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Vol. 24. Núm. 9.
Páginas 398-404 (diciembre 2000)
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Vol. 24. Núm. 9.
Páginas 398-404 (diciembre 2000)
Acceso a texto completo
Estudio comparativo de la eficacia resucitadora de Ringer lactato, gelatinas y solución salina hipertónica al 2% en un modelo experimental canino de hemorragia aguda
Comparative Study of the Resuscitation Efficacy of Lactated Ringer’s Solution, Gelatins And 2% Hypertonic Saline Solution In An Experimental Canine Model Of Acute Hemorrhage
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J.M. Rabanal*,1, R. Mons**, I. Seco**, R. Calvo*, A. Quesada*, L. García-Castrillo*
* Departamento de Anestesiología y Cuidados Intensivos
** Servicio de Cirugía General y Torácica. Hospital Universitario Marqués de Valdecilla. Santander
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Objetivo

Estudiar la eficacia resucitadora de tres tipos de fluidos (Ringer lactato, gelatinas y solución salina hipertónica al 2%) en un modelo canino de hemorragia aguda.

Material y método

Se estudiaron 18 perros anestesiados y monitorizados sometidos a hemorragia gradual. De forma aleatorizada se realizó la resucitación con Ringer lactato (3 ml por ml de sangre extraída) (n = 6), con gelatinas (1 ml por ml de sangre extraída) (n = 6), y con solución salina hipertónica al 2% (1 ml por ml de sangre extraída) (n = 6).

Resultados

Los tres tipos de fluidos fueron eficaces en la resucitación según los parámetros clásicos (presión arterial, gasto cardíaco y presiones de llenado cardíacas). Las gelatinas incrementaron en mayor medida el gasto cardíaco, el transporte del O2 y el consumo de O2. El Ringer lactato incrementó el shunt pulmonar.

Conclusiones

Las gelatinas poseen mayor eficacia resucitadora que el Ringer lactato según los parámetros estudiados. La solución salina hipertónica al 2% no es superior al Ringer lactato o las gelatinas a pesar de incrementar significativamente la natremia.

Palabras clave:
coloides
solución salina hipertónica
shock hemorrágico
fluidoterapia
anestesia experimental
Objective

To study three differents solutions for resuscitation (lactated Ringer, hypertonic saline 2% and urea gelatin) in an experimental dog model for acute bleeding.

Materials and method

Eighteen dogs were anesthesied and monitorized. The dogs were bled down to 35% of their blood volume and randomized to recieve lactated Ringer (3 ml for ml blood lost) (n = 6), hypertonic saline 2% (1 ml for ml blood lost) (n = 6) or gelatines (1 ml for ml blood lost) (n = 6).

Results

All solutions studied were effective in restoring cardiac output, cardiac filling pressure and blood pressure. Pulmonary shunt increased with lactated Ringer.

Conclusions

Gelatines show more resuscitative effecacy than lactated Ringer. Hypertonic saline 2% is not superior to lactated Ringer or gelatines in resuscitation from hemorrhagic shock. Lactated Ringer increased pulmonary shunt.

Key words:
colloids
hypertonic saline
crystalloids
hemorrhagic shock
fluidotherapy
anesthesia experimental
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Copyright © 2000. Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L.
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