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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The tumor lysis syndrome &#40;TLS&#41; is a life-threatening complication caused by the massive release of nucleic acids&#44; potassium and phosphate into the blood&#46; This complication is the result of tumor cell lysis&#44; which may occur due to treatment of drug sensitive and is characterized by rapid capacity of proliferation&#44; that is often hematological origin&#46; Moreover&#44; the TLS can be observed before starting the treatment due to spontaneous tumor cell death&#44; and frequently worsens when chemotherapy is initiated&#46; TLS has high mortality&#44; so that its prevention continues to be the most important therapeutic measure&#46; In the intensive care unit &#40;ICU&#41;&#44; physicians should be aware of the clinical characteristics of TLS&#44; which results in severe electrolyte metabolism disorders&#44; especially hyperkalemia&#44; hyperphosphatemia and hypocalcemia&#44; and acute kidney injury which is a major cause of ICU mortality&#46; An adequate strategy for the management of the TLS&#44; combining hydration&#44; urate oxidase&#44; and an early admission to ICU can control this complication in most patients&#46; The aim of this review is to provide diagnostic tools that allow to the ICU physician to recognize the population at high risk for developing the TLS&#44; and outline a proper strategy for treating and preventing this serious complication&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome de lisis tumoral &#40;SLT&#41; es una complicaci&#243;n potencialmente letal provocada por la liberaci&#243;n masiva de &#225;cidos nucleicos&#44; potasio y fosfato hacia la circulaci&#243;n sist&#233;mica&#46; Este cuadro es el resultado de la lisis celular de neoplasias&#44; con frecuencia hematol&#243;gicas&#44; las cuales se caracterizan por una r&#225;pida capacidad de proliferaci&#243;n y alta sensibilidad a f&#225;rmacos&#46; Por otra parte&#44; el SLT se puede observar por muerte celular espont&#225;nea previo al inicio del tratamiento citorreductor&#44; agrav&#225;ndose luego de iniciada la quimioterapia&#46; El SLT presenta una alta mortalidad&#44; por lo que su prevenci&#243;n contin&#250;a siendo la medida terap&#233;utica m&#225;s importante&#46; En la unidad de cuidados intensivos los m&#233;dicos deben conocer su cuadro cl&#237;nico&#44; el cual se caracteriza por la existencia de graves trastornos del metabolismo hidroelectrol&#237;tico&#44; en particular hiperpotasemia&#44; hiperfosfatemia e hipocalcemia y por la aparici&#243;n de una lesi&#243;n renal aguda&#46; Una adecuada intervenci&#243;n terap&#233;utica implica la r&#225;pida admisi&#243;n a unidad de cuidados intensivos&#44; hidrataci&#243;n intravenosa y aporte de la enzima urato-oxidasa como las medidas m&#225;s importantes&#46; El objetivo de la presente revisi&#243;n es proporcionar herramientas diagn&#243;sticas y terap&#233;uticas que le permiten al m&#233;dico intensivista reconocer la poblaci&#243;n en riesgo de desarrollar este s&#237;ndrome&#44; as&#237; como establecer una adecuada estrategia terap&#233;utica y profil&#225;ctica&#46;</p>"
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Tumor lysis syndrome in intensive therapy: diagnostic and therapeutic encare
Síndrome de lisis tumoral en terapia intensiva: encare diagnóstico y terapéutico
G. Burghi
Corresponding author
burghig@gmail.com

Corresponding author.
, D. Berrutti, W. Manzanares
Cátedra y Centro de Tratamiento Intensivo del Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The tumor lysis syndrome &#40;TLS&#41; is a life-threatening complication caused by the massive release of nucleic acids&#44; potassium and phosphate into the blood&#46; This complication is the result of tumor cell lysis&#44; which may occur due to treatment of drug sensitive and is characterized by rapid capacity of proliferation&#44; that is often hematological origin&#46; Moreover&#44; the TLS can be observed before starting the treatment due to spontaneous tumor cell death&#44; and frequently worsens when chemotherapy is initiated&#46; TLS has high mortality&#44; so that its prevention continues to be the most important therapeutic measure&#46; In the intensive care unit &#40;ICU&#41;&#44; physicians should be aware of the clinical characteristics of TLS&#44; which results in severe electrolyte metabolism disorders&#44; especially hyperkalemia&#44; hyperphosphatemia and hypocalcemia&#44; and acute kidney injury which is a major cause of ICU mortality&#46; An adequate strategy for the management of the TLS&#44; combining hydration&#44; urate oxidase&#44; and an early admission to ICU can control this complication in most patients&#46; The aim of this review is to provide diagnostic tools that allow to the ICU physician to recognize the population at high risk for developing the TLS&#44; and outline a proper strategy for treating and preventing this serious complication&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome de lisis tumoral &#40;SLT&#41; es una complicaci&#243;n potencialmente letal provocada por la liberaci&#243;n masiva de &#225;cidos nucleicos&#44; potasio y fosfato hacia la circulaci&#243;n sist&#233;mica&#46; Este cuadro es el resultado de la lisis celular de neoplasias&#44; con frecuencia hematol&#243;gicas&#44; las cuales se caracterizan por una r&#225;pida capacidad de proliferaci&#243;n y alta sensibilidad a f&#225;rmacos&#46; Por otra parte&#44; el SLT se puede observar por muerte celular espont&#225;nea previo al inicio del tratamiento citorreductor&#44; agrav&#225;ndose luego de iniciada la quimioterapia&#46; El SLT presenta una alta mortalidad&#44; por lo que su prevenci&#243;n contin&#250;a siendo la medida terap&#233;utica m&#225;s importante&#46; En la unidad de cuidados intensivos los m&#233;dicos deben conocer su cuadro cl&#237;nico&#44; el cual se caracteriza por la existencia de graves trastornos del metabolismo hidroelectrol&#237;tico&#44; en particular hiperpotasemia&#44; hiperfosfatemia e hipocalcemia y por la aparici&#243;n de una lesi&#243;n renal aguda&#46; Una adecuada intervenci&#243;n terap&#233;utica implica la r&#225;pida admisi&#243;n a unidad de cuidados intensivos&#44; hidrataci&#243;n intravenosa y aporte de la enzima urato-oxidasa como las medidas m&#225;s importantes&#46; El objetivo de la presente revisi&#243;n es proporcionar herramientas diagn&#243;sticas y terap&#233;uticas que le permiten al m&#233;dico intensivista reconocer la poblaci&#243;n en riesgo de desarrollar este s&#237;ndrome&#44; as&#237; como establecer una adecuada estrategia terap&#233;utica y profil&#225;ctica&#46;</p>"
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