Unexplained hyperammonemia in critically ill oncological patients: An emerging complication of gemcitabine-cisplatin therapy

Escudero-Acha, Patricia; Arroyo Diez, Marta; Abajo Miranda, Alfredo; Martínez Elizalde, Junkal; Fisac Cuadrado, Lourdes; Fernández Ratero, José Antonio

doi:10.1016/j.medine.2025.502270

Medicina Intensiva (English Edition)

ISSN: 2173-5727

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DOI: 10.1016/j.medine.2025.502270

Available online 26 September 2025

Unexplained hyperammonemia in critically ill oncological patients: An emerging complication of gemcitabine-cisplatin therapy

Hiperamonemia inexplicada en pacientes oncológicos críticos: una complicación emergente del tratamiento con gemcitabina-cisplatino

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Patricia Escudero-Acha

, Marta Arroyo Diez, Alfredo Abajo Miranda, Junkal Martínez Elizalde, Lourdes Fisac Cuadrado, José Antonio Fernández Ratero

Servicio de Medicina Intensiva, Hospital Universitario de Burgos, Burgos, Spain

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Table 1. Published cases in the literature of idiopathic hyperammonemic encephalopathy related to gemcitabine therapy.

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