre la temperatura corporal y la mortalidad a los 28 días en pacientes con sepsis: Un estudio observacional retrospectivo
Wei Yanga, Dan Zhoua, Hui Penga, Huilin Jiangb,
Corresponding author
lifisher@126.com

Corresponding authors.
, Weifeng Chena,
Corresponding author
weifeng@ldy.edu.rs

Corresponding authors.
a Department of General Practice, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518035, Guangdong Province, China
b Department of Emergency, The Second Affiliated Hospital, Guangzhou Medical University, No. 250 Changgang East Road, Guangzhou, 510260, Guangdong Province, China
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Tables (4)
Table 1. Baseline characteristics and 28-day mortality according to the tertiles of body temperature (n = 18056).
Table 2. The unadjusted association between baseline variables and 28-day mortality (n = 18056).
Table 3. Relationship between body temperature and 28-day mortality in different models (n = 18056).
Table 4. The result of two-piecewise linear regression model.
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Abstract
Objective

This study explored the association between body temperature and 28-day septic ICU hospital mortality.

Design

Retrospective cohort analysis.

Setting

208 ICUs in the United States.

Patients or participants

Sepsis patients from 2014–2015 eICU Collaborative Research Database.

Interventions

Binary logistic regression models, Generalized Additive Model (GAM), Two-Piece Binary Logistic Regression Model.

Main variables of interest

Body temperature, 28-day inpatient mortality.

Results

Nonlinear relationship observed; hypothermia (≤36.67 ℃) associated with increased mortality (adjusted OR = 0.74, 95% CI: 0.70–0.80, p < 0.0001).

Conclusions

Hypothermia in sepsis correlates with higher mortality; rewarming's potential benefit warrants further exploration.

Keywords:
Body temperature
Sepsis
Nonlinear relationship
Generalized additive model
Smooth curve fitting
Resumen
Objetivo

Investigar la asociación entre la temperatura corporal y la mortalidad hospitalaria a los 28 días en pacientes sépticos en UCI.

Diseño

Análisis de cohorte retrospectivo.

Ámbito

UCI en los Estados Unidos.

Pacientes o participantes

Pacientes con sepsis de la base de datos de investigación colaborativa eICU de 2014-2015.

Intervenciones

Modelos de regresión logística binaria, Modelo Aditivo Generalizado (GAM), Modelo de Regresión Logística Binaria en Dos Partes.

Variables de interés principale

Temperatura corporal, mortalidad hospitalaria a los 28 días.

Resultados

Se observó una relación no lineal; la hipotermia (≤36.67℃) se asoció con mayor mortalidad (OR ajustada = 0.74, IC del 95% 0.70-0.80, p < 0.0001).

Conclusiones

La hipotermia en la sepsis se correlaciona con una mayor mortalidad; se justifica explorar más el posible beneficio del recalentamiento.

Palabras clave:
Temperatura corporal
Sepsis
Relación no lineal
Modelo aditivo generalizado
Ajuste suave de curvas

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