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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In the last decade severe sepsis and septic shock have been the subject of intense study&#44; and the expanding body of scientific evidence has afforded better and more in-depth understanding of this pathology&#46; A simple PubMed search of these terms shows that in the period between 1001 and 2011&#44; the number of published articles doubled that of the preceding decade&#46; Severe sepsis is characterized by high mortality&#44; particularly when associated to shock&#46; Moreover&#44; several epidemiological studies have reported an increase in the incidence of severe sepsis&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Please tag and link citations&#47;tables&#47;figures throughout the text accordingly&#46; In Spain&#44; the incidence of severe sepsis is 104 cases per 100&#44;000<span class="elsevierStyleHsp" style=""></span>inhabitants&#47;year&#44; while the incidence of septic shock is 31 cases per 100&#44;000<span class="elsevierStyleHsp" style=""></span>inhabitants&#47;year&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The Surviving Sepsis Campaign &#40;SSC&#41; was launched in 2002&#44; as an important effort to understand and adequately treat severe sepsis and septic shock&#46; This is an international initiative&#44; sustained by different scientific societies dedicated to critical care throughout the world&#44; with the purpose of reducing mortality attributable to this pathology through the development and implementation of clinical practice guides&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> One of the most relevant contributions of the SSC has been the &#8220;time-dependency&#8221; concept&#44; i&#46;e&#46;&#44; in the same way as in other acute disease conditions&#44; the lesser the time elapsed from the onset of damage to the adoption of treatment measures&#44; the lesser the incidence of organ dysfunction and thus also of patient mortality&#46; An illustrative way of referring to this would be&#58; &#8220;Time is tissue&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Accordingly&#44; the SSC guide includes the recommendation to provide treatment with the shortest delay possible once the diagnosis has been established&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">It is well known that the development of management guides alone does not lead to changes in daily clinical practice&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Consequently&#44; phase III of the SSC comprised the development of multimodal continuous education programs to ensure that up to date knowledge is conveniently transferred to the routine care of septic patients&#46; These programs incorporated &#8220;bundles&#8221; of measures designed to objectively evaluate adherence to the treatment guides&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The Edusepsis study&#44; carried out in 59 Spanish Intensive Care Units &#40;ICUs&#41;&#44; demonstrated that the application of an educational program aiming to improve adherence to the SCC guides leads to increased compliance with the treatment &#8220;bundles&#8221;&#44; and to a decrease in mortality associated to severe sepsis&#47;septic shock&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> This project also helped the participating ICUs to improve the evaluation of their own clinical practice&#46; An example of this is provided by the Department of Intensive Care Medicine of Donostia Hospital in Guip&#250;zcoa&#44; where the creation of a proprietary registry has allowed the Department to evaluate and improve the management of patients with severe sepsis and septic shock &#8211; the results obtained being reflected in the article published in the present issue of <span class="elsevierStyleItalic">Medicina Intensiva</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Thanks to the work of Azk&#225;rate et al&#46;&#44; and based on their own objective data rather than on mere impressions&#44; it is possible to identify areas offering opportunities for improvement in the treatment of sepsis and to implement interventions designed to improve the results obtained&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">At present&#44; the intensivists of several hospitals are conducting initiatives to improve coordination in the management of sepsis&#44; including for example the introduction of the Sepsis Code&#44; Multidisciplinary Sepsis Units or Rapid Response Teams especially dedicated to sepsis&#46; These initiatives imply a change in paradigm in which the intensivist is required to play a role outside the ICU in order to offer early treatment for these patients&#46; In parallel to the efforts launched in each center&#44; in the course of the present year a new intervention has been made in over 100 centers throughout Spain&#46; The ABISS-Edusepsis study evaluates a multiple intervention designed to improve early empirical antibiotic treatment in sepsis with the purpose of reducing mortality&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We believe that only through continuous and coordinated effort will we be able to reduce mortality in septic patients and improve the quality of life of the population&#46; Much has been done&#44; but much also remains to be done&#46;</p></span>"
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Editorial
Severe sepsis and septic shock: Everything done, everything to be done
Sepsis grave y shock séptico: Todo hecho, todo por hacer
E. Piacentini, R. Ferrer
Servicio de Medicina Intensiva, Hospital Universitario Mutua de Terrassa, Universidad de Barcelona, CIBER Enfermedades Respiratorias, Terrassa, Barcelona, Spain
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    "titulo" => "Severe sepsis and septic shock&#58; Everything done&#44; everything to be done"
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        "autoresLista" => "E&#46; Piacentini, R&#46; Ferrer"
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            "entidad" => "Servicio de Medicina Intensiva&#44; Hospital Universitario Mutua de Terrassa&#44; Universidad de Barcelona&#44; CIBER Enfermedades Respiratorias&#44; Terrassa&#44; Barcelona&#44; Spain"
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      "es" => array:1 [
        "titulo" => "Sepsis grave y shock s&#233;ptico&#58; Todo hecho&#44; todo por hacer"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In the last decade severe sepsis and septic shock have been the subject of intense study&#44; and the expanding body of scientific evidence has afforded better and more in-depth understanding of this pathology&#46; A simple PubMed search of these terms shows that in the period between 1001 and 2011&#44; the number of published articles doubled that of the preceding decade&#46; Severe sepsis is characterized by high mortality&#44; particularly when associated to shock&#46; Moreover&#44; several epidemiological studies have reported an increase in the incidence of severe sepsis&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Please tag and link citations&#47;tables&#47;figures throughout the text accordingly&#46; In Spain&#44; the incidence of severe sepsis is 104 cases per 100&#44;000<span class="elsevierStyleHsp" style=""></span>inhabitants&#47;year&#44; while the incidence of septic shock is 31 cases per 100&#44;000<span class="elsevierStyleHsp" style=""></span>inhabitants&#47;year&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The Surviving Sepsis Campaign &#40;SSC&#41; was launched in 2002&#44; as an important effort to understand and adequately treat severe sepsis and septic shock&#46; This is an international initiative&#44; sustained by different scientific societies dedicated to critical care throughout the world&#44; with the purpose of reducing mortality attributable to this pathology through the development and implementation of clinical practice guides&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> One of the most relevant contributions of the SSC has been the &#8220;time-dependency&#8221; concept&#44; i&#46;e&#46;&#44; in the same way as in other acute disease conditions&#44; the lesser the time elapsed from the onset of damage to the adoption of treatment measures&#44; the lesser the incidence of organ dysfunction and thus also of patient mortality&#46; An illustrative way of referring to this would be&#58; &#8220;Time is tissue&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Accordingly&#44; the SSC guide includes the recommendation to provide treatment with the shortest delay possible once the diagnosis has been established&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">It is well known that the development of management guides alone does not lead to changes in daily clinical practice&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Consequently&#44; phase III of the SSC comprised the development of multimodal continuous education programs to ensure that up to date knowledge is conveniently transferred to the routine care of septic patients&#46; These programs incorporated &#8220;bundles&#8221; of measures designed to objectively evaluate adherence to the treatment guides&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The Edusepsis study&#44; carried out in 59 Spanish Intensive Care Units &#40;ICUs&#41;&#44; demonstrated that the application of an educational program aiming to improve adherence to the SCC guides leads to increased compliance with the treatment &#8220;bundles&#8221;&#44; and to a decrease in mortality associated to severe sepsis&#47;septic shock&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> This project also helped the participating ICUs to improve the evaluation of their own clinical practice&#46; An example of this is provided by the Department of Intensive Care Medicine of Donostia Hospital in Guip&#250;zcoa&#44; where the creation of a proprietary registry has allowed the Department to evaluate and improve the management of patients with severe sepsis and septic shock &#8211; the results obtained being reflected in the article published in the present issue of <span class="elsevierStyleItalic">Medicina Intensiva</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Thanks to the work of Azk&#225;rate et al&#46;&#44; and based on their own objective data rather than on mere impressions&#44; it is possible to identify areas offering opportunities for improvement in the treatment of sepsis and to implement interventions designed to improve the results obtained&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">At present&#44; the intensivists of several hospitals are conducting initiatives to improve coordination in the management of sepsis&#44; including for example the introduction of the Sepsis Code&#44; Multidisciplinary Sepsis Units or Rapid Response Teams especially dedicated to sepsis&#46; These initiatives imply a change in paradigm in which the intensivist is required to play a role outside the ICU in order to offer early treatment for these patients&#46; In parallel to the efforts launched in each center&#44; in the course of the present year a new intervention has been made in over 100 centers throughout Spain&#46; The ABISS-Edusepsis study evaluates a multiple intervention designed to improve early empirical antibiotic treatment in sepsis with the purpose of reducing mortality&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We believe that only through continuous and coordinated effort will we be able to reduce mortality in septic patients and improve the quality of life of the population&#46; Much has been done&#44; but much also remains to be done&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Piacentini E&#44; Ferrer R&#46; Sepsis grave y shock s&#233;ptico&#58; Todo hecho&#44; todo por hacer&#46; 2012&#59;36&#58;245&#8211;6&#46;</p>"
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