array:23 [
  "pii" => "S0210569100796367"
  "issn" => "02105691"
  "doi" => "10.1016/S0210-5691(00)79636-7"
  "estado" => "S300"
  "fechaPublicacion" => "2000-12-01"
  "aid" => "79636"
  "copyright" => "Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L."
  "copyrightAnyo" => "2000"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Med Intensiva. 2000;24:413-7"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 11601
    "formatos" => array:3 [
      "EPUB" => 175
      "HTML" => 3461
      "PDF" => 7965
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0210569100796379"
    "issn" => "02105691"
    "doi" => "10.1016/S0210-5691(00)79637-9"
    "estado" => "S300"
    "fechaPublicacion" => "2000-12-01"
    "aid" => "79637"
    "copyright" => "Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Med Intensiva. 2000;24:418-20"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4242
      "formatos" => array:3 [
        "EPUB" => 183
        "HTML" => 1683
        "PDF" => 2376
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Síndrome de Holt-Oram"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "418"
          "paginaFinal" => "420"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Holt-Oram Syndrome"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A. Canabal Berlanga, S. Sáez Noguero, C. Martín Parra, D. Cabestrero Alonso, T. Álvarez Pérez, A. Robas Gómez"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "A."
              "apellidos" => "Canabal Berlanga"
            ]
            1 => array:2 [
              "nombre" => "S."
              "apellidos" => "Sáez Noguero"
            ]
            2 => array:2 [
              "nombre" => "C."
              "apellidos" => "Martín Parra"
            ]
            3 => array:2 [
              "nombre" => "D."
              "apellidos" => "Cabestrero Alonso"
            ]
            4 => array:2 [
              "nombre" => "T."
              "apellidos" => "Álvarez Pérez"
            ]
            5 => array:2 [
              "nombre" => "A."
              "apellidos" => "Robas Gómez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796379?idApp=WMIE"
    "url" => "/02105691/0000002400000009/v1_201304241206/S0210569100796379/v1_201304241206/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0210569100796355"
    "issn" => "02105691"
    "doi" => "10.1016/S0210-5691(00)79635-5"
    "estado" => "S300"
    "fechaPublicacion" => "2000-12-01"
    "aid" => "79635"
    "copyright" => "Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "rev"
    "cita" => "Med Intensiva. 2000;24:405-12"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 9532
      "formatos" => array:3 [
        "EPUB" => 157
        "HTML" => 1919
        "PDF" => 7456
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Estado epiléptico"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "405"
          "paginaFinal" => "412"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Status Epilepticus"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "O. Barakat, M.J. Fernández Pérez, J.A. Corrales Cruz, F.J. González Fernández, G. Izquierdo Ayuso, J. Fajardo Gálvez"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "O."
              "apellidos" => "Barakat"
            ]
            1 => array:2 [
              "nombre" => "M.J."
              "apellidos" => "Fernández Pérez"
            ]
            2 => array:2 [
              "nombre" => "J.A."
              "apellidos" => "Corrales Cruz"
            ]
            3 => array:2 [
              "nombre" => "F.J."
              "apellidos" => "González Fernández"
            ]
            4 => array:2 [
              "nombre" => "G."
              "apellidos" => "Izquierdo Ayuso"
            ]
            5 => array:2 [
              "nombre" => "J."
              "apellidos" => "Fajardo Gálvez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796355?idApp=WMIE"
    "url" => "/02105691/0000002400000009/v1_201304241206/S0210569100796355/v1_201304241206/es/main.assets"
  ]
  "es" => array:13 [
    "idiomaDefecto" => true
    "titulo" => "Coma metabólico secundario a sertralina"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "413"
        "paginaFinal" => "417"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J. López, M. Casares, G. Soriano, A. Madero, M.T. Jurado, R. Jordà"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "J."
            "apellidos" => "López"
            "email" => array:1 [
              0 => "Lopezlibano@hotmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Casares"
          ]
          2 => array:2 [
            "nombre" => "G&#46;"
            "apellidos" => "Soriano"
          ]
          3 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Madero"
          ]
          4 => array:2 [
            "nombre" => "M&#46;T&#46;"
            "apellidos" => "Jurado"
          ]
          5 => array:2 [
            "nombre" => "R&#46;"
            "apellidos" => "Jord&#224;"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Unidad de Cuidados Intensivos&#46; Hospital Son Dureta&#46; Mallorca"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "1"
            "correspondencia" => "Correspondencia&#58; Dr&#46; J&#46; L&#243;pez&#46; C&#47; Moragues&#44; 7&#44; 2&#46;&#186; 1&#46;&#170;&#46; 07006 Palma de Mallorca"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Sertraline-Induced Metabolic Coma"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaAceptado" => "2000-10-13"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec82383"
          "palabras" => array:3 [
            0 => "sertralina"
            1 => "SSIADH"
            2 => "coma"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec82384"
          "palabras" => array:3 [
            0 => "sertraline"
            1 => "syndrome of inappropriate secretion of antidiuretic hormone"
            2 => "coma"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La sertralina es un f&#225;rmaco inhibidor de la recaptaci&#243;n de serotonina en el sistema nervioso central que se utiliza como antidepresivo&#46; Entre sus efectos secundarios se ha descrito la presentaci&#243;n de s&#237;ndrome de secreci&#243;n inadecuada de ADH&#44; especialmente en individuos de edad avanzada&#46; En la mayor&#237;a de los pacientes afectados&#44; los s&#237;ntomas revistieron escasa gravedad y pudieron ser r&#225;pidamente revertidos&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Presentamos los casos de 2 mujeres de mediana edad que desarrollaron SSIADH e hiponatremia severa despu&#233;s de haber seguido tratamiento con sertralina&#46; Ambas ingresaron en nuestra unidad de cuidados intensivos en estado de coma inferior o igual a 8 puntos en la escala de Glasgow y necesitaron ventilaci&#243;n mec&#225;nica invasiva&#46;</p>"
      ]
      "en" => array:1 [
        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Sertraline selectively inhibits the reuptake of serotonin in the central nervous system and is used as an antidepressant drug&#46; The syndrome of inappropriate secretion of antidiuretic hormone &#40;SIADH&#41;&#44; especially in the elderly&#44; has been described as one of its adverse affects&#46; In most patients&#44; symptoms were mild and soon disappeared&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We present the cases of two middle-aged women who developed SIADH and severe hyponatremia after sertraline treatment&#46; Both were admitted to our intensive care unit in a state of coma lower or equal to 8 points in the Glasgow Coma Scale and required invasive mechanical ventilation&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:12 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence of selective serotonin reuptake inhibitor &#40;SSRI&#41; induced hyponatremia due to the syndrome of inappropiate antidiuretic hormone &#40;SIADH&#41; secretion in the elderly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;P&#46; Bouman"
                            1 => "G&#46; Pinner"
                            2 => "Johnson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Geriatr Psychiatry"
                        "fecha" => "1998"
                        "volumen" => "13"
                        "paginaInicial" => "12"
                        "paginaFinal" => "15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9489575"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hyponatremia and the syndrome of inappropiate secretion of antidiuretic hormone associated with the use of selective serotonin reuptake inhibitors&#58; a rewiew of spontaneous reports"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46;A&#46; Liu"
                            1 => "N&#46; Mittmann"
                            2 => "S&#46;R&#46; Knwles"
                            3 => "N&#46;H&#46; Shear"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "CMAJ"
                        "fecha" => "1996"
                        "volumen" => "155"
                        "paginaInicial" => "519"
                        "paginaFinal" => "527"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8804257"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Adverse Drugs Reaction Advisory Committee&#46; Selective serotonin reuptake inhibitors and SIADH"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med J Aust"
                        "fecha" => "1996"
                        "volumen" => "164"
                        "paginaInicial" => "562"
                        "paginaFinal" => "563"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8649298"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Drug therapy for geriatric depression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Bressler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Drugs aging"
                        "fecha" => "1993"
                        "volumen" => "3"
                        "paginaInicial" => "195"
                        "paginaFinal" => "219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8324296"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of selective serotonin reuptake inhibitors on cytochrome P4502D6 &#40;CYP2D6&#41; activity in human liver microsomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;K&#46; Crewe"
                            1 => "N&#46;S&#46; Lennnard"
                            2 => "G&#46;T&#46; Tucker"
                            3 => "F&#46;R&#46; Woods"
                            4 => "R&#46;E&#46; Haddock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Clin Pharmac"
                        "fecha" => "1992"
                        "volumen" => "34"
                        "paginaInicial" => "262"
                        "paginaFinal" => "265"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of SIADH with selective serotonin reuptake inhibitors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;H&#46; Woo"
                            1 => "M&#46;A&#46; Smythe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Pharmacother"
                        "fecha" => "1997"
                        "volumen" => "31"
                        "paginaInicial" => "108"
                        "paginaFinal" => "110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8997475"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of sertraline in a patient with recurrent hyponatremia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Catalano"
                            1 => "S&#46;N&#46; Kanfer"
                            2 => "M&#46;C&#46; Catalano"
                            3 => "V&#46;A&#46; lberts"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gen Hosp Psychiatry"
                        "fecha" => "1996"
                        "volumen" => "18"
                        "paginaInicial" => "278"
                        "paginaFinal" => "283"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8832263"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hyponatremia due to sodium valproate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;J&#46; Branten"
                            1 => "J&#46;F&#46;M&#46; Wetzels"
                            2 => "A&#46;M&#46; Weber"
                            3 => "R&#46;A&#46;P&#46; Koene"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ana.410430219"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Neurol"
                        "fecha" => "1998"
                        "volumen" => "43"
                        "paginaInicial" => "265"
                        "paginaFinal" => "266"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9485070"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Elevated plasma antidiuretic hormone levels in status asthmaticus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;W&#46; Baker"
                            1 => "S&#46; Yerger"
                            2 => "W&#46; Segar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "1976"
                        "volumen" => "51"
                        "paginaInicial" => "31"
                        "paginaFinal" => "34"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1249995"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute asthma and antidiuretic hormone secretion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46;P&#46; Dawson"
                            1 => "D&#46;M&#46; Fergusson"
                            2 => "J&#46; West"
                            3 => "C&#46; Wynne"
                            4 => "W&#46;A&#46; Sadler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1983"
                        "volumen" => "38"
                        "paginaInicial" => "589"
                        "paginaFinal" => "591"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6612649"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Selective serotonin reuptake inhibitors&#58; infrecuent medical adverse effects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;J&#46; Goldberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Fam Med"
                        "fecha" => "1998"
                        "volumen" => "7"
                        "paginaInicial" => "78"
                        "paginaFinal" => "84"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9443704"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The syndrome of inappropiate secretion of antidiuretic hormone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46;C&#46; Bartter"
                            1 => "W&#46;B&#46; Schartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1967"
                        "volumen" => "42"
                        "paginaInicial" => "790"
                        "paginaFinal" => "806"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5337379"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/02105691/0000002400000009/v1_201304241206/S0210569100796367/v1_201304241206/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "438"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Notas cl&#237;nicas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02105691/0000002400000009/v1_201304241206/S0210569100796367/v1_201304241206/es/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569100796367?idApp=WMIE"
]
Compartir
Información de la revista
Vol. 24. Núm. 9.
Páginas 413-417 (diciembre 2000)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 24. Núm. 9.
Páginas 413-417 (diciembre 2000)
Acceso a texto completo
Coma metabólico secundario a sertralina
Sertraline-Induced Metabolic Coma
Visitas
26747
J. López1
Autor para correspondencia
Lopezlibano@hotmail.com

Correspondencia: Dr. J. López. C/ Moragues, 7, 2.º 1.ª. 07006 Palma de Mallorca
, M. Casares, G. Soriano, A. Madero, M.T. Jurado, R. Jordà
Unidad de Cuidados Intensivos. Hospital Son Dureta. Mallorca
Este artículo ha recibido
Información del artículo
Resumen
Bibliografía
Descargar PDF
Estadísticas

La sertralina es un fármaco inhibidor de la recaptación de serotonina en el sistema nervioso central que se utiliza como antidepresivo. Entre sus efectos secundarios se ha descrito la presentación de síndrome de secreción inadecuada de ADH, especialmente en individuos de edad avanzada. En la mayoría de los pacientes afectados, los síntomas revistieron escasa gravedad y pudieron ser rápidamente revertidos.

Presentamos los casos de 2 mujeres de mediana edad que desarrollaron SSIADH e hiponatremia severa después de haber seguido tratamiento con sertralina. Ambas ingresaron en nuestra unidad de cuidados intensivos en estado de coma inferior o igual a 8 puntos en la escala de Glasgow y necesitaron ventilación mecánica invasiva.

Palabras clave:
sertralina
SSIADH
coma

Sertraline selectively inhibits the reuptake of serotonin in the central nervous system and is used as an antidepressant drug. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH), especially in the elderly, has been described as one of its adverse affects. In most patients, symptoms were mild and soon disappeared.

We present the cases of two middle-aged women who developed SIADH and severe hyponatremia after sertraline treatment. Both were admitted to our intensive care unit in a state of coma lower or equal to 8 points in the Glasgow Coma Scale and required invasive mechanical ventilation.

Key words:
sertraline
syndrome of inappropriate secretion of antidiuretic hormone
coma
El Texto completo está disponible en PDF
Bibliografía
[1.]
W.P. Bouman, G. Pinner, Johnson.
Incidence of selective serotonin reuptake inhibitor (SSRI) induced hyponatremia due to the syndrome of inappropiate antidiuretic hormone (SIADH) secretion in the elderly.
Int J Geriatr Psychiatry, 13 (1998), pp. 12-15
[2.]
B.A. Liu, N. Mittmann, S.R. Knwles, N.H. Shear.
Hyponatremia and the syndrome of inappropiate secretion of antidiuretic hormone associated with the use of selective serotonin reuptake inhibitors: a rewiew of spontaneous reports.
CMAJ, 155 (1996), pp. 519-527
[3.]
Adverse Drugs Reaction Advisory Committee. Selective serotonin reuptake inhibitors and SIADH.
Med J Aust, 164 (1996), pp. 562-563
[4.]
R. Bressler.
Drug therapy for geriatric depression.
Drugs aging, 3 (1993), pp. 195-219
[5.]
H.K. Crewe, N.S. Lennnard, G.T. Tucker, F.R. Woods, R.E. Haddock.
The effect of selective serotonin reuptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.
Br J Clin Pharmac, 34 (1992), pp. 262-265
[6.]
M.H. Woo, M.A. Smythe.
Association of SIADH with selective serotonin reuptake inhibitors.
Ann Pharmacother, 31 (1997), pp. 108-110
[7.]
G. Catalano, S.N. Kanfer, M.C. Catalano, V.A. lberts.
The role of sertraline in a patient with recurrent hyponatremia.
Gen Hosp Psychiatry, 18 (1996), pp. 278-283
[8.]
A.J. Branten, J.F.M. Wetzels, A.M. Weber, R.A.P. Koene.
Hyponatremia due to sodium valproate.
Ann Neurol, 43 (1998), pp. 265-266
[9.]
J.W. Baker, S. Yerger, W. Segar.
Elevated plasma antidiuretic hormone levels in status asthmaticus.
Mayo Clin Proc, 51 (1976), pp. 31-34
[10.]
K.P. Dawson, D.M. Fergusson, J. West, C. Wynne, W.A. Sadler.
Acute asthma and antidiuretic hormone secretion.
Thorax, 38 (1983), pp. 589-591
[11.]
R.J. Goldberg.
Selective serotonin reuptake inhibitors: infrecuent medical adverse effects.
Arch Fam Med, 7 (1998), pp. 78-84
[12.]
F.C. Bartter, W.B. Schartz.
The syndrome of inappropiate secretion of antidiuretic hormone.
Am J Med, 42 (1967), pp. 790-806
Copyright © 2000. Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L.
Descargar PDF
Idiomas
Medicina Intensiva
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?