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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se efect&#250;a una revisi&#243;n de las caracter&#237;sticas y significado de la respuesta inflamatoria&#46; Se describen las reacciones programadas que se desencadenan cuando la respuesta inflamatoria se generaliza y se analizan los mecanismos de puesta en marcha y finalizaci&#243;n del proceso&#46;</p> <span class="elsevierStyleSectionTitle">Material</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Revisi&#243;n bibliogr&#225;fica de los estudios recogidos en Medline&#46;</p> <span class="elsevierStyleSectionTitle">Resumen de la revisi&#243;n</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Tras la agresi&#243;n se desencadena una serie de respuestas org&#225;nicas programadas que tienden a limitar el cuadro inflamatorio&#46; La p&#233;rdida del control local induce una respuesta inflamatoria generalizada&#44; r&#225;pida y ampliada&#44; controlada humoral y celularmente &#40;complemento&#44; cininas&#44; coagulaci&#243;n y cascada fibrinol&#237;tica&#41; y desencadenada por la activaci&#243;n conjunta de fagocitos y c&#233;lulas endoteliales&#46; Si esta respuesta inflamatoria no es adecuadamente modulada&#44; se origina un sindrome inflamatorio sist&#233;mico&#44; que puede alterar el metabolismo intermediario y el funcionalismo de los diferentes &#243;rganos&#46; Se describe el complejo entramado de los mediadores de la inflamaci&#243;n&#44; as&#237; como sus relaciones con la respuesta neuroendocrina y con la respuesta de fase aguda&#46; Se pasa revista a los mecanismos que ponen en marcha la respuesta inflamatoria y a los sistemas org&#225;nicos establecidos para su modulaci&#243;n o contrarregulaci&#243;n&#46; Se concluye en la necesidad de sistematizar el estudio de las diferentes respuestas a la inflamaci&#243;n&#44; con fines pron&#243;sticos y terap&#233;uticos&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Inflammatory response characteristics and significance are reviewed&#46; The programmed reactions which are displayed when the reactions is widespread and those mechanisms involved in its onset and ending are analysed&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Systematic review of Medline&#8217;s bibliography&#46;</p> <span class="elsevierStyleSectionTitle">Review&#8217;s summary</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">When injury ensues&#44; there are several programmed reactions displayed which tend to restrict the inflammatory reaction&#46; When local control is overwhelmed&#44; a quick and generalized reaction promoted by the joint activation of phagocytes and endotelial cells and under humoral and cellular control &#40;complement&#44; citokynes&#44; clotting and fibrinolysis&#41; takes place&#46; As long as this inflammatory reaction is not adequately suppressed&#44; a systemic inflammatory syndrome ensues which may disturb the intermediate metabolism and several organ function&#46; Inflammatory mediators are described&#44; as well as their role in the neuroendocrine and in the acute phase reaction&#46; Mechanisms involved in the onset of the inflammatory reaction and its up or downregulation are reviewd&#46; To sum up&#44; we stress the need of systematic approaches to study the different reactions to inflammation if we try to achieve improvements in prognosis and therapy&#46;</p>"
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Vol. 24. Núm. 8.
Páginas 353-360 (noviembre 2000)
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Vol. 24. Núm. 8.
Páginas 353-360 (noviembre 2000)
Acceso a texto completo
Respuesta inflamatoria sistémica: fisiopatología y mediadores
Systemic inflammatory response: pathophysiology and mediators
Visitas
484533
A. García de lorenzo y mateos*,1, J. López martínez**, M. Ssánchez castilla***
* Servicio de Medicina Intensiva. Hospital Universitario La Paz
** Unidad de Cuidados Intensivos
*** Servicio de Anestesia y Reanimación. Hospital Severo Ochoa. Leganés. Madrid
Este artículo ha recibido
Información del artículo
Introducción

Se efectúa una revisión de las características y significado de la respuesta inflamatoria. Se describen las reacciones programadas que se desencadenan cuando la respuesta inflamatoria se generaliza y se analizan los mecanismos de puesta en marcha y finalización del proceso.

Material

Revisión bibliográfica de los estudios recogidos en Medline.

Resumen de la revisión

Tras la agresión se desencadena una serie de respuestas orgánicas programadas que tienden a limitar el cuadro inflamatorio. La pérdida del control local induce una respuesta inflamatoria generalizada, rápida y ampliada, controlada humoral y celularmente (complemento, cininas, coagulación y cascada fibrinolítica) y desencadenada por la activación conjunta de fagocitos y células endoteliales. Si esta respuesta inflamatoria no es adecuadamente modulada, se origina un sindrome inflamatorio sistémico, que puede alterar el metabolismo intermediario y el funcionalismo de los diferentes órganos. Se describe el complejo entramado de los mediadores de la inflamación, así como sus relaciones con la respuesta neuroendocrina y con la respuesta de fase aguda. Se pasa revista a los mecanismos que ponen en marcha la respuesta inflamatoria y a los sistemas orgánicos establecidos para su modulación o contrarregulación. Se concluye en la necesidad de sistematizar el estudio de las diferentes respuestas a la inflamación, con fines pronósticos y terapéuticos.

Palabras clave:
inflamación
Sirs
citocinas
mediadores inflamatorios
Introduction

Inflammatory response characteristics and significance are reviewed. The programmed reactions which are displayed when the reactions is widespread and those mechanisms involved in its onset and ending are analysed.

Methods

Systematic review of Medline’s bibliography.

Review’s summary

When injury ensues, there are several programmed reactions displayed which tend to restrict the inflammatory reaction. When local control is overwhelmed, a quick and generalized reaction promoted by the joint activation of phagocytes and endotelial cells and under humoral and cellular control (complement, citokynes, clotting and fibrinolysis) takes place. As long as this inflammatory reaction is not adequately suppressed, a systemic inflammatory syndrome ensues which may disturb the intermediate metabolism and several organ function. Inflammatory mediators are described, as well as their role in the neuroendocrine and in the acute phase reaction. Mechanisms involved in the onset of the inflammatory reaction and its up or downregulation are reviewd. To sum up, we stress the need of systematic approaches to study the different reactions to inflammation if we try to achieve improvements in prognosis and therapy.

Key words:
Inflammation
Sirs
citokines
inflammatory mediators
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Copyright © 2000. Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L.
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