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Clinical Significance of Acute Coronary Syndrome with Transient ST-Segment Elevation
Significado clínico del síndrome coronario agudo con elevación transitoria del segmento ST
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Arroyo Úcar, A. Domínguez-Rodríguez, R. Juárez Prera, G. Blanco Palacios, C. Hernández García, M. Carrillo-Pérez Tome, P. Abreu-González" "autores" => array:7 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Arroyo Úcar" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Domínguez-Rodríguez" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Juárez Prera" ] 3 => array:2 [ "nombre" => "G." "apellidos" => "Blanco Palacios" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Hernández García" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Carrillo-Pérez Tome" ] 6 => array:2 [ "nombre" => "P." "apellidos" => "Abreu-González" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572711000038?idApp=WMIE" "url" => "/21735727/0000003500000005/v2_201212101038/S2173572711000038/v2_201212101038/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Clinical Significance of Acute Coronary Syndrome with Transient ST-Segment Elevation" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "267" "paginaFinal" => "269" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Latour-Pérez, J.B. Cabello" "autores" => array:2 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Latour-Pérez" "email" => array:1 [ 0 => "jlatour@coma.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J.B." "apellidos" => "Cabello" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Intensiva, Hospital General Universitario de Elche, Elche, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital General Universitario de Alicante, Coordinación de CASP-España, Alicante, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Significado clínico del síndrome coronario agudo con elevación transitoria del segmento ST" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The electrocardiographic evidence of injury appears in the presence of evident diastolic depolarization due to an important reduction in blood supply or other non-ischemic causal factors. This in turn leads to a “defective” transmembrane action potential reflected upon the ECG tracing as an ST-segment deviation. When diastolic depolarization occurs at subendocardial level, an ST-segment descent appears on the ECG, while depolarization at subepicardial (or transmural) level gives rise to ST-segment elevation.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In patients with acute coronary syndrome (ACS), the ST-segment elevation pattern is associated to rupture or fissuring of an unstable atheroma plaque, with acute thrombotic occlusion of an epicardial artery in a patient without previous important ischemia (ACS with ST-segment elevation [ACSSTE]). When occlusion is incomplete or distal flow is present thanks to collateral circulation, ST-segment elevation is not observed (ACS without ST-segment elevation [ACSWSTE]).<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4</span></a> The initial management of ACSSTE involves emergency aperture of permeation of the affected artery through pharmacological (thrombolysis) or mechanical means (percutaneous revascularization). In contrast, thrombolysis is not effective in ACSWSTE, and coronary revascularization in such cases is not an immediate emergency concern.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In a small group of patients ST-segment elevation is transient (less than 20<span class="elsevierStyleHsp" style=""></span>min). According to the current criteria of the International Society for Holter and Noninvasive Electrocardiology,<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> such cases correspond to patients with a “predominance of ST-segment elevation” that are in turn subclassified according to the degree of elevation of the myocardial necrosis markers as either “aborted infarctions” or “infarctions without ST-segment elevation”. The main ACS management guides have not defined a specific designation for these patients, and include ACS with transient ST-segment elevation within the group of ACSWSTE.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In this number of <span class="elsevierStyleSmallCaps">Medicina Intensiva</span>, Arroyo-Úcar et al.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> report that patients with ACS and transient ST-segment elevation exhibit a characteristic profile that differentiates them from the rest of patients with ACSWSTE: younger age, a greater prevalence of males and smokers, a lesser elevation of the necrosis markers, a greater ejection fraction and a higher prevalence of single-vessel disease.</p><p id="par0025" class="elsevierStylePara elsevierViewall">These results are consistent with those of the previous studies. In this context, Drew et al.,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> in a study involving continuous ST-segment monitorization, found patients with episodes of ST-segment elevation to have a greater frequency of single-vessel disease, while patients with ST-segment depression showed more frequent multivessel disease.</p><p id="par0030" class="elsevierStylePara elsevierViewall">In turn, Meisel et al.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> found that in comparison with the group of patients with persistent ST-segment elevation, those with ACS and transient ST-segment elevation showed a lesser creatine kinase peak, a greater ejection fraction, less extensive coronary disease, a greater prevalence of TIMI III flow, and fewer coronary events over the course of follow-up.</p><p id="par0035" class="elsevierStylePara elsevierViewall">This profile of limited myocardial damage with normal systolic function refers us to the known good prognosis of patients with ACSSTE that normalize their ST-segment after thrombolysis,<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,9</span></a> or to the patients subjected to primary percutaneous coronary revascularization with initial TIMI III flow.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> However, in the recent metaanalysis of individual patients included in the FRISC-II, RITA and ICTUS trials, the cardiovascular mortality or infarction risk was found to be practically identical in the patients with transient elevation of depression of the ST-segment (19.2% versus 19.4%, respectively).<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Some authors have suggested that initial conservative management may be indicated in these cases, considering their supposedly good prognosis.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> However, as correctly commented by Arroyo-Úcar et al., the treatment of ACS with transient ST-segment elevation has not been well established, and the ACSWSTE management guides offer no specific recommendations for such cases.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,4</span></a> Therefore, an important gap in knowledge is found in this field that must be filled by future research work.</p><p id="par0045" class="elsevierStylePara elsevierViewall">It should be mentioned that the study of ACS with transient ST-segment elevation poses some specific difficulties. Firstly, transient ST-segment elevation is not a nosologic entity as such but rather a clinical sign that may be due to causes other than coronary thrombosis, such as coronary vasospasm (variant angina) or transient apical dysfunction syndrome (tako-tsubo syndrome),<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">13</span></a> among other anecdotal conditions<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14–17</span></a> with different therapeutic connotations. On the other hand, the dividing or differentiating lines between some of these disease conditions have not been well defined.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> The section of the ARIAM study corresponding to 2010 identified 64 patients with transient ST-segment elevation out of a total of 1379 patients with an initial diagnosis of ACS (4.6%); of these, 3 were classified as corresponding to Prinzmetal angina, 12 as unstable angina (“aborted infarctions”), 45 as infarctions, and 4 as other conditions/causes (unpublished data).</p><p id="par0050" class="elsevierStylePara elsevierViewall">Secondly, the dynamic nature of ACS must be stressed, with frequent episodes of myocardial ischemia due to thrombus formation and lysis, intermittent vasoconstriction and platelet thrombus embolization.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> As an example, we can consider the case of a patient with persistent subepicardial damage secondary to thrombotic occlusion of an artery, exhibiting spontaneous reperfusion. Depending on the moment of the ECG recording, the patient may be classified as presenting ACSSTE (early ECG), ACS with transient ST-segment elevation (ECG tracing immediately before reperfusion), or ACSWSTE (late ECG tracing).</p><p id="par0055" class="elsevierStylePara elsevierViewall">In principle, continuous ST-segment monitoring with multiple leads could obviate the low sensitivity associated with surface ECG recordings in detecting transient ST-segment elevation. Caution is required, however, since studies with conventional ECG and those based on continuous ECG monitorization differ not only in the diagnostic tool used but also in the population under evaluation. In the former case, subjects with transient ST-segment elevation are patients who have probably experienced spontaneous reperfusion. The latter case in turn corresponds to individuals who continue to suffer ischemic episodes, and is therefore at an increased risk of developing coronary events.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20,21</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In any case, the scientific evidence regarding the management of these patients should be derived from randomized clinical trials involving patients with ACS with transient ST-segment elevation. Until such information becomes available, non-randomized studies fitting for treatment tendencies or systematic reviews of randomized trials (analyses of subgroups according to the initial ECG pattern) could contribute useful evidence for decision taking in this important group of patients.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2011-03-13" "fechaAceptado" => "2011-03-14" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Latour-Pérez J, Cabello JB. Significado clínico del síndrome coronario agudo con elevación transitoria del segmento ST. 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| Year/Month | Html | Total | |
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| 2024 November | 10 | 12 | 22 |
| 2024 October | 51 | 59 | 110 |
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| 2024 May | 75 | 49 | 124 |
| 2024 April | 70 | 35 | 105 |
| 2024 March | 62 | 26 | 88 |
| 2024 February | 76 | 44 | 120 |
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| 2023 December | 76 | 40 | 116 |
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| 2023 October | 78 | 25 | 103 |
| 2023 September | 51 | 30 | 81 |
| 2023 August | 22 | 19 | 41 |
| 2023 July | 43 | 21 | 64 |
| 2023 June | 17 | 10 | 27 |
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